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Volumn 88, Issue 10, 2009, Pages 1149-1156

Fibrogenesis in kidney transplantation: Potential targets for prevention and therapy

Author keywords

EMT; Fibrosis; TGF

Indexed keywords

1 [5 CHLORO 2 [2 [4 (4 FLUOROBENZYL) 2 METHYL 1 PIPERAZINYL] 2 OXOETHOXY]PHENYL]UREA; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ALEMTUZUMAB; ALPHA TOCOPHEROL; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANTIFIBROTIC AGENT; ANTIOXIDANT; APOCYNIN; ARGININE; BASILIXIMAB; BELATACEPT; CHEMOKINE; CHEMOKINE RECEPTOR ANTAGONIST; CORTICOSTEROID; CYCLOSPORIN A; CYTOKINE RECEPTOR ANTAGONIST; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIPHENYLIODONIUM SALT; LOSARTAN; MET RANTES ANTAGONIST; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PIRFENIDONE; PROTEIN INHIBITOR; RAPAMYCIN; SMAD3 INHIBITOR; SMALL INTERFERING RNA; TACROLIMUS; TRANSFORMING GROWTH FACTOR BETA 1 ANTAGONIST; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 73849095809     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181bcccea     Document Type: Review
Times cited : (40)

References (69)
  • 1
    • 33644677802 scopus 로고    scopus 로고
    • Predicting subsequent decline in kidney allograft function from early surveillance biopsies
    • Cosio FG, Grande JP, Wadei H, et al. Predicting subsequent decline in kidney allograft function from early surveillance biopsies. Am J Transplant 2005; 5: 2464.
    • (2005) Am J Transplant , vol.5 , pp. 2464
    • Cosio, F.G.1    Grande, J.P.2    Wadei, H.3
  • 2
    • 34249052234 scopus 로고    scopus 로고
    • F-beta in renal injury and disease
    • Bottinger EP. TG. F-beta in renal injury and disease. Semin Nephrol 2007; 27: 309.
    • (2007) Semin Nephrol , vol.27 , pp. 309
    • Bottinger, E.P.1
  • 3
    • 36248929390 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition and chronic allograft tubulointerstitial fibrosis
    • Bedi S, Vidyasagar A, DjamaliA. Epithelial-to-mesenchymal transition and chronic allograft tubulointerstitial fibrosis. Transplant Rev (Orlando) 2008; 22: 1.
    • (2008) Transplant Rev (Orlando) , vol.22 , pp. 1
    • Bedi, S.1    Vidyasagar, A.2    Djamali, A.3
  • 4
    • 49649101155 scopus 로고    scopus 로고
    • Early epithelial phenotypic changes predict graft fibrosis
    • Hertig A, Anglicheau D, Verine J, et al. Early epithelial phenotypic changes predict graft fibrosis. J Am Soc Nephrol 2008; 19: 1584.
    • (2008) J Am Soc Nephrol , vol.19 , pp. 1584
    • Hertig, A.1    Anglicheau, D.2    Verine, J.3
  • 5
    • 67651005404 scopus 로고    scopus 로고
    • EMT: When epithelial cells decide to become mesenchymal-like cells
    • Kalluri R. EMT: When epithelial cells decide to become mesenchymal-like cells. J Clin Invest 2009; 119: 1417.
    • (2009) J Clin Invest , vol.119 , pp. 1417
    • Kalluri, R.1
  • 6
    • 68549091057 scopus 로고    scopus 로고
    • Fibroblast activation and myofibroblast generation in obstructive nephropathy
    • Grande MT, Lopez-Novoa JM. Fibroblast activation and myofibroblast generation in obstructive nephropathy. Nat Rev Nephrol 2009; 5: 319.
    • (2009) Nat Rev Nephrol , vol.5 , pp. 319
    • Grande, M.T.1    Lopez-Novoa, J.M.2
  • 7
    • 33847701747 scopus 로고    scopus 로고
    • Beneficial effects of CCR1 blockade on the progression of chronic renal allograft damage
    • Bedke J, Kiss E, Schaefer L, et al. Beneficial effects of CCR1 blockade on the progression of chronic renal allograft damage. Am J Transplant 2007; 7: 527.
