Synthesis and in-vitro pharmacological evaluation of new 5-HT1A receptor ligands containing a benzotriazinone nucleus

Archiv der Pharmazie

Volumn 341, Issue 1, 2008, Pages 20-27

  Fiorino, Ferdinando ^a   Severino, Beatrice ^a   De Angelis, Francesca ^a   Perissutti, Elisa ^a   Frecentese, Francesco ^a   Massarelli, Paola ^b   Bruni, Giancarlo ^b   Collavoli, Elga ^b   Santagada, Vincenzo ^a   Caliendo, Giuseppe ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

Author keywords

5 HT receptors; Benzotriazinone; Microwave assisted synthesis; Serotonin

Indexed keywords

3 (2 (4 (NAPHTHALEN 1 YL)PIPERAZIN 1 YL)ETHYL)BENZO[DEXTRO][1,2,3]TRIAZIN 4 (3H)ONE; 3 (2 (4 (NAPHTHALEN 1 YL)PIPERAZIN 1YL)ETHYL)BENZO[DEXTRO][1,2,3]TRIAZIN 4 (3H)ONE; 3 (2 (4 (QUINOLYN 8 YL)PIPERAZIN 1YL)ETHYL)BENZO[DEXTRO][1,2,3]TRIAZIN 4 (3H)ONE; 3 (2 (4 CYCLOHEXYLPIPERAZIN 1 YL)ETHYL)BENZO[DEXTRO][1,2,3]TRIAZIN 4 (3H)ONE; 3 (3 (4 (NAPHTHALEN 1 YL)PIPERAZIN 1YL)PROPYL)BENZO[DEXTRO][1,2,3]TRIAZIN 4 (3H)ONE; 3 (3 (4 (QUINOLYN 8 YL)PIPERAZIN 1YL)PROPYL)BENZO[DEXTRO][1,2,3]TRIAZIN 4 (3H)ONE; 3 (3 (4 CYCLOHEXYLPIPERAZIN 1 YL)PROPYL)BENZO[DEXTRO][1,2,3]TRIAZIN 4 (3H)ONE; 3 (CHLOROALKYL) 1,2,3 BENZOTRIAZIN 4 (3H)ONE; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING ASSAY; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REACTION TIME; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING SITES; CEREBRAL CORTEX; CORPUS STRIATUM; LIGANDS; MALE; MICROWAVES; NAPHTHALENES; PIPERAZINES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT1A; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

EID: 38949108249     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200700151     Document Type: Article

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