메뉴 건너뛰기




Volumn 44, Issue 12, 2007, Pages 3204-3210

Regulation of the murine inducible nitric oxide synthase gene by dexamethasone involves a heterogeneous nuclear ribonucleoprotein I (hnRNPI) dependent pathway

Author keywords

3 UTR; Dexamethasone; hnRNP; iNOS; mRNA stability; Post transcriptional regulation

Indexed keywords

DEXAMETHASONE; GAMMA INTERFERON; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 1; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MESSENGER RNA; UNCLASSIFIED DRUG;

EID: 34247253736     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2007.01.029     Document Type: Article
Times cited : (12)

References (33)
  • 1
    • 0032925361 scopus 로고    scopus 로고
    • Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-gamma
    • Ajizian S.J., English B.K., and Meals E.A. Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-gamma. J. Infect. Dis. 179 (1999) 939-944
    • (1999) J. Infect. Dis. , vol.179 , pp. 939-944
    • Ajizian, S.J.1    English, B.K.2    Meals, E.A.3
  • 2
    • 0029126879 scopus 로고
    • mRNA decay mediated by two distinct AU-rich elements from c-fos and granulocyte-macrophage colony-stimulating factor transcripts: different deadenylation kinetics and uncoupling from translation
    • Chen C.Y., Xu N., and Shyu A.B. mRNA decay mediated by two distinct AU-rich elements from c-fos and granulocyte-macrophage colony-stimulating factor transcripts: different deadenylation kinetics and uncoupling from translation. Mol. Cell. Biol. 15 (1995) 5777-5788
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 5777-5788
    • Chen, C.Y.1    Xu, N.2    Shyu, A.B.3
  • 3
  • 4
    • 0031771622 scopus 로고    scopus 로고
    • Stabilization of granulocyte-macrophage colony-stimulating factor RNA in a human eosinophil-like cell line requires the AUUUA motifs
    • Esnault S., Jarzembowski J.A., and Malter J.S. Stabilization of granulocyte-macrophage colony-stimulating factor RNA in a human eosinophil-like cell line requires the AUUUA motifs. Proc. Assoc. Am. Phys. 110 (1998) 575-584
    • (1998) Proc. Assoc. Am. Phys. , vol.110 , pp. 575-584
    • Esnault, S.1    Jarzembowski, J.A.2    Malter, J.S.3
  • 6
    • 0034698066 scopus 로고    scopus 로고
    • Glucocorticoid-mediated destabilization of cyclin D3 mRNA involves RNA-protein interactions in the 3'-untranslated region of the mRNA
    • Garcia-Gras E.A., Chi P., and Thompson E.A. Glucocorticoid-mediated destabilization of cyclin D3 mRNA involves RNA-protein interactions in the 3'-untranslated region of the mRNA. J. Biol. Chem. 275 (2000) 22001-22008
    • (2000) J. Biol. Chem. , vol.275 , pp. 22001-22008
    • Garcia-Gras, E.A.1    Chi, P.2    Thompson, E.A.3
  • 7
    • 0038392886 scopus 로고    scopus 로고
    • Interplay between transcriptional and post-transcriptional regulation of Cyp2a5 expression
    • Glisovic T., Söderberg M., Christian K., Lang M., and Raffalli-Mathieu F. Interplay between transcriptional and post-transcriptional regulation of Cyp2a5 expression. Biochem. Pharmacol. 65 (2003) 1653-1661
    • (2003) Biochem. Pharmacol. , vol.65 , pp. 1653-1661
    • Glisovic, T.1    Söderberg, M.2    Christian, K.3    Lang, M.4    Raffalli-Mathieu, F.5
  • 8
    • 13844270512 scopus 로고    scopus 로고
    • Inhibition of tristetraprolin expression by dexamethasone in activated macrophages
    • Jalonen U., Lahti A., Korhonen R., Kankaanranta H., and Moilanen E. Inhibition of tristetraprolin expression by dexamethasone in activated macrophages. Biochem. Pharmacol. 69 (2005) 733-740
    • (2005) Biochem. Pharmacol. , vol.69 , pp. 733-740
    • Jalonen, U.1    Lahti, A.2    Korhonen, R.3    Kankaanranta, H.4    Moilanen, E.5
  • 9
    • 0034691522 scopus 로고    scopus 로고
    • Dexamethasone inhibits IL-1 beta gene expression in LPS-stimulated RAW 264.7 cells by blocking NF-kappa B/Rel and AP-1 activation
