Differential effects of protein kinase C on human vascular smooth muscle cell proliferation and migration

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 281, Issue 1 50-1, 2001, Pages

  Itoh, Hiroyuki ^a   Yamamura, Shinji ^a   Ware, J Anthony ^b   Zhuang, Shaobin ^a   Mii, Shinsuke ^a   Liu, Bo ^a   Kent, K Craig ^a,c  

^a WEILL CORNELL MEDICAL CENTER   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

cAMP; cAMP dependent protein kinase; Isoenzymes; Signal transduction

Indexed keywords

CHELERYTHRINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; FORSKOLIN; INDOLACTAM V; ISOENZYME; PHORBOL DIBUTYRATE; PHORBOL ESTER; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETAI; PROTEIN KINASE C DELTA; PROTEIN KINASE C EPSILON; UNCLASSIFIED DRUG;

ARTERY INTIMA PROLIFERATION; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CHEMOTAXIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SAPHENOUS VEIN; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

EID: 0034809792     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2001.281.1.h359     Document Type: Article

References (57)

1. Dissociation of vasoconstrictor-stimulated basic fibroblast growth factor expression from hypertrophic growth in cultured vascular smooth muscle cells. Relevant role of protein kinase C
2. Activation of protein kinase C inhibits keratinocyte migration
3. The adhesion plaque protein, talin, is phosphorylated in vivo in chicken embryo fibroblasts exposed to a tumor-promoting phorbol ester
4. Protein kinase C zeta isoform is critical for mitogenic signal transduction
5. Prevention of stenosis after reconstruction: Pharmacologic control of intimal hyperplasia
6. A myristoylated psuedopeptide, a novel protein kinase C inhibitor
7. Novel (Rp)-cAMPS analogues as tools for inhibition of cAMP-kinase in cell culture. Basal cAMP-kinase activity modulates interleukin-1β action
8. Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells
9. Differentiation of vascular smooth muscle cells and the regulation of protein kinase C-α
10. Platelet-derived growth factor and angiotensin II induce different spatial distribution of protein kinase C-α and -β in vascular smooth muscle cells
11. Enhancement of migration by protein kinase C alpha and inhibition of proliferation and cell cycle progression by protein kinase C delta in capillary endothelial cells
12. Chelerythrine is a potent and specific inhibitor of protein kinase C
13. Protein kinase C α expression is required for heparin inhibition of rat smooth muscle cell proliferation in vitro and in vivo
14. Pressure promotes DNA synthesis in rat cultured vascular smooth muscle cells
15. Adrenomedullin as a novel antimigration factor of vascular smooth muscle cells
16. 2+-independent contraction in vascular smooth muscle
17. The adenylyl cyclases as integrators of transmembrane signal transduction
18. The role of integrins in saphenous vein vascular smooth muscle cell migration
19. The role of protein kinase C in migration of rat glioma cells from spheroid cultures
20. Differential activation of adenylyl cyclase by protein kinase C isoenzymes
21. Phorbol myristate acetate (PMA) suppresses polarization and locomotion and alters F-actin content of Walker carcinosarcoma cells
22. Requirement for protein kinase C activation in basic fibroblast growth factor-induced human endothelial cell proliferation
23. 2+-independent isoforms of protein kinase C differentially translocate in smooth muscle
24. Antiplatelet effects of chelerythrine chloride isolated from Zanthoxylum simulans
25. Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats
26. Regulatory effects of platelet-derived growth factor-AA homodimer on migration of vascular smooth muscle cells
27. Protein kinase C-α regulates proliferation but not apoptosis in rat coronary vascular smooth muscle cells
28. Protein kinase-ζ mediates angiotensin II activation of ERK1/2 in vascular smooth muscle cells
29. Oleic acid-induced mitogenic signaling in vascular smooth muscle cells. A role for protein kinase C
30. Staurosporine, a protein kinase C inhibitor interferes with proliferation of arterial smooth muscle cells
31. Stimulation of tissue plasminogen activator production by retinoic acid: Synergistic effect on protein kinase C-mediated activation
32. Reorganization of alpha-actinin and vinculin induced by phorbol ester in living cells
33. Macrophage interactions with laminin: PMA selectively induces the adherence and spreading of mouse macrophages on a laminin substratum
34. Mitogen-activated protein kinase and proliferation of vascular smooth muscle cells
35. Transforming growth factor-beta inhibits human vascular smooth muscle cell growth and migration
36. A protein kinase C isozyme is translocated to cytoskeletal elements on activation
37. Activation of the ζ isozyme of protein kinase C by phosphatidylinositol 3,4,5-triphosphate
38. Extracellular matrix proteins are potent agonists of human smooth muscle cell migration
39. Platelet-derived growth factor and extracellular matrix proteins provide a synergistic stimulus for human vascular smooth muscle cell migration
40. Smooth muscle cell migration and proliferation are mediated by distinct phases of activation of the intracellular messenger mitogen-activated protein kinase
41. PKCα regultes β1 integrin-dpendent cell motility through association ans control of integrin traffic
42. Inhibition of chemotactic peptide-induced development of cell polarity and locomotion by the protein kinase C inhibitor CGP 41251 in human neutrophils correlates with inhibition of protein phosphorylation
43. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
44. Phorbol ester modulation of cyclic AMP accumulation in a primary culture of rat aortic smooth muscle cells
45. G-protein mediated signaling in cholesterol-enriched arterial smooth muscle cells. 2. Role of protein kinase C-delta in the regulation of eicosanoid production
46. The actions of prostaglandin E2 on potassium currents in rat tail artery vascular smooth muscle cells: Regulation by protein kinase A and protein kinase C
47. The small GTP-protein rac regulates growth factor-induced membrane ruffling
48. Regulation of motility in bovine brain endothelial cells
49. 1/S inhibition
50. Cell-permeable non-hydrolyzable cAMP derivatives as tools for analysis of signaling pathways controlling gene regulation in Dictyostelium
51. 45Ca fluxes in isolated smooth muscle cells
52. Inhibition of protein kinase C by N-myristoylated peptide substrate analogs
53. Protein kinase C isoenzymes in airways smooth muscle
54. Identification of the protein kinase C isoenzymes in human lung and airways smooth muscle at the protein and mRNA level
55. The role of intracellular calcium in migration of human vascular smooth muscle cells
56. Role of protein kinase C in attachment, spreading and migration of human endothelial cells
57. A monoclonal antibody to the phosphorylated form of glial fibrillary acidic protein: Application to non-radioactive method for measuring protein kinase activities