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Volumn 84, Issue 3, 2010, Pages 1243-1253

Characterization of T-cell responses in macaques immunized with a single dose of HIV DNA vaccine

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; GAG PROTEIN; GAMMA INTERFERON; GRANZYME B; INTERLEUKIN 15;

EID: 73949137353     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.01846-09     Document Type: Article
Times cited : (10)

References (65)
  • 1
  • 2
    • 16544395818 scopus 로고    scopus 로고
    • The injection of plasmid DNA in mouse muscle results in lifelong persistence of DNA, gene expression, and humoral response
    • Armengol, G., L. M. Ruiz, and S. Orduz. 2004. The injection of plasmid DNA in mouse muscle results in lifelong persistence of DNA, gene expression, and humoral response. Mol. Biotechnol. 27:109-118.
    • (2004) Mol. Biotechnol , vol.27 , pp. 109-118
    • Armengol, G.1    Ruiz, L.M.2    Orduz, S.3
  • 3
    • 12344300389 scopus 로고    scopus 로고
    • + T cells from most HIV-1-infected patients, even when challenged with mature dendritic cells, lack functional recall memory to HIV gag but not other viruses
    • + T cells from most HIV-1-infected patients, even when challenged with mature dendritic cells, lack functional recall memory to HIV gag but not other viruses. Eur. J. Immunol. 35:159-170.
    • (2005) Eur. J. Immunol , vol.35 , pp. 159-170
    • Arrode, G.1    Finke, J.S.2    Zebroski, H.3    Siegal, F.P.4    Steinman, R.M.5
  • 4
    • 46149101177 scopus 로고    scopus 로고
    • Nef modulates the immunogenicity of Gag encoded in a non-infectious HIV DNA vaccine
    • Arrode, G., R. Hegde, Y. Jin, D. K. Singh, O. Narayan, and Y. Chebloune. 2008. Nef modulates the immunogenicity of Gag encoded in a non-infectious HIV DNA vaccine. Vaccine 26:3795-3804.
    • (2008) Vaccine , vol.26 , pp. 3795-3804
    • Arrode, G.1    Hegde, R.2    Jin, Y.3    Singh, D.K.4    Narayan, O.5    Chebloune, Y.6
  • 6
    • 67749143592 scopus 로고    scopus 로고
    • Visualization of in vivo electroporation-mediated transgene expression in experimental tumors by optical and magnetic resonance imaging
    • Aung, W., S. Hasegawa, M. Koshikawa-Yano, T. Obata, H. Ikehira, T. Furukawa, I. Aoki, and T. Saga. 2009. Visualization of in vivo electroporation-mediated transgene expression in experimental tumors by optical and magnetic resonance imaging. Gene Ther. 16:830-839.
    • (2009) Gene Ther , vol.16 , pp. 830-839
    • Aung, W.1    Hasegawa, S.2    Koshikawa-Yano, M.3    Obata, T.4    Ikehira, H.5    Furukawa, T.6    Aoki, I.7    Saga, T.8
  • 7
    • 1942455782 scopus 로고    scopus 로고
    • Increased gene expression and inflammatory cell infiltration caused by electroporation are both important for improving the efficacy of DNA vaccines
    • Babiuk, S., M. E. Baca-Estrada, M. Foldvari, D. M. Middleton, D. Rabussay, G. Widera, and L. A. Babiuk. 2004. Increased gene expression and inflammatory cell infiltration caused by electroporation are both important for improving the efficacy of DNA vaccines. J. Biotechnol. 110:1-10.
    • (2004) J. Biotechnol , vol.110 , pp. 1-10
    • Babiuk, S.1    Baca-Estrada, M.E.2    Foldvari, M.3    Middleton, D.M.4    Rabussay, D.5    Widera, G.6    Babiuk, L.A.7
  • 8
    • 45749099294 scopus 로고    scopus 로고
    • Multifunctional T-cell characteristics induced by a polyvalent DNA prime/protein boost human immunodeficiency virus type 1 vaccine regimen given to healthy adults are dependent on the route and dose of administration
    • Bansal, A., B. Jackson, K. West, S. Wang, S. Lu, J. S. Kennedy, and P. A. Goepfert. 2008. Multifunctional T-cell characteristics induced by a polyvalent DNA prime/protein boost human immunodeficiency virus type 1 vaccine regimen given to healthy adults are dependent on the route and dose of administration. J. Virol. 82:6458-6469.