    • (2007) Am J Transplant , vol.7 , pp. 527
    • Bedke, J.1    Kiss, E.2    Schaefer, L.3
  • 8
    • 2542502538 scopus 로고    scopus 로고
    • Late onset of treatment with a chemokine receptor CCR1 antagonist prevents progression of lupus nephritis in MRL-Fas(lpr) mice
    • Anders HJ, Belemezova E, Eis V, et al. Late onset of treatment with a chemokine receptor CCR1 antagonist prevents progression of lupus nephritis in MRL-Fas(lpr) mice. J Am Soc Nephrol 2004; 15: 1504.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 1504
    • Anders, H.J.1    Belemezova, E.2    Eis, V.3
  • 9
    • 21544463993 scopus 로고    scopus 로고
    • CCR1 blockade reduces interstitial inflammation and fibrosis in mice with glomerulosclerosis and ne-phrotic syndrome
    • Vielhauer V, Berning E, Eis V, et al. CCR1 blockade reduces interstitial inflammation and fibrosis in mice with glomerulosclerosis and ne-phrotic syndrome. Kidney Int 2004; 66: 2264.
    • (2004) Kidney Int , vol.66 , pp. 2264
    • Vielhauer, V.1    Berning, E.2    Eis, V.3
  • 10
    • 0036150991 scopus 로고    scopus 로고
    • A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation
    • Anders HJ, Vielhauer V, Frink M, et al. A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation. J Clin Invest 2002; 109: 251.
    • (2002) J Clin Invest , vol.109 , pp. 251
    • Anders, H.J.1    Vielhauer, V.2    Frink, M.3
  • 11
    • 0036158099 scopus 로고    scopus 로고
    • Early application of Met-RANTES ameliorates chronic allograft nephropathy
    • Song E, Zou H, Yao Y, et al. Early application of Met-RANTES ameliorates chronic allograft nephropathy. Kidney Int 2002; 61: 676.
    • (2002) Kidney Int , vol.61 , pp. 676
    • Song, E.1    Zou, H.2    Yao, Y.3
  • 12
    • 38449122654 scopus 로고    scopus 로고
    • The role of chemokines and chemokine receptors in diabetic nephropathy
    • Ruster C, Wolf G. The role of chemokines and chemokine receptors in diabetic nephropathy. Front Biosci 2008; 13: 944.
    • (2008) Front Biosci , vol.13 , pp. 944
    • Ruster, C.1    Wolf, G.2
  • 13
    • 34548419397 scopus 로고    scopus 로고
    • OS as a common pathway to chronic tubulointerstitial injury in kidney allografts
    • Djamali A. OS as a common pathway to chronic tubulointerstitial injury in kidney allografts. Am J Physiol Renal Physiol 2007; 293: F445.
    • (2007) Am J Physiol Renal Physiol , vol.293
    • Djamali, A.1
  • 14
    • 20544437490 scopus 로고    scopus 로고
    • Role of reactive oxygen species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells
    • Rhyu DY, Yang Y, Ha H, et al. Role of reactive oxygen species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells. J Am Soc Nephrol 2005; 16: 667.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 667
    • Rhyu, D.Y.1    Yang, Y.2    Ha, H.3
  • 15
    • 58049219027 scopus 로고    scopus 로고
    • Nox-2 is a modulator of fibrogenesis in kidney allografts
    • Djamali A, Vidyasagar A, Adulla M, et al. Nox-2 is a modulator of fibrogenesis in kidney allografts. Am J Transplant 2009; 9: 74.
    • (2009) Am J Transplant , vol.9 , pp. 74
    • Djamali, A.1    Vidyasagar, A.2    Adulla, M.3
  • 16
    • 0037332180 scopus 로고    scopus 로고
    • Long-term dietary L-arginine supplementation attenuates proteinuria and focal glomerulo-sclerosis in experimental chronic renal transplant failure
    • Albrecht EW, van Goor H, Smit-van Oosten A, et al. Long-term dietary L-arginine supplementation attenuates proteinuria and focal glomerulo-sclerosis in experimental chronic renal transplant failure. Nitric Oxide 2003; 8: 53.
    • (2003) Nitric Oxide , vol.8 , pp. 53
    • Albrecht, E.W.1    Van Goor, H.2    Smit-Van Oosten, A.3
  • 17
    • 0042839686 scopus 로고    scopus 로고
    • Oxidative stress in chronic renal allograft nephropathy in rats: Effects of long-term treatment with carvedilol, BM 910228, or alpha-tocopherol
    • Gottmann U, Oltersdorf J, Schaub M, et al. Oxidative stress in chronic renal allograft nephropathy in rats: Effects of long-term treatment with carvedilol, BM 910228, or alpha-tocopherol. J Cardiovasc Pharmacol 2003; 42: 442.
