-
1
-
-
33646204900
-
A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors
-
Albers M, Blume B, Schlueter T, Wright MB, Kober I, Kremoser C, Deuschle U, and Koegl M (2006) A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors. J Biol Chem 281:4920-4930.
-
(2006)
J Biol Chem
, vol.281
, pp. 4920-4930
-
-
Albers, M.1
Blume, B.2
Schlueter, T.3
Wright, M.B.4
Kober, I.5
Kremoser, C.6
Deuschle, U.7
Koegl, M.8
-
2
-
-
0348147584
-
Oxysterol and 9-cis-retinoic acid stimulate the group IIA secretory phospholipase A2 gene in rat smooth-muscle cells
-
Antonio V, Janvier B, Brouillet A, Andreani M, and Raymondjean M (2003) Oxysterol and 9-cis-retinoic acid stimulate the group IIA secretory phospholipase A2 gene in rat smooth-muscle cells. Biochem J 376:351-360.
-
(2003)
Biochem J
, vol.376
, pp. 351-360
-
-
Antonio, V.1
Janvier, B.2
Brouillet, A.3
Andreani, M.4
Raymondjean, M.5
-
3
-
-
0036250811
-
Alu repeats and human genomic diversity
-
Batzer MA and Deininger PL (2002) Alu repeats and human genomic diversity. Nat Rev Genet 3:370-379.
-
(2002)
Nat Rev Genet
, vol.3
, pp. 370-379
-
-
Batzer, M.A.1
Deininger, P.L.2
-
4
-
-
0030724392
-
Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein
-
Brasaemle DL, Barber T, Wolins NE, Serrero G, Blanchette-Mackie EJ, and Londos C (1997) Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein. J Lipid Res 38:2249-2263.
-
(1997)
J Lipid Res
, vol.38
, pp. 2249-2263
-
-
Brasaemle, D.L.1
Barber, T.2
Wolins, N.E.3
Serrero, G.4
Blanchette-Mackie, E.J.5
Londos, C.6
-
5
-
-
31344437783
-
Protection against fatty liver but normal adipogenesis in mice lacking adipose differentiation-related protein
-
Chang BH, Li L, Paul A, Taniguchi S, Nannegari V, Heird WC, and Chan L (2006) Protection against fatty liver but normal adipogenesis in mice lacking adipose differentiation-related protein. Mol Cell Biol 26:1063-1076.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 1063-1076
-
-
Chang, B.H.1
Li, L.2
Paul, A.3
Taniguchi, S.4
Nannegari, V.5
Heird, W.C.6
Chan, L.7
-
6
-
-
0037417726
-
PPARdelta is a very low-density lipoprotein sensor in macrophages
-
Chawla A, Lee CH, Barak Y, He W, Rosenfeld J, Liao D, Han J, Kang H, and Evans RM (2003) PPARdelta is a very low-density lipoprotein sensor in macrophages. Proc Natl Acad Sci U S A 100:1268-1273.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 1268-1273
-
-
Chawla, A.1
Lee, C.H.2
Barak, Y.3
He, W.4
Rosenfeld, J.5
Liao, D.6
Han, J.7
Kang, H.8
Evans, R.M.9
-
7
-
-
0037046543
-
Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines
-
Collins JL, Fivush AM, Watson MA, Galardi CM, Lewis MC, Moore LB, Parks DJ, Wilson JG, Tippin TK, Binz JG, et al. (2002) Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J Med Chem 45:1963-1966.
-
(2002)
J Med Chem
, vol.45
, pp. 1963-1966
-
-
Collins, J.L.1
Fivush, A.M.2
Watson, M.A.3
Galardi, C.M.4
Lewis, M.C.5
Moore, L.B.6
Parks, D.J.7
Wilson, J.G.8
Tippin, T.K.9
Binz, J.G.10
-
8
-
-
33646863002
-
PPARalpha activators and fasting induce the expression of adipose differentiation-related protein in liver
-
Dalen KT, Ulven SM, Arntsen BM, Solaas K, and Nebb HI (2006) PPARalpha activators and fasting induce the expression of adipose differentiation-related protein in liver. J Lipid Res 47:931-943.