    • (2008) J. Virol , vol.82 , pp. 6458-6469
    • Bansal, A.1    Jackson, B.2    West, K.3    Wang, S.4    Lu, S.5    Kennedy, J.S.6    Goepfert, P.A.7
  • 10
    • 53349160053 scopus 로고    scopus 로고
    • Challenges in the development of an HIV-1 vaccine
    • Barouch, D. H. 2008. Challenges in the development of an HIV-1 vaccine. Nature 455:613-619.
    • (2008) Nature , vol.455 , pp. 613-619
    • Barouch, D.H.1
  • 14
    • 42049083555 scopus 로고    scopus 로고
    • T cell responses generated by HIV vaccines in clinical trials
    • De Rosa, S. D., and M. J. McElrath. 2008. T cell responses generated by HIV vaccines in clinical trials. Curr. Opin. HIV AIDS 3:375-379.
    • (2008) Curr. Opin. HIV AIDS , vol.3 , pp. 375-379
    • De Rosa, S.D.1    McElrath, M.J.2
  • 15
    • 61849154036 scopus 로고    scopus 로고
    • Co-immunization with IL-15 enhances cellular immune responses induced by a vif-deleted simian immunodeficiency virus proviral DNA vaccine and confers partial protection against vaginal challenge with SIVmac251
    • Dubie, R. A., S. Maksaereekul, B. L. Shacklett, D. Lemongello, K. S. Cole, F. Villinger, S. A. Blozis, P. A. Luciw, and E. E. Sparger. 2009. Co-immunization with IL-15 enhances cellular immune responses induced by a vif-deleted simian immunodeficiency virus proviral DNA vaccine and confers partial protection against vaginal challenge with SIVmac251. Virology 386:109-121.
    • (2009) Virology , vol.386 , pp. 109-121
    • Dubie, R.A.1    Maksaereekul, S.2    Shacklett, B.L.3    Lemongello, D.4    Cole, K.S.5    Villinger, F.6    Blozis, S.A.7    Luciw, P.A.8    Sparger, E.E.9
  • 17
    • 42049102821 scopus 로고    scopus 로고
    • Wanted: Correlates of vaccine-induced protection against simian immunodeficiency virus
    • Friedrich, T. C., and D. I. Watkins. 2008. Wanted: correlates of vaccine-induced protection against simian immunodeficiency virus. Curr. Opin. HIV AIDS 3:393-398.
    • (2008) Curr. Opin. HIV AIDS , vol.3 , pp. 393-398
    • Friedrich, T.C.1    Watkins, D.I.2
  • 19
    • 0031657208 scopus 로고    scopus 로고
    • Intranasal administration of HIV-DNA vaccine formulated with a polymer, carboxymethylcellulose, augments mucosal antibody production and cell-mediated immune response
    • Hamajima, K., S. Sasaki, J. Fukushima, T. Kaneko, K. Q. Xin, I. Kudoh, and K. Okuda. 1998. Intranasal administration of HIV-DNA vaccine formulated with a polymer, carboxymethylcellulose, augments mucosal antibody production and cell-mediated immune response. Clin. Immunol. Immunopathol. 88:205-210.
    • (1998) Clin. Immunol. Immunopathol , vol.88 , pp. 205-210
    • Hamajima, K.1    Sasaki, S.2    Fukushima, J.3    Kaneko, T.4    Xin, K.Q.5    Kudoh, I.6    Okuda, K.7
  • 21
    • 27744537422 scopus 로고    scopus 로고
    • Antigen expression kinetics and immune responses of mice immunized with noninfectious simian-human immunodeficiency virus DNA
    • Hegde, R., Z. Liu, G. Mackay, M. Smith, Y. Chebloune, O. Narayan, and D. K. Singh. 2005. Antigen expression kinetics and immune responses of mice immunized with noninfectious simian-human immunodeficiency virus DNA. J. Virol. 79:14688-14697.
    • (2005) J. Virol , vol.79 , pp. 14688-14697
    • Hegde, R.1    Liu, Z.2    Mackay, G.3    Smith, M.4    Chebloune, Y.5    Narayan, O.6    Singh, D.K.7
  • 23
    • 34248149301 scopus 로고    scopus 로고
    • Optimization and validation of an 8-color intracellular cytokine staining (ICS) assay to quantify antigen-specific T cells induced by vaccination
    • Horton, H., E. P. Thomas, J. A. Stucky, I. Frank, Z. Moodie, Y. Huang, Y. L. Chiu, M. J. McElrath, and S. C. De Rosa. 2007. Optimization and validation of an 8-color intracellular cytokine staining (ICS) assay to quantify antigen-specific T cells induced by vaccination. J. Immunol. Methods 323:39-54.
