Musculoskeletal molecular imaging: a comprehensive overview

Trends in Biotechnology

Volumn 28, Issue 2, 2010, Pages 93-101

  Reumann, Marie K ^a   Weiser, Mitchell C ^a   Mayer Kuckuk, Philipp ^a  

^a HOSPITAL FOR SPECIAL SURGERY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE DESTRUCTION; BONE FRACTURE; CELL BIOLOGY; CELL THERAPY; CELLULAR PROCESS; CLINICAL IMAGING; EMERGING APPLICATIONS; FLUORESCENCE TECHNIQUE; IN-VIVO; MOLECULAR IMAGING; NON-INVASIVE; OSTEOLYSIS;

BIOLOGICAL MATERIALS; CYTOLOGY; GENE THERAPY; MEDICAL IMAGING;

BONE;

BIOMATERIAL; BISPHOSPHONIC ACID DERIVATIVE; BONE MORPHOGENETIC PROTEIN 2; CALCIUM PHOSPHATE; ESTROGEN; ESTROGEN RECEPTOR; FLUORINE 18; GENTAMICIN; GREEN FLUORESCENT PROTEIN; HORMONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; METHOTREXATE; OPADRONATE; OSTEOCALCIN; OSTEOGENIC PROTEIN 1; OSTEOPROTEGERIN; PAMIDRONIC ACID; PARVOVIRUS VECTOR; TITANIUM; UNCLASSIFIED DRUG; ZOLEDRONIC ACID;

ADIPOSE TISSUE CELL; ARTHRITIS; BIOLUMINESCENCE; BONE CANCER; BONE DESTRUCTION; BONE METASTASIS; BONE REGENERATION; CELL ACTIVITY; CELL THERAPY; COMPUTER ASSISTED TOMOGRAPHY; CYTOLOGY; FLUORESCENCE ANALYSIS; FRACTURE; GENE THERAPY; GENE TRANSFER; HUMAN; IN VIVO STUDY; MEDICAL RESEARCH; MESENCHYMAL STEM CELL; MOLECULAR BIOLOGY; MOLECULAR IMAGING; MUSCULOSKELETAL DISEASE; NON INVASIVE MEASUREMENT; NONHUMAN; ONCOLOGY; ORTHOPEDICS; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; OSTEOMYELITIS; OUTCOME ASSESSMENT; PATHOLOGICAL ANATOMY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REPORTER GENE; REVIEW; RHEUMATOID ARTHRITIS; RHEUMATOLOGY; STAPHYLOCOCCUS AUREUS; TISSUE ENGINEERING; TOOTH IMPLANTATION; TREATMENT OUTCOME;

FLUORESCENCE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; LUMINESCENT MEASUREMENTS; MOLECULAR IMAGING; MUSCULOSKELETAL DISEASES;

EID: 74049096174     PISSN: 01677799     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibtech.2009.11.004     Document Type: Review

References (91)

