메뉴 건너뛰기




Volumn 684, Issue 1-2, 2010, Pages 81-89

Nitric oxide mediated DNA double strand breaks induced in proliferating bystander cells after α-particle irradiation

Author keywords

Particle irradiation; Bystander effect; Cell proliferation; DNA double strand breaks; Nitric oxide

Indexed keywords

BINDING PROTEIN; DIMETHYL SULFOXIDE; DOUBLE STRANDED DNA; NITRIC OXIDE; P53 BINDING PROTEIN 1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

EID: 73949161269     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2009.12.004     Document Type: Article
Times cited : (46)

References (54)
  • 1
    • 0033963935 scopus 로고    scopus 로고
    • Basal nitric oxide limits immune, nervous and cardiovascular excitation: human endothelia express a mu opiate receptor
    • Stefano G.B., Goumon Y., Bilfinger T.V., Welters I.D., and Cadet P. Basal nitric oxide limits immune, nervous and cardiovascular excitation: human endothelia express a mu opiate receptor. Progress Neurobiol. 60 (2000) 513-530
    • (2000) Progress Neurobiol. , vol.60 , pp. 513-530
    • Stefano, G.B.1    Goumon, Y.2    Bilfinger, T.V.3    Welters, I.D.4    Cadet, P.5
  • 2
    • 0031623305 scopus 로고    scopus 로고
    • Nitric oxide signaling: would you believe that a simple free radical could be a second messenger, autacoid, paracrine substance, neurotransmitter, and hormone?
    • Murad F. Nitric oxide signaling: would you believe that a simple free radical could be a second messenger, autacoid, paracrine substance, neurotransmitter, and hormone?. Recent Prog. Horm. Res. 53 (1998) 43-60
    • (1998) Recent Prog. Horm. Res. , vol.53 , pp. 43-60
    • Murad, F.1
  • 3
    • 0037105317 scopus 로고    scopus 로고
    • Peroxynitrite activates kinases of the Src family and upregulates tyrosine phosphorylation signaling
    • Minetti M., Mallozzi C., and Di Stasi A.M. Peroxynitrite activates kinases of the Src family and upregulates tyrosine phosphorylation signaling. Free Radic. Biol. Med. 33 (2002) 744-754
    • (2002) Free Radic. Biol. Med. , vol.33 , pp. 744-754
    • Minetti, M.1    Mallozzi, C.2    Di Stasi, A.M.3
  • 4
    • 0029805172 scopus 로고    scopus 로고
    • Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
    • Beckman J.S., and Koppenol W.H. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am. J. Physiol. Cell Physiol. 271 (1996) C1424-C1437
    • (1996) Am. J. Physiol. Cell Physiol. , vol.271
    • Beckman, J.S.1    Koppenol, W.H.2
  • 5
    • 0025189864 scopus 로고
    • Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide
    • Beckman J.S., Beckman T.W., Chen J., Marshall P.A., and Freeman B.A. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. U.S.A. 87 (1990) 1620-1624
    • (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 1620-1624
    • Beckman, J.S.1    Beckman, T.W.2    Chen, J.3    Marshall, P.A.4    Freeman, B.A.5
  • 6
    • 0012221203 scopus 로고    scopus 로고
    • Interactions between superoxide and nitric oxide: implications in DNA damage and mutagenesis
    • Jourd'heuil D., Kang D., and Grisham M.B. Interactions between superoxide and nitric oxide: implications in DNA damage and mutagenesis. Front Biosci. 2 (1997) 189-196
    • (1997) Front Biosci. , vol.2 , pp. 189-196
    • Jourd'heuil, D.1    Kang, D.2    Grisham, M.B.3
  • 7
    • 0029417334 scopus 로고
    • Presence of the m3 opiate receptor in endothelial cells: coupling to nitric oxide production and vasodilation
