Bystander cell proliferation is modulated by the number of adjacent cells that were exposed to ionizing radiation

Cytometry Part A

Volumn 66, Issue 1, 2005, Pages 62-70

  Gerashchenko, Bogdan I ^a   Howell, Roger W ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Adjacent cells; Beta particles; Bystander cells; Co culture; Flow cytometry; Gamma rays; H 3; Proliferation ratio; Radiation; Thymidine; Tritium

Indexed keywords

CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER; THYMIDINE;

ANIMAL CELL; ARTICLE; BYSTANDER EFFECT; CELL CULTURE; CELL FRACTIONATION; CELL LABELING; CELL METABOLISM; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; ELECTRON; EPITHELIUM CELL; FLOW CYTOMETRY; GAMMA RADIATION; IONIZING RADIATION; ISOTOPE LABELING; MATHEMATICAL COMPUTING; NONHUMAN; PRIORITY JOURNAL; RAT; STAINING; STATISTICAL ANALYSIS; TIME;

ANIMALS; BYSTANDER EFFECT; CELL COUNT; CELL LINE; CELL PROLIFERATION; COCULTURE TECHNIQUES; EPITHELIAL CELLS; FLOW CYTOMETRY; GAMMA RAYS; INTERCELLULAR JUNCTIONS; LIVER; RATS; TRITIUM;

EID: 20944439880     PISSN: 15524922     EISSN: None     Source Type: Journal    
DOI: 10.1002/cyto.a.20150     Document Type: Article

References (28)

1. Little JB. Radiation carcinogenesis. Carcinogenesis 2000;21:394-404.
2. Mothersill C, Seymour C. Radiation-induced bystander effects: past history and future directions. Radiat Res 2001;155:759-767.
3. Goldberg Z, Lehnert BE. Radiation-induced effects in unirradiated cells: a review and implications in cancer. Int J Oncol 2002;21:337-349.
4. Morgan WF. Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitro. Radiat Res 2003;159:567-580.
5. Morgan WF. Non-targeted and delayed effects of exposure to ionizing radiation: II. Radiation-induced genomic instability and bystander effects in vivo, clastogenic factors and transgenerational effects. Radiat Res 2003;159:581-596.
6. Azzam EI, de Toledo SM, Little JB. Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect. Oncogene 2003;22:7050-7057.
7. Iyer R, Lehnert BE. Factors underlying the cell growth-related bystander responses to alpha particles. Cancer Res. 2000;60:1290-1298.
8. Shao C, Furusawa Y, Aoki M, Matsumoto H, Ando K. Nitric oxide-mediated bystander effect induced by heavy-ions in human salivary gland tumour cells. Int J Radiat Biol 2002;78:837-844.
9. Gerashchenko BI, Howell RW. Flow cytometry as a strategy to study radiation-induced bystander effects in co-culture systems. Cytometry 2003;54A:1-7.
10. Gerashchenko BI, Howell RW. Cell proximity is a prerequisite for the proliferative response of bystander cells co-cultured with cells irradiated with gamma-rays. Cytometry 2003;56A:71-80.
11. Gerashchenko BI, Howell RW. Proliferative response of bystander cells adjacent to cells with incorporated radioactivity. Cytometry 2004;60A:155-164.
12. Azzam EI, de Toledo SM, Gooding T, Little JB. Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles. Radiat. Res 1998;150:497-504.
13. Bishayee A, Rao DV, Howell RW. Evidence for pronounced bystander effects caused by nonuniform distributions of radioactivity using a novel three-dimensional tissue culture model. Radiat Res 1999;152: 88-97.
14. Zhou H, Randers-Pehrson G, Waldren CA, Vannais D, Hall EJ, Hei TK. Induction of a bystander mutagenic effect of alpha particles in mammalian cells. Proc Natl Acad Sci USA 2000;97:2099-2104.
15. Azzam EI, de Toledo SM, Little JB. Direct evidence for the participation of gap-junction mediated intercellular communication in the transmission of damage signals from alpha-particle irradiated to non-irradiated cells. Proc Natl Acad Sci USA 2001;98: 473-478.
16. Hickman AW, Jaramillo RJ, Lechner JF, Johnson NF. Alpha-particle-induced p53 protein expression in a rat lung epithelial cell strain. Cancer Res 1994;54:5797-5800.
17. Lehnert BE, Goodwin EH. Extracellular factor(s) following exposure to alpha particles can cause sister chromatid exchanges in normal human cells. Cancer Res 1997;57:2164-2171.
18. Narayanan PK, Goodwin EH, Lehnert BE. Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells. Cancer Res 1997;57:3963-3971.
19. Mothersill C, Seymour CB. Cell-cell contact during gamma irradiation is not required to induce a bystander effect in normal human keratinocytes: Evidence for release during irradiation of a signal controlling survival into the medium. Radiat Res 1998;149:252-262.
20. Narayanan PK, LaRue KEA, Goodwin EH, Lehnert BE. Alpha particles induce the production of interleukin-8 by human cells. Radiat Res 1999;152:57-63.
21. Mitchell SA, Randers-Pehrson G, Brenner DJ, Hall EJ. The bystander response in C3H 10T1/2 cells: the influence of cell-to-cell contact. Radiat Res 2004;161:397-401.
22. Tsao MS, Smith JD, Nelson KG, Grisham JW. A diploid epithelial cell line from normal adult rat liver with phenotypic properties of 'oval' cells. Exp Cell Res 1984;154:38-52.
23. Gerashchenko BI, Azzam EI, Howell RW. Characterization of cell-cycle progression and growth of WB-F344 normal rat liver epithelial cells following gamma-ray exposure. Cytometry 2004;61A:134-141.
24. Haughland RP. Handbook of fluorescent probes and research chemicals. Eugene, OR: Molecular Probes; 1996. p 377-398.
25. Bishayee A, Hill HZ, Stein D, Rao DV, Howell RW. Free-radical initiated and gap junction-mediated bystander effect due to nonuniform distribution of incorporated radioactivity in a three-dimensional tissue culture model. Radiat Res 2001;155:335-344.
26. 125I. Micron 2002;33:127-132.
27. Marko NF, Dieffenbach PB, Yan G, Ceryak S, Howell RW, McCaffrey TA, Hu VW. Does metabolic radiolabeling stimulate the stress response? Differential cellular responses to internal beta versus external gamma radiation. FASEB J 2003;17:1470-1486.
28. Burdon RH. Superoxide and hydrogen peroxide in relation to mammalian cell proliferation. Free Rad Biol Med 1995;18:775-794.