The modulatory influence of polymorphism of the serotonin transporter gene on characteristics of mental maladaptation in relatives of patients with endogenous psychoses

Neuroscience and Behavioral Physiology

Volumn 38, Issue 3, 2008, Pages 253-258

  Alfimova, M V ^a   Golimbet, V E ^a   Korovaitseva, G I ^a   Lezheiko, T V ^a   Abramova, L I ^a   Kaleda, V G ^a   Barkhatova, A N ^a  

^a MENTAL HEALTH RESEARCH CENTER   (Russian Federation)

Author keywords

Endogenous psychoses; Family distress; Genetics; Serotonin transporter gene

Indexed keywords

SEROTONIN TRANSPORTER;

ADULT; AFFECTIVE PSYCHOSIS; ANXIETY; ARTICLE; ATTENTION; CHRONIC STRESS; CONTROLLED STUDY; DEPRESSION; DISTRESS SYNDROME; ENDOGENOUS PSYCHOSIS; FAMILY STRESS; FEMALE; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HUMAN; HYPOCHONDRIASIS; MAJOR CLINICAL STUDY; MALADJUSTMENT; MALE; MENTAL DISEASE; MINNESOTA MULTIPHASIC PERSONALITY INVENTORY; PARANOIA; PROMOTER REGION; PSYCHOLOGICAL RATING SCALE; RELATIVE; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA;

ADAPTATION, PSYCHOLOGICAL; ADULT; FAMILY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; PEDIGREE; POLYMORPHISM, GENETIC; PSYCHOTIC DISORDERS; SCHIZOPHRENIA; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEX FACTORS; STRESS, PSYCHOLOGICAL;

EID: 39049132123     PISSN: 00970549     EISSN: 1573899X     Source Type: Journal    
DOI: 10.1007/s11055-008-0037-8     Document Type: Article

References (40)

