True density analysis of a freeze-dried amorphous sugar matrix

Journal of Pharmaceutical Sciences

Volumn 97, Issue 7, 2008, Pages 2789-2797

  Imamura, Koreyoshi ^a   Maruyama, Yoshinobu ^a   Tanaka, Kazuhiro ^a   Yokoyama, Tohru ^a   Imanaka, Hiroyuki ^a   Nakanishi, Kazuhiro ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

Compression; Excipients; Freeze drying; Glass; Molecular dynamics

Indexed keywords

1 O ALPHA DEXTRO GLUCOPYRANOSYL ALPHA DEXTRO GLUCOPYRANOSIDE; 4 O ALPHA DEXTRO GLUCOPYRANOSYL ALPHA DEXTRO GLUCOPYRANOSIDE; BETA DEXTRO FRUCTOFURANOSYL ALPHA DEXTRO GLUCOPYRANOSIDE; CARBOHYDRATE DERIVATIVE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CHEMICAL STRUCTURE; DENSITOMETRY; FREEZE DRYING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; PHYSICAL CHEMISTRY; PYCNOMETRY; SIMULATION;

EID: 52449103218     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21202     Document Type: Article

References (22)

1. van den Dries IJ, van Dusschoten D, Hemminga MA, van der Linden E. 2000. Effects of water content and molecular weight on spin probe and water mobility in malto-oligomer glasses. J Phys Chem B 104:10126-10132.
2. Imamura K, Sakaura K, Ohyama K, Fukushima A, Imanaka H, Sakiyama T, Nakanishi K. 2006. Temperature scanning FTIR analysis of hydrogen bonding states of various saccharides in amorphous matrixes below and above their glass transition temperatures. J Phys Chem B 110:15094-15099.
3. Hancock BC, Zografi G. 1994. The relationship between the glass transition temperature and the water content of amorphous pharmaceutical solids. Pharm Res 11:471-477.
4. Sebhatu T, Ahlneck C, Alderborn G. 1997. The effect of moisture content on the compression and bond-formation properties of amorphous lactose particles. Int J Pharm 146:101-114.
5. Burger A, Henck J-O, Rollinger JM, Weissnicht AA. 2000. Energy/temperature diagram and compression behavior of the polymorphs of D-mannitol. J Pharm Sci 89:457-468.
6. Christensen KL, Pedersen GP, Kristensen HG. 2002. Physical stability of redispersible dry emulsions containing amorphous sucrose. Eur J Pharm Biopharm 53:147-153.
7. Berggren J, Frenning G, Alderborn G. 2004. Compression behavior and tablet-forming ability of spray-dried amorphous composite particles. Eur J Pharm Sci 22:191-200.
8. Elversson J, Millqvist-Fureby A. 2005. Particle size and density in spray drying-Effects of carbohydrate properties. J Pharm Sci 94:2049-2060.
9. Sun C. 2005. True density of microcrystalline cellulose. J Pharm Sci 94:2132-2134.
10. Sun C. 2005. Quantifying errors in tableting data analysis using the Ryshkewitch equation due to inaccurate true density. J Pharm Sci 94:2061-2068.
11. British Standard Institution. 1958. British standard Glossary of terms relating to powders. British Standards Institution, London.
12. Kauzman W. 1948. The nature of the glassy state and the behavior of liquids at low temperatures. Chem Rev 43:219-256.
13. Allinger NL, Yuh YH, Lii J-J. 1977. Conformational analysis. 130.A Hydrocarbon force field utilizing V1 and V2 torsional terms. J Am Chem Soc 99:8127-8134.
14. HyperChem, Computational Chemistry, Hypercube Inc. 1996. Using Molecular Mechanics Methods. pp 101-106.
15. Hancock BC, Zografi G. 1997. Characteristics and significance of the amorphous state in pharmaceutical systems. J Pharm Sci 86:1-12.
16. Sun C. 2004. A novel method for deriving true density of pharmaceutical solids including hydrates and water-containing powders. J Pharm Sci 93: 646-653.
17. Budvari S. 1989. Merck Index. Rahway: Merck &Co.
18. Saleki-Gerhardt A, Ahlneck C, Zografi G. 1994. Assessment of disorder in crystalline solids. Int J Pharm 101:237-247.
19. Zhang J, Zografi G. 2000. The relationship between "BET"- and "Free Volume"-derived parameters for water vapor absorption into amorphous solids. J Pharm Sci 89:1063-1072.
20. Zhang J, Zografi G. 2001. Water vapor absorption into amorphous sucrose-poly(vinylpyrrolidone) and trehalose-poly(vinyl pyrrolidone) mixtures. J Pharm Sci 90:1375-1385.
21. Wolkers WF, Oliver AE, Tablin F, Crowe JH. 2004. A Fourier-transform infrared spectroscopy study of sugar glasses. Carbohydr Res 339:1077-1092.
22. http://winmostar.com/