Breakdown of pulmonary host defense in the immunocompromised host cancer chemotherapy

Proceedings of the American Thoracic Society

Volumn 2, Issue 5, 2005, Pages 445-448

  Joos, Ladina ^a   Tamm, Michael ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Chemotherapy; Immunocompromised hosts; Neutropenia; Pulmonary infections

Indexed keywords

ALEMTUZUMAB; ANTINEOPLASTIC AGENT; BLEOMYCIN; BUSULFAN; CYCLOPHOSPHAMIDE; METHOTREXATE; MONOCLONAL ANTIBODY; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; TAXANE DERIVATIVE;

ADULT RESPIRATORY DISTRESS SYNDROME; AUTOIMMUNE DISEASE; BACTERIAL INFECTION; BRONCHOSCOPY; CANCER CHEMOTHERAPY; CLINICAL TRIAL; COMORBIDITY; CONFERENCE PAPER; CYTOPENIA; DIAGNOSTIC PROCEDURE; DRUG HYPERSENSITIVITY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HOST RESISTANCE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE DEFICIENCY; IMMUNE SYSTEM; INFECTION COMPLICATION; INTERSTITIAL PNEUMONIA; LUNG INFECTION; LUNG INFILTRATE; LUNG SMALL CELL CANCER; LUNG TOXICITY; MYCOSIS; NEUTROPENIA; ORGAN TRANSPLANTATION; PRACTICE GUIDELINE; RISK FACTOR; STEM CELL TRANSPLANTATION; TREATMENT OUTCOME; VIRUS INFECTION;

ANTINEOPLASTIC AGENTS; DISEASE SUSCEPTIBILITY; FEMALE; HIV INFECTIONS; HUMANS; IMMUNOCOMPROMISED HOST; LUNG DISEASES; LUNG DISEASES, FUNGAL; MALE; NEOPLASMS; NEUTROPENIA; PNEUMONIA, BACTERIAL; PNEUMONIA, VIRAL; PREVALENCE; PROGNOSIS; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX;

EID: 31144447911     PISSN: 15463222     EISSN: 15463222     Source Type: Journal    
DOI: 10.1513/pats.200508-097JS     Document Type: Conference Paper

References (36)

