Effects of P-glycoprotein and Mrp2 inhibitors on the hepatobiliary disposition of rhodamine 123 and its glucuronidated metabolite in isolated perfused rat livers

Journal of Pharmaceutical Sciences

Volumn 99, Issue 1, 2010, Pages 455-466

  Parasrampuria, Ridhi ^a   Mehvar, Reza ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Biliary excretion; Cyclosporine; Dibromosulfophthalein; Efflux pumps; Hepatic metabolism; Hepatobiliary disposition; Isolated rat liver perfusion; Microsomes; Rhodamine 123; Rhodamine 123 glucuronide

Indexed keywords

CYCLOSPORIN A; DIBROMOSULFOPHTHALEIN; DRUG METABOLITE; GLUCURONIDE; RHODAMINE 123;

ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BILIARY EXCRETION; CONTROLLED STUDY; DEACYLATION; DRUG CLEARANCE; DRUG DISPOSITION; DRUG GLUCURONIDATION; DRUG HALF LIFE; HEPATOBILIARY SYSTEM; LIVER PERFUSION; MALE; NONHUMAN; RAT;

EID: 73949115272     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21831     Document Type: Article

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