    • Stefano G.B., Hartman A., Bilfinger T.V., Magazine H.I., Liu Y., Casares F., et al. Presence of the m3 opiate receptor in endothelial cells: coupling to nitric oxide production and vasodilation. J. Biol. Chem. 270 (1995) 30290-30293
    • (1995) J. Biol. Chem. , vol.270 , pp. 30290-30293
    • Stefano, G.B.1    Hartman, A.2    Bilfinger, T.V.3    Magazine, H.I.4    Liu, Y.5    Casares, F.6
  • 9
    • 0037013331 scopus 로고    scopus 로고
    • Activation of constitutive nitric-oxide synthase activity is an early signaling event induced by ionizing radiation
    • Leach J.K., Black S.M., Schmidt-Ullrich R.K., and Mikkelsen R.B. Activation of constitutive nitric-oxide synthase activity is an early signaling event induced by ionizing radiation. J. Biol. Chem. 277 (2002) 15400-15406
    • (2002) J. Biol. Chem. , vol.277 , pp. 15400-15406
    • Leach, J.K.1    Black, S.M.2    Schmidt-Ullrich, R.K.3    Mikkelsen, R.B.4
  • 10
    • 0026454677 scopus 로고
    • Induction of sister chromatid exchanges by extremely low doses of alpha-particles
    • Nagasawa H., and Little J.B. Induction of sister chromatid exchanges by extremely low doses of alpha-particles. Cancer Res. 52 (1992) 6394-6396
    • (1992) Cancer Res. , vol.52 , pp. 6394-6396
    • Nagasawa, H.1    Little, J.B.2
  • 12
    • 0034161938 scopus 로고    scopus 로고
    • Factors underlying the cell growth-related bystander responses to alpha particles
    • Iyer R., and Lehnert B.E. Factors underlying the cell growth-related bystander responses to alpha particles. Cancer Res. 60 (2000) 1290-1298
    • (2000) Cancer Res. , vol.60 , pp. 1290-1298
    • Iyer, R.1    Lehnert, B.E.2
  • 13
    • 0036149168 scopus 로고    scopus 로고
    • Alpha-particle-induced increases in the radioresistance of normal human bystander cells
    • Iyer R., and Lehnert B.E. Alpha-particle-induced increases in the radioresistance of normal human bystander cells. Radiat. Res. 157 (2002) 3-7
    • (2002) Radiat. Res. , vol.157 , pp. 3-7
    • Iyer, R.1    Lehnert, B.E.2
  • 14
    • 0347386413 scopus 로고    scopus 로고
    • Flow cytometry as a strategy to study radiation-induced bystander effects in co-culture systems
    • Gerashchenko B.I., and Howell R.W. Flow cytometry as a strategy to study radiation-induced bystander effects in co-culture systems. Cytometry Part A 54A (2003) 1-7
    • (2003) Cytometry Part A , vol.54 A , pp. 1-7
    • Gerashchenko, B.I.1    Howell, R.W.2
  • 15
    • 44949163716 scopus 로고    scopus 로고
    • Quantitative assessment of cell proliferation in the co-culture of mixed cell populations by flow cytometry
    • Gerashchenko B.I. Quantitative assessment of cell proliferation in the co-culture of mixed cell populations by flow cytometry. Cytometry Part A 73A (2008) 492-493
    • (2008) Cytometry Part A , vol.73 A , pp. 492-493
    • Gerashchenko, B.I.1
  • 16
    • 0348048742 scopus 로고    scopus 로고
    • Cell proximity is a prerequisite for the proliferative response of bystander cells co-cultured with cells irradiated with γ-rays
    • Gerashchenko B.I., and Howell R.W. Cell proximity is a prerequisite for the proliferative response of bystander cells co-cultured with cells irradiated with γ-rays. Cytometry Part A 56A (2003) 71-80
    • (2003) Cytometry Part A , vol.56 A , pp. 71-80
    • Gerashchenko, B.I.1    Howell, R.W.2
  • 17
    • 4043069119 scopus 로고    scopus 로고
    • Proliferative response of bystander cells adjacent to cells with incorporated radioactivity