1. Bodey GP, Buckley M, Sathe YS, Freireich EJ. Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia. Ann Intern Med 1966;64:328-340.
2. Cheson BD. Infectious and immunosuppressive complications of purine analog therapy. J Clin Oncol 1995;13:2431-2448.
3. Ozer H, Armitage JO, Bennett CL, Crawford J, Demetri GD, Pizzo PA, Schiffer CA, Smith TJ, Somlo G, Wade JC, et al. 2000 update of recommendations for the use of hematopoietic colony-stimulating factors: evidence-based, clinical practice guidelines. American Society of Clinical Oncology Growth Factors Expert Panel. J Clin Oncol 2000;18:3558-3585.
4. Hubel K, Hegener K, Schnell R, Mansmann G, Oberhauser F, Staib P, Diehl V, Engert A. Suppressed neutrophil function as a risk factor for severe infection after cytotoxic chemotherapy in patients with acute nonlymphocytic leukemia. Ann Hematol 1999;78:73-77.
5. Maschmeyer G, Link H, Hiddemann W, Meyer P, Helmerking M, Eisenmann E, Schmitt J, Adam D. Pulmonary infiltrations in febrile patients with neutropenia: risk factors and outcome under empirical antimicrobial therapy in a randomized multicenter study. Cancer 1994;73:2296-2304.
6. Cersosimo RJ. Monoclonal antibodies in the treatment of cancer, part 2. Am J Health Syst Pharm 2003;60:1631-1641. [Quiz: 1642-1643.]
7. Cersosimo RJ. Monoclonal antibodies in the treatment of cancer, Part 1. Am J Health Syst Pharm 2003;60:1531-1548.
8. Gibbs SD, Westerman DA, McCormack C, Seymour JF, Miles Prince H. Severe and prolonged myeloid haematopoietic toxicity with myelodysplastic features following alemtuzumab therapy in patients with peripheral T-cell lymphoproliferative disorders. Br J Haematol 2005;130:87-91.
9. Wisplinghoff H, Seifert H, Wenzel RP, Edmond MB. Current trends in the epidemiology of nosocomial bloodstream infections in patients with hematological malignancies and solid neoplasms in hospitals in the United States. Clin Infect Dis 2003;36:1103-1110.
10. Hughes WT, Armstrong D, Bodey GP, Bow EJ, Brown AE, Calandra T, Feld R, Pizzo PA, Rolston KV, Shenep JL, et al. 2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clin Infect Dis 2002;34:730-751.
11. Elting LS, Rubenstein EB, Rolston KV, Bodey GP. Outcomes of bacteremia in patients with cancer and neutropenia: observations from two decades of epidemiological and clinical trials. Clin Infect Dis 1997;25:247-259.
12. Sumaraju V, Smith LG, Smith SM. Infectious complications in asplenic hosts. Infect Dis Clin North Am 2001;15:551-565, x.
13. Karakas Z, Agaoglu L, Taravari B, Saribeyoglu E, Somer A, Guler N, Unuvar A, Anak S, Yalcin I, Devecioglu O. Pulmonary tuberculosis in children with Hodgkin's lymphoma. Hematol J 2003;4:78-81.
14. Saugier-Veber P, Devergie A, Sulahian A, Ribaud P, Traore F, Bourdeau-Esperou H, Gluckman E, Derouin F. Epidemiology and diagnosis of invasive pulmonary aspergillosis in bone marrow transplant patients: results of a 5 year retrospective study. Bone Marrow Transplant 1993;12:121-124.
15. Denning DW. Therapeutic outcome in invasive aspergillosis. Clin Infect Dis 1996;23:608-615.
16. Reichenberger F, Habicht J, Matt P, Frei R, Soler M, Bolliger CT, Dalquen P, Gratwohl A, Tamm M. Diagnostic yield of bronchoscopy in histologically proven invasive pulmonary aspergillosis. Bone Marrow Transplant 1999;24:1195-1199.
17. Sonnet S, Buitrago-Tellez CH, Tamm M, Christen S, Steinbrich W. Direct detection of angioinvasive pulmonary aspergillosis in immunosuppressed patients: preliminary results with high-resolution 16-MDCT angiography. AJR Am J Roentgenol 2005;184:746-751.
18. Reichenberger F, Habicht J, Kaim A, Dalquen P, Bernet F, Schlapfer R, Stulz P, Perruchoud AP, Tichelli A, Gratwohl A, et al. Lung resection for invasive pulmonary aspergillosis in neutropenic patients with hematologic diseases. Am J Respir Crit Care Med 1998;158:885-890.
19. Yale SH, Limper AH. Pneumocystis carinii pneumonia in patients without acquired immunodeficiency syndrome: associated illness and prior corticosteroid therapy. Mayo Clin Proc 1996;71:5-13.
20. Zahar JR, Robin M, Azoulay E, Fieux F, Nitenberg G, Schlemmer B. Pneumocystis carinii pneumonia in critically ill patients with malignancy: a descriptive study. Clin Infect Dis 2002;35:929-934.
21. Prellner T, Flamholc L, Haidl S, Lindholm K, Widell A. Herpes simplex virus: the most frequently isolated pathogen in the lungs of patients with severe respiratory distress. Scand J Infect Dis 1992;24:283-292.
22. Feldman S, Stokes DC. Varicella zoster and herpes simplex virus pneumonias. Semin Respir Infect 1987;2:84-94.
23. Whimbey E, Englund JA, Couch RB. Community respiratory virus infections in immunocompromised patients with cancer. Am J Med 1997;102:10-18 (discussion: 25-26).
24. Ebbert JO, Limper AH. Respiratory syncytial virus pneumonitis in immunocompromised adults: clinical features and outcome. Respiration (Herrlisheim) 2005;72:263-269.
25. Anaissie EJ, Mahfouz TH, Aslan T, Pouli A, Desikan R, Fassas A, Barlogie B. The natural history of respiratory syncytial virus infection in cancer and transplant patients: implications for management. Blood 2004;103:1611-1617.
26. Crawford J, Ozer H, Stoller R, Johnson D, Lyman G, Tabbara I, Kris M, Grous J, Picozzi V, Rausch G, et al. Reduction by granulocyte colony-stimulating factor of fever and neutropenia induced by chemotherapy in patients with small-cell lung cancer. N Engl J Med 1991;325:164-170.
27. Sleijfer S. Bleomycin-induced pneumonitis. Chest 2001;120:617-624.
28. Oliner H, Schwartz R, Rubio F, Dameshek W. Interstitial pulmonary fibrosis following busulfan therapy. Am J Med 1961;31:134-139.
29. Malik SW, Myers JL, DeRemee RA, Specks U. Lung toxicity associated with cyclophosphamide use: two distinct patterns. Am J Respir Crit Care Med 1996;154:1851-1856.
30. Wong P, Leung AN, Berry GJ, Atkins KA, Montoya JG, Ruoss SJ, Stockdale FE. Paclitaxel-induced hypersensitivity pneumonitis: radiographic and CT findings. AJR Am J Roentgenol 2001;176:718-720.
31. Stover DE, Zaman MB, Hajdu SI, Lange M, Gold J, Armstrong D. Bronchoalveolar lavage in the diagnosis of diffuse pulmonary infiltrates in the immunosuppressed host. Ann Intern Med 1984;101:1-7.
32. Chhajed PN, Tamm M, Glanville AR. Role of flexible bronchoscopy in lung transplantation. Semin Respir Crit Care Med 2004;25:413-423.
33. Reichenberger F, Habicht JM, Gratwohl A, Tamm M. Diagnosis and treatment of invasive pulmonary aspergillosis in neutropenic patients. Eur Respir J 2002;19:743-755.
34. Tamm M, Reichenberger F, McGandy CE, Stalder A, Tietz A, Dalquen P, Perruchoud AP, Cathomas G. Diagnosis of pulmonary Kaposi's sarcoma by detection of human herpes virus 8 in bronchoalveolar lavage. Am J Respir Crit Care Med 1998;157:458-463.
35. Tamm M, Traenkle P, Grilli B, Soler M, Bolliger CT, Dalquen P, Cathomas G. Pulmonary cytomegalovirus infection in immunocompromised patients. Chest 2001;119:838-843.
36. Bass J, White DA. Thoracentesis in patients with hematologic malignancy: yield and safety. Chest 2005;127:2101-2105.