Knockout and mutant rats

Neuromethods

Volumn 44, Issue , 2010, Pages 13-31

  Müller, Mareike ^a   Olivier, Jocelien ^a   Homberg, Judith ^a  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

Author keywords

5 HT; Addiction; Autism; Depression; Dopamine; DRD1; Knockout; Schizophrenia; Serotonin; SERT

Indexed keywords

COCAINE; DOPAMINE 1 RECEPTOR; ETHYLNITROSOUREA; GENOMIC DNA; PSYCHOSTIMULANT AGENT; SEROTONIN; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR;

AMNESIA; AROUSAL; AUTISM; BEHAVIOR; CIRCADIAN RHYTHM; COGNITION; DEPRESSION; DOPAMINERGIC SYSTEM; DRUG DEPENDENCE; EMBRYONIC STEM CELL; EMOTION; ENVIRONMENTAL FACTOR; FOOD INTAKE; GENE FUNCTION; GENE REPLICATION; GENE TARGETING; GENETIC MODEL; GENOTYPE; HEREDITY; LEARNING; LOCOMOTION; MENTAL DISEASE; MISSENSE MUTATION; MOTIVATION; MUTAGENESIS; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT STRAIN; REVIEW; SCHIZOPHRENIA; SENSORIMOTOR INTEGRATION; SINGLE NUCLEOTIDE POLYMORPHISM; SLEEP; SOCIAL BEHAVIOR; SOCIAL INTERACTION; TRANSGENIC RAT; TREATMENT RESPONSE; WORKING MEMORY;

ANIMALIA; RATTUS;

EID: 73849089051     PISSN: 08932336     EISSN: 19406045     Source Type: Book Series    
DOI: 10.1007/978-1-60761-474-6_2     Document Type: Review

References (78)