    • (2007) J. Immunol. Methods , vol.323 , pp. 39-54
    • Horton, H.1    Thomas, E.P.2    Stucky, J.A.3    Frank, I.4    Moodie, Z.5    Huang, Y.6    Chiu, Y.L.7    McElrath, M.J.8    De Rosa, S.C.9
  • 24
    • 0030806029 scopus 로고    scopus 로고
    • Induction of vigorous cytotoxic T-lymphocyte responses by live attenuated simian immunodeficiency virus
    • Johnson, R. P., R. L. Glickman, J. Q. Yang, A. Kaur, J. T. Dion, M. J. Mulligan, and R. C. Desrosiers. 1997. Induction of vigorous cytotoxic T-lymphocyte responses by live attenuated simian immunodeficiency virus. J. Virol. 71:7711-7718.
    • (1997) J. Virol , vol.71 , pp. 7711-7718
    • Johnson, R.P.1    Glickman, R.L.2    Yang, J.Q.3    Kaur, A.4    Dion, J.T.5    Mulligan, M.J.6    Desrosiers, R.C.7
  • 25
    • 50449090525 scopus 로고    scopus 로고
    • An HIV vaccine-challenges and prospects
    • Johnston, M. I., and A. S. Fauci. 2008. An HIV vaccine-challenges and prospects. N. Engl. J. Med. 359:888-890.
    • (2008) N. Engl. J. Med , vol.359 , pp. 888-890
    • Johnston, M.I.1    Fauci, A.S.2
  • 28
    • 33846101731 scopus 로고    scopus 로고
    • + T-cell responses to different HIV proteins have discordant associations with viral load. Nat. Med. 13:46-53.
    • + T-cell responses to different HIV proteins have discordant associations with viral load. Nat. Med. 13:46-53.
  • 29
    • 69249211230 scopus 로고    scopus 로고
    • T-cell vaccine strategies for human immunodeficiency virus, the virus with a thousand faces
    • Korber, B. T., N. L. Letvin, and B. F. Haynes. 2009. T-cell vaccine strategies for human immunodeficiency virus, the virus with a thousand faces. J. Virol. 83:8300-8314.
    • (2009) J. Virol , vol.83 , pp. 8300-8314
    • Korber, B.T.1    Letvin, N.L.2    Haynes, B.F.3
  • 30
    • 52449104809 scopus 로고    scopus 로고
    • DNA vaccines: Ready for prime time?
    • Kutzler, M. A., and D. B. Weiner. 2008. DNA vaccines: ready for prime time? Nat. Rev. Genet. 9:776-788.
    • (2008) Nat. Rev. Genet , vol.9 , pp. 776-788
    • Kutzler, M.A.1    Weiner, D.B.2
  • 31
    • 35348955182 scopus 로고    scopus 로고
    • Adjuvanting a DNA vaccine with a TLR9 ligand plus Flt3 ligand results in enhanced cellular immunity against the simian immunodeficiency virus
    • Kwissa, M., R. R. Amara, H. L. Robinson, B. Moss, S. Alkan, A. Jabbar, F. Villinger, and B. Pulendran. 2007. Adjuvanting a DNA vaccine with a TLR9 ligand plus Flt3 ligand results in enhanced cellular immunity against the simian immunodeficiency virus. J. Exp. Med. 204:2733-2746.
    • (2007) J. Exp. Med , vol.204 , pp. 2733-2746
    • Kwissa, M.1    Amara, R.R.2    Robinson, H.L.3    Moss, B.4    Alkan, S.5    Jabbar, A.6    Villinger, F.7    Pulendran, B.8
  • 33
    • 33947095436 scopus 로고    scopus 로고
    • Dose-response studies for the elicitation of CD8 T cells by a DNA vaccine, used alone or as the prime for a modified vaccinia Ankara boost
    • Liu, J., M. Hellerstein, M. McDonnel, R. R. Amara, L. S. Wyatt, B. Moss, and H. L. Robinson. 2007. Dose-response studies for the elicitation of CD8 T cells by a DNA vaccine, used alone or as the prime for a modified vaccinia Ankara boost. Vaccine 25:2951-2958.