-
(2006)
J Lipid Res
, vol.47
, pp. 931-943
-
-
Dalen, K.T.1
Ulven, S.M.2
Arntsen, B.M.3
Solaas, K.4
Nebb, H.I.5
-
9
-
-
0142223221
-
The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands
-
Farnegardh M, Bonn T, Sun S, Ljunggren J, Ahola H, Wilhelmsson A, Gustafsson JA, and Carlquist M (2003) The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands. J Biol Chem 278:38821-38828.
-
(2003)
J Biol Chem
, vol.278
, pp. 38821-38828
-
-
Farnegardh, M.1
Bonn, T.2
Sun, S.3
Ljunggren, J.4
Ahola, H.5
Wilhelmsson, A.6
Gustafsson, J.A.7
Carlquist, M.8
-
10
-
-
0037072732
-
Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles
-
Grefhorst A, Elzinga BM, Voshol PJ, Plosch T, Kok T, Bloks VW, van der Sluijs FH, Havekes LM, Romijn JA, Verkade HJ, et al. (2002) Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles. J Biol Chem 277:34182-34190.
-
(2002)
J Biol Chem
, vol.277
, pp. 34182-34190
-
-
Grefhorst, A.1
Elzinga, B.M.2
Voshol, P.J.3
Plosch, T.4
Kok, T.5
Bloks, V.W.6
van der Sluijs, F.H.7
Havekes, L.M.8
Romijn, J.A.9
Verkade, H.J.10
-
11
-
-
25444501883
-
Synthetic LXR agonists increase LDL in CETP species
-
Groot PH, Pearce NJ, Yates JW, Stocker C, Sauermelch C, Doe CP, Willette RN, Olzinski A, Peters T, d'Epagnier D, et al. (2005) Synthetic LXR agonists increase LDL in CETP species. J Lipid Res 46:2182-2191.
-
(2005)
J Lipid Res
, vol.46
, pp. 2182-2191
-
-
Groot, P.H.1
Pearce, N.J.2
Yates, J.W.3
Stocker, C.4
Sauermelch, C.5
Doe, C.P.6
Willette, R.N.7
Olzinski, A.8
Peters, T.9
d'Epagnier, D.10
-
12
-
-
4744354632
-
T0901317 is a dual LXR/FXR agonist
-
Houck KA, Borchert KM, Hepler CD, Thomas JS, Bramlett KS, Michael LF, and Burris TP (2004) T0901317 is a dual LXR/FXR agonist. Mol Genet Metab 83:184-187.
-
(2004)
Mol Genet Metab
, vol.83
, pp. 184-187
-
-
Houck, K.A.1
Borchert, K.M.2
Hepler, C.D.3
Thomas, J.S.4
Bramlett, K.S.5
Michael, L.F.6
Burris, T.P.7
-
13
-
-
0036786517
-
ADRP stimulates lipid accumulation and lipid droplet formation in murine fibroblasts
-
Imamura M, Inoguchi T, Ikuyama S, Taniguchi S, Kobayashi K, Nakashima N, and Nawata H (2002) ADRP stimulates lipid accumulation and lipid droplet formation in murine fibroblasts. Am J Physiol Endocrinol Metab 283:E775-E783.
-
(2002)
Am J Physiol Endocrinol Metab
, vol.283
-
-
Imamura, M.1
Inoguchi, T.2
Ikuyama, S.3
Taniguchi, S.4
Kobayashi, K.5
Nakashima, N.6
Nawata, H.7
-
14
-
-
65649129652
-
GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus
-
Jakobsson T, Venteclef N, Toresson G, Damdimopoulos AE, Ehrlund A, Lou X, Sanyal S, Steffensen KR, Gustafsson JA, and Treuter E (2009) GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus. Mol Cell 34:510-518.
