Prednisolone causes anxiety- and depression-like behaviors and altered expression of apoptotic genes in mice hippocampus

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 34, Issue 1, 2010, Pages 159-165

  Kajiyama, Yu ^a,b   Iijima, Yoshimi ^a   Chiba, Shuichi ^a   Furuta, Miyako ^a   Ninomiya, Midori ^a,b   Izumi, Aiko ^a   Shibata, Shigenobu ^b   Kunugi, Hiroshi ^a,c  

^a NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^b WASEDA UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Anxiety; Depression; Hippocampus; Microarray; Prednisolone

Indexed keywords

ANGIOTENSINOGEN; BIOLOGICAL MARKER; CYCLIN DEPENDENT KINASE INHIBITOR 1A; ELASTIN MICROFIBRIL INTERFACE LOCATED PROTEIN 2; FK 506 BINDING PROTEIN 5; GLYCOGEN SYNTHASE KINASE 3BETA; NFKBIA PROTEIN; PLEKHF1 PROTEIN; PREDNISOLONE; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SERUM AND GLUCOCORTICOID REGULATED KINASE 3; SLC22A6 PROTEIN; TSC22D3 PROTEIN; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; APOPTOSIS; ARTICLE; BEHAVIOR CHANGE; BRAIN DAMAGE; CONTROLLED STUDY; DEPRESSION; FORCED SWIMMING TEST; GENE EXPRESSION; HIPPOCAMPUS; MALE; MAZE TEST; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; OPEN FIELD TEST; PREPULSE INHIBITION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ACOUSTIC STIMULATION; ANIMALS; ANXIETY; APOPTOSIS; DEPRESSION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EXPLORATORY BEHAVIOR; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HINDLIMB SUSPENSION; HIPPOCAMPUS; MALE; MAZE LEARNING; MICE; MICE, INBRED C57BL; NEURAL INHIBITION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PREDNISOLONE; SIGNAL TRANSDUCTION; STARTLE REACTION; SWIMMING;

EID: 73649110230     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2009.10.018     Document Type: Article

References (50)