    • Jeon Y.J., Han S.H., Lee Y.W., Lee M., Yang K.H., and Kim H.M. Dexamethasone inhibits IL-1 beta gene expression in LPS-stimulated RAW 264.7 cells by blocking NF-kappa B/Rel and AP-1 activation. Immunopharmacology 48 (2000) 173-183
    • (2000) Immunopharmacology , vol.48 , pp. 173-183
    • Jeon, Y.J.1    Han, S.H.2    Lee, Y.W.3    Lee, M.4    Yang, K.H.5    Kim, H.M.6
  • 10
    • 1442333588 scopus 로고    scopus 로고
    • Inhibition of p38 and ERK MAP kinases blocks endotoxin-induced nitric oxide production and differentially modulates cytokine expression
    • Kim S.H., Kim J., and Sharma R.P. Inhibition of p38 and ERK MAP kinases blocks endotoxin-induced nitric oxide production and differentially modulates cytokine expression. Pharmacol. Res. 49 (2004) 433-439
    • (2004) Pharmacol. Res. , vol.49 , pp. 433-439
    • Kim, S.H.1    Kim, J.2    Sharma, R.P.3
  • 11
    • 0030060927 scopus 로고    scopus 로고
    • Glucocorticoids inhibit the induction of nitric oxide synthase II by down-regulating cytokine-induced activity of transcription factor nuclear factor-kappa B
    • Kleinert H., Euchenhofer C., Ihrig-Biedert I., and Förstermann U. Glucocorticoids inhibit the induction of nitric oxide synthase II by down-regulating cytokine-induced activity of transcription factor nuclear factor-kappa B. Mol. Pharmacol. 49 (1996) 15-21
    • (1996) Mol. Pharmacol. , vol.49 , pp. 15-21
    • Kleinert, H.1    Euchenhofer, C.2    Ihrig-Biedert, I.3    Förstermann, U.4
  • 12
    • 0036765329 scopus 로고    scopus 로고
    • Dexamethasone inhibits inducible nitric-oxide synthase expression and nitric oxide production by destabilizing mRNA in lipopolysaccharide-treated macrophages
    • Korhonen R., Lahti A., Hämäläinen M., Kankaanranta H., and Moilanen E. Dexamethasone inhibits inducible nitric-oxide synthase expression and nitric oxide production by destabilizing mRNA in lipopolysaccharide-treated macrophages. Mol. Pharmacol. 62 (2002) 698-704
    • (2002) Mol. Pharmacol. , vol.62 , pp. 698-704
    • Korhonen, R.1    Lahti, A.2    Hämäläinen, M.3    Kankaanranta, H.4    Moilanen, E.5
  • 13
    • 0030070297 scopus 로고    scopus 로고
    • Molecular mechanisms of dexamethasone inhibition of nitric oxide synthase expression in interleukin 1 beta-stimulated mesangial cells: evidence for the involvement of transcriptional and posttranscriptional regulation
    • Kunz D., Walker G., Eberhardt W., and Pfeilschifter J. Molecular mechanisms of dexamethasone inhibition of nitric oxide synthase expression in interleukin 1 beta-stimulated mesangial cells: evidence for the involvement of transcriptional and posttranscriptional regulation. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 255-259
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 255-259
    • Kunz, D.1    Walker, G.2    Eberhardt, W.3    Pfeilschifter, J.4
  • 14
    • 0042844654 scopus 로고    scopus 로고
    • c-Jun NH2-terminal kinase inhibitor anthra(1,9-cd)pyrazol-6(2H)-one reduces inducible nitric-oxide synthase expression by destabilizing mRNA in activated macrophages
    • Lahti A., Jalonen U., Kankaanranta H., and Moilanen E. c-Jun NH2-terminal kinase inhibitor anthra(1,9-cd)pyrazol-6(2H)-one reduces inducible nitric-oxide synthase expression by destabilizing mRNA in activated macrophages. Mol. Pharmacol. 64 (2003) 308-315
    • (2003) Mol. Pharmacol. , vol.64 , pp. 308-315
    • Lahti, A.1    Jalonen, U.2    Kankaanranta, H.3    Moilanen, E.4
  • 15
    • 0035138742 scopus 로고    scopus 로고
    • Dexamethasone destabilizes cyclooxygenase 2 mRNA by inhibiting mitogen-activated protein kinase p38
    • Lasa M., Brook M., Saklatvala J., and Clark A.R. Dexamethasone destabilizes cyclooxygenase 2 mRNA by inhibiting mitogen-activated protein kinase p38. Mol. Cell. Biol. 21 (2001) 771-780
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 771-780
    • Lasa, M.1    Brook, M.2    Saklatvala, J.3    Clark, A.R.4
  • 16
    • 0036841288 scopus 로고    scopus 로고
    • Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38
    • Lasa M., Abraham S.M., Boucheron C., Saklatvala J., and Clark A.R. Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38. Mol. Cell. Biol. 22 (2002) 7802-7811
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 7802-7811
    • Lasa, M.1    Abraham, S.M.2    Boucheron, C.3    Saklatvala, J.4    Clark, A.R.5
  • 17
    • 24144499990 scopus 로고    scopus 로고
    • Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR
    • Linker K., Pautz A., Fechir M., Hubrich T., Greeve J., and Kleinert H. Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR. Nucleic Acids Res. 33 (2005) 4813-4827
    • (2005) Nucleic Acids Res. , vol.33 , pp. 4813-4827
    • Linker, K.1    Pautz, A.2    Fechir, M.3    Hubrich, T.4    Greeve, J.5    Kleinert, H.6
  • 19
    • 10144224274 scopus 로고    scopus 로고
    • Nitric oxide synthase type II mRNA stability is translation- and transcription-dependent
    • Park S.K., and Murphy S. Nitric oxide synthase type II mRNA stability is translation- and transcription-dependent. J. Neurochem. 67 (1996) 1766-1769
    • (1996) J. Neurochem. , vol.67 , pp. 1766-1769
    • Park, S.K.1    Murphy, S.2
  • 20
    • 0026100340 scopus 로고
    • The AU-rich sequences in the 3' untranslated region mediate the increased turnover of interferon mRNA induced by glucocorticoids
    • Peppel K., Vinci J.M., and Baglioni C. The AU-rich sequences in the 3' untranslated region mediate the increased turnover of interferon mRNA induced by glucocorticoids. J. Exp. Med. 173 (1991) 349-355
    • (1991) J. Exp. Med. , vol.173 , pp. 349-355
    • Peppel, K.1    Vinci, J.M.2    Baglioni, C.3
  • 21
    • 0025672648 scopus 로고
    • Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells
    • Radomski M.W., Palmer R.M., and Moncada S. Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 87 (1990) 10043-10047
    • (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 10043-10047
    • Radomski, M.W.1    Palmer, R.M.2    Moncada, S.3
  • 22
    • 0028107237 scopus 로고
    • Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor
    • Ray A., and Prefontaine K.E. Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor. Proc. Natl. Acad. Sci. U. S.A. 91 (1994) 752-756
    • (1994) Proc. Natl. Acad. Sci. U. S.A. , vol.91 , pp. 752-756
    • Ray, A.1    Prefontaine, K.E.2
  • 23
    • 0029809863 scopus 로고    scopus 로고
    • Down-regulation of cytokine-induced cyclo-oxygenase-2 transcript isoforms by dexamethasone: evidence for post-transcriptional regulation
    • Ristimäki A., Narko K., and Hla T. Down-regulation of cytokine-induced cyclo-oxygenase-2 transcript isoforms by dexamethasone: evidence for post-transcriptional regulation. Biochem. J. 318 Pt. 1 (1996) 325-331
    • (1996) Biochem. J. , vol.318 , Issue.PART 1 , pp. 325-331
    • Ristimäki, A.1    Narko, K.2    Hla, T.3
  • 24
    • 0034714259 scopus 로고    scopus 로고
    • Complex contribution of the 3'-untranslated region to the expressional regulation of the human inducible nitric-oxide synthase gene. Involvement of the RNA-binding protein HuR.
    • Rodriguez-Pascual F., Hausding M., Ihrig-Biedert I., Furneaux H., Levy A.P., Förstermann U., and Kleinert H. Complex contribution of the 3'-untranslated region to the expressional regulation of the human inducible nitric-oxide synthase gene. Involvement of the RNA-binding protein HuR. J. Biol. Chem. 275 (2000) 26040-26049
    • (2000) J. Biol. Chem. , vol.275 , pp. 26040-26049
    • Rodriguez-Pascual, F.1    Hausding, M.2    Ihrig-Biedert, I.3    Furneaux, H.4    Levy, A.P.5    Förstermann, U.6    Kleinert, H.7
  • 26
    • 0028879819 scopus 로고
    • Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids
    • Scheinman R.I., Cogswell P.C., Lofquist A.K., and Baldwin Jr. A.S. Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids. Science 270 (1995) 283-286
    • (1995) Science , vol.270 , pp. 283-286