1. Dalley JW, Cardinal RN, Robbins TW (2004) Prefrontal executive and congnitive functions in rodents: neural and neurochemical substrates. Neurosci Biobehav Rev 28:771-784
2. Stemple DL (2004) TILLING - a highthroughput harvest for functional genomics. Nat Rev Genet 5(2):145-150
3. Noveroske JK, Weber JS, Justice MJ (2000) The mutagenic action of N-ethyl-N-nitrosourea in the mouse. Mamm Genome 11(7):478-483
4. Jansen G, Hazendonk E, Thijssen KL et al (1997) Reverse genetics by chemical mutagenesis in Caenorhabditis elegans. Nat Genet 17:119-121
5. Bentley A, MacLennan B, Calvo J et al (2000) Targeted recovery of mutations in drosophila. Genetics 156:1169-1173
6. Wienholds E, Schulte-Merker S, Waldericht B et al (2002) Target-selected inactivation of the zebrafish rag1 gene. Science 297:99-102
7. McCallum CM, Comai L, Greene EA et al (2000) Targeted screening for induced mutations. Nat Biotechnol 18:455-457
8. Till BJ, Reynolds SH, Weil C et al (2004) Discovery of induced point mutations in maize genes by TILLING. BMC Plant Biol 28:4-12
9. Perry JA, Wang TL, Welham TJ et al (2003) A TILLING reverse genetics tool and a webaccessible collection of mutants of the legume Lotus japonicus. Plant Physiol 131:866-871
10. Zan Y, Haag JD, Chen KS et al (2003) Production of knockout rats using ENU mutagenesis and a yeast-based screening assay. Nat Biotechnol 21(6):645-651
11. Smits BM, Mudde JB, Plasterk RH et al (2004) Target-selected mutagenesis of the rat. Genomics 83(2):332-334
12. Smits BM, Mudde JB, van de Belt J et al (2006) Generation of gene knockouts and mutant models in the laboratory rat by ENU-driven target-selected mutagenesis. Pharmacogenet Genomics 16(3):159-169
13. Amos-Landgraf JM, Kwong LN, Kendziorski CM et al (2007) A target-selected Apc-mutant rat kindred enhances the modeling of familial human colon cancer. Proc Natl Acad Sci USA 104(10):4036-4041
14. Homberg JR, Olivier JDA, Smits BMG et al (2007) Characterization of the serotonin transporter knockout rat: A selective change in the functioning of the serotonergic system. Neuroscience 146:1662-1676
15. van Boxtel R, Toonen PW, van Roekel H et al (2008) Lack of DNA mismatch repair protein MSH6 in the rat results in hereditary nonpolyposis colorectal cancer-like tumorigenesis. Carcinogenesis 29(6):1290-1297
16. Baker KE, Parker R (2004) Nonsensemediated mRNA decay: terminating erroneous gene expression. Curr Opin Cell Biol 16:293-299
17. Takada A, Curzon G (1995) Presynaptic regulation of extracellular serotonin concentration in brain. In: Wong DT, Bymaster FP, Engleman EA (eds) Serotonin in the central nervous system and periphery, 7th edn. Elsevier Science B.V., Oxford, England, p 3
18. Murphy DL, Andrews AM, Wichems CH et al (1998) Brain serotonin neurotransmission: an overview and update with an emphasis on serotonin subsystem heterogeneity, multiple receptors, interactions with other neurotransmitter systems and consequent implications for understanding the action of serotonergic drugs. J Clin Psychiatry 59(Suppl 15):4-12
19. Homberg JR, Pattij T, Janssen MCW et al (2007) Serotonin transporter deficiency in rats improves inhibitory control but not behavioral flexibility. Eur J Neurosci 26(7):2066-2073
20. Rogers DC, Fisher EM, Brown SD et al (1997) Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment. Mamm Genome 8:711-713
21. Kravitz EA (2000) Serotonin and aggression: Insights gained from a lobster model system and speculations on the role of amine neurons in a complex behavior. J Comp Phyiol [A] 186:221-238
22. Ursin R (2000) Serotonin and sleep. Sleep Med Rev 6:55-69
23. Richards KS, Simon DJ, Pulver SR et al (2003) Serotonin in the developing stomatogastric system of the lobster, Homarus americanus. J Neurobiol 54:380-392
24. Graeff FG, Guimaraes FS, De Andrade TG et al (1996) Role of 5-HT in stress, anxiety and depression. Pharmacol Biochem Behav 54:129-141
25. Hull EM, Lorrain DS, Du J, Matuszewich L et al (1999) Hormone-neurotransmitter interactions in the control of sexual behavior. Behav Brain Res 205:105-116
26. Evenden JL (1999) Varieties of impulsivity. Psychopharmacology 146:348-361
27. Olivier B (2004) Serotonin and aggression. Ann NY Acad Sci 1036:382-392
28. Linnoila M, Virkkunen M, Scheinin M et al (1983) Low cerebrospinal-fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from non-impulsive violent behavior. Life Sci 33:2609-2614