    • Gerashchenko B.I., and Howell R.W. Proliferative response of bystander cells adjacent to cells with incorporated radioactivity. Cytometry Part A 60A (2004) 155-164
    • (2004) Cytometry Part A , vol.60 A , pp. 155-164
    • Gerashchenko, B.I.1    Howell, R.W.2
  • 18
    • 20944439880 scopus 로고    scopus 로고
    • Bystander cell proliferation is modulated by the number of adjacent cells that were exposed to ionizing radiation
    • Gerashchenko B.I., and Howell R.W. Bystander cell proliferation is modulated by the number of adjacent cells that were exposed to ionizing radiation. Cytometry Part A 66A (2005) 62-70
    • (2005) Cytometry Part A , vol.66 A , pp. 62-70
    • Gerashchenko, B.I.1    Howell, R.W.2
  • 19
    • 0027848672 scopus 로고
    • DNA lesions, inducible DNA repair, and cell division: three key factors in mutagenesis and carcinogenesis
    • Ames B.N., Shigenaga M.K., and Gold L.S. DNA lesions, inducible DNA repair, and cell division: three key factors in mutagenesis and carcinogenesis. Environ. Health Perspect. 101 Suppl. 5 (1993) 35-44
    • (1993) Environ. Health Perspect. , vol.101 , Issue.SUPPL. 5 , pp. 35-44
    • Ames, B.N.1    Shigenaga, M.K.2    Gold, L.S.3
  • 20
    • 77949887510 scopus 로고    scopus 로고
    • Handbook of molecular probes, 10th
    • Haegland R.P. Handbook of molecular probes, 10th. Molecular Probes (2005) 642-649
    • (2005) Molecular Probes , pp. 642-649
    • Haegland, R.P.1
  • 21
  • 22
    • 42049122330 scopus 로고    scopus 로고
    • Mitochondrial function and nuclear factor-kappaB-mediated signaling in radiation-induced bystander effects
    • Zhou H., Ivanov V.N., Lien Y.C., Davidson M., and Hei T.K. Mitochondrial function and nuclear factor-kappaB-mediated signaling in radiation-induced bystander effects. Cancer Res. 68 (2008) 2233-2240
    • (2008) Cancer Res. , vol.68 , pp. 2233-2240
    • Zhou, H.1    Ivanov, V.N.2    Lien, Y.C.3    Davidson, M.4    Hei, T.K.5
  • 24
    • 0036906303 scopus 로고    scopus 로고
    • Checkpoint signalling: focusing on 53BP1
    • Abraham R.T. Checkpoint signalling: focusing on 53BP1. Nat. Cell Biol. 4 (2002) E277-E279
    • (2002) Nat. Cell Biol. , vol.4
    • Abraham, R.T.1
  • 25
    • 0034739853 scopus 로고    scopus 로고
    • p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks
    • Schultz L.B., Chehab N.H., Malikzay A., and Halazonetis T.D. p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. J. Cell Biol. 151 (2000) 1381-1390
    • (2000) J. Cell Biol. , vol.151 , pp. 1381-1390
    • Schultz, L.B.1    Chehab, N.H.2    Malikzay, A.3    Halazonetis, T.D.4
  • 26
    • 34250879092 scopus 로고    scopus 로고
    • Cytoplasmic irradiation induces mitochondrial-dependent 53BP1 protein relocalization in irradiated and bystander cells
    • Tartier L., Gilchrist S., Burdak-Rothkamm S., Folkard M., and Prise K.M. Cytoplasmic irradiation induces mitochondrial-dependent 53BP1 protein relocalization in irradiated and bystander cells. Cancer Res. 67 (2007) 5872-5879
    • (2007) Cancer Res. , vol.67 , pp. 5872-5879
    • Tartier, L.1    Gilchrist, S.2    Burdak-Rothkamm, S.3    Folkard, M.4    Prise, K.M.5
  • 27
    • 0347988236 scopus 로고    scopus 로고
    • Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains
    • Aten J.A., Stap J., Krawczyk P.M., van Oven C.H., Hoebe R.A., Essers J., and Kanaar R. Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains. Science 303 (2004) 92-95