    • (2003) J Cardiovasc Pharmacol , vol.42 , pp. 442
    • Gottmann, U.1    Oltersdorf, J.2    Schaub, M.3
  • 18
    • 0027979555 scopus 로고
    • The beneficial effect of human recombinant superoxide dismutase on acute and chronic rejection events in recipients of cadaveric renal transplants
    • Land W, Schneeberger H, Schleibner S, et al. The beneficial effect of human recombinant superoxide dismutase on acute and chronic rejection events in recipients of cadaveric renal transplants. Transplantation 1994; 57: 211.
    • (1994) Transplantation , vol.57 , pp. 211
    • Land, W.1    Schneeberger, H.2    Schleibner, S.3
  • 19
    • 0027505597 scopus 로고
    • A randomized double-blind trial of the use of human recombinant superoxide dismutase in renal transplantation
    • Pollak R, Andrisevic JH, Maddux MS, et al. A randomized double-blind trial of the use of human recombinant superoxide dismutase in renal transplantation. Transplantation 1993; 55: 57.
    • (1993) Transplantation , vol.55 , pp. 57
    • Pollak, R.1    Andrisevic, J.H.2    Maddux, M.S.3
  • 20
    • 21344467016 scopus 로고    scopus 로고
    • Calcineurin inhibitor withdrawal from sirolimus-based therapy in kidney transplantation: A systematic review of randomized trials
    • Mulay AV, Hussain N, Fergusson D, et al. Calcineurin inhibitor withdrawal from sirolimus-based therapy in kidney transplantation: A systematic review of randomized trials. Am J Transplant 2005; 5: 1748.
    • (2005) Am J Transplant , vol.5 , pp. 1748
    • Mulay, A.V.1    Hussain, N.2    Fergusson, D.3
  • 21
    • 37349034394 scopus 로고    scopus 로고
    • Reduced exposure to cal-cineurin inhibitors in renal transplantation
    • Ekberg H, Tedesco-Silva H, Demirbas A, et al. Reduced exposure to cal-cineurin inhibitors in renal transplantation. N Engl J Med 2007; 357: 2562.
    • (2007) N Engl J Med , vol.357 , pp. 2562
    • Ekberg, H.1    Tedesco-Silva, H.2    Demirbas, A.3
  • 22
    • 0032490341 scopus 로고    scopus 로고
    • Prope tolerance, perioperative cam-path 1H, and low-dose cyclosporine monotherapy in renal allograft recipients
    • Calne R, Friend P, Moffatt S, et al. Prope tolerance, perioperative cam-path 1H, and low-dose cyclosporine monotherapy in renal allograft recipients. Lancet 1998; 351: 1701.
    • (1998) Lancet , vol.351 , pp. 1701
    • Calne, R.1    Friend, P.2    Moffatt, S.3
  • 23
    • 0038805159 scopus 로고    scopus 로고
    • Campath-1H induction plus rapamycin monotherapy for renal transplantation: Results of a pilot study
    • Knechtle SJ, Pirsch JD, Fechner H, et al. Campath-1H induction plus rapamycin monotherapy for renal transplantation: Results of a pilot study. Am J Transplant 2003; 3: 722.
    • (2003) Am J Transplant , vol.3 , pp. 722
    • Knechtle, S.J.1    Pirsch, J.D.2    Fechner, H.3
  • 24
    • 37549043953 scopus 로고    scopus 로고
    • Alemtuzumab (Campath-1H) in kidney transplantation
    • Ciancio G, Burke GW III. Alemtuzumab (Campath-1H) in kidney transplantation. Am J Transplant 2008; 8: 15.
    • (2008) Am J Transplant , vol.8 , pp. 15
    • Ciancio, G.1    Burke Iii, G.W.2
  • 25
    • 23944502334 scopus 로고    scopus 로고
    • Costimulation blockade with belatacept in renal transplantation
    • Vincenti F, Larsen C, Durrbach A, et al. Costimulation blockade with belatacept in renal transplantation. N Engl J Med 2005; 353: 770.
