Solid lipid nanoparticles for applications in gene therapy: A review of the state of the art

Expert Opinion on Drug Delivery

Volumn 7, Issue 1, 2010, Pages 7-18

  Bond, Maria Luisa ^a   Craparo, Emanuela Fabiola ^b  

^a CNR   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

Author keywords

Cationic solid lipid nanoparticles; Gene delivery; Gene therapy; Non viral vectors

Indexed keywords

SOLID LIPID NANOPARTICLE;

GENE DELIVERY SYSTEM; GENE THERAPY; HUMAN; REVIEW; SCANNING ELECTROCHEMICAL MICROSCOPY;

DNA; GENE THERAPY; GENETIC VECTORS; LIPIDS; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES;

EID: 73649102110     PISSN: 17425247     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425240903362410     Document Type: Review

References (73)

1. Kennington E. Neurodegenerative disease: gene therapy delivers an alternative approach to Alzheimer's disease. Nat Rev Drug Discov 2009;8:275
2. Verhoeyen E, Costa C, Cosset FL. Lentiviral vector gene transfer into human T cells. Methods in molecular biology. Clifton NJ 2009;506:97-114
3. Brunetti-Pierri N, Ng P. Progress and prospects: gene therapy for genetic diseases with helper-dependent adenoviral vectors. Gene Ther 2008;15:553-560
4. Walther W, Stein U, Voss C, et al. Stability analysis for long-term storage of naked DNA: impact on nonviral in vivo gene transfer. Anal Biochem 2003;318:230-235
5. Shi F, Rakhmilevich AL, Heise CP, et al. Intratumoral injection of interleukin-12 plasmid DNA, either naked or in complex with cationic lipid, results in similar tumor regression in a murine model. Mol Cancer Ther 2002;1:949-957
6. Morille M, Passirani C, Vonarbourg A, et al. Progress in developing cationic vectors for non-viral systemic gene therapy against cancer. Biomaterials 2008;29:3477-3496
7. EL-ANEED A. An overview of current delivery systems in cancer gene therapy. J Control Release 2004;94:1-14
8. Katas H, Alpar HO. Development and characterisation of chitosan nanoparticles for siRNA delivery. J Control Release 2006;115:216-225
9. Kim TH, Kim SI, Akaike T, Cho CS. Synergisic effect of poly(ethylenimine) on the transfection efficiency of galactosylated chitosan/DNA complexes. J Control Release 2005;105:354-366
10. Check E. Harmful potential of viral vectors fuels doubt over gene therapy. Nature 2003;423:573-574
11. Li Z, Dullmann J, Schiedlmeier B, et al. Murine leukemia induced by retroviral gene marking. Science 2002;296:497
12. Bhavsar MD, Amiji MM. Polymeric nano- and microparticle technologies for oral gene delivery. Expert Opin Drug Deliv 2007;4:197-213
13. Jin S, Ye K. Nanoparticle-mediated drug delivery and gene therapy. Biotechnol Prog 2007;23:32-41
14. Kaneda Y, Tabata Y. Non-viral vectors for cancer therapy. Cancer Sci 2006;97:348-354
15. Zhdanov RI, Podobed OV, Vlassov VV. Cationic lipid-DNA complexes lipoplexes-for gene transfer and therapy. Bioelettrochemistry 2002;58:53-64
16. Brown MD, Schatzlein AG, Uchegbu IF. Gene delivery with synthetic (non viral) carriers. Int J Pharm 2001;229:1-21
17. Portney NG, Ozkan M. Nano-oncology: drug delivery, imaging, and sensing. Anal Bional Chem 2006;384:620-630
18. Souto EB, MÜLLER RH. Lipid nanoparticles (SLN and NLC) for drug delivery. In: Domb A, Tobata Y, Kumar R, Farber S, editors, Nanoparticles for pharmaceutical applications. California, USA: American Scientific Publishers; 2007
19. Almeida AJ, Souto E. Solid lipid nanoparticles as a drug delivery system for peptides and proteins. Adv Drug Deliv Rev 2007;59:478-490 (Pubitemid 47260710)
20. Müller RH, Keck CM. Challenges and solutions for the delivery of biotech drugsa review of drug nanocrystal technology and lipid nanoparticles. J Biotechnol 2004;113:151-170
21. Müller RH, Radtke M, Wissing SA. solid lipid nanoparticles and nanostructured lipid carriers. In: Nalwa HS, editor, Encyclopedia of nanoscience and nanotechnology. California, USA: American Scientific Publishers; 2004
22. Mehnert W, Mader K. Solid lipid nanoparticles-production, characterization and applications. Adv Drug Deliv Rev 2001;47:165-196
23. Pedersen N, Hansen S, Heydenreich AV, et al. Solid lipid nanoparticles can effectively bind DNA, streptavidin and biotinylated ligands. Eur J Pharm Biopharm 2006;62:155-162
