Hepatic disposition and effects of nitric oxide donors: Rapid and concentration-dependent reduction in the cytochrome P450-mediated drug metabolism in isolated perfused rat livers

Journal of Pharmacology and Experimental Therapeutics

Volumn 310, Issue 2, 2004, Pages 718-727

  Vuppugalla, Ragini ^a   Mehvar, Reza ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPROTEIN; CYTOCHROME P450; CYTOCHROME P450 2D1; CYTOKINE; ISOENZYME; ISOSORBIDE DINITRATE; NITRATE; NITRIC OXIDE; NITRIC OXIDE DONOR; NITROPRUSSIDE SODIUM;

ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG DISPOSITION; DRUG EFFECT; DRUG METABOLISM; ENZYME ACTIVITY; INFLAMMATION; LIVER PERFUSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; LIVER; MALE; NITRIC OXIDE; NITRIC OXIDE DONORS; PERFUSION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 3343020844     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.065557     Document Type: Article

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