    • Scheinman, R.I.1    Cogswell, P.C.2    Lofquist, A.K.3    Baldwin Jr., A.S.4
  • 28
    • 0028787096 scopus 로고
    • Effect of transcription inhibitors on the iron-dependent degradation of transferrin receptor mRNA
    • Seiser C., Posch M., Thompson N., and Kuhn L.C. Effect of transcription inhibitors on the iron-dependent degradation of transferrin receptor mRNA. J. Biol. Chem. 270 (1995) 29400-29406
    • (1995) J. Biol. Chem. , vol.270 , pp. 29400-29406
    • Seiser, C.1    Posch, M.2    Thompson, N.3    Kuhn, L.C.4
  • 29
    • 0036070957 scopus 로고    scopus 로고
    • Inflammation modulates the interaction of heterogeneous nuclear ribonucleoprotein (hnRNP) I/polypyrimidine tract binding protein and hnRNP L with the 3'untranslated region of the murine inducible nitric-oxide synthase mRNA
    • Söderberg M., Raffalli-Mathieu F., and Lang M.A. Inflammation modulates the interaction of heterogeneous nuclear ribonucleoprotein (hnRNP) I/polypyrimidine tract binding protein and hnRNP L with the 3'untranslated region of the murine inducible nitric-oxide synthase mRNA. Mol. Pharmacol. 62 (2002) 423-431
    • (2002) Mol. Pharmacol. , vol.62 , pp. 423-431
    • Söderberg, M.1    Raffalli-Mathieu, F.2    Lang, M.A.3
  • 30
    • 33747868143 scopus 로고    scopus 로고
    • Identification of a regulatory cis-element within the 3'untranslated region of the murine inducible nitric-oxide synthase (iNOS) mRNA: interaction with heterogeneous nuclear ribonucleoproteins I and L and role in the iNOS gene expression
    • (Epub 2006)
    • Söderberg M., Raffalli-Mathieu F., and Lang M.A. Identification of a regulatory cis-element within the 3'untranslated region of the murine inducible nitric-oxide synthase (iNOS) mRNA: interaction with heterogeneous nuclear ribonucleoproteins I and L and role in the iNOS gene expression. Mol. Immunol. 44 (2007) 434-442 (Epub 2006)
    • (2007) Mol. Immunol. , vol.44 , pp. 434-442
    • Söderberg, M.1    Raffalli-Mathieu, F.2    Lang, M.A.3
  • 31
    • 0027203305 scopus 로고
    • Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta
    • Vodovotz Y., Bogdan C., Paik J., Xie Q.W., and Nathan C. Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta. J. Exp. Med. 178 (1993) 605-613
    • (1993) J. Exp. Med. , vol.178 , pp. 605-613
    • Vodovotz, Y.1    Bogdan, C.2    Paik, J.3    Xie, Q.W.4    Nathan, C.5
  • 32
    • 0030960334 scopus 로고    scopus 로고
    • Mechanisms of suppression of inducible nitric-oxide synthase (iNOS) expression in interferon (IFN)-gamma-stimulated RAW 264.7 cells by dexamethasone. Evidence for glucocorticoid-induced degradation of iNOS protein by calpain as a key step in post-transcriptional regulation
    • Walker G., Pfeilschifter J., and Kunz D. Mechanisms of suppression of inducible nitric-oxide synthase (iNOS) expression in interferon (IFN)-gamma-stimulated RAW 264.7 cells by dexamethasone. Evidence for glucocorticoid-induced degradation of iNOS protein by calpain as a key step in post-transcriptional regulation. J. Biol. Chem. 272 (1997) 16679-16687
    • (1997) J. Biol. Chem. , vol.272 , pp. 16679-16687
    • Walker, G.1    Pfeilschifter, J.2    Kunz, D.3
  • 33
    • 0028206469 scopus 로고
    • Dual mechanism for the control of inducible-type NO synthase gene expression in macrophages during activation by interferon-gamma and bacterial lipopolysaccharide. Transcriptional and post-transcriptional regulation
    • Weisz A., Oguchi S., Cicatiello L., and Esumi H. Dual mechanism for the control of inducible-type NO synthase gene expression in macrophages during activation by interferon-gamma and bacterial lipopolysaccharide. Transcriptional and post-transcriptional regulation. J. Biol. Chem. 269 (1994) 8324-8333
    • (1994) J. Biol. Chem. , vol.269 , pp. 8324-8333
    • Weisz, A.1    Oguchi, S.2    Cicatiello, L.3    Esumi, H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.