24. Montana G, Bondi' ML, Carrotta R, et al. Employment of cationic solid-lipid nanoparticles as RNA carriers. Bioconjugate Chem 2007;18:302-308
25. Tabatt K, Kneuer C, Sameti M, et al. Transfection with different colloidal systems: comparison of solid lipid nanoparticles and liposomes. J Control Rel 2004;97:321-332
26. Tabatt K, Sameti M, Olbrich C, et al. Effect of cationic and matrix lipid composition on solid lipid nanoparticle-mediated gene transfer. Eur J Pharm Biopharm 2004;57:155-162
27. Rudolph C, Schillinger U, Ortiz A, et al. Application of novel solid lipid nanoparticle (SLN)-gene vector formulations based on dimeric HIV-1 TAT-peptide in vitro and in vivo. Pharm Res 2004;21:1662-1669
28. Olbrich C, Bakowsky U, Lehr CM, et al. Cationic solid-lipid nanoparticles can efficiently bind and transfect plasmid DNA. J Control Release 2001;77:345-355
29. Del Pozo-Rodriguez A, Delgado D, Solinis MA, et al. Solid lipid nanoparticles: formulation factors affecting cell transfection capacity. Int J Pharm 2007;339:261-268
30. Del Pozo-Rodríguez A, Delgado D, Solinís MA, et al. Solid lipid nanoparticles for retinal gene therapy: transfection and intracellular trafficking in RPE cells. Int J Pharm 2008;360:177-183
31. Del Pozo-Rodríguez C, Solinís MA, Gascón AR, Pedraz JL. Short- and long-term stability study of lyophilized solid lipid nanoparticles for gene therapy. Eur J Pharm Biopharm 2009;71:181-189
32. Del Pozo-Rodríguez A, Pujals S, Delgado D, et al. A proline-rich peptide improves cell transfection of solid lipid nanoparticle-based non-viral vectors. J Control Release (2009) 133:52-59
33. Ye J, Wang A, Liu C, et al. Anionic solid lipid nanoparticles supported on protamine/DNA complexes. Nanotechnology 2008;19:285708-285716
34. Choi SH, Jin S, Lee M, et al. Novel cationic solid lipid nanoparticles enhanced p53 gene transfer to lung cancer cells. Eur J Pharm Biopharm 2008;68:545-554
35. Bondì ML, Craparo EF, Giammona G, et al. Nanostructured lipid carriers-containing anticancer compounds: preparation, characterization, and cytotoxicity studies. Drug Deliv 2007;14:61-67
36. Asasutjarit R, Lorenzen SI, Sirivichayakul S, et al. Effect of solid lipid nanoparticles formulation compositions on their size, zeta potential and potential for in vitro pHIS-HIV-Hugag transfection. Pharm Res 2007;24:1098-1107
37. Yu W, Liu C, Ye J, et al. Novel cationic SLN containing a synthesized single-tailed lipid as a modifier for gene delivery. Nanotechnology 2009;20:215102-215112
38. Freitas C, Müller RH. Stability determination of solid lipid nanoparticles (SLNTM) in aqueous dispersion after addition of electrolyte. J Microencapsul 1999;16:59-71
39. Schwarz C, Mehnert W. Freeze-drying of drug-free and drug-loaded solid lipid nanoparticles (SLN). Int J Pharm 1997;157:171-179 (Pubitemid 27471169)
40. Wissing SA, Kayser O, Müller RH. Solid lipid nanoparticles for parenteral drug delivery. Adv Drug Deliv Rev 2004;56:1257-1272
41. Gebhart CL, Kabanov AV. Evaluation of polyplexes as gene transfer agents. J Control Release 2001;73:401-416
42. Belting M, Sandgren S, Wittrup A. Nuclear delivery of macromolecules: barriers and carriers. Adv Drug Deliv Rev 2005;57:505-527
43. Li W, Szoka FC Jr. Lipid-based nanoparticles for nucleic acid delivery. Pharm Res 2007;24(3):438-449
44. Opanasopit P, Nishikawa M, Hashida M. Factors affecting drug and gene delivery: effects of interaction with blood components. Crit Rev Ther Drug Carr Syst 2002;19:191-233
45. Zhang J, Lan CQ, Post M, et al. Design of nanoparticles as drug carriers for cancer therapy. Cancer Genomic Proteomic 2006;3:147-157
46. Khalil IA, Kogure K, Akita H, Harashima H. Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery Pharmacol Rev (2006) 58:32-45 (Pubitemid 43313695)
47. Zuhorn IS, Kalicharan R, Hoekstra D. Lipoplex-mediated transfection of mammalian cells occurs through the cholesterol-dependent clathrin-mediated pathway of endocytosis. J Biol Chem 2002;277:18021-18028
48. Labat-Moleur F, Steffan AM, Brisson C, et al. An electron microscopy study into the mechanism of gene transfer with lipopolyamines. Gene Ther 1996;3:1010-1017
