Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor agonists

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 4, 2008, Pages 1966-1982

  Shimada, Itsuro ^a   Maeno, Kyoichi ^a   Kazuta, Ken ichi ^a   Kubota, Hideki ^a   Kimizuka, Tetsuya ^a   Kimura, Yasuharu ^a   Hatanaka, Ken ichi ^a   Naitou, Yuki ^a   Wanibuchi, Fumikazu ^a   Sakamoto, Shuichi ^a   Tsukamoto, Shin ichi ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

5 HT2C receptor agonist; Binding affinity; Indazole; YM348

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; 1 (1H FURO[2,3 G]INDAZOL 1 YL)PROPAN 2 AMINE; 1 (3 ETHYL 1H FURO[2,3 G]INDAZOL 1 YL)PROPAN 2 AMINE; 1 (3 METHOXY 1H FURO[2,3 G]INDAZOL 1 YL)PROPAN 2 AMINE; 1 (3 METHYL 1H FURO[2,3 G]INDAZOL 1 YL)PROPAN 2 AMINE; 1 (3 PROPYL 1H FURO[2,3 G]INDAZOL 1 YL)PROPAN 2 AMINE; 1 (3,7 DIETHYL 1H FURO[2,3 G]INDAZOL 1 YL)PROPAN 2 AMINE; 1 (5 FLUORO 1H INDAZOL 1 YL)PROPAN 2 AMINE; 1 (5,6 DICHLORO 1H INDAZOL 1 YL)PROPAN 2 AMINE; 1 (6 FLUORO 1H INDAZOL 1 YL)PROPAN 2 AMINE; 1 (6 METHOXY 1H INDAZOL 1 YL)PROPAN 2 AMINE; 1 (6,7 DICHLORO 1H INDAZOL 1 YL)PROPAN 2 AMINE; 1 (7 CHLORO 6 METHOXY 1H INDAZOL 1 YL)PROPAN 2 AMINE; 1 (7 ETHYL 1H FURO[2,3 G]INDAZOL 1 YL)PROPAN 2 AMINE; 1 (7 ETHYL 3 METHOXY 1H FURO[2,3 G]INDAZOL 1 YL)PROPAN 2 AMINE; 1 (7 ETHYL 3 METHYL 1H FURO[2,3 G]INDAZOL 1 YL)PROPAN 2 AMINE; 1 (7 ISOPROPYL 1H FURO[2,3 G]INDAZOL 1 YL)PROPAN 2 AMINE; 1 (7 METHYL 1H FURO[2,3 G]INDAZOL 1 YL)PROPAN 2 AMINE; 2 (6 CHLORO 5 FLUORO 1 INDOLYL) 1 METHYLETHYLAMINE; 2 (7 ETHYL 1H FURO[2,3 G]INDAZOL 1 YL) 1 METHYLETHYLAMINE; INDAZOLE DERIVATIVE; SEROTONIN; SEROTONIN 2A RECEPTOR; SEROTONIN 2B RECEPTOR; SEROTONIN 2C AGONIST; SEROTONIN 2C RECEPTOR; UNCLASSIFIED DRUG; YM 348;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; MALