Cyclic AMP and protein kinase A stimulate Cdc42: Role of A2 adenosine receptors in human mast cells

Molecular Pharmacology

Volumn 58, Issue 5, 2000, Pages 903-910

  Feoktistov, Igor ^a,b   Goldstein, Anna E ^a   Biaggioni, Italo ^a,b  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 BROMO CYCLIC AMP; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENYLATE CYCLASE; CALYCULIN A; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; FORSKOLIN; G PROTEIN COUPLED RECEPTOR; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN CDC42;

ANIMAL CELL; ARTICLE; CELL STRAIN COS7; CHO CELL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ERYTHROLEUKEMIA CELL; FIBROBLAST; HUMAN; HUMAN CELL; MAST CELL; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

EID: 0033785506     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.58.5.903     Document Type: Article

References (35)

1. P1 and P2 receptors in cell growth and differentiation
2. Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation
3. Apoptosis by 2-chloro-2'-deoxyadenosine and 2-chloro-adenosine in human peripheral blood mononuclear cells
4. Characterization of Rac and Cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases
5. Potential drug targets: Small GT-Pases that regulate leukocyte function
6. Stimulation of the A(2A) adenosine receptor increases expression of the tyrosine hydroxylase gene
7. Purines and their roles in apoptosis
8. Adenosine and asthma
9. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
10. cAMP-induced morphological changes are counteracted by the activated RhoA small GTPase and the Rho Kinase ROKalpha
11. 2 receptors
12. Adenosine A(2B) receptors evoke interleukin-8 secretion in human mast cells: An enprofylline-sensitive mechanism with implications for asthma
13. Pharmacological characterization of adenosine A(2B) receptors: Studies in human mast cells co-expressing A(2A) and A(2B) adenosine receptor subtypes
14. Role of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinase kinase in adenosine A(2B) receptor-mediated interleukin-8 production in human mast cells
15. 1 receptors via a cholera toxin-sensitive mechanism in human erythroleukemia cells
16. Adenosine A(2B) receptors: A novel therapeutic target in asthma?
17. Structure and function of cyclic nucleotide-dependent protein kinases
18. A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho
19. A(2B) adenosine and P(2Y2) receptors stimulate mitogen-activated protein kinase in human embryonic kidney-293 cells: Cross-talk between cyclic AMP and protein kinase C pathways
20. Adenosine receptor activation induces vascular endothelial growth factor in human retinal endothelial cells
21. Selective control of membrane ruffling and actin plaque assembly by the Rho GTPases Rac1 and Cdc42 in Fc?RI-activated rat basophilic leukemia (RBL-2H3) cells
22. Nerve growth factor (NGF) expression in rat microglia is induced by adenosine A(2A) receptors
23. Recent developments in selective agonists and antagonists acting at purine and pyrimidine receptors
24. Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity
25. A family of cAMP-binding proteins that directly activate Rap1
26. Comparative pharmacology of human adenosine receptor subtypes: Characterization of stably transfected receptors in CHO cells
27. Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes
28. Elevation of intracellular cAMP inhibits RhoA activation and integrin-dependent leukocyte adhesion induced by chemoattractants
29. Purinoceptors in the regulation of cell growth and differentiation
30. A nonradioactive biochemical characterization of membrane proteins using enhanced chemiluminescence
31. Stimulation of the mitogen-activated protein kinase via the A(2A)-adenosine receptor in primary human endothelial cells
32. cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap 1-dependent pathway
33. Rapid protein kinase assay using phosphocellulose-paper absorption
34. Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1
35. Cyclic nucleotide gated channels as regulators of CNS development and plasticity