-
(2009)
Mol Cell
, vol.34
, pp. 510-518
-
-
Jakobsson, T.1
Venteclef, N.2
Toresson, G.3
Damdimopoulos, A.E.4
Ehrlund, A.5
Lou, X.6
Sanyal, S.7
Steffensen, K.R.8
Gustafsson, J.A.9
Treuter, E.10
-
15
-
-
0037385266
-
LXRs: New therapeutic targets in atherosclerosis?
-
Joseph SB and Tontonoz P (2003) LXRs: new therapeutic targets in atherosclerosis? Curr Opin Pharmacol 3:192-197.
-
(2003)
Curr Opin Pharmacol
, vol.3
, pp. 192-197
-
-
Joseph, S.B.1
Tontonoz, P.2
-
16
-
-
34548487854
-
22-Hydroxycholesterols regulate lipid metabolism differently than T0901317 in human myotubes
-
Kase ET, Andersen B, Nebb HI, Rustan AC, and Thoresen GH (2006) 22-Hydroxycholesterols regulate lipid metabolism differently than T0901317 in human myotubes. Biochim Biophys Acta 1761:1515-1522.
-
(2006)
Biochim Biophys Acta
, vol.1761
, pp. 1515-1522
-
-
Kase, E.T.1
Andersen, B.2
Nebb, H.I.3
Rustan, A.C.4
Thoresen, G.H.5
-
17
-
-
34748836338
-
Physiological differences between human and rat primary hepatocytes in response to liver X receptor activation by 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyl oxy]phenylacetic acid hydrochloride (GW3965)
-
Kotokorpi P, Ellis E, Parini P, Nilsson LM, Strom S, Steffensen KR, Gustafsson JA, and Mode A (2007) Physiological differences between human and rat primary hepatocytes in response to liver X receptor activation by 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyl oxy]phenylacetic acid hydrochloride (GW3965). Mol Pharmacol 72:947-955.
-
(2007)
Mol Pharmacol
, vol.72
, pp. 947-955
-
-
Kotokorpi, P.1
Ellis, E.2
Parini, P.3
Nilsson, L.M.4
Strom, S.5
Steffensen, K.R.6
Gustafsson, J.A.7
Mode, A.8
-
18
-
-
0034773966
-
Autoregulation of the human liver X receptor alpha promoter
-
Laffitte BA, Joseph SB, Walczak R, Pei L, Wilpitz DC, Collins JL, and Tontonoz P (2001) Autoregulation of the human liver X receptor alpha promoter. Mol Cell Biol 21:7558-7568.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 7558-7568
-
-
Laffitte, B.A.1
Joseph, S.B.2
Walczak, R.3
Pei, L.4
Wilpitz, D.C.5
Collins, J.L.6
Tontonoz, P.7
-
19
-
-
0037085365
-
Oxysterol activators of liver X receptor and 9-cis-retinoic acid promote sequential steps in the synthesis and secretion of tumor necrosis factor-alpha from human monocytes
-
Landis MS, Patel HV, and Capone JP (2002) Oxysterol activators of liver X receptor and 9-cis-retinoic acid promote sequential steps in the synthesis and secretion of tumor necrosis factor-alpha from human monocytes. J Biol Chem 277:4713-4721.
-
(2002)
J Biol Chem
, vol.277
, pp. 4713-4721
-
-
Landis, M.S.1
Patel, H.V.2
Capone, J.P.3
-
20
-
-
0036188910
-
Induction of human liver X receptor alpha gene expression via an autoregulatory loop mechanism
-
Li Y, Bolten C, Bhat BG, Woodring-Dietz J, Li S, Prayaga SK, Xia C, and Lala DS (2002) Induction of human liver X receptor alpha gene expression via an autoregulatory loop mechanism. Mol Endocrinol 16:506-514.