    • (2004) Science , vol.303 , pp. 92-95
    • Aten, J.A.1    Stap, J.2    Krawczyk, P.M.3    van Oven, C.H.4    Hoebe, R.A.5    Essers, J.6    Kanaar, R.7
  • 28
    • 0034693730 scopus 로고    scopus 로고
    • The in vitro micronucleus technique
    • Fenech M. The in vitro micronucleus technique. Mutat. Res. 455 (2000) 81-95
    • (2000) Mutat. Res. , vol.455 , pp. 81-95
    • Fenech, M.1
  • 29
    • 0036736438 scopus 로고    scopus 로고
    • Nitric oxide-mediated bystander effect induced by heavy-ions in human salivary gland tumour cells
    • Shao C., Furusawa Y., Aoki M., Matsumoto H., and Ando K. Nitric oxide-mediated bystander effect induced by heavy-ions in human salivary gland tumour cells. Int. J. Radiat. Biol. 78 (2002) 837-844
    • (2002) Int. J. Radiat. Biol. , vol.78 , pp. 837-844
    • Shao, C.1    Furusawa, Y.2    Aoki, M.3    Matsumoto, H.4    Ando, K.5
  • 30
    • 0346365364 scopus 로고    scopus 로고
    • Nitric oxide-mediated signaling in the bystander response of individually targeted glioma cells
    • Shao C., Stewart V., Folkardn M., Michael B.D., and Prise K.M. Nitric oxide-mediated signaling in the bystander response of individually targeted glioma cells. Cancer Res. 63 (2003) 8437-8442
    • (2003) Cancer Res. , vol.63 , pp. 8437-8442
    • Shao, C.1    Stewart, V.2    Folkardn, M.3    Michael, B.D.4    Prise, K.M.5
  • 32
    • 34147190372 scopus 로고    scopus 로고
    • Constitutive nitric oxide acting as a possible intercellular signaling molecule in the initiation of radiation-induced DNA double strand breaks in non-irradiated bystander cells
    • Han W., Wu L.J., Chen S.P., Bao L.Z., Zhang L.L., Jiang E.K., Zhao Y., Xu A., Hei T.K., and Yu Z.L. Constitutive nitric oxide acting as a possible intercellular signaling molecule in the initiation of radiation-induced DNA double strand breaks in non-irradiated bystander cells. Oncogene 26 (2007) 2330-2339
    • (2007) Oncogene , vol.26 , pp. 2330-2339
    • Han, W.1    Wu, L.J.2    Chen, S.P.3    Bao, L.Z.4    Zhang, L.L.5    Jiang, E.K.6    Zhao, Y.7    Xu, A.8    Hei, T.K.9    Yu, Z.L.10
  • 33
    • 12344310463 scopus 로고    scopus 로고
    • Integrative radiation carcinogenesis: interactions between cell and tissue responses to DNA damage
    • Barcellos-Hoff M.H. Integrative radiation carcinogenesis: interactions between cell and tissue responses to DNA damage. Semin. Cancer Biol. 15 (2005) 138-148
    • (2005) Semin. Cancer Biol. , vol.15 , pp. 138-148
    • Barcellos-Hoff, M.H.1
  • 34
    • 38349054294 scopus 로고    scopus 로고
    • Role of TGF-β1 and nitric oxide in the bystander response of irradiated glioma cells
    • Shao C., Folkard M., and Prise K.M. Role of TGF-β1 and nitric oxide in the bystander response of irradiated glioma cells. Oncogene 27 (2008) 434-440
    • (2008) Oncogene , vol.27 , pp. 434-440
    • Shao, C.1    Folkard, M.2    Prise, K.M.3
  • 35
    • 37849039565 scopus 로고    scopus 로고
    • Signaling factors for irradiated glioma cells induced bystander responses in fibroblasts
    • Shao C., Prise K.M., and Folkard M. Signaling factors for irradiated glioma cells induced bystander responses in fibroblasts. Mutat. Res. 638 (2008) 139-145
    • (2008) Mutat. Res. , vol.638 , pp. 139-145
    • Shao, C.1    Prise, K.M.2    Folkard, M.3
  • 37
    • 0344936731 scopus 로고    scopus 로고
    • Nitric oxide: cytotoxicity versus cytoprotection-how, why, when, and where?