1. Blasberg R.G., and Tjuvajev J.G. Molecular-genetic imaging: current and future perspectives. J. Clin. Invest. 111 (2003) 1620-1629
2. Gross S., and Piwnica-Worms D. Spying on cancer: molecular imaging in vivo with genetically encoded reporters. Cancer Cell 7 (2005) 5-15
3. Massoud T.F., and Gambhir S.S. Molecular imaging in living subjects: seeing fundamental biological processes in a new light. Genes Dev. 17 (2003) 545-580
4. Weissleder R., and Mahmood U. Molecular imaging. Radiology 219 (2001) 316-333
5. Honigman A., et al. Imaging transgene expression in live animals. Mol. Ther. 4 (2001) 239-249
6. Iris B., et al. Molecular imaging of the skeleton: quantitative real-time bioluminescence monitoring gene expression in bone repair and development. J. Bone Miner. Res. 18 (2003) 570-578
7. Silva M.J., et al. In vivo skeletal imaging of 18F-fluoride with positron emission tomography reveals damage- and time-dependent responses to fatigue loading in the rat ulna. Bone 39 (2006) 229-236
8. Zaheer A., et al. In vivo near-infrared fluorescence imaging of osteoblastic activity. Nat. Biotechnol. 19 (2001) 1148-1154
9. Kozloff K.M., et al. Noninvasive optical detection of bone mineral. J. Bone Miner. Res. 22 (2007) 1208-1216
10. Kozloff K.M., et al. Non-invasive optical detection of cathepsin K-mediated fluorescence reveals osteoclast activity in vitro and in vivo. Bone 44 (2009) 190-198
11. Sprague J.E., et al. Noninvasive imaging of osteoclasts in parathyroid hormone-induced osteolysis using a 64Cu-labeled RGD peptide. J. Nucl. Med. 48 (2007) 311-318
12. Ciana P., et al. Engineering of a mouse for the in vivo profiling of estrogen receptor activity. Mol. Endocrinol. 15 (2001) 1104-1113
13. Ciana P., et al. In vivo imaging of transcriptionally active estrogen receptors. Nat. Med. 9 (2003) 82-86
14. Zhang N., et al. An inducible nitric oxide synthase-luciferase reporter system for in vivo testing of anti-inflammatory compounds in transgenic mice. J. Immunol. 170 (2003) 6307-6319
15. Zhang N., et al. Serum amyloid A-luciferase transgenic mice: response to sepsis, acute arthritis, and contact hypersensitivity and the effects of proteasome inhibition. J. Immunol. 174 (2005) 8125-8134
16. Carlsen H., et al. In vivo imaging of NF-kappa B activity. J. Immunol. 168 (2002) 1441-1446
17. Bennink R.J., et al. Biodistribution and radiation dosimetry of 99mTc-HMPAO-labeled monocytes in patients with rheumatoid arthritis. J. Nucl. Med. 49 (2008) 1380-1385
18. Chen W.T., et al. Arthritis imaging using a near-infrared fluorescence folate-targeted probe. Arthritis Res. Ther. 7 (2005) R310-R317
19. Hansch A., et al. Diagnosis of arthritis using near-infrared fluorochrome Cy5.5. Invest. Radiol. 39 (2004) 626-632
20. Hansch A., et al. In vivo imaging of experimental arthritis with near-infrared fluorescence. Arthritis Rheum. 50 (2004) 961-967
21. Nakajima A., et al. Visualization of antigen-specific T cell in living arthritic mice. J. Nippon Med. Sch. 73 (2006) 298-299
22. Nakajima A., et al. Antigen-specific T cell-mediated gene therapy in collagen-induced arthritis. J. Clin. Invest. 107 (2001) 1293-1301
23. Simon G.H., et al. Optical imaging of experimental arthritis using allogeneic leukocytes labeled with a near-infrared fluorescent probe. Eur. J. Nucl. Med. Mol. Imaging 33 (2006) 998-1006
24. Tarner I.H., et al. Retroviral gene therapy of collagen-induced arthritis by local delivery of IL-4. Clin. Immunol. 105 (2002) 304-314
25. Turk M.J., et al. Folate-targeted imaging of activated macrophages in rats with adjuvant-induced arthritis. Arthritis Rheum. 46 (2002) 1947-1955
26. Yaghoubi S.S., et al. Multimodality imaging of T-cell hybridoma trafficking in collagen-induced arthritic mice: image-based estimation of the number of cells accumulating in mouse paws. J. Biomed. Opt. 12 (2007) 064025-1-064025-11
27. Nakashima-Matsushita N., et al. Selective expression of folate receptor beta and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis. Arthritis Rheum. 42 (1999) 1609-1616
28. Paulos C.M., et al. Folate-targeted immunotherapy effectively treats established adjuvant and collagen-induced arthritis. Arthritis Res. Ther. 8 (2006) R77
29. McQueen F.M., Ostergaard, and M. Established rheumatoid arthritis - new imaging modalities. Best Pract. Res. Clin. Rheumatol. 21 (2007) 841-856
30. Wipke B.T., et al. Dynamic visualization of a joint-specific autoimmune response through positron emission tomography. Nat. Immunol. 3 (2002) 366-372
31. Wipke B.T., et al. Staging the initiation of autoantibody-induced arthritis: a critical role for immune complexes. J. Immunol. 172 (2004) 7694-7702