1. Alonso L., Okada H., Pasolli H.A., Wakeham A., You-Ten A.I., Mak T.W., et al. Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle. J Cell Biol 170 (2005) 559-570
2. Alva-Sánchez C., Sánchez-Huerta K., Arroyo-Helguera O., Anguiano B., Aceves C., and Pacheco-Rosado J. The maintenance of hippocampal pyramidal neuron populations is dependent on the modulation of specific cell cycle regulators by thyroid hormones. Brain Res 1271 (2009) 27-35
3. American College of Rheumatology Ad Hoc Committee on Systemic Lupus Erythematosus Guidelines. Guidelines for referral and management of systemic lupus erythematosus in adults. Arthritis Rheum 42 (1999) 1785-1796
4. Ayroldi E., Zollo O., Bastianelli A., Marchetti C., Agostini M., Di Virgilio R., et al. GILZ mediates the antiproliferative activity of glucocorticoids by negative regulation of Ras signaling. J Clin Invest 117 (2007) 1605-1615
5. Bai F., Li X., Clay M., Lindstrom T., and Skolnick P. Intra- and interstrain differences in models of "behavioral despair". Pharmacol Biochem Behav 70 (2001) 187-192
6. Baldwin A.S. Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. J Clin Invest 107 (2001) 241-246
7. Binder E.B., Salyakina D., Lichtner P., Wochnik G.M., Ising M., Putz B., et al. Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Nat Genet 36 (2004) 1319-1325
8. Bolanos S.H., Khan D.A., Hanczyc M., Bauer M.S., Dhanani N., and Brown E.S. Assessment of mood states in patients receiving long-term corticosteroid therapy and in controls with patient-rated and clinician-rated scales. Ann Allergy Asthma Immunol 92 (2004) 500-505
9. Bouwmeester T., Bauch A., Ruffner H., Angrand P.O., Bergamini G., Croughton K., et al. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat Cell Biol 6 (2004) 97-105
10. Brown E.S., Khan D.A., and Nejtek V.A. The psychiatric side effects of corticosteroids. Ann Allergy Asthma Immunol 83 (1999) 495-503
11. Brown E.S., Rush A.J., and McEwen B.S. Hippocampal remodeling and damage by corticosteroids: implications for mood disorders. Neuropsychopharmacology 21 (1999) 474-484
12. Brown E.S., Woolston D.J., Frol A., Bobadilla L., Khan D.A., Hanczyc M., et al. Hippocampal volume, spectroscopy, cognition, and mood in patients receiving corticosteroid therapy. Biol Psychiatry 55 (2004) 538-545
13. Brown E.S., Vera E., Frol A.B., Woolston D.J., and Johnson B. Effects of chronic prednisone therapy on mood and memory. J Affect Disord 99 (2007) 279-283
14. Campbell S., Marriott M., Nahmias C., and MacQueen G.M. Lower hippocampal volume in patients suffering from depression: a meta-analysis. Am J Psychiatry 161 (2004) 598-607
15. Chen W., Li N., Chen T., Han Y., Li C., Wang Y., et al. The lysosome-associated apoptosis-inducing protein containing the pleckstrin homology (PH) and FYVE domains (LAPF), representative of a novel family of PH and FYVE domain-containing proteins, induces caspase-independent apoptosis via the lysosomal-mitochondrial pathway. J Biol Chem 280 (2005) 40985-40995
16. de Kloet E.R., Joels M., and Holsboer F. Stress and the brain: from adaptation to disease. Nat Rev Neurosci 6 (2005) 463-475
17. Delfino D.V., Agostini M., Spinicelli S., Vito P., and Riccardi C. Decrease of Bcl-xL and augmentation of thymocyte apoptosis in GILZ overexpressing transgenic mice. Blood 104 (2004) 4134-4141
18. Doliana R., Bot S., Bonaldo P., and Colombatti A. EMI, a novel cysteine-rich domain of EMILINs and other extracellular proteins, interacts with the gC1q domains and participates in multimerization. FEBS Lett 484 (2000) 164-168
19. Geiger T., Rordorf C., Cosenti-Vargas A., Ferrini P.G., Widler L., Glatt M., and Vosbeck K. CGP 47969A: effect on collagen induced arthritis in DBA/1 mice. J Rheumatol 21 (1994) 1992-1997
20. Gonzalez-Perez O., Ramos-Remus C., Garcia-Estrada J., and Luquin S. Prednisone induces anxiety and glial cerebral changes in rats. J Rheumatol 28 (2001) 2529-2534
21. Gregus A., Wintink A.J., Davis A.C., and Kalynchuk L.E. Effect of repeated corticosterone injections and restraint stress on anxiety and depression-like behavior in male rats. Behav Brain Res 156 (2005) 105-114
22. Hickie I., Naismith S., Ward P.B., Turner K., Scott E., Mitchell P., et al. Reduced hippocampal volumes and memory loss in patients with early- and late-onset depression. Br J Psychiatry 186 (2005) 197-202
23. Hill M.N., Brotto L.A., Lee T.T., and Gorzalka B.B. Corticosterone attenuates the antidepressant-like effects elicited by melatonin in the forced swim test in both male and female rats. Prog Neuropsychopharmacol Biol Psychiatry 27 (2003) 905-911