-
(2002)
Mol Endocrinol
, vol.16
, pp. 506-514
-
-
Li, Y.1
Bolten, C.2
Bhat, B.G.3
Woodring-Dietz, J.4
Li, S.5
Prayaga, S.K.6
Xia, C.7
Lala, D.S.8
-
21
-
-
0033071156
-
Perilipins, ADRP, and other proteins that associate with intracellular neutral lipid droplets in animal cells
-
Londos C, Brasaemle DL, Schultz CJ, Segrest JP, and Kimmel AR (1999) Perilipins, ADRP, and other proteins that associate with intracellular neutral lipid droplets in animal cells. Semin Cell Dev Biol 10:51-58.
-
(1999)
Semin Cell Dev Biol
, vol.10
, pp. 51-58
-
-
Londos, C.1
Brasaemle, D.L.2
Schultz, C.J.3
Segrest, J.P.4
Kimmel, A.R.5
-
22
-
-
33745942915
-
Adipocyte differentiation-related protein promotes fatty acid storage in cytosolic triglycerides and inhibits secretion of very low-density lipoproteins
-
Magnusson B, Asp L, Bostrom P, Ruiz M, Stillemark-Billton P, Linden D, Boren J, and Olofsson SO (2006) Adipocyte differentiation-related protein promotes fatty acid storage in cytosolic triglycerides and inhibits secretion of very low-density lipoproteins. Arterioscler Thromb Vasc Biol 26:1566-1571.
-
(2006)
Arterioscler Thromb Vasc Biol
, vol.26
, pp. 1566-1571
-
-
Magnusson, B.1
Asp, L.2
Bostrom, P.3
Ruiz, M.4
Stillemark-Billton, P.5
Linden, D.6
Boren, J.7
Olofsson, S.O.8
-
23
-
-
15744386871
-
Nuclear receptors as targets for drug development: Regulation of cholesterol and bile acid metabolism by nuclear receptors
-
Makishima M (2005) Nuclear receptors as targets for drug development: regulation of cholesterol and bile acid metabolism by nuclear receptors. J Pharmacol Sci 97:177-183.
-
(2005)
J Pharmacol Sci
, vol.97
, pp. 177-183
-
-
Makishima, M.1
-
24
-
-
33845934193
-
The arginase II gene is an anti-inflammatory target of liver X receptor in macrophages
-
Marathe C, Bradley MN, Hong C, Lopez F, Ruiz de Galarreta CM, Tontonoz P, and Castrillo A (2006) The arginase II gene is an anti-inflammatory target of liver X receptor in macrophages. J Biol Chem 281:32197-32206.
-
(2006)
J Biol Chem
, vol.281
, pp. 32197-32206
-
-
Marathe, C.1
Bradley, M.N.2
Hong, C.3
Lopez, F.4
Ruiz de Galarreta, C.M.5
Tontonoz, P.6
Castrillo, A.7
-
25
-
-
33646168160
-
Lipid droplets: A unified view of a dynamic organelle
-
Martin S and Parton RG (2006) Lipid droplets: a unified view of a dynamic organelle. Nat Rev Mol Cell Biol 7:373-378.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 373-378
-
-
Martin, S.1
Parton, R.G.2
-
26
-
-
3442894108
-
Raising HDL cholesterol without inducing hepatic steatosis and hypertriglyceridemia by a selective LXR modulator
-
Miao B, Zondlo S, Gibbs S, Cromley D, Hosagrahara VP, Kirchgessner TG, Billheimer J, and Mukherjee R (2004) Raising HDL cholesterol without inducing hepatic steatosis and hypertriglyceridemia by a selective LXR modulator. J Lipid Res 45:1410-1417.