    • (2005) N Engl J Med , vol.353 , pp. 770
    • Vincenti, F.1    Larsen, C.2    Durrbach, A.3
  • 26
    • 73849137256 scopus 로고    scopus 로고
    • Renal benefit of belatacept vs cyclosporine in kidney transplant patients is not impacted by acute rejection (BENEFIT Study)
    • abstr 100
    • Larsen FV, Grinyo JM, Charpentier B, et al. Renal benefit of belatacept vs cyclosporine in kidney transplant patients is not impacted by acute rejection (BENEFIT Study). Am J Transplant 2009; abstr 100.
    • (2009) Am J Transplant
    • Larsen, F.V.1    Grinyo, J.M.2    Charpentier, B.3
  • 27
    • 0037154324 scopus 로고    scopus 로고
    • The AT(1)-type angiotensin receptor in ox-idative stress and atherogenesis, part I: Oxidative stress and atherogen-esis
    • Nickenig G, Harrison DG. The AT(1)-type angiotensin receptor in ox-idative stress and atherogenesis, part I: Oxidative stress and atherogen-esis. Circulation 2002; 105: 393.
    • (2002) Circulation , vol.105 , pp. 393
    • Nickenig, G.1    Harrison, D.G.2
  • 29
    • 0037974569 scopus 로고    scopus 로고
    • Effects of ANG II type 1 and 2 receptors on oxidative stress, renal NADPH oxidase, and SOD expression
    • Chabrashvili T, Kitiyakara C, Blau J, et al. Effects of ANG II type 1 and 2 receptors on oxidative stress, renal NADPH oxidase, and SOD expression. Am J Physiol Regul Integr Comp Physiol 2003; 285: R117.
    • (2003) Am J Physiol Regul Integr Comp Physiol , vol.285
    • Chabrashvili, T.1    Kitiyakara, C.2    Blau, J.3
  • 30
    • 29144521901 scopus 로고    scopus 로고
    • Blockade of the renin-angiotensin-aldosterone system: A key therapeutic strategy to reduce renal and cardiovascular events in patients with diabetes
    • Burnier M, Zanchi A. Blockade of the renin-angiotensin-aldosterone system: A key therapeutic strategy to reduce renal and cardiovascular events in patients with diabetes. J Hypertens 2006; 24: 11.
    • (2006) J Hypertens , vol.24 , pp. 11
    • Burnier, M.1    Zanchi, A.2
  • 31
    • 0031718621 scopus 로고    scopus 로고
    • Chronic allograft ne-phropathy in the rat is improved by angiotensin II receptor blockade but not by calcium channel antagonism
    • Amuchastegui SC, Azzollini N, Mister M, et al. Chronic allograft ne-phropathy in the rat is improved by angiotensin II receptor blockade but not by calcium channel antagonism. J Am Soc Nephrol 1998; 9: 1948.
    • (1998) J Am Soc Nephrol , vol.9 , pp. 1948
    • Amuchastegui, S.C.1    Azzollini, N.2    Mister, M.3
  • 32
    • 33645451066 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibitor or angiotensin II type 1 receptor antagonist therapy is associated with prolonged patient and graft survival after renal transplantation
    • Heinze G, Mitterbauer C, Regele H, et al. Angiotensin-converting enzyme inhibitor or angiotensin II type 1 receptor antagonist therapy is associated with prolonged patient and graft survival after renal transplantation. J Am Soc Nephrol 2006; 17: 889.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 889
    • Heinze, G.1    Mitterbauer, C.2    Regele, H.3
  • 33
    • 33750726741 scopus 로고    scopus 로고
    • No improvement of patient or graft survival in transplant recipients treated with angiotensin-converting enzyme inhibitors or angiotensin II type 1 receptor blockers: A Collaborative Transplant Study Report
    • Opelz G, Zeier M, Laux G, et al. No improvement of patient or graft survival in transplant recipients treated with angiotensin-converting enzyme inhibitors or angiotensin II type 1 receptor blockers: A Collaborative Transplant Study Report. J Am Soc Nephrol 2006; 17: 3257.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 3257
    • Opelz, G.1    Zeier, M.2    Laux, G.3
  • 34
    • 34548301629 scopus 로고    scopus 로고
    • Renin angiotensin system blockade in kidney transplantation: A systematic review of the evidence
    • Hiremath S, Fergusson D, Doucette S, et al. Renin angiotensin system blockade in kidney transplantation: A systematic review of the evidence. Am J Transplant 2007; 7: 2350.
