Increased cAMP levels modulate transforming growth factor-β/smad-induced expression of extracellular matrix components and other key fibroblast effector functions

Journal of Biological Chemistry

Volumn 285, Issue 1, 2010, Pages 409-421

  Schiller, Meinhard ^a   Dennler, Sylviane ^b   Anderegg, Ulf ^c   Kokot, Agatha ^a   Simon, Jan C ^c   Luger, Thomas A ^a   Mauviel, Alain ^b,d   Böhm, Markus ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b INSERM   (France)

^c UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^d SAINT LOUIS HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEINS; CAMP-RESPONSE ELEMENT-BINDING PROTEINS; CELL LAYERS; CONNECTIVE TISSUE GROWTH FACTOR; EXTRACELLULAR MATRICES; EXTRACELLULAR MATRIX COMPONENTS; FIBROBLAST MIGRATION; FORSKOLIN; FUNCTIONAL ASSAYS; GENE TRANSCRIPTIONS; HUMAN DERMAL FIBROBLASTS; HYALURONAN; INDUCED INTERACTION; INDUCTIVE EFFECTS; INHIBITORY EFFECT; INTRACELLULAR CAMP; MATRIX METALLOPROTEINASE-1; MOLECULAR BASIS; NEUROPEPTIDES; NUCLEAR TRANSLOCATIONS; OVER-EXPRESSION; PLASMINOGEN ACTIVATOR INHIBITOR; SYNTHASES; TISSUE INHIBITOR; TRANSACTIVATION; TRANSCRIPTIONAL CO-ACTIVATORS; TRANSFORMING GROWTH FACTORS;

BINDING ENERGY; BINDING SITES; BIOACTIVITY; BIOCHEMISTRY; CELL CULTURE; COLLAGEN; ENZYME ACTIVITY; ENZYME INHIBITION; FIBROBLASTS; MUSCULOSKELETAL SYSTEM; PEPTIDES; PHOSPHORYLATION; TISSUE; TRANSCRIPTION;

FETAL MONITORING;

ADENYLATE CYCLASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HYALURONIC ACID; PROTEIN P300; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; ATTENUATION; BINDING SITE; CELL MIGRATION; CONTROLLED STUDY; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; FIBROBLAST; GENE OVEREXPRESSION; GENE TRANSLOCATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE; ANIMALS; CELL MOVEMENT; CELL NUCLEUS; COLLAGEN; CONNECTIVE TISSUE GROWTH FACTOR; CYCLIC AMP; DERMIS; E1A-ASSOCIATED P300 PROTEIN; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; EXTRACELLULAR MATRIX PROTEINS; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; HYALURONIC ACID; MICE; NIH 3T3 CELLS; PHOSPHORYLATION; PROTEASE INHIBITORS; PROTEIN TRANSPORT; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 73649119185     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.038620     Document Type: Article

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