    • (2007) Vaccine , vol.25 , pp. 2951-2958
    • Liu, J.1    Hellerstein, M.2    McDonnel, M.3    Amara, R.R.4    Wyatt, L.S.5    Moss, B.6    Robinson, H.L.7
  • 34
    • 43949114521 scopus 로고    scopus 로고
    • Recruitment of antigen-presenting cells to the site of inoculation and augmentation of human immunodeficiency virus type 1 DNA vaccine immunogenicity by in vivo electroporation
    • Liu, J., R. Kjeken, I. Mathiesen, and D. H. Barouch. 2008. Recruitment of antigen-presenting cells to the site of inoculation and augmentation of human immunodeficiency virus type 1 DNA vaccine immunogenicity by in vivo electroporation. J. Virol. 82:5643-5649.
    • (2008) J. Virol , vol.82 , pp. 5643-5649
    • Liu, J.1    Kjeken, R.2    Mathiesen, I.3    Barouch, D.H.4
  • 39
    • 41949104713 scopus 로고    scopus 로고
    • Vaccine protection by live, attenuated simian immunodeficiency virus in the absence of high-titer antibody responses and high-frequency cellular immune responses measurable in the periphery
    • Mansfield, K., S. M. Lang, M. C. Gauduin, H. B. Sanford, J. D. Lifson, R. P. Johnson, and R. C. Desrosiers. 2008. Vaccine protection by live, attenuated simian immunodeficiency virus in the absence of high-titer antibody responses and high-frequency cellular immune responses measurable in the periphery. J. Virol. 82:4135-4148.
    • (2008) J. Virol , vol.82 , pp. 4135-4148
    • Mansfield, K.1    Lang, S.M.2    Gauduin, M.C.3    Sanford, H.B.4    Lifson, J.D.5    Johnson, R.P.6    Desrosiers, R.C.7
  • 41
    • 57449109484 scopus 로고    scopus 로고
    • + T cells is required for HIV-infected cell elimination associated with immune control. Immunity 29:1009-1021.
    • + T cells is required for HIV-infected cell elimination associated with immune control. Immunity 29:1009-1021.
  • 44
    • 52449110778 scopus 로고    scopus 로고
    • Quantitative real-time PCR study on persistence of pDNA vaccine pVax-Hsp60 TM814 in beef muscles
    • Orság, P., V. Kvardova, M. Raska, A. D. Miller, M. Ledvina, and J. Turanek. 2008. Quantitative real-time PCR study on persistence of pDNA vaccine pVax-Hsp60 TM814 in beef muscles. Genet. Vaccines Ther. 6:11.
    • (2008) Genet. Vaccines Ther , vol.6 , pp. 11
    • Orság, P.1    Kvardova, V.2    Raska, M.3    Miller, A.D.4    Ledvina, M.5    Turanek, J.6
  • 45
    • 4043060710 scopus 로고    scopus 로고
    • Correlates of immune protection in HIV-1 infection: What we know, what we don't know, what we should know
    • Pantaleo, G., and R. A. Koup. 2004. Correlates of immune protection in HIV-1 infection: what we know, what we don't know, what we should know. Nat. Med. 10:806-810.
    • (2004) Nat. Med , vol.10 , pp. 806-810
    • Pantaleo, G.1    Koup, R.A.2
  • 46
    • 0004419163 scopus 로고    scopus 로고
    • Apoptotic and necrotic cell death are both induced by electroporation in HL60 human promyeloid leukaemia cells
    • Piñero, J., M. Lopez-Baena, T. Ortiz, and F. Cortes. 1997. Apoptotic and necrotic cell death are both induced by electroporation in HL60 human promyeloid leukaemia cells. Apoptosis 2:330-336.
    • (1997) Apoptosis , vol.2 , pp. 330-336
    • Piñero, J.1    Lopez-Baena, M.2    Ortiz, T.3    Cortes, F.4
  • 48
    • 56649111197 scopus 로고    scopus 로고
    • Failure of the Merck HIV vaccine: An uncertain step forward
    • Robb, M. L. 2008. Failure of the Merck HIV vaccine: an uncertain step forward. Lancet 372:1857-1858.
    • (2008) Lancet , vol.372 , pp. 1857-1858
    • Robb, M.L.1
  • 49
    • 33845442886 scopus 로고    scopus 로고
    • Phase 1 clinical trials of the National Institutes of Health Vaccine Research Center HIV/AIDS candidate vaccines
    • Robinson, H. L., and K. J. Weinhold. 2006. Phase 1 clinical trials of the National Institutes of Health Vaccine Research Center HIV/AIDS candidate vaccines. J. Infect. Dis. 194:1625-1627.
    • (2006) J. Infect. Dis , vol.194 , pp. 1625-1627
    • Robinson, H.L.1    Weinhold, K.J.2
  • 51
    • 0031926264 scopus 로고    scopus 로고
    • Induction of systemic and mucosal immune responses to human immunodeficiency virus type 1 by a DNA vaccine formulated with QS-21 saponin adjuvant via intramuscular and intranasal routes
    • Sasaki, S., K. Sumino, K. Hamajima, J. Fukushima, N. Ishii, S. Kawamoto, H. Mohri, C. R. Kensil, and K. Okuda. 1998. Induction of systemic and mucosal immune responses to human immunodeficiency virus type 1 by a DNA vaccine formulated with QS-21 saponin adjuvant via intramuscular and intranasal routes. J. Virol. 72:4931-4939.
    • (1998) J. Virol , vol.72 , pp. 4931-4939
    • Sasaki, S.1    Sumino, K.2    Hamajima, K.3    Fukushima, J.4    Ishii, N.5    Kawamoto, S.6    Mohri, H.7    Kensil, C.R.8    Okuda, K.9
  • 52
    • 42049085289 scopus 로고    scopus 로고
    • Correlates of antibody-mediated protection against HIV infection
    • Sattentau, Q. 2008. Correlates of antibody-mediated protection against HIV infection. Curr. Opin. HIV AIDS 3:368-374.
    • (2008) Curr. Opin. HIV AIDS , vol.3 , pp. 368-374
    • Sattentau, Q.1
  • 53
    • 38749096240 scopus 로고    scopus 로고
    • The failed HIV Merck vaccine study: A step back or a launching point for future vaccine development?
    • Sekaly, R. P. 2008. The failed HIV Merck vaccine study: a step back or a launching point for future vaccine development? J. Exp. Med. 205:7-12.
    • (2008) J. Exp. Med , vol.205 , pp. 7-12
    • Sekaly, R.P.1
  • 55
    • 0036394888 scopus 로고    scopus 로고
    • Systemic infection and limited replication of SHIV vaccine virus in brains of macaques inoculated intracerebrally with infectious viral DNA
    • Smith, M. S., Y. Niu, Z. Li, I. Adany, D. M. Pinson, Z. Q. Liu, T. Berry, D. Sheffer, F. Jia, and O. Narayan. 2002. Systemic infection and limited replication of SHIV vaccine virus in brains of macaques inoculated intracerebrally with infectious viral DNA. Virology 301:130-135.
    • (2002) Virology , vol.301 , pp. 130-135
    • Smith, M.S.1    Niu, Y.2    Li, Z.3    Adany, I.4    Pinson, D.M.5    Liu, Z.Q.6    Berry, T.7    Sheffer, D.8    Jia, F.9    Narayan, O.10
  • 56
    • 0027465288 scopus 로고
    • Electroporation and DNAdependent cell death in murine macrophages
    • Stacey, K. J., I. L. Ross, and D. A. Hume. 1993. Electroporation and DNAdependent cell death in murine macrophages. Immunol. Cell Biol. 71:75-85.
    • (1993) Immunol. Cell Biol , vol.71 , pp. 75-85
    • Stacey, K.J.1    Ross, I.L.2    Hume, D.A.3
  • 57
    • 0029129385 scopus 로고
    • Comparative sequence analysis of cytokine genes from human and nonhuman primates
    • Villinger, F., S. S. Brar, A. Mayne, N. Chikkala, and A. A. Ansari. 1995. Comparative sequence analysis of cytokine genes from human and nonhuman primates. J. Immunol. 155:3946-3954.
    • (1995) J. Immunol , vol.155 , pp. 3946-3954
    • Villinger, F.1    Brar, S.S.2    Mayne, A.3    Chikkala, N.4    Ansari, A.A.5
  • 58
    • 50149089799 scopus 로고    scopus 로고
    • Generation of specific effector and memory T cells with gutand secondary lymphoid tissue-homing potential by oral attenuated CVD 909 typhoid vaccine in humans
    • Wahid, R., R. Salerno-Goncalves, C. O. Tacket, M. M. Levine, and M. B. Sztein. 2008. Generation of specific effector and memory T cells with gutand secondary lymphoid tissue-homing potential by oral attenuated CVD 909 typhoid vaccine in humans. Mucosal Immunol. 1:389-398.
    • (2008) Mucosal Immunol , vol.1 , pp. 389-398
    • Wahid, R.1    Salerno-Goncalves, R.2    Tacket, C.O.3    Levine, M.M.4    Sztein, M.B.5
  • 59
    • 44949100369 scopus 로고    scopus 로고
    • Nonhuman primate models and the failure of the Merck HIV-1 vaccine in humans
    • Watkins, D. I., D. R. Burton, E. G. Kallas, J. P. Moore, and W. C. Koff. 2008. Nonhuman primate models and the failure of the Merck HIV-1 vaccine in humans. Nat. Med. 14:617-621.
    • (2008) Nat. Med , vol.14 , pp. 617-621
    • Watkins, D.I.1    Burton, D.R.2    Kallas, E.G.3    Moore, J.P.4    Koff, W.C.5
  • 60
    • 0027474245 scopus 로고
    • Electroporation: A general phenomenon for manipulating cells and tissues
    • Weaver, J. C. 1993. Electroporation: a general phenomenon for manipulating cells and tissues. J. Cell Biochem. 51:426-435.
    • (1993) J. Cell Biochem , vol.51 , pp. 426-435
    • Weaver, J.C.1
  • 61
    • 0032849066 scopus 로고    scopus 로고
    • Protection by live, attenuated simian immunodeficiency virus against heterologous challenge
    • Wyand, M. S., K. Manson, D. C. Montefiori, J. D. Lifson, R. P. Johnson, and R. C. Desrosiers. 1999. Protection by live, attenuated simian immunodeficiency virus against heterologous challenge. J. Virol. 73:8356-8363.
    • (1999) J. Virol , vol.73 , pp. 8356-8363
    • Wyand, M.S.1    Manson, K.2    Montefiori, D.C.3    Lifson, J.D.4    Johnson, R.P.5    Desrosiers, R.C.6
  • 62
    • 67349094564 scopus 로고    scopus 로고
    • Novel SIVmac DNA vaccines encoding Env, Pol and Gag consensus proteins elicit strong cellular immune responses in cynomolgus macaques
    • Yan, J., D. A. Hokey, M. P. Morrow, N. Corbitt, K. Harris, D. Harris, and D. B. Weiner. 2009. Novel SIVmac DNA vaccines encoding Env, Pol and Gag consensus proteins elicit strong cellular immune responses in cynomolgus macaques. Vaccine 27:3260-3266.
    • (2009) Vaccine , vol.27 , pp. 3260-3266
    • Yan, J.1    Hokey, D.A.2    Morrow, M.P.3    Corbitt, N.4    Harris, K.5    Harris, D.6    Weiner, D.B.7
  • 63
    • 33846301454 scopus 로고    scopus 로고
    • Enhanced cellular immune responses elicited by an engineered HIV-1 subtype B consensus-based envelope DNA vaccine
    • Yan, J., H. Yoon, S. Kumar, M. P. Ramanathan, N. Corbitt, M. Kutzler, A. Dai, J. D. Boyer, and D. B. Weiner. 2007. Enhanced cellular immune responses elicited by an engineered HIV-1 subtype B consensus-based envelope DNA vaccine. Mol. Ther. 15:411-421.
    • (2007) Mol. Ther , vol.15 , pp. 411-421
    • Yan, J.1    Yoon, H.2    Kumar, S.3    Ramanathan, M.P.4    Corbitt, N.5    Kutzler, M.6    Dai, A.7    Boyer, J.D.8    Weiner, D.B.9
  • 64
    • 57049162985 scopus 로고    scopus 로고
    • Longitudinal study to assess the safety and efficacy of a live-attenuated SHIV vaccine in long term immunized rhesus macaques
    • Yankee, T. M., D. Sheffer, Z. Liu, S. Dhillon, F. Jia, Y. Chebloune, E. B. Stephens, and O. Narayan. 2009. Longitudinal study to assess the safety and efficacy of a live-attenuated SHIV vaccine in long term immunized rhesus macaques. Virology 383:103-111.
    • (2009) Virology , vol.383 , pp. 103-111
    • Yankee, T.M.1    Sheffer, D.2    Liu, Z.3    Dhillon, S.4    Jia, F.5    Chebloune, Y.6    Stephens, E.B.7    Narayan, O.8


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