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Volumn 7, Issue 1, 2004, Pages 47-54

Hepatic disposition of cyclosporine A in isolated perfused rat livers

Author keywords

[No Author keywords available]

Indexed keywords

BUFFER; CYCLOSPORIN A;

EID: 2442506851     PISSN: 14821826     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (10)

References (28)
  • 1
    • 0021327063 scopus 로고
    • Disposition of cyclosporine in several animal species and man. I. Structural elucidation of its metabolites
    • Maurer, G., Loosli, H. R., Schreier, E., and Keller, B. Disposition of cyclosporine in several animal species and man. I. Structural elucidation of its metabolites. Drug Metab. Dispos. 12: 120-126, 1984.
    • (1984) Drug Metab. Dispos. , vol.12 , pp. 120-126
    • Maurer, G.1    Loosli, H.R.2    Schreier, E.3    Keller, B.4
  • 2
    • 0023921505 scopus 로고
    • Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs
    • Kronbach, T., Fischer, V., and Meyer, U. A. Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs. Clin. Pharmacol. Ther. 43: 630-635, 1988.
    • (1988) Clin. Pharmacol. Ther. , vol.43 , pp. 630-635
    • Kronbach, T.1    Fischer, V.2    Meyer, U.A.3
  • 4
    • 0025719746 scopus 로고
    • First-pass metabolism of cyclosporin by the gut
    • Kolars, J. C., Awni, W. M., Merion, R. M., and Watkins, P. B. First-pass metabolism of cyclosporin by the gut. Lancet 338: 1488-1490, 1991.
    • (1991) Lancet , vol.338 , pp. 1488-1490
    • Kolars, J.C.1    Awni, W.M.2    Merion, R.M.3    Watkins, P.B.4
  • 6
    • 0028820208 scopus 로고
    • Differentiation of absorption and first-pass gut and hepatic metabolism in humans: Studies with cyclosporine
    • Wu, C. Y., Benet, L. Z., Hebert, M. F., Gupta, S. K., Rowland, M., Gomez, D. Y., and Wacher, V. J. Differentiation of absorption and first-pass gut and hepatic metabolism in humans: Studies with cyclosporine. Clin. Pharmacol. Ther. 58: 492-497, 1995.
    • (1995) Clin. Pharmacol. Ther. , vol.58 , pp. 492-497
    • Wu, C.Y.1    Benet, L.Z.2    Hebert, M.F.3    Gupta, S.K.4    Rowland, M.5    Gomez, D.Y.6    Wacher, V.J.7
  • 7
    • 0027174992 scopus 로고
    • Cyclosporin clinical pharmacokinetics
    • Fahr, A. Cyclosporin clinical pharmacokinetics. Clin. Pharmacokinet. 24: 472-495, 1993.
    • (1993) Clin. Pharmacokinet. , vol.24 , pp. 472-495
    • Fahr, A.1
  • 8
    • 0023197640 scopus 로고
    • Tissue distribution, disposition, and metabolism of cyclosporine in rats
    • Wagner, O., Schreier, E., Heitz, F., and Maurer, G. Tissue distribution, disposition, and metabolism of cyclosporine in rats. Drug Metab. Dispos. 15: 377-383., 1987.
    • (1987) Drug Metab. Dispos. , vol.15 , pp. 377-383
    • Wagner, O.1    Schreier, E.2    Heitz, F.3    Maurer, G.4
  • 9
    • 0023712859 scopus 로고
    • Cyclosporine pharmacokinetics in rats and interspecies comparison in dogs, rabbits, rats, and humans
    • Sangalli, L., Bortolotti, A., Jiritano, L., and Bonati, M. Cyclosporine pharmacokinetics in rats and interspecies comparison in dogs, rabbits, rats, and humans. Drug Metab. Dispos. 16: 749-753, 1988.
    • (1988) Drug Metab. Dispos. , vol.16 , pp. 749-753
    • Sangalli, L.1    Bortolotti, A.2    Jiritano, L.3    Bonati, M.4
  • 10
    • 0034002641 scopus 로고    scopus 로고
    • Dependency of cyclosporine tissue distribution and metabolism on the age and gender of rats after a single intravenous dose
    • Molpeceres, J., Chacon, M., Guzman, M., Aberturas, M. R., and Berges, L. Dependency of cyclosporine tissue distribution and metabolism on the age and gender of rats after a single intravenous dose. Int. J. Pharm. 197: 129-141, 2000.
    • (2000) Int. J. Pharm. , vol.197 , pp. 129-141
    • Molpeceres, J.1    Chacon, M.2    Guzman, M.3    Aberturas, M.R.4    Berges, L.5
  • 11
    • 0029058633 scopus 로고