49. Felgner PL, Tsai YJ, Sukhu L, et al. Improved cationic lipid formulations for in vivo gene therapy. Ann NY Acad Sci 1995;772:126-139
50. Felgner PL, Gadek TR, Holm M, et al. Lipofection: a highly efficient, lipid-mediated DNA transfection procedure. Proc Natl Acad Sci USA 1987;84:7413-7417
51. Cotten M, Langle-Rouault F, Kirlappos H, et al. Transferrin-polycation- mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels. Proc Natl Acad Sci USA 1990;87:4033-4037
52. Melchior F, Gerace L. Mechanisms of nuclear protein import. Curr Opin Cell Biol 1995;7:310-318
53. Lechardeur D, Verkman AS, Lukacs L. Intracellular routing of plasmid DNA during non-viral gene transfer. Adv Drug Deliv Rev 2005;57:755-767
54. Pollard H, Remy JS, Loussouarn G, et al. Polyethylenimine but not cationic lipids promotes transgene delivery to the nucleus in mammalian cells. J Biol Chem 1998;273:7507-7511
55. Akita H, Ito R, Khalil IA, et al. Quantitative threedimensional analysis of the intracellular trafficking of plasmid DNA transfected by a nonviral gene delivery system using confocal laser scanning microscopy. Mol Ther 2004;9:443-451
56. Han SO, Mahato RI, Sung YK, Kim SW. Development of biomaterials for gene therapy. Mol Ther 2000;2:302-317
57. Sakurai F, Inoue R, Nishino Y, et al. Effect of DNA/liposome mixing ratio on the physicochemical characteristics, cellular uptake and intracellular trafficking of plasmid DNA/cationic liposome complexes and subsequent gene expression. J Control Release 2000;66:255-269
58. Müller RH, Mader K, Gohla S. Solid lipid nanoparticles (SLN) for controlled drug delivery-a review of the state of art. Eur J Pharm Biopharm 2006;50:161-177
59. Heydenreich AV, Westmeier R, Pedersen N, Poulsen Hskristensen HG. Preparation and purification of cationic solid lipid nanospheres-effects on particle size, physical stability and cell toxicity. Int J Pharm 2003;254:83-87
60. Gasco MR. Solid lipid nanospheres from warm microemulsions. Pharm Technol Eur 1997;9:52-54,56-58
61. Bondi' ML, Azzolina A, Craparo EF, et al. Novel cationic solid-lipid nanoparticles as non-viral vectors for gene delivery. J Drug Target 2007;15:295-301
62. Siekmann B, Westesen K. Investigation on solid lipid nanoparticles prepared by precipitation in o/w emulsion. Eur J Pharm Biopharm 1996;43:104-109
63. Sjöström B, Bergenstahl B. Preparation of submicron drug particles in lecithin-stabilized o/w emulsions. Model studies of the precipitation of cholesteryl acetate. Int J Pharm 1992;88:53-62
64. Kiwada H, Matsuo H, Harashima H. Identification of proteins mediating clearance of liposomes using a liver perfusion system. Adv Drug Deliv Rev 1998;32:61-79
65. Lunau M, Lemke A, Walther K, et al. An improved method for counting bacteria from sediments and turbid environments by epifluorescence microscopy. Environ Microbiol 2005;7:961-968
66. Teare JM, Islam R, Flanagan R, et al. Measurement of nucleic acid concentrations using the DyNA Quant and the GeneQuant. Biotechniques 1997;22:1170-1174
67. Valle O, Lien T, Knutsen G. Fluorometric determination of DNA and RNA in Chlamydomonas using ethidium bromide. J Biochem Biophys Methods 1981;4:271-277
68. Available from: http://www.malvernusa. com/LabEng/products/zetasizer/ zetasizer. htm Zetasizer Nano Series
69. Hu FQ, Yuan H, Zhang HH, Fang M. Preparation of solid lipid nanoparticles with clobetasol propionate by a novel solvent diffusion method in aqueous system and physicochemical characterization. Int J Pharm 2002;239:121-128
70. Remaut K, Sanders NN, Fayazpour F, et al. Influence of plasmid DNA topology on the transfection properties of DOTAP/ DOPE lipoplexes. J Control Release 2006;115:335-343
71. Middaugh CR, Evans RK, Montgomery DL, Casimiro DR. Analysis of plasmid DNA from a pharmaceutical perspective. J Pharm Sci 1998;87:130-146
72. Sanders NN, De Smedt SC, Demeester J. In: MCGRATH BM, WALSH G, editors, Therapeutics enzymes. Taylor & Francis Group, Boca Raton; 2006. p. 97-116
73. Vighi E, Ruozi B, Montanari M, et al. Re-dispersible cationic solid lipid nanoparticles (SLNs) freeze-dried without cryoprotectors: characterization and ability to bind the pEGFP-plasmid. Eur J Pharm Biopharm 2007;67:320-328