The solid-state stability of amorphous quinapril in the presence of β-cyclodextrins

Journal of Pharmaceutical Sciences

Volumn 91, Issue 1, 2002, Pages 229-243

  Li, Jinjiang ^a   Guo, Yushen ^b   Zografi, George ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Chemical degradation; Complexation; Cyclodextrins; Glass transition; Quinapril

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; BETA CYCLODEXTRIN; DEXTRAN; QUINAPRIL; TREHALOSE;

ARTICLE; COMPLEX FORMATION; DRUG DEGRADATION; DRUG MIXTURE; DRUG STABILITY; FREEZE DRYING; GLASS TRANSITION TEMPERATURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFRARED RADIATION; PHASE SEPARATION; PROTON NUCLEAR MAGNETIC RESONANCE; SOLID STATE;

EID: 0036143366     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10014     Document Type: Article

References (33)

1. Thermal induced organic reactions in the solid state
2. Characteristics and significance of the amorphous state in pharmaceutical systems
3. How does residual water affect the solid-state degradation of drugs in the amorphous state?
4. Crystallization of amorphous indomethacin above and below its glass transition temperature
5. Mechanical activation of pharmaceutical systems
6. The molecular basis of moisture effects on the physical and chemical stability of drugs in the solid state
7. Effects of processing on the solid-state methyl transfer of tetraglycine methyl ester
8. Physical characteristics and chemical degradation of amorphous quinapril hydrochloride
9. Effects of lyophilization on the physical characteristics and chemical stability of amorphous quinapril hydrochloride
10. Mixing behavior of colyophilized binary systems
11. The stability of cyclodextrin complexes in solution
12. Importance of glass transition temperature in accelerated stability testing of amorphous solids: Case study using a lyophilized aspirin formulation
13. Influence of formulation technique for hydroxypropyl-β-cyclodextrin on the stability of aspirin in HFA 134a
14. The effect of humidity on the stability of diclofenac sodium in inclusion complex with β-cyclodextrin in the solid state
15. Preparation of cinnarizine/β-cyclodextrin inclusion complex by spray-drying method and the stability of complex in solid state
16. Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds: A divergence of structure - Activity relationships for non-sulfhydryl and sulfhydryl types
17. Field-induced thermally stimulated currents
18. High-field nuclear magnetic resonance techniques for the investigation of a β-cyclodextrin: Indomethacin inclusion complex
19. The inclusion compounds of β-cyclodextrin with 4-substituted benzoic acid and benzaldehyde drugs studied by proton nuclear magnetic resonance spectroscopy
20. Inclusion complexation of steroid hormones with cyclodextrins in water and in solid phase
21. Improvement of dissolution properties of furosemide by complexation with β-cyclodextrin
22. Molecular behavior, dissolution characteristics and chemical stability of aspirin in the ground mixture and in the inclusion complex with di-O-methyl-β-cyclodextrin
23. Perspectives: Perspective on the glass transition
24. Cyclodextrins
25. A method for predicting the free energies of complexation between β-cyclodextrin and guest molecules
26. Population characteristics of cyclodextrin complex stabilities in aqueous solution
27. Formation of cyclodextrin inclusion complexes with corticosteroids: Their characterization and stability