32. Ji H., et al. Arthritis critically dependent on innate immune system players. Immunity 16 (2002) 157-168
33. Lai W.F., et al. Early diagnosis of osteoarthritis using cathepsin B sensitive near-infrared fluorescent probes. Osteoarthritis Cartilage 12 (2004) 239-244
34. Wunder A., et al. In vivo imaging of protease activity in arthritis: a novel approach for monitoring treatment response. Arthritis Rheum. 50 (2004) 2459-2465
35. Wunder A., et al. Methotrexate-induced accumulation of fluorescent annexin V in collagen-induced arthritis. Mol. Imaging 4 (2005) 1-6
36. Chen W.T., et al. Imaging reactive oxygen species in arthritis. Mol. Imaging 3 (2004) 159-162
37. Canon J.R., et al. Inhibition of RANKL blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasis. Clin. Exp. Metastasis 25 (2008) 119-129
38. Peyruchaud O., et al. Early detection of bone metastases in a murine model using fluorescent human breast cancer cells: application to the use of the bisphosphonate zoledronic acid in the treatment of osteolytic lesions. J. Bone Miner. Res. 16 (2001) 2027-2034
39. van der Pluijm G., et al. Interference with the microenvironmental support impairs the de novo formation of bone metastases in vivo. Cancer Res. 65 (2005) 7682-7690
40. Chanda D., et al. Systemic osteoprotegerin gene therapy restores tumor-induced bone loss in a therapeutic model of breast cancer bone metastasis. Mol. Ther. 16 (2008) 871-878
41. Bandyopadhyay A., et al. Inhibition of pulmonary and skeletal metastasis by a transforming growth factor-beta type I receptor kinase inhibitor. Cancer Res. 66 (2006) 6714-6721
42. Kang Y., et al. Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway. Proc. Natl. Acad. Sci. U S A 102 (2005) 13909-13914
43. Buijs J.T., et al. Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer. Cancer Res. 67 (2007) 8742-8751
44. Murray L.J., et al. SU11248 inhibits tumor growth and CSF-1R-dependent osteolysis in an experimental breast cancer bone metastasis model. Clin. Exp. Metastasis 20 (2003) 757-766
45. Kalikin L.M., et al. In vivo visualization of metastatic prostate cancer and quantitation of disease progression in immunocompromised mice. Cancer Biol. Ther. 2 (2003) 656-660
46. Thudi N.K., et al. Zoledronic acid decreased osteolysis but not bone metastasis in a nude mouse model of canine prostate cancer with mixed bone lesions. Prostate 68 (2008) 1116-1125
47. Yang M., et al. The bisphosphonate olpadronate inhibits skeletal prostate cancer progression in a green fluorescent protein nude mouse model. Clin. Cancer Res. 12 (2006) 2602-2606
48. Burton D.W., et al. Monitoring of skeletal progression of prostate cancer by GFP imaging, X-ray, and serum OPG and PTHrP. Prostate 62 (2005) 275-281
49. Schneider A., et al. Bone turnover mediates preferential localization of prostate cancer in the skeleton. Endocrinology 146 (2005) 1727-1736
50. Miller R.E., et al. RANK ligand inhibition plus docetaxel improves survival and reduces tumor burden in a murine model of prostate cancer bone metastasis. Mol. Cancer Ther. 7 (2008) 2160-2169
51. Buijs J.T., et al. BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo. Am. J. Pathol. 171 (2007) 1047-1057
52. Fritz V., et al. Antitumoral activity and osteogenic potential of mesenchymal stem cells expressing the urokinase-type plasminogen antagonist amino-terminal fragment in a murine model of osteolytic tumor. Stem Cells 26 (2008) 2981-2990
53. Hirbe A.C., et al. Granulocyte colony-stimulating factor enhances bone tumor growth in mice in an osteoclast-dependent manner. Blood 109 (2007) 3424-3431
54. Sims Jr. T.L., et al. Neural progenitor cell-mediated delivery of osteoprotegerin limits disease progression in a preclinical model of neuroblastoma bone metastasis. J. Pediatr. Surg. 44, 204-210; discussion (2009) 210-211
55. Tannehill-Gregg S.H., et al. The effect of zoledronic acid and osteoprotegerin on growth of human lung cancer in the tibias of nude mice. Clin. Exp. Metastasis. 23 (2006) 19-31
56. Mouchess M.L., et al. Multimodal imaging analysis of tumor progression and bone resorption in a murine cancer model. J. Comput. Assist Tomogr. 30 (2006) 525-534
57. Zhang J., et al. In vivo real-time imaging of TGF-beta-induced transcriptional activation of the RANK ligand gene promoter in intraosseous prostate cancer. Prostate 59 (2004) 360-369
58. Serganova I., et al. Multimodality imaging of TGF{beta} signaling in breast cancer metastases. FASEB J. 23 (2009) 2662-2672
59. Sheyn D., et al. Ultrasound-based nonviral gene delivery induces bone formation in vivo. Gene Ther. 15 (2008) 257-266
