Efficient microwave combinatorial synthesis of novel indolic arylpiperazine derivatives as serotoninergic ligands

European Journal of Medicinal Chemistry

Volumn 45, Issue 2, 2010, Pages 752-759

  Frecentese, Francesco ^a   Fiorino, Ferdinando ^a   Perissutti, Elisa ^a   Severino, Beatrice ^a   Magli, Elisa ^a   Esposito, Antonella ^a   De Angelis, Francesca ^a   Massarelli, Paola ^b   Nencini, Cristina ^b   Viti, Barbara ^b   Santagada, Vincenzo ^a   Caliendo, Giuseppe ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

Author keywords

Arylpiperazines; Combinatorial chemistry; Microwave irradiation; Serotonin

Indexed keywords

ANTICONVULSIVE AGENT; ANXIOLYTIC AGENT; ATYPICAL ANTIPSYCHOTIC AGENT; ETHYL 5 [3 (4 O TOLYLPIPERAZIN 1 YL)PROPOXY] 1H INDOLE 2 CARBOXYLATE; ETHYL 5 [3 [4 (2 CHLOROPHENYL)PIPERAZIN 1 YL]PROPOXY] 1H INDOLE 2 CARBOXYLATE; ETHYL 5 [3 [4 (2 CYANOPHENYL)PIPERAZIN 1 YL]PROPOXY] 1H INDOLE 1 CARBOXYLATE; ETHYL 5 [3 [4 (2 FUROYL)PIPERAZIN 1 YL]PROPOXY] 1H INDOLE 2 CARBOXYLATE; ETHYL 5 [3 [4 (3 CHLOROPHENYL)PIPERAZIN 1 YL]PROPOXY] 1H INDOLE 2 CARBOXYLATE; ETHYL 5 [3 [4 (3,4 DICHLOROPHENYL)PIPERAZIN 1 YL]PROPOXY] 1H INDOLE 2 CARBOXYLATE; ETHYL 5 [3 [4 (4 CHLOROPHENYL)PIPERAZIN 1 YL]PROPOXY] 1H INDOLE 2 CARBOXYLATE; ETHYL 5 [3 [4 (4 METHOXYPHENYL)PIPERAZIN 1 YL]PROPOXY] 1H INDOLE 2 CARBOXYLATE; ETHYL 5 [3 [4 (4 NITROPHENYL)PIPERAZIN 1 YL]PROPOXY] 1H INDOLE 2 CARBOXYLATE; ETHYL 5 [3 [4 (PYRIDIN 2 YL)PIPERAZIN 1 YL]PROPOXY] 1H INDOLE 2 CARBOXYLATE; ETHYL 5 [3 [4 [(BENZO[D][1,3]DIOXOL 5 YL)METHYL]PIPERAZIN 1 YL]PROPOXY] 1H INDOLE 2 CARBOXYLATE; ETHYL 5 [3 [4 [3 (TRIFLUOROMETHYL)PHENYL]PIPERAZIN 1 YL]PROPOXY] 1H INDOLE 2 CARBOXYLATE; INDOLE DERIVATIVE; NUCLEOPHILE; PIPERAZINE DERIVATIVE; POTASSIUM CARBONATE; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR; SEROTONIN AGONIST; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BINDING ASSAY; COMBINATORIAL CHEMISTRY; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; INTERMETHOD COMPARISON; MALE; MICROWAVE IRRADIATION; NONHUMAN; RAT; REACTION TIME; RECEPTOR AFFINITY; STEREOCHEMISTRY; SUBSTITUTION REACTION; TRANQUILIZING ACTIVITY;

ANIMALS; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG EVALUATION, PRECLINICAL; INDOLES; LIGANDS; MALE; MICROWAVES; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; SEROTONIN;

EID: 73549099330     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.11.023     Document Type: Article

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