    • Time course of cyclosporine and its metabolites in blood, liver and spleen of naive Lewis rats: Comparison with data obtained in transplanted animals
    • Wacher, V. J., Liu, T., Roberts, J. P., Ascher, N. L., and Benet, L. Z. Time course of cyclosporine and its metabolites in blood, liver and spleen of naive Lewis rats: Comparison with data obtained in transplanted animals. Biopharm. Drug Dispos. 16: 303-312, 1995.
    • (1995) Biopharm. Drug Dispos. , vol.16 , pp. 303-312
    • Wacher, V.J.1    Liu, T.2    Roberts, J.P.3    Ascher, N.L.4    Benet, L.Z.5
  • 12
    • 0026015774 scopus 로고
    • Physiologic modeling of cyclosporine kinetics in rat and man
    • Bernareggi, A. and Rowland, M. Physiologic modeling of cyclosporine kinetics in rat and man. J. Pharmacokinet. Biopharm. 19: 21-50, 1991.
    • (1991) J. Pharmacokinet. Biopharm. , vol.19 , pp. 21-50
    • Bernareggi, A.1    Rowland, M.2
  • 13
    • 0026560776 scopus 로고
    • Transport and metabolism of cyclosporine in isolated rat hepatocytes. The effects of lipids
    • Prueksaritanont, T., Koike, M., Hoener, B. A., and Benet, L. Z. Transport and metabolism of cyclosporine in isolated rat hepatocytes. The effects of lipids. Biochem. Pharmacol. 43: 1997-2006., 1992.
    • (1992) Biochem. Pharmacol. , vol.43 , pp. 1997-2006
    • Prueksaritanont, T.1    Koike, M.2    Hoener, B.A.3    Benet, L.Z.4
  • 14
    • 0347626159 scopus 로고    scopus 로고
    • Current immunosuppressive agents: Efficacy, side effects, and utilization
    • Smith, J. M., Nemeth, T. L., and McDonald, R. A. Current immunosuppressive agents: efficacy, side effects, and utilization. Pediat. Clin. N. Amer. 50: 1283-1300, 2003.
    • (2003) Pediat. Clin. N. Amer. , vol.50 , pp. 1283-1300
    • Smith, J.M.1    Nemeth, T.L.2    McDonald, R.A.3
  • 15
    • 0026688788 scopus 로고
    • Effects of low-density lipoprotein and ethinyl estradiol on cyclosporine metabolism in isolated rat liver perfusions
    • Prueksaritanont, T., Hoener, B. A., and Benet, L. Z. Effects of low-density lipoprotein and ethinyl estradiol on cyclosporine metabolism in isolated rat liver perfusions. Drug Metab. Dispos. 20: 547-552, 1992.
    • (1992) Drug Metab. Dispos. , vol.20 , pp. 547-552
    • Prueksaritanont, T.1    Hoener, B.A.2    Benet, L.Z.3
  • 16
    • 0022369121 scopus 로고
    • A new method for assessment of drug disposition in muscle: Application of statistical moment theory to local perfusion systems
    • Kakutani, T., Yamaoka, K., Hashida, M., and Sezaki, H. A new method for assessment of drug disposition in muscle: Application of statistical moment theory to local perfusion systems. J. Pharmacokinet. Biopharm. 13: 609-631, 1985.
    • (1985) J. Pharmacokinet. Biopharm. , vol.13 , pp. 609-631
    • Kakutani, T.1    Yamaoka, K.2    Hashida, M.3    Sezaki, H.4
  • 17
    • 0028525202 scopus 로고
    • Molecular weight dependent tissue accumulation of dextrans: In vivo studies in rats
    • Mehvar, R., Robinson, M. A., and Reynolds, J. M. Molecular weight dependent tissue accumulation of dextrans: in vivo studies in rats. J. Pharm. Sci. 83: 1495-1499, 1994.
    • (1994) J. Pharm. Sci. , vol.83 , pp. 1495-1499
    • Mehvar, R.1    Robinson, M.A.2    Reynolds, J.M.3
  • 18
    • 0021961581 scopus 로고
    • Blood volume in the rat
    • Lee, H. B. and Blaufox, M. D. Blood volume in the rat. J. Nucl. Med. 26: 72-76, 1985.
    • (1985) J. Nucl. Med. , vol.26 , pp. 72-76
    • Lee, H.B.1    Blaufox, M.D.2
  • 19
    • 0036147134 scopus 로고    scopus 로고
    • Development and application of an isolated perfused rat liver model to study the stimulation and inhibition of tumor necrosis factor-α production ex vivo
    • Mehvar, R. and Zhang, X. P. Development and application of an isolated perfused rat liver model to study the stimulation and inhibition of tumor necrosis factor-α production ex vivo. Pharm. Res. 19: 47-53, 2002.
