Edaravone prevents iNOS expression by inhibiting its promoter transactivation and mRNA stability in cytokine-stimulated hepatocytes

Nitric Oxide - Biology and Chemistry

Volumn 18, Issue 2, 2008, Pages 105-112

  Yoshida, Hideyuki ^a   Kwon, A Hon ^a   Kaibori, Masaki ^a   Tsuji, Katsushige ^a   Habara, Kozo ^a   Yamada, Masanori ^a   Kamiyama, Yasuo ^a   Nishizawa, Mikio ^a,b   Ito, Seiji ^a   Okumura, Tadayoshi ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b RITSUMEIKAN UNIVERSITY   (Japan)

Author keywords

Edaravone; Inducible nitric oxide synthase; Interleukin 1 ; mRNA stability; Nuclear factor B; Type I interleukin 1 receptor

Indexed keywords

CYTOKINE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1BETA; MESSENGER RNA; NORPHENAZONE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

3' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INDUCTION; LIVER CELL; LIVER INJURY; MALE; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; RNA STABILITY; UPREGULATION;

ANIMALS; ANTIPYRINE; CELLS, CULTURED; FREE RADICAL SCAVENGERS; HEPATOCYTES; INTERLEUKIN-1BETA; MALE; NITRIC OXIDE SYNTHASE TYPE II; PROMOTER REGIONS (GENETICS); RATS; RATS, WISTAR; RNA, MESSENGER; TRANS-ACTIVATION (GENETICS);

RATTUS;

EID: 38749119753     PISSN: 10898603     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.niox.2007.11.003     Document Type: Article

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