In vivo effects of cyclosporin A and ketoconazole on the pharmacokinetics of representative substrates for P-glycoprotein and cytochrome P450 (CYP) 3A in rats

Biological and Pharmaceutical Bulletin

Volumn 28, Issue 2, 2005, Pages 316-322

  Kageyama, Michiharu ^a   Namiki, Hitomi ^a   Fukushima, Hiroto ^a   Ito, Yukako ^a   Shibata, Nobuhito ^a   Takada, Kanji ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Cyclosporin A; CYP3A; Drug interaction; Ketoconazole; P glycoprotein; Substrate

Indexed keywords

CYCLOSPORIN A; CYTOCHROME P450 3A; ERYTHROMYCIN; GLYCOPROTEIN P; INDINAVIR; KETOCONAZOLE; NELFINAVIR; PROTEIN INHIBITOR; RHODAMINE 123; CYCLOSPORIN; ENZYME INHIBITOR; N DEMETHYLASE; UNSPECIFIC MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BILIARY EXCRETION; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG POTENCY; ENZYME SUBSTRATE; EVALUATION; IN VIVO STUDY; INHIBITION KINETICS; INTESTINE FUNCTION; JEJUNUM; LIVER METABOLISM; MALE; NONHUMAN; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; RAT; RISK FACTOR; ANIMAL; COMPARATIVE STUDY; DRUG EFFECT; ENZYME SPECIFICITY; PHYSIOLOGY; WISTAR RAT;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CYCLOSPORINE; CYTOCHROME P-450 CYP3A; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; KETOCONAZOLE; MALE; OXIDOREDUCTASES, N-DEMETHYLATING; P-GLYCOPROTEIN; RATS; RATS, WISTAR; SUBSTRATE SPECIFICITY;

EID: 19444367783     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.28.316     Document Type: Article

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