60. Yazici C., et al. The effect of surface demineralization of cortical bone allograft on the properties of recombinant adeno-associated virus coatings. Biomaterials 29 (2008) 3882-3887
61. Dunn C.A., et al. BMP gene delivery for alveolar bone engineering at dental implant defects. Mol. Ther. 11 (2005) 294-299
62. Gafni Y., et al. Gene therapy platform for bone regeneration using an exogenously regulated, AAV-2-based gene expression system. Mol. Ther. 9 (2004) 587-595
63. Leo B.M., et al. In vivo bioluminescent imaging of virus-mediated gene transfer and transduced cell transplantation in the intervertebral disc. Spine 29 (2004) 838-844
64. Olivo C., et al. In vivo bioluminescence imaging study to monitor ectopic bone formation by luciferase gene marked mesenchymal stem cells. J. Orthop. Res. 26 (2008) 901-909
65. Degano I.R., et al. Bioluminescence imaging of calvarial bone repair using bone marrow and adipose tissue-derived mesenchymal stem cells. Biomaterials 29 (2008) 427-437
66. Lee S.W., et al. Stem cell-mediated accelerated bone healing observed with in vivo molecular and small animal imaging technologies in a model of skeletal injury. J. Orthop. Res. 27 (2008) 295-302
67. Barberi T., et al. Derivation of engraftable skeletal myoblasts from human embryonic stem cells. Nat. Med. 13 (2007) 642-648
68. Jing X.H., et al. In vivo MR imaging tracking of magnetic iron oxide nanoparticle labeled, engineered, autologous bone marrow mesenchymal stem cells following intra-articular injection. Joint Bone Spine 75 (2008) 432-438
69. Feeley B.T., et al. In vivo molecular imaging of adenoviral versus lentiviral gene therapy in two bone formation models. J. Orthop. Res. 24 (2006) 1709-1721
70. Hasharoni A., et al. Murine spinal fusion induced by engineered mesenchymal stem cells that conditionally express bone morphogenetic protein-2. J. Neurosurg. Spine 3 (2005) 47-52
71. Aslan H., et al. Advanced molecular profiling in vivo detects novel function of dickkopf-3 in the regulation of bone formation. J. Bone Miner. Res. 21 (2006) 1935-1945
72. Zilberman Y., et al. Fluorescence molecular tomography enables in vivo visualization and quantification of nonunion fracture repair induced by genetically engineered mesenchymal stem cells. J. Orthop. Res. 26 (2008) 522-530
73. Ren P.G., et al. Systemic trafficking of macrophages induced by bone cement particles in nude mice. Biomaterials 29 (2008) 4760-4765
74. Li D., et al. Quantitative mouse model of implant-associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity. J. Orthop. Res. 26 (2008) 96-105
75. Caplan A.I., et al. Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. J. Cell Physiol. 213 (2007) 341-347
76. Pittenger M.F., et al. Multilineage potential of adult human mesenchymal stem cells. Science 284 (1999) 143-147
77. Gambhir S.S., et al. Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography. Proc. Natl. Acad. Sci. U S A 96 (1999) 2333-2338
78. Tjuvajev J.G., et al. Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy. Cancer Res. 56 (1996) 4087-4095
79. Contag C.H., et al. Visualizing gene expression in living mammals using a bioluminescent reporter. Photochem. Photobiol. 66 (1997) 523-531
80. Pichler B.J., et al. Latest advances in molecular imaging instrumentation. J. Nucl. Med. 49 suppl 2 (2008) 5S-23S
81. Weissleder R., et al. In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nat. Biotechnol. 17 (1999) 375-378
82. Weissleder R. Molecular imaging in cancer. Science 312 (2006) 1168-1171
83. Jaffer F.A., et al. Molecular imaging of cardiovascular disease. Circulation 116 (2007) 1052-1061
84. Hildebrandt I.J., and Gambhir S.S. Molecular imaging applications for immunology. Clin. Immunol. 111 (2004) 210-224
85. Hutchens M., and Luker G.D. Applications of bioluminescence imaging to the study of infectious diseases. Cell Microbiol. 9 (2007) 2315-2322
86. Biswal S., et al. Molecular imaging: integration of molecular imaging into the musculoskeletal imaging practice. Radiology 244 (2007) 651-671
87. Mayer-Kuckuk P., and Boskey A.L. Molecular imaging promotes progress in orthopedic research. Bone 39 (2006) 965-977
88. Zilberman Y., et al. Bioluminescent imaging in bone. Methods Mol. Biol. 455 (2008) 261-272
89. Pichler B.J., et al. Multimodal imaging approaches: PET/CT and PET/MRI. Handb. Exp. Pharmacol. 185 pt 1 (2008) 109-132
90. Ntziachristos V., et al. Looking and listening to light: the evolution of whole-body photonic imaging. Nat. Biotechnol. 23 (2005) 313-320
91. Weissleder R., and Ntziachristos V. Shedding light onto live molecular targets. Nat. Med. 9 (2003) 123-128