    • Kroncke K.D., Fehsel K., and Kolb-Bachofen V. Nitric oxide: cytotoxicity versus cytoprotection-how, why, when, and where?. Nitric Oxide 1 (1997) 107-120
    • (1997) Nitric Oxide , vol.1 , pp. 107-120
    • Kroncke, K.D.1    Fehsel, K.2    Kolb-Bachofen, V.3
  • 38
    • 0028051746 scopus 로고
    • Tyrosine phosphorylation and activation of NADPH oxidase in human neutrophils: a possible role for MAP kinases and for a 75 kDa protein
    • Dusi S., Donini M., and Rossi F. Tyrosine phosphorylation and activation of NADPH oxidase in human neutrophils: a possible role for MAP kinases and for a 75 kDa protein. Biochem. J. 304 (1994) 243-250
    • (1994) Biochem. J. , vol.304 , pp. 243-250
    • Dusi, S.1    Donini, M.2    Rossi, F.3
  • 40
    • 0034817385 scopus 로고    scopus 로고
    • Dopamine regulates Na-K-ATPase in alveolar epithelial cells via MAPK-ERK-dependent mechanisms
    • Guerrero C., Lecuona E., Pesce L., Ridge K.M., and Sznajder J.I. Dopamine regulates Na-K-ATPase in alveolar epithelial cells via MAPK-ERK-dependent mechanisms. Am. J. Physiol. 281 (2001) L79-L85
    • (2001) Am. J. Physiol. , vol.281
    • Guerrero, C.1    Lecuona, E.2    Pesce, L.3    Ridge, K.M.4    Sznajder, J.I.5
  • 41
    • 0031195049 scopus 로고    scopus 로고
    • Reactivity of nitrogen monoxide species with NADH: implications for nitric oxide-dependent posttranslational protein modification
    • Ewing J.F., Janero D.R., Grinnell T.A., Schroeder J.D., and Garvey D.S. Reactivity of nitrogen monoxide species with NADH: implications for nitric oxide-dependent posttranslational protein modification. Arch. Biochem. Biophys. 343 (1997) 131-139
    • (1997) Arch. Biochem. Biophys. , vol.343 , pp. 131-139
    • Ewing, J.F.1    Janero, D.R.2    Grinnell, T.A.3    Schroeder, J.D.4    Garvey, D.S.5
  • 43
    • 0034057899 scopus 로고    scopus 로고
    • Chemical hormesis in cell growth: a molecular target at the cell surface
    • Morre D.J. Chemical hormesis in cell growth: a molecular target at the cell surface. J. Appl. Toxicol. 20 (2000) 157-163
    • (2000) J. Appl. Toxicol. , vol.20 , pp. 157-163
    • Morre, D.J.1
  • 44
    • 33646002984 scopus 로고    scopus 로고
    • Nitric oxide stimulates PC12 cell proliferation via cGMP and inhibits at higher concentrations mainly via energy depletion
    • Bal-Price A., Gartlon J., and Brown G.C. Nitric oxide stimulates PC12 cell proliferation via cGMP and inhibits at higher concentrations mainly via energy depletion. Nitric Oxide 14 (2006) 238-246
    • (2006) Nitric Oxide , vol.14 , pp. 238-246
    • Bal-Price, A.1    Gartlon, J.2    Brown, G.C.3
  • 45
    • 0034656164 scopus 로고    scopus 로고
    • Indirect inhibition of mitochondrial dihydroorotate dehydrogenase activity by nitric oxide
    • Beuneu C., Auger R., LoZer M., Guissani A., Lemaire G., and Lepoivre M. Indirect inhibition of mitochondrial dihydroorotate dehydrogenase activity by nitric oxide. Free Radic. Biol. Med. 28 (2000) 1206-1213
    • (2000) Free Radic. Biol. Med. , vol.28 , pp. 1206-1213
    • Beuneu, C.1    Auger, R.2    LoZer, M.3    Guissani, A.4    Lemaire, G.5    Lepoivre, M.6
  • 47
    • 0006812769 scopus 로고
    • Potential genotoxicity of chronically elevated nitric oxide: a review
    • Liu R.H., and Hotchkiss J.H. Potential genotoxicity of chronically elevated nitric oxide: a review. Mutat. Res. 339 (1995) 73-89