1. M. V. Alfimova, V. I. Trubnikov, V. V. Bondar', et al., "Psychometrically identified personality anomalies in relatives of patients with schizophrenia and schizoaffective disorders," Zh. Nevrol. Psikhiat., 101, No. 8, 100-104 (2001).
2. F. B. Berezin, M. P. Miroshnikov, and R. V. Rozhanets, Multilateral Investigations of Personality in Clinical Medicine and Psychological Hygiene [in Russian], Meditsina, Moscow (1976).
3. A. V. Val'dman and Yu. A. Aleksandrovskii, The Psychopharmacology of Neurotic Disorders [in Russian], Meditsina, Moscow (1987).
4. I. P. Lapin, Stress. Anxiety. Depression. Alcoholism. Epilepsy. (Neurokynurenic Mechanisms and New Approaches to Treatment [in Russian], DEAN, St. Petersburg (2004).
5. N. A. Mazaeva, T. M. Siryachenko, and O. A. Suetina, "Age characteristics of non-psychotic forms of psychogenia induced by daily stresses," Zh. Nevrol. Psikhiat., 104, No. 6, 14-20 (2004).
6. S. N. Mosolov, Psychometric Scales for Assessment of the Symptomatology of Schizophrenia and the Concepts of Positive and Negative Disorders [in Russian], Moscow (2001).
7. V. M. Rusalov, "A new adapted version of the EPI personality test," Psikhol. Zh., 8, No. 1, 113-126 (1987).
8. L. N. Sobchik, An Introduction to the Psychology of Individuality [in Russian], Institute of Applied Psychology, Moscow (1998).
9. T. A. Solokhina, The Quality of Psychiatric Care (Organizational and Economic Aspects) [in Russian], Author's Abstract of Doctoral Thesis in Medical Sciences, Moscow (2003).
10. T. E. Fuller, Schizophrenia. A Handbook for Doctors, Patients, and their Family Members [in Russian], Piter, St. Petersburg (1996).
11. Yu. L. Khanin, "Studies of anxiety in sport," Vopr. Psikhol., 6, 94-106 (1978).
12. S. Brown and J. Wistle, "People with schizophrenia and their families," Brit. J. Psychiat., 173, 139-144 (1998).
13. A. Caspi, K. Sugden, T. E. Moffatt, et al., "Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene," Science, 301, 386-389 (2003).
14. M. S. Clark, E. S. Vincow, T. J. Sexton, and J. F. Neumaier, "Increased expression of 5-HT1B receptor in dorsal raphe nucleus decreases fear-potentiated startle in a stress dependent manner," Brain Res., 1007, 86-97 (2004).
15. D. G. Dyck, R. Short, and P. P. Vitaliano, "Predictors of burden and infectious illness in schizophrenia caregivers," Psychosom. Med., 61, 411-419 (1999).
16. T. C. Eley, K. Sugden, A. Corsico, et al., "Gene-environment interaction analysis of serotonin system markers with adolescent depression," Mol. Psychiat., 9, 908-915 (2004).
17. M. Ferriter and N. Huband, "Experiences of parents with a son or daughter suffering from schizophrenia," J. Psychiat. Ment. Health Nurs., 10, 552-560 (2003).
18. L. M. Gerace, D. Camilleri, and L. Ayres, "Sibling perspectives on schizophrenia and the family," Schizophr. Bull., 19, 637-647 (1993).
19. N. A. Gillespie, G. Zhu, A. C. Heath, et al., "The genetic aetiology of somatic distress," Psychol. Med., 30, 1051-1061 (2000).
20. N. A. Gillespie, J. B. Whitfield, B. Williams, et al., "The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression," Psychol. Med., 35, 101-111 (2005).
21. V. E. Golimbet, M. V. Alfimova, T. Shcherbatikh, et al., "Serotonin transporter gene polymorphism and schizoid personality traits in the patients with psychosis and psychiatrically well subjects," Wld. J. Biol. Psychiat., 4, 25-29 (2003).
22. X. Gonda, G. Juhasz, A. Laszik, et al., "Subthreshold depression is linked to the functional polymorphism of the 5HT transporter gene," J. Affect. Dis., 87, 291-297 (2005).
23. H. J. Grabe, M. Lange, B. Wolff, et al., "Mental and physical distress is modulated by a polymorphism in the 5-HT transporter gene interacting with social stressors and chronic disease burden," Mol. Psychiat., 10, 220-224 (2005).
24. I. Hickie, B. Bennett, A. Lloyd, et al., "Complex genetic and environmental relationships between psychological distress, fatigue and immune functioning: A twin study," Psychol. Med., 29, 269-277 (1999).
25. M. C. Holmes, K. L. French, and J. R. Seckl, "Modulation of serotonin and corticosteroid receptor gene expression in the rat hippocampus with circadian rhythm and stress," Brain Res. Mol. Brain Res., 28, 186-192 (1995).
26. J. Kaufman, B. Z. Yang, H. Douglas-Palumberi, et al., "Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children," Biol. Psychiat., 59 (in press) (2006).
27. H. J. Lee, M. S. Lee, R. H. Kang, et al., "Influence of the serotonin transporter promoter gene polymorphism on susceptibility to post-traumatic stress disorder," Depress. Anxiety, 21, 135-139 (2005).
28. K. P. Lesch, D. Bengel, A. Heils, et al., "Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region," Science, 274, 1527-1531 (1996).
29. K. P. Lesch and R. Moessner, "Genetically driven variation in serotonin uptake: Is there a link to affective spectrum, neurodevelopmental and neurodegenerative disorders?" Biol. Psychiat., 44, 179-192 (1998).
30. T. Mizuno, M. Aoki, T. Shimada, et al., "Gender difference in association between polymorphism of serotonin transporter gene regulatory region and anxiety," J. Psychosom. Res., 60, 91-97 (2006).
31. P. Mormede, H. Courvoisier, A. Ramos, et al., "Molecular genetic approaches to investigate individual variations in behavioral and neuroendocrine stress responses," Psychoneuroendocrinology, 27, 563-583 (2002).
32. M. R. Munafo, T. G. Clark, L. R. Moore, et al., "Genetic polymorphisms and personality in healthy adults: A systematic review and meta-analysis," Mol. Psychiat., 8, 471-484 (2003).
33. M. R. Munafo, T. G. Clark, K. H. Roberts, and B. C. Johnstone, "Neuroticism mediates the association of the serotonin transporter gene with lifetime major depression," Neuropsychobiology, 53, 1-8 (2005).
34. S. Noh and R. J. Turner, "Living with psychiatric patients implications for the mental health of family members," Soc. Sci. Med., 25, 263-271 (1987).
35. M. R. Salleh, "The burden of care of schizophrenia in Malay families," Acta Psychiat. Scand., 89, 180-185 (1994).
36. R. L. Sjoberg, K. W. Nilsson, N. Nordquist, et al., "Development of depression: Sex and the interaction between environment and a promoter polymorphism of the serotonin transporter gene," Int. J. Neuropsychopharmacol., 15, 1-7 (2005).
37. S. F. Stoltenberg, G. R. Twitchell, G. L. Hanna, et al., "Serotonin transporter promoter polymorphism, peripheral indexes of serotonin function, and personality measures in families with alcoholism," Amer. J. Med. Genet., 114, 230-234 (2002).
38. K. L. Subotnik, R. F. Asarnow, K. H. Nuechterlein, et al., "MMPI vulnerability indicators for schizophrenia and attention deficit disorder: UCLA family study of biological parents of offspring with childhood-onset schizophrenia or ADHD," Sub. Behav. Genet., 35, No. 2, 159-175 (2005).
39. D. I. Ukpong and R. O. Makanjuola, "Emotional distress and strain in relatives of patients with severe mental disorders: A comparative study," West Afr. J. Med., 22, 139-142 (2003).
40. I. C. Weaver, P. La Plante, S. Weaver, et al., "Early environmental regulation of hippocampal glucocorticoid receptor gene expression: characterization of intracellular mediators and potential genomic target sites," Mol. Cell Endocrinol., 185, 205-218 (2001).