    • (2007) Am J Transplant , vol.7 , pp. 2350
    • Hiremath, S.1    Fergusson, D.2    Doucette, S.3
  • 35
    • 24644487312 scopus 로고    scopus 로고
    • TGF-beta and epithelial-to-mesenchymal transitions
    • ZavadilJ, Bottinger EP. TGF-beta and epithelial-to-mesenchymal transitions. Oncogene 2005; 24: 5764.
    • (2005) Oncogene , vol.24 , pp. 5764
    • Zavadil, J.1    Bottinger, E.P.2
  • 36
    • 33745819270 scopus 로고    scopus 로고
    • Chronic allograft nephropathy: Intraepithelial signals generated by transforming growth factor-beta and bone morphogenetic protein-7
    • Tyler JR, Robertson H, Booth TA, et al. Chronic allograft nephropathy: Intraepithelial signals generated by transforming growth factor-beta and bone morphogenetic protein-7. Am J Transplant 2006; 6: 1367.
    • (2006) Am J Transplant , vol.6 , pp. 1367
    • Tyler, J.R.1    Robertson, H.2    Booth, T.A.3
  • 37
    • 0032894729 scopus 로고    scopus 로고
    • Chronic rejection of mouse kidney allografts
    • Mannon RB, Kopp JB, Ruiz P, et al. Chronic rejection of mouse kidney allografts. Kidney Int 1999; 55: 1935.
    • (1999) Kidney Int , vol.55 , pp. 1935
    • Mannon, R.B.1    Kopp, J.B.2    Ruiz, P.3
  • 38
    • 0033608710 scopus 로고    scopus 로고
    • Transforming growth factor (TGF)-beta mimics and anti-TGF-beta antibody abrogates the in vivo effects of cyclosporine: Demonstration of a direct role of TGF-beta in immunosuppression and nephrotoxicity of cyclosporine
    • Khanna AK, Cairns VR, Becker CG, et al. Transforming growth factor (TGF)-beta mimics and anti-TGF-beta antibody abrogates the in vivo effects of cyclosporine: Demonstration of a direct role of TGF-beta in immunosuppression and nephrotoxicity of cyclosporine. Transplantation 1999; 67: 882.
    • (1999) Transplantation , vol.67 , pp. 882
    • Khanna, A.K.1    Cairns, V.R.2    Becker, C.G.3
  • 39
    • 0026799402 scopus 로고
    • Targeted disruption of the mouse transforming growth factor-beta1 gene resultsin multifocal inflammatory disease
    • Shull MM, Ormsby I, Kier AB, et al. Targeted disruption of the mouse transforming growth factor-beta1 gene resultsin multifocal inflammatory disease. Nature 1992; 359: 693.
    • (1992) Nature , vol.359 , pp. 693
    • Shull, M.M.1    Ormsby, I.2    Kier, A.B.3
  • 40
    • 0037181103 scopus 로고    scopus 로고
    • High transforming growth factor-beta and extracellular matrix mRNA response in renal allografts during early acute rejection is associated with absence of chronic rejection
    • Eikmans M, Sijpkens YW, Baelde HJ, et al. High transforming growth factor-beta and extracellular matrix mRNA response in renal allografts during early acute rejection is associated with absence of chronic rejection. Transplantation 2002; 73: 573.
    • (2002) Transplantation , vol.73 , pp. 573
    • Eikmans, M.1    Sijpkens, Y.W.2    Baelde, H.J.3
  • 41
    • 0031474029 scopus 로고    scopus 로고
    • Pirfenidone prevents collagen accumulation in the remnant kidney in rats with partial nephrectomy
    • Shimizu T, Fukagawa M, Kuroda T, et al. Pirfenidone prevents collagen accumulation in the remnant kidney in rats with partial nephrectomy. Kidney Int Suppl 1997; 63: S239.
    • (1997) Kidney Int Suppl , vol.63
    • Shimizu, T.1    Fukagawa, M.2    Kuroda, T.3
  • 42
    • 0031834709 scopus 로고    scopus 로고
    • Pirfenidone improves renal function and fibrosis in the post-obstructed kidney
    • Shimizu T, Kuroda T, Hata S, et al. Pirfenidone improves renal function and fibrosis in the post-obstructed kidney. Kidney Int 1998; 54: 99.