29. LeMarquand DG, Pihl RO, Young SN et al (1998) Tryptophan depletion, executive functions and disinhibition in aggressive, adolescent males. Neuropsychopharmacol 19:333-341
30. Fuller RW (1997) The influence of fluoxetine on aggressive behavior. Neuropsychopharmacol 16:373-374
31. Brady KT, Myrick H, McElroy S (1998) The relationship between substance use disorders, impulse control disorders and pathological aggression. Am J Addict 7:221-230
32. Cherek DR, Lane SD (2000) Fenfluramine effects on impulsivity in a sample of adults with and without history of conduct disorder. Psychopharmacol 152:149-156
33. Clark L, Roiser JP, Cools R et al (2005) Stop signal response inhibition is not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers:implications for the 5-HT theory of impulsivity. Psychopharmacol 182:570-578
34. Cools R, Blackwell A, Clark L et al (2005) Tryptophan depletion disrupts the motivational guidance of goaldirected behavior as a function of trait impulsivity. Neuropsychopharmacol 30:1362-1373
35. Watson KK, Ghodasra JH, Platt ML (2009) Serotonin transporter genotype modulates social reward and punishment in rhesus macaques. PLoS ONE 4(1):e4156
36. Clarke HF, Dalley JW, Crofts HS et al (2004) Cognitive inflexibility after prefrontal serotonin depletion. Science 304:878-880
37. Fox MA, Andrews AM, Wendland JR et al (2007) A pharmacological analysis of mice with a targeted disruption of the serotonin transporter. Psychopharmacol 195(2):147-166
38. Brune CW, Kim SJ, Salt J et al (2006) 5-HTTLPR Genotype-specific phenotype in children and adolescents with autism. Am J Psychiatry 163(12):2148-2156
39. Coppen A, Eccleston E, Craft I et al (1973) Letter: Total and free plasma-tryptophan concentration and oral contraception. Lancet 2:1498
40. Cowen PJ, Parry-Billings M, Newsholme EA (1989) Decreased plasma tryptophan levels in major depression. J Affect Disord 16:27-31
41. Asberg M, Thorén P, Träskman L et al (1976) "Serotonin depression" - a biochemical subgroup within the affective disorders? Science 191:478-480
42. Owens MJ, Nemeroff CB (1998) The serotonin transporter and depression. Depress Anxiety 8:5-12
43. Olivier JDA, van der Hart MGC, van Swelm RPL et al (2008) A study in male and female serotonin transporter knockout rats: An animal model for anxiety and depression disorders. Neuroscience 152(3):573-584
44. Saykin AJ, Shtasel D, Gur RE et al (1994) Neuropsychological deficits in neuroleptic naïve patients with first-episode schizophrenia. Arch Gen Psychiatry 51:124-131
45. Geyer MA, Braff DL (1982) Habituation of the blink reflex in normal and schizophrenic patients. Psychophysiol 19:1-6
46. Cadenhead KS, Geyer MA, Braff DL (1993) Impaired startle prepulse inhibition and habituation in schizotypal patients. Am J Psychiatry 150:1862-1867
47. Olivier JD, Jans LA, Korte-Bouws GA, Korte SM, Deen PM, Cools AR, Ellenbroek BA, Blokland A (2008) Acute tryptophan depletion dose dependently impairs object memory in serotonin transporter knoctout rats. Psychopharmacology (Berl), 200(2): 243-254
48. Uhl GR, Grow RW (2004) The burden of complex genetics in brain disorders. Arch Gen Psychiatry 61:223-229
49. Mannelli P, Patkar AA, Peindl K et al (2006) Polymorphism in the serotonin transporter gene and moderators of prolactin response to metachlorophenylpiperazine in African- American cocaine abusers and controls. Psychiatry Res 144:99-108
50. Gerra G, Zaivovic A, Garofano L et al (2007) Perceived parenting behaviour in the childhood of cocaine users: relationship with genotype and personality traits. Am J Med Genet B Neuropsychiatr Genet 144:52-57
51. Homberg JR, De Boer SF, Raaso HS et al (2008) Adaptations in pre- and postsynaptic 5-HT1A receptor function and cocaine supersensitivity in serotonin transporter knockout rats. Psychopharmacology (Berl) 200(3):367-380
52. David SP, Murthy NV, Rabiner EA et al (2005) A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans. J Neurosci 25:2586-2590
53. Lesch KP, Gutknecht L (2005) Pharmacogentics of the serotonin transporter. Prog Neuropsychopharmacol Biol Psychiatry 29:1062-1073
54. Mann JJ, Huang YY, Underwood MD et al (2000) Serotonin transporter gene promoter polymorphism. (5-HTTLPR) and prefrontal cortical binding in major depression and suicide. Arch Gen Psychiatry 57:729-738
55. Caspi A, Sugden K, Moffitt TE et al (2003) Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301(5631):291-293