-
(2004)
J Lipid Res
, vol.45
, pp. 1410-1417
-
-
Miao, B.1
Zondlo, S.2
Gibbs, S.3
Cromley, D.4
Hosagrahara, V.P.5
Kirchgessner, T.G.6
Billheimer, J.7
Mukherjee, R.8
-
28
-
-
34247093820
-
T0901317 is a potent PXR ligand: Implications for the biology ascribed to LXR
-
Mitro N, Vargas L, Romeo R, Koder A, and Saez E (2007) T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR. FEBS Lett 581:1721-1726.
-
(2007)
FEBS Lett
, vol.581
, pp. 1721-1726
-
-
Mitro, N.1
Vargas, L.2
Romeo, R.3
Koder, A.4
Saez, E.5
-
29
-
-
67349092825
-
Lipid droplets as dynamic organelles connecting storage and efflux of lipids
-
Olofsson SO, Bostrom P, Andersson L, Rutberg M, Perman J, and Boren J (2009) Lipid droplets as dynamic organelles connecting storage and efflux of lipids. Biochim Biophys Acta 1791:448-458.
-
(2009)
Biochim Biophys Acta
, vol.1791
, pp. 448-458
-
-
Olofsson, S.O.1
Bostrom, P.2
Andersson, L.3
Rutberg, M.4
Perman, J.5
Boren, J.6
-
30
-
-
52949139843
-
Selective partial agonism of liver X receptor alpha is related to differential corepressor recruitment
-
Phelan CA, Weaver JM, Steger DJ, Joshi S, Maslany JT, Collins JL, Zuercher WJ, Willson TM, Walker M, Jaye M, et al. (2008) Selective partial agonism of liver X receptor alpha is related to differential corepressor recruitment. Mol Endocrinol 22:2241-2249.
-
(2008)
Mol Endocrinol
, vol.22
, pp. 2241-2249
-
-
Phelan, C.A.1
Weaver, J.M.2
Steger, D.J.3
Joshi, S.4
Maslany, J.T.5
Collins, J.L.6
Zuercher, W.J.7
Willson, T.M.8
Walker, M.9
Jaye, M.10
-
31
-
-
14844311992
-
Prediction of nuclear hormone receptor response elements
-
Sandelin A and Wasserman WW (2005) Prediction of nuclear hormone receptor response elements. Mol Endocrinol 19:595-606.
-
(2005)
Mol Endocrinol
, vol.19
, pp. 595-606
-
-
Sandelin, A.1
Wasserman, W.W.2
-
32
-
-
0034669171
-
Role of LXRs in control of lipogenesis
-
Schultz JR, Tu H, Luk A, Repa JJ, Medina JC, Li L, Schwendner S, Wang S, Thoolen M, Mangelsdorf DJ, et al. (2000) Role of LXRs in control of lipogenesis. Genes Dev 14:2831-2838.
-
(2000)
Genes Dev
, vol.14
, pp. 2831-2838
-
-
Schultz, J.R.1
Tu, H.2
Luk, A.3
Repa, J.J.4
Medina, J.C.5
Li, L.6
Schwendner, S.7
Wang, S.8
Thoolen, M.9
Mangelsdorf, D.J.10
-
33
-
-
0037192501
-
Molecular determinants for the tissue specificity of SERMs
-
Shang Y and Brown M (2002) Molecular determinants for the tissue specificity of SERMs. Science 295:2465-2468.
-
(2002)
Science
, vol.295
, pp. 2465-2468
-
-
Shang, Y.1
Brown, M.2
-
34
-
-
0029737488
-
Use of human hepatocytes to study P450 gene induction
-
Strom SC, Pisarov LA, Dorko K, Thompson MT, Schuetz JD, and Schuetz EG (1996) Use of human hepatocytes to study P450 gene induction. Methods Enzymol 272: 388-401.