    • (1998) Kidney Int , vol.54 , pp. 99
    • Shimizu, T.1    Kuroda, T.2    Hata, S.3
  • 43
    • 0347996179 scopus 로고    scopus 로고
    • Pirfenidone treatment decreases transforming growth factor-beta1 and matrix proteins and ameliorates fibrosis in chronic cyclosporine nephrotoxicity
    • Shihab FS, Bennett WM, Yi H, et al. Pirfenidone treatment decreases transforming growth factor-beta1 and matrix proteins and ameliorates fibrosis in chronic cyclosporine nephrotoxicity. Am J Transplant 2002; 2: 111.
    • (2002) Am J Transplant , vol.2 , pp. 111
    • Shihab, F.S.1    Bennett, W.M.2    Yi, H.3
  • 44
    • 20544468146 scopus 로고    scopus 로고
    • Pirfenidone inhibits lung allograft fibrosis through L-arginine-arginase pathway
    • Liu H, Drew P, Gaugler AC, et al. Pirfenidone inhibits lung allograft fibrosis through L-arginine-arginase pathway. Am J Transplant 2005; 5: 1256.
    • (2005) Am J Transplant , vol.5 , pp. 1256
    • Liu, H.1    Drew, P.2    Gaugler, A.C.3
  • 45
    • 34548834734 scopus 로고    scopus 로고
    • Pirfenidone slows renal function decline in patients with focal segmental glomerulosclerosis
    • Cho ME, Smith DC, Branton MH, et al. Pirfenidone slows renal function decline in patients with focal segmental glomerulosclerosis. Clin J Am Soc Nephrol 2007; 2: 906.
    • (2007) Clin J Am Soc Nephrol , vol.2 , pp. 906
    • Cho, M.E.1    Smith, D.C.2    Branton, M.H.3
  • 46
    • 33645063200 scopus 로고    scopus 로고
    • Rho/Rho kinase asapotential target for the treatment of renal disease
    • Wakino S, Kanda T, Hayashi K. Rho/Rho kinase asapotential target for the treatment of renal disease. Drug News Perspect 2005; 18: 639.
    • (2005) Drug News Perspect , vol.18 , pp. 639
    • Wakino, S.1    Kanda, T.2    Hayashi, K.3
  • 47
    • 0346727324 scopus 로고    scopus 로고
    • Targeted disruption of TGF-beta1/ Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
    • Sato M, Muragaki Y, Saika S, et al. Targeted disruption of TGF-beta1/ Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. J Clin Invest 2003; 112: 1486.
    • (2003) J Clin Invest , vol.112 , pp. 1486
    • Sato, M.1    Muragaki, Y.2    Saika, S.3
  • 48
    • 0036236193 scopus 로고    scopus 로고
    • Y-27632 prevents tubulo-interstitial fibrosis in mouse kidneys with unilateral ureteral obstruction
    • Nagatoya K, Moriyama T, Kawada N, et al. Y-27632 prevents tubulo-interstitial fibrosis in mouse kidneys with unilateral ureteral obstruction. Kidney Int 2002; 61: 1684.
    • (2002) Kidney Int , vol.61 , pp. 1684
    • Nagatoya, K.1    Moriyama, T.2    Kawada, N.3
  • 49
    • 34547945446 scopus 로고    scopus 로고
    • Fasudil attenuates myocardial fibrosis in association with inhibition of monocyte/macrophage infiltration in the heart of DOCA/salt hypertensive rats
    • Ishimaru K, Ueno H, Kagitani S, et al. Fasudil attenuates myocardial fibrosis in association with inhibition of monocyte/macrophage infiltration in the heart of DOCA/salt hypertensive rats. J Cardiovasc Pharmacol 2007; 50: 187.
    • (2007) J Cardiovasc Pharmacol , vol.50 , pp. 187
    • Ishimaru, K.1    Ueno, H.2    Kagitani, S.3
  • 50
    • 33947364443 scopus 로고    scopus 로고
    • A rho-kinase inhibitor, fasudil, prevents development of diabetes and nephropathy in insulin-resistant diabetic rats
    • Kikuchi Y, Yamada M, Imakiire T, et al. A rho-kinase inhibitor, fasudil, prevents development of diabetes and nephropathy in insulin-resistant diabetic rats. J Endocrinol 2007; 192: 595.
