Dexamethasone inhibits the induction of inos gene expression through destabilization of its mrna in proinflammatory cytokine-stimulated hepatocytes

Shock

Volumn 33, Issue 1, 2010, Pages 64-69

  Ozaki, Takashi ^a   Habara, Kozo ^a   Matsui, Kosuke ^a   Kaibori, Masaki ^a   Kwon, A Hon ^a   Ito, Seiji ^b   Nishizawa, Mikio ^c   Okumura, Tadayoshi ^b,d  

^a Department of Surgery ^*

^b KANSAI MEDICAL UNIVERSITY   (Japan)

^c Dentistry and Nursing

^d RITSUMEIKAN UNIVERSITY   (Japan)

Author keywords

Dexamethasone; IL 1 ; INOS; MRNA stability; Nuclear factor B; Type I IL 1 receptor

Indexed keywords

COMPLEMENTARY DNA; CYTOKINE; DEXAMETHASONE; GLUCOCORTICOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1 RECEPTOR; MESSENGER RNA; RECOMBINANT INTERLEUKIN 1BETA;

3' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME INDUCTION; GENE EXPRESSION; INFLAMMATION; LIVER CELL; LIVER CELL CULTURE; LIVER INJURY; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PROMOTER REGION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELLS, CULTURED; CYTOKINES; DEXAMETHASONE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HEPATOCYTES; HUMANS; INTERLEUKIN-1BETA; L-LACTATE DEHYDROGENASE; MALE; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; NITROGEN OXIDES; PROMOTER REGIONS, GENETIC; RATS; RATS, WISTAR; RECEPTORS, INTERLEUKIN-1 TYPE I; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA STABILITY;

EID: 73849134417     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/SHK.0b013e3181a7fd74     Document Type: Article

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