-
(1996)
Methods Enzymol
, vol.272
, pp. 388-401
-
-
Strom, S.C.1
Pisarov, L.A.2
Dorko, K.3
Thompson, M.T.4
Schuetz, J.D.5
Schuetz, E.G.6
-
35
-
-
15744363183
-
A PPAR response element regulates transcription of the gene for human adipose differentiation-related protein
-
Targett-Adams P, McElwee MJ, Ehrenborg E, Gustafsson MC, Palmer CN and McLauchlan J (2005) A PPAR response element regulates transcription of the gene for human adipose differentiation-related protein. Biochim Biophys Acta 1728(1-2):95-104.
-
(2005)
Biochim Biophys Acta
, vol.1728
, Issue.1-2
, pp. 95-104
-
-
Targett-Adams, P.1
McElwee, M.J.2
Ehrenborg, E.3
Gustafsson, M.C.4
Palmer, C.N.5
McLauchlan, J.6
-
36
-
-
33645526855
-
-
Tobin KA, Harsem NK, Dalen KT, Staff AC, Nebb HI, and Duttaroy AK (2006) Regulation of ADRP expression by long-chain polyunsaturated fatty acids in BeWo cells, a human placental choriocarcinoma cell line. J Lipid Res 47:815-823.
-
Tobin KA, Harsem NK, Dalen KT, Staff AC, Nebb HI, and Duttaroy AK (2006) Regulation of ADRP expression by long-chain polyunsaturated fatty acids in BeWo cells, a human placental choriocarcinoma cell line. J Lipid Res 47:815-823.
-
-
-
-
37
-
-
53449099325
-
Inhibition of ADRP prevents diet-induced insulin resistance
-
Varela GM, Antwi DA, Dhir R, Yin X, Singhal NS, Graham MJ, Crooke RM, and Ahima RS (2008) Inhibition of ADRP prevents diet-induced insulin resistance. Am J Physiol Gastrointest Liver Physiol 295:G621-G628.
-
(2008)
Am J Physiol Gastrointest Liver Physiol
, vol.295
-
-
Varela, G.M.1
Antwi, D.A.2
Dhir, R.3
Yin, X.4
Singhal, N.S.5
Graham, M.J.6
Crooke, R.M.7
Ahima, R.S.8
-
38
-
-
34247191518
-
Classification and predictive modeling of liver X receptor response elements
-
Varga G and Su C (2007) Classification and predictive modeling of liver X receptor response elements. BioDrugs 21:117-124.
-
(2007)
BioDrugs
, vol.21
, pp. 117-124
-
-
Varga, G.1
Su, C.2
-
39
-
-
55549139504
-
Regulation of cholesterologenesis by the oxysterol receptor, LXRalpha
-
Wang Y, Rogers PM, Su C, Varga G, Stayrook KR, and Burris TP (2008) Regulation of cholesterologenesis by the oxysterol receptor, LXRalpha. J Biol Chem 283: 26332-26339.
-
(2008)
J Biol Chem
, vol.283
, pp. 26332-26339
-
-
Wang, Y.1
Rogers, P.M.2
Su, C.3
Varga, G.4
Stayrook, K.R.5
Burris, T.P.6
-
40
-
-
28244465107
-
Expression of adipose differentiation-related protein (ADRP) is conjointly regulated by PU. 1 and AP-1 in macrophages
-
Wei P, Taniguchi S, Sakai Y, Imamura M, Inoguchi T, Nawata H, Oda S, Nakabeppu Y, Nishimura J, and Ikuyama S (2005) Expression of adipose differentiation-related protein (ADRP) is conjointly regulated by PU. 1 and AP-1 in macrophages. J Biochem 138:399-412.
-
(2005)
J Biochem
, vol.138
, pp. 399-412
-
-
Wei, P.1
Taniguchi, S.2
Sakai, Y.3
Imamura, M.4
Inoguchi, T.5
Nawata, H.6
Oda, S.7
Nakabeppu, Y.8
Nishimura, J.9
Ikuyama, S.10
|