    • (2007) J Endocrinol , vol.192 , pp. 595
    • Kikuchi, Y.1    Yamada, M.2    Imakiire, T.3
  • 51
    • 0037195584 scopus 로고    scopus 로고
    • Fasudil attenuates interstitial fibrosis in rat kidneys with unilateral ureteral obstruction
    • Satoh S, Yamaguchi T, Hitomi A, et al. Fasudil attenuates interstitial fibrosis in rat kidneys with unilateral ureteral obstruction. Eur J Pharmacol 2002; 455: 169.
    • (2002) Eur J Pharmacol , vol.455 , pp. 169
    • Satoh, S.1    Yamaguchi, T.2    Hitomi, A.3
  • 52
    • 0031225015 scopus 로고    scopus 로고
    • Connective tissue growth factor: A mediator of TGF-beta action on fibroblasts
    • Grotendorst GR. Connective tissue growth factor: A mediator of TGF-beta action on fibroblasts. Cytokine Growth Factor Rev 1997; 8: 171.
    • (1997) Cytokine Growth Factor Rev , vol.8 , pp. 171
    • Grotendorst, G.R.1
  • 54
    • 33748486969 scopus 로고    scopus 로고
    • Connective tissue growth factor is a biomarker and mediator of kidney allograft fibrosis
    • Cheng O, Thuillier R, Sampson E, et al. Connective tissue growth factor is a biomarker and mediator of kidney allograft fibrosis. Am J Transplant 2006; 6: 2292.
    • (2006) Am J Transplant , vol.6 , pp. 2292
    • Cheng, O.1    Thuillier, R.2    Sampson, E.3
  • 55
    • 51249090127 scopus 로고    scopus 로고
    • Inhibition of connective tissue growth factor by small interfering RNA prevents renal fibrosis in rats undergoing chronic allograft nephropathy
    • Luo GH, Lu YP, Song J, et al. Inhibition of connective tissue growth factor by small interfering RNA prevents renal fibrosis in rats undergoing chronic allograft nephropathy. Transplant Proc 2008; 40: 2365.
    • (2008) Transplant Proc , vol.40 , pp. 2365
    • Luo, G.H.1    Lu, Y.P.2    Song, J.3
  • 56
    • 0038093327 scopus 로고    scopus 로고
    • Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development
    • Ivkovic S, Yoon BS, Popoff SN, et al. Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development 2003; 130: 2779.
    • (2003) Development , vol.130 , pp. 2779
    • Ivkovic, S.1    Yoon, B.S.2    Popoff, S.N.3
  • 57
    • 34447625374 scopus 로고    scopus 로고
    • Uncoupling of the VEGF-endothelial nitric oxide axis in diabetic nephropathy: An explanation for the paradoxical effects of VEGF in renal disease
    • Nakagawa T. Uncoupling of the VEGF-endothelial nitric oxide axis in diabetic nephropathy: An explanation for the paradoxical effects of VEGF in renal disease. Am J Physiol Renal Physiol 2007; 292: F1665.
    • (2007) Am J Physiol Renal Physiol , vol.292
    • Nakagawa, T.1
  • 58
    • 44249108138 scopus 로고    scopus 로고
    • Anti-VEGF therapy: The search for clinical bi-omarkers
    • Longo R, Gasparini G. Anti-VEGF therapy: The search for clinical bi-omarkers. Expert Rev Mol Diagn 2008; 8: 301.
    • (2008) Expert Rev Mol Diagn , vol.8 , pp. 301
    • Longo, R.1    Gasparini, G.2
  • 59
    • 16244410452 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression and cyclosporine toxicity in renal allograft rejection
    • Ozdemir BH, Ozdemir FN, Haberal N, et al. Vascular endothelial growth factor expression and cyclosporine toxicity in renal allograft rejection. Am J Transplant 2005; 5(4 pt 1): 766.
    • (2005) Am J Transplant , vol.5 , Issue.4 PART 1 , pp. 766
    • Ozdemir, B.H.1    Ozdemir, F.N.2    Haberal, N.3
  • 60
    • 52049123764 scopus 로고    scopus 로고
    • HGF as a renotrophic and anti-fibrotic regulator in chronic renal disease
    • Mizuno S, Matsumoto K, Nakamura T. HGF as a renotrophic and anti-fibrotic regulator in chronic renal disease. Front Biosci 2008; 13: 7072.