    • (2002) Pharm. Res. , vol.19 , pp. 47-53
    • Mehvar, R.1    Zhang, X.P.2
  • 20
    • 0027986693 scopus 로고
    • Enantioselective kinetics of verapamil and norverapamil in isolated perfused rat livers
    • Mehvar, R., Reynolds, J. M., Robinson, M. A., and Longstreth, J. A. Enantioselective kinetics of verapamil and norverapamil in isolated perfused rat livers. Pharm. Res. 11: 1815-1819, 1994.
    • (1994) Pharm. Res. , vol.11 , pp. 1815-1819
    • Mehvar, R.1    Reynolds, J.M.2    Robinson, M.A.3    Longstreth, J.A.4
  • 21
    • 0037172366 scopus 로고    scopus 로고
    • High-performance liquid chromatographic analysis of cyclosporin A in rat blood and liver using a commercially available internal standard
    • Chimalakonda, A. P., Shah, R. B., and Mehvar, R. High-performance liquid chromatographic analysis of cyclosporin A in rat blood and liver using a commercially available internal standard. J. Chromatogr. B 772: 107-114, 2002.
    • (2002) J. Chromatogr. B , vol.772 , pp. 107-114
    • Chimalakonda, A.P.1    Shah, R.B.2    Mehvar, R.3
  • 22
    • 0027093289 scopus 로고
    • Molecular weight-dependent pharmacokinetics of fluorescein-labeled dextrans in rats
    • Mehvar, R. and Shepard, T. L. Molecular weight-dependent pharmacokinetics of fluorescein-labeled dextrans in rats. J. Pharm. Sci. 81: 908-912, 1992.
    • (1992) J. Pharm. Sci. , vol.81 , pp. 908-912
    • Mehvar, R.1    Shepard, T.L.2
  • 23
    • 0030800331 scopus 로고    scopus 로고
    • Reevaluation of cyclosporine induced hepatotoxicity in the isolated perfused rat liver
    • Deters, M., Strubelt, O., and Younes, M. Reevaluation of cyclosporine induced hepatotoxicity in the isolated perfused rat liver. Toxicology 123: 197-206, 1997.
    • (1997) Toxicology , vol.123 , pp. 197-206
    • Deters, M.1    Strubelt, O.2    Younes, M.3
  • 26
    • 0022651554 scopus 로고
    • Demographic factors affecting the pharmacokinetics of cyclosporine estimated by radioimmunoassay
    • Kahan, B. D., Kramer, W. G., Wideman, C., Flechner, S. M., Lorber, M. I., and Van Buren, C. T. Demographic factors affecting the pharmacokinetics of cyclosporine estimated by radioimmunoassay. Transplantation 41: 459-464, 1986.
    • (1986) Transplantation , vol.41 , pp. 459-464
    • Kahan, B.D.1    Kramer, W.G.2    Wideman, C.3    Flechner, S.M.4    Lorber, M.I.5    Van Buren, C.T.6
  • 27
    • 0027250712 scopus 로고
    • Cyclosporine metabolism by rat liver microsomes. Evidence for involvement of enzyme(s) other than cytochromes P-450 3A
    • Prueksaritanont, T., Correia, M. A., Rettie, A. E., Swinney, D. C., Thomas, P. E., and Benet, L. Z. Cyclosporine metabolism by rat liver microsomes. Evidence for involvement of enzyme(s) other than cytochromes P-450 3A. Drug Metab. Dispos. 21: 730-737., 1993.
    • (1993) Drug Metab. Dispos. , vol.21 , pp. 730-737
    • Prueksaritanont, T.1    Correia, M.A.2    Rettie, A.E.3    Swinney, D.C.4    Thomas, P.E.5    Benet, L.Z.6
  • 28
    • 0024227389 scopus 로고
    • Effects of perfusate flow rate on measured blood volume, disse space, intracellular water space, and drug extraction in the perfused rat liver preparation: Characterization by the multiple indicator dilution technique
    • Pang, K. S., Lee, W. F., Cherry, W. F., Yuen, V., Accaputo, J., Fayz, S., Schwab, A. J., and Goresky, C. A. Effects of perfusate flow rate on measured blood volume, disse space, intracellular water space, and drug extraction in the perfused rat liver preparation: characterization by the multiple indicator dilution technique. J. Pharmacokinet. Biopharm. 16: 595-631, 1988.
    • (1988) J. Pharmacokinet. Biopharm. , vol.16 , pp. 595-631
    • Pang, K.S.1    Lee, W.F.2    Cherry, W.F.3    Yuen, V.4    Accaputo, J.5    Fayz, S.6    Schwab, A.J.7    Goresky, C.A.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.