The impact of thermal treatment on the stability of freeze dried amorphous pharmaceuticals: I. Dimer formation in sodium ethacrynate

Journal of Pharmaceutical Sciences

Volumn 99, Issue 2, 2010, Pages 663-682

  Wang, Bingquan ^a   Pikal, Michael J ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Aging; Annealing; Calorimetry; Chemical stability; Dynamics by neutron scattering; Enthalpy recovery; Ethacrynate; Fast local dynamics; Fictive temperature; Free volume; Freeze drying; Global dynamics; Molecular mobility; Solid state; Structural relaxation time; Thermal treatment

Indexed keywords

DIMER; ETACRYNIC ACID; ETACRYNIC ACID SODIUM; SODIUM; SUCROSE; TREHALOSE; UNCLASSIFIED DRUG;

ARTICLE; DEGRADATION; DENSITY; DIMERIZATION; DRUG FORMULATION; DRUG STABILITY; ENTHALPY; FREEZE DRYING; HEAT TREATMENT; MOLECULAR DYNAMICS; NEUTRON SCATTERING; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLID; TEMPERATURE;

EID: 74049108586     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21959     Document Type: Article

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