56. Alfimova MV, Golimbet VE, Korovaitseva GI et al (2008) The modulatory influence of polymorphism of the serotonin transporter gene on characteristics of mental maladaptation in relatives of patients with endogenous psychoses. Neurosci Behav Physiol 38(3):253-258
57. Drago J, Gerfen CR, Lachowicz JE et al (1994) Altered striatal function in a mutant mouse lacking D1A dopamine receptors. Proc Natl Acad Sci USA 91(26):12564-12568
58. Drago J, Gerfen CR, Westphal H et al (1996) D1 dopamine receptor-deficient mouse: cocaine-induced regulation of immediateearly gene and substance P expression in the striatum. Neuroscience 74(3):813-823
59. Xu M (2007) Lack of self-administration of cocaine in dopamine D1 receptor knock-out mice. J Neurosci 27(48):13140-13150
60. Al-Fulaij MA, Ren Y, Beinborn M et al (2008) Pharmacological analysis of human D1 and D2 dopamine receptor missense variants. J Mol Neurosci 34(3):211-223
61. Batel P, Houchi H, Daoust M et al (2008) A haplotype of the DRD1 gene is associated with alcohol dependence. Alcohol Clin Exp Res 32(4):567-572
62. Hettinger JA, Liu X, Schwartz CE et al (2008) A DRD1 haplotype is associated with risk for autism spectrum disorders in male-only affected sib-pair families. Am J Med Genet B Neuropsychiatr Genet 147B(5):628-636
63. Lane HY, Liu YC, Huang CL et al (2008) Prefrontal executive function and D1, D3, 5-HT2A and 5-HT6 receptor gene variations in healthy adults. J Psychiatry Neurosci 33(1):47-53
64. Rouillon C, Abraini JH, David HN (2008) Prefrontal cortex and basolateral amygdala modulation of dopamine-mediated locomotion in the nucleus accumbens core. Exp Neurol 212(1):213-217
65. Diaz Heijtz R, Castellanos FX (2006) Differential effects of a selective dopamine D1-like receptor agonist on motor activity and c-fos expression in the frontal-striatal circuitry of SHR and Wistar-Kyoto rats. Behav Brain Funct 26:2-18
66. Doherty JM, Masten VL, Powell SB et al (2008) Contributions of dopamine D1, D2 and D3 receptor subtypes to the disruptive effects of cocaine on prepulse inhibition in mice. Neuropsychopharmacol 33(11):2648-2656
67. Granado N, Ortiz O, Suárez LM et al (2008) D1 but not D5 dopamine receptors are critical for LTP, spatial learning, and LTP-Induced arc and zif268 expression in the hippocampus. Cereb Cortex 18(1):1-12
68. Okubo Y, Suhara T, Suzuki K et al (1997) Decreased prefrontal dopamine D1 receptor in schizophrenia revealed by PET. Nature 385:578-579
69. Tracy JI, de Leon J, Qureshi G et al (1996) Repetitive behaviors in schizophrenia: a single disturbance or discrete symptoms? Schizophr Res 20(1-2):221-229
70. Berridge KC, Aldridge JW (2000) Superstereotypx. I. Enhancement of a complex movement sequence by systemic dopamine D1agonists. Synapse 37(3):194-204
71. Di Chiara G, Imperato A (1988) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci USA 85(14):5274-5278
72. Froehlich JC, Harts J, Lumeng L et al (1988) Differences in response to the aversive properties of ethanol in rats selectively bred for oral ethanol preference. Pharmacol Biochem Behav 31(1):215-222
73. Fumagalli F, Pasquale L, Racagni G et al (2006) Dynamic regulation of fibroblast growth factor 2 (FGF-2) gene expression in the rat brain following single and repeated cocaine administration. J Neurochem 96(4):996-1004
74. Fumagalli F, Franchi C, Caffino L et al (2008) Single session of cocaine intravenous selfadministration shapes goal-oriented behaviours and up-regulates Arc mRNA levels in rat medial prefrontal cortex. Int J Neuropsychopharmacol 25:1-7
75. Li A, Guo H, Luo X et al (2006) Apomorphineinduced activation of dopamine receptors modulates FGF-2 expression in astrocytic cultures and promotes survival of dopaminergic neurons. FASEB J 20(8):1263-1265
76. Roceri M, Molteni R, Fumagalli F et al (2001) Stimulatroy role of dopamine on fibroblast growth factor-2 expression in rat striatum. J Neurochem 76(4):990-997
77. Moro H, Sato H, Ida I et al (2007) Effects of SKF-38393, a dopamine D1 receptor agonist on expression of amphetamine-induced behavioral sensitization and expression of immediate early gene arc in prefrontal cortex of rats. Pharmacol Biochem Behav 87(1):56-64
78. Caine SB, Thomsen M, Gabriel KI et al (2007) Lack of self-administration of cocaine in dopamine D1 receptor knock-out mice. J Neurosci 27(48):13140-13150