    • (2008) Front Biosci , vol.13 , pp. 7072
    • Mizuno, S.1    Matsumoto, K.2    Nakamura, T.3
  • 61
    • 2942635909 scopus 로고    scopus 로고
    • Hepatocyte growth factor in kidney fibrosis: Therapeutic potential and mechanisms ofaction
    • Liu Y. Hepatocyte growth factor in kidney fibrosis: Therapeutic potential and mechanisms ofaction. AmJ Physiol Renal Physiol 2004; 287: F7.
    • (2004) AmJ Physiol Renal Physiol , vol.287
    • Liu, Y.1
  • 62
    • 0035005796 scopus 로고    scopus 로고
    • Hepatocyte growth factor prevents the development of chronic allograft nephropathy in rats
    • Azuma H, Takahara S, Matsumoto K, et al. Hepatocyte growth factor prevents the development of chronic allograft nephropathy in rats. J Am Soc Nephrol 2001; 12: 1280.
    • (2001) J Am Soc Nephrol , vol.12 , pp. 1280
    • Azuma, H.1    Takahara, S.2    Matsumoto, K.3
  • 63
    • 33746154515 scopus 로고    scopus 로고
    • HGF gene therapy attenuates renal allograft scarring bypreventing the profibrotic inflammatory-induced mechanisms
    • Herrero-Fresneda I, Torras J, Franquesa M, et al. HGF gene therapy attenuates renal allograft scarring bypreventing the profibrotic inflammatory-induced mechanisms. Kidney Int 2006; 70: 265.
    • (2006) Kidney Int , vol.70 , pp. 265
    • Herrero-Fresneda, I.1    Torras, J.2    Franquesa, M.3
  • 64
    • 50949129278 scopus 로고    scopus 로고
    • Results of a double-blind, placebo-controlled study to assess the safety of intramuscular injection of hepatocyte growth factor plasmid to improve limb perfusion in patients with critical limb ischemia
    • Powell RJ, Simons M, Mendelsohn FO, et al. Results of a double-blind, placebo-controlled study to assess the safety of intramuscular injection of hepatocyte growth factor plasmid to improve limb perfusion in patients with critical limb ischemia. Circulation 2008; 118: 58.
    • (2008) Circulation , vol.118 , pp. 58
    • Powell, R.J.1    Simons, M.2    Mendelsohn, F.O.3
  • 65
    • 34848855124 scopus 로고    scopus 로고
    • The MET receptor tyrosine kinase in invasion and metastasis
    • Benvenuti S, Comoglio PM. The MET receptor tyrosine kinase in invasion and metastasis. J Cell Physiol 2007; 213: 316.
    • (2007) J Cell Physiol , vol.213 , pp. 316
    • Benvenuti, S.1    Comoglio, P.M.2
  • 66
    • 42549116610 scopus 로고    scopus 로고
    • Bone morphogenetic protein-7 (BMP7) in chronic kidney disease
    • Mitu G, Hirschberg R. Bone morphogenetic protein-7 (BMP7) in chronic kidney disease. Front Biosci 2008; 13: 4726.
    • (2008) Front Biosci , vol.13 , pp. 4726
    • Mitu, G.1    Hirschberg, R.2
  • 67
    • 0038717407 scopus 로고    scopus 로고
    • BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury
    • Zeisberg M, Hanai J, Sugimoto H, et al. BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med 2003; 9: 964.
    • (2003) Nat Med , vol.9 , pp. 964
    • Zeisberg, M.1    Hanai, J.2    Sugimoto, H.3
  • 68
    • 47749136233 scopus 로고    scopus 로고
    • Reversal of experimental renal fibrosis by BMP7 provides insights into novel therapeutic strategies for chronic kidney disease
    • Zeisberg M, Kalluri R. Reversal of experimental renal fibrosis by BMP7 provides insights into novel therapeutic strategies for chronic kidney disease. Pediatr Nephrol 2008; 23: 1395.
    • (2008) Pediatr Nephrol , vol.23 , pp. 1395
    • Zeisberg, M.1    Kalluri, R.2
  • 69
    • 43049088050 scopus 로고    scopus 로고
    • The use of bone morphogenetic protein in spine fusion
    • Hsu WK, Wang JC. The use of bone morphogenetic protein in spine fusion. Spine J 2008; 8: 419.
    • (2008) Spine J , vol.8 , pp. 419
    • Hsu, W.K.1    Wang, J.C.2


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