24. Ising M., Künzel H.E., Binder E.B., Nickel T., Modell S., and Holsboer F. The combined dexamethasone/CRH test as a potential surrogate marker in depression. Prog Neuropsychopharmacol Biol Psychiatry 29 (2005) 1085-1093
25. Ising M., Depping A.M., Siebertz A., Lucae S., Unschuld P.G., Kloiber S., et al. Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls. Eur J NeuroSci 28 (2008) 389-398
26. Jope R.S., and Bijur G.N. Mood stabilizers, glycogen synthase kinase-3beta and cell survival. Mol Psychiatry 7 Suppl 1 (2002) S35-S45
27. Kakinuma Y., Hama H., Sugiyama F., Goto K., Murakami K., and Fukamizu A. Anti-apoptotic action of angiotensin fragments to neuronal cells from angiotensinogen knock-out mice. Neurosci Lett 232 (1997) 167-170
28. Kalynchuk L.E., Gregus A., Boudreau D., and Perrot-Sinal T.S. Corticosterone increases depression-like behavior, with some effects on predator odor-induced defensive behavior, in male and female rats. Behav Neurosci 118 (2004) 1365-1377
29. Kucharczak J., Simmons M.J., Fan Y., and Gelinas C. To be, or not to be: NF-kappaB is the answer-role of Rel/NF-kappaB in the regulation of apoptosis. Oncogene 22 (2003) 8961-8982
30. Kunugi H., Urushibara T., and Nanko S. Combined DEX/CRH test among Japanese patients with major depression. J Psychiatr Res 38 (2004) 123-128
31. Kunugi H., Ida I., Owashi T., Kimura M., Inoue Y., Nakagawa S., et al. Assessment of the dexamethasone/CRH test as a state-dependent marker for hypothalamic-pituitary-adrenal (HPA) axis abnormalities in major depressive episode: a Multicenter Study. Neuropsychopharmacology 31 (2006) 212-220
32. Lewis D.A., and Smith R.E. Steroid-induced psychiatric syndromes. A report of 14 cases and a review of the literature. J Affect Disord 5 (1983) 319-332
33. Ling M.H., Perry P.J., and Tsuang M.T. Side effects of corticosteroid therapy. Psychiatric aspects. Arch Gen Psychiatry 38 (1981) 471-477
34. Mattiasson G., Shamloo M., Gido G., Mathi K., Tomasevic G., Yi S., et al. Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma. Nat Med 9 (2003) 1062-1068
35. McEwen B.S. Glucocorticoids, depression, and mood disorders: structural remodeling in the brain. Metabolism 54 (2005) 20-23
36. Mikosz C.A., Brickley D.R., Sharkey M.S., Moran T.W., and Conzen S.D. Glucocorticoid receptor-mediated protection from apoptosis is associated with induction of the serine/threonine survival kinase gene, sgk-1. J Biol Chem 276 (2001) 16649-16654
37. Mongiat M., Ligresti G., Marastoni S., Lorenzon E., Doliana R., and Colombatti A. Regulation of the extrinsic apoptotic pathway by the extracellular matrix glycoprotein EMILIN2. Mol Cell Biol 27 (2007) 7176-7187
38. Nigam S.K., Bush K.T., and Bhatnagar V. Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues. Nat Clin Pract Nephrol 3 (2007) 443-448
39. Patten S.B. Exogenous corticosteroids and major depression in the general population. J Psychosom Res 49 (2000) 447-449
40. Rodriguez R., and Meuth M. Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress. Mol Biol Cell 17 (2006) 402-412
41. Rokudai S., Aikawa Y., Tagata Y., Tsuchida N., Taya Y., and Kitabayashi I. Monocytic leukemia zinc finger (MOZ) interacts with p53 to induce p21 expression and cell-cycle arrest. J Biol Chem 284 (2009) 237-244
42. Sapolsky R.M. Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch Gen Psychiatry 57 (2000) 925-935
43. Sheline Y.I. Neuroimaging studies of mood disorder effects on the brain. Biol Psychiatry 54 (2003) 338-352
44. Sher L. Combined dexamethasone suppression-corticotropin-releasing hormone stimulation test in studies of depression, alcoholism, and suicidal behavior. Sci World J 6 (2006) 1398-1404
45. Sonino N., Fava G.A., Raffi A.R., Boscaro M., and Fallo F. Clinical correlates of major depression in Cushing's disease. Psychopathology 31 (1998) 302-306
46. Ströhle A., and Holsboer F. Stress responsive neurohormones in depression and anxiety. Pharmacopsychiatry 36 (2003) 207-214
47. Tomlinson E.S., Maggs J.L., Park B.K., and Back D.J. Dexamethasone metabolism in vitro: species differences. J Steroid Biochem Mol Biol 62 (1997) 345-352
48. Videbech P., and Ravnkilde B. Hippocampal volume and depression: a meta-analysis of MRI studies. Am J Psychiatry 161 (2004) 1957-1966
49. Wolkowitz O.M., Rubinow D., Doran A.R., Breier A., Berrettini W.H., Kling M.A., and Pickar D. Prednisone effects on neurochemistry and behavior. Preliminary findings. Arch Gen Psychiatry 47 (1990) 963-968
50. Zhao Y., Ma R., Shen J., Su H., Xing D., and Du L. A mouse model of depression induced by repeated corticosterone injections. Eur J Pharmacol 581 (2008) 113-120