    • (1995) Mutat. Res. , vol.339 , pp. 73-89
    • Liu, R.H.1    Hotchkiss, J.H.2
  • 48
    • 34347392534 scopus 로고    scopus 로고
    • Proteome analysis of proliferative response of bystander cells adjacent to cells exposed to ionizing radiation
    • Gerashchenko B.I., Yamagata A., Oofusa K., Yoshizato K., Toledo S.M., and Howell R.W. Proteome analysis of proliferative response of bystander cells adjacent to cells exposed to ionizing radiation. Proteomics 7 (2007) 2000-2008
    • (2007) Proteomics , vol.7 , pp. 2000-2008
    • Gerashchenko, B.I.1    Yamagata, A.2    Oofusa, K.3    Yoshizato, K.4    Toledo, S.M.5    Howell, R.W.6
  • 49
    • 0023684923 scopus 로고
    • The nuclear matrix protein, numatrin (B23), is associated with growth factor-induced mitogenesis in Swiss 3T3 fibroblasts and with T lymphocyte proliferation stimulated by lectins and anti-T cell antigen receptor antibody
    • Feuerstein N., Spiegel S., and Mond J.J. The nuclear matrix protein, numatrin (B23), is associated with growth factor-induced mitogenesis in Swiss 3T3 fibroblasts and with T lymphocyte proliferation stimulated by lectins and anti-T cell antigen receptor antibody. J. Cell Biol. 107 (1988) 1629-1642
    • (1988) J. Cell Biol. , vol.107 , pp. 1629-1642
    • Feuerstein, N.1    Spiegel, S.2    Mond, J.J.3
  • 50
    • 0024595908 scopus 로고
    • Characterization of the cDNA encoding human nucleophosmin and studies of its role in normal and abnormal growth
    • Chan W.Y., Liu Q.R., Borjigin J., and Busch H. Characterization of the cDNA encoding human nucleophosmin and studies of its role in normal and abnormal growth. Biochemistry 28 (1989) 1033-1039
    • (1989) Biochemistry , vol.28 , pp. 1033-1039
    • Chan, W.Y.1    Liu, Q.R.2    Borjigin, J.3    Busch, H.4
  • 51
    • 0344309360 scopus 로고    scopus 로고
    • Nucleophosmin/B23 is a proliferate shuttle protein associated with nuclear matrix
    • Yun J.P., Chew E.C., Liew C.T., and Chan J.Y. Nucleophosmin/B23 is a proliferate shuttle protein associated with nuclear matrix. J. Cell. Biochem. 90 (2003) 1140-1148
    • (2003) J. Cell. Biochem. , vol.90 , pp. 1140-1148
    • Yun, J.P.1    Chew, E.C.2    Liew, C.T.3    Chan, J.Y.4
  • 52
    • 0033590973 scopus 로고    scopus 로고
    • Down-regulation of nucleophosmin/B23 mRNA delays the entry of cells into mitosis
    • Jiang P.S., and Yung B.Y. Down-regulation of nucleophosmin/B23 mRNA delays the entry of cells into mitosis. Biochem. Biophys. Res. Commun. 257 (1999) 865-870
    • (1999) Biochem. Biophys. Res. Commun. , vol.257 , pp. 865-870
    • Jiang, P.S.1    Yung, B.Y.2
  • 53
    • 0035902108 scopus 로고    scopus 로고
    • Genome maintenance mechanisms for preventing cancer
    • Hoeijmakers J.H. Genome maintenance mechanisms for preventing cancer. Nature 411 (2001) 366-374
    • (2001) Nature , vol.411 , pp. 366-374
    • Hoeijmakers, J.H.1
  • 54
    • 0035289717 scopus 로고    scopus 로고
    • Chromosomal stability and the DNA double-stranded break connection
    • Van Gent D.C., Hoeijmakers J.H., and Kanaar R. Chromosomal stability and the DNA double-stranded break connection. Nat. Rev. Genet. 2 (2001) 196-206
    • (2001) Nat. Rev. Genet. , vol.2 , pp. 196-206
    • Van Gent, D.C.1    Hoeijmakers, J.H.2    Kanaar, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.