Postthymic maturation influences the CD8 T cell response to antigen

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 12, 2009, Pages 4799-4804

  Makaroff, Lydia E ^a   Hendricks, Deborah W ^a   Niec, Rachel E ^a   Fink, Pamela J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Memory T cells; Recent thymic emigrants

Indexed keywords

CELL MARKER; CYTOKINE; ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL EXPERIMENT; ANTIGEN DETECTION; ANTIGEN EXPRESSION; ARTICLE; BACKCROSSING; BACTERIAL INFECTION; CD8+ T LYMPHOCYTE; CELL MATURATION; CELL STIMULATION; CELL SUSPENSION; CYTOKINE PRODUCTION; EFFECTOR CELL; FLOW CYTOMETRY; IMMUNE RESPONSE; INFECTION; MEMORY CELL; MOUSE; NONHUMAN; PRE T LYMPHOCYTE; PRIORITY JOURNAL; RECENT THYMIC EMIGRANT; T LYMPHOCYTE ACTIVATION; THYMECTOMY; ANIMAL; BIOSYNTHESIS; CELL DIFFERENTIATION; CYTOLOGY; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MICROBIOLOGY; THYMUS; TIME; VIROLOGY; VIRUS;

BACTERIA (MICROORGANISMS);

ANIMALS; ANTIGENS; BACTERIAL INFECTIONS; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CYTOKINES; IMMUNOLOGIC MEMORY; LYMPHOCYTE ACTIVATION; MICE; RECEPTORS, ANTIGEN, T-CELL; THYMUS GLAND; TIME FACTORS; VIRUSES;

EID: 63849270941     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0812354106     Document Type: Article

References (26)

1. Williams MA, Bevan MJ (2007) Effector and memory CTL differentiation. Annu Rev Immunol 25:171-192.
2. + T cell memory. Nat Rev Immunol 8:107-119.
3. Joshi NS, Kaech SM (2008) Effector CD8 T cell development: A balancing act between memory cell potential and terminal differentiation. J Immunol 180:1309-1315.
4. Saparov A, et al. (1999) Interleukin-2 expression by a subpopulation of primary T cells is linked to enhanced memory/effector function. Immunity 11:271-280.
5. Yu W, et al. (1999) Continued RAG expression in late stages of B cell development and no apparent reinduction after immunization. Nature 400:682-687.
6. Boursalian TE, Golub J, Soper DM, Cooper CJ, Fink PJ (2004) Continued maturation of thymic emigrants in the periphery. Nat Immunol 5:418-425.
7. McCaughtry TM, Wilden MS, Hogquist KA (2007) Thymic emigration revisited. J Exp Med 204:2513-2520.
8. Hale JS, Boursalian TE, Turk GL, Fink PJ (2006) Thymic output in aged mice. Proc Natl Acad Sci USA 103:8447-8452.
9. Houston EG, Jr, Nechanitzky R, Fink PJ (2008) Cutting edge: Contact with secondary lymphoid organs drives postthymic T cell maturation. J Immunol 181:5213-5217.
10. + T cell memory via TRAIL-mediated activation-induced cell death. Nature 434:88-93.
11. + T cell help. J Immunol 180:4570-4576.
12. Sarkar S, et al. (2008) Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates. J Exp Med 205:625-640.
13. Chang JT, et al. (2007) Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science 315:1687-1691.
14. AdkinsB,LeclercC,Marshall-ClarkeS(2004)Neonatal adaptive immunity comes of age. Nat Rev Immunol 4:553-564.
15. Voehringer D, et al. (2001)Viral infections induce abundant numbers of senescent CD8 T cells. J Immunol 167:4838-4843.
16. Lundmark F, et al. (2007) Variation in interleukin 7 receptor α chain (IL-7R) influences risk of multiple sclerosis. Nat Genet 39:1108-1113.
17. + T cell fates via the graded expression of T-bet transcription factor. Immunity 27:281-295.
18. + T cells. J Immunol 155:1873-1883.
19. Jaakkola I, Merinen M, Jalkanen S, Hanninen A (2003) Ly6C induces clustering of LFA-1 (CD11a/CD18) and is involved in subtype-specific adhesion of CD8 T cells. J Immunol 170:1283-1290.
20. Hogquist KA, et al. (1994) T cell receptor antagonist peptides induce positive selection. Cell 76:17-27.
21. Pircher H, et al. (1990) Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo. Nature 346:629-633.
22. Ehst BD, Ingulli E, Jenkins MK (2003) Development of a novel transgenic mouse for the study of interactions between CD4 and CD8 T cells during graft rejection. Am J Trans 3:1355-1362.
23. Boursalian TE, Bottomly K (1999) Survival of naive CD4T cells: Roles of restricting versus selecting MHC class II and cytokine milieu. J Immunol 162:3795-3801.
24. + T cells. J Immunol 165:5537-5543.
25. Foulds KE, et al. (2002) Cutting edge: CD4 and CD8 T cells are intrinsically different in their proliferative responses. J Immunol 168:1528-1532.
26. Sun JC, Bevan MJ (2003) Defective CD8 Tcell memory after acute infection without CD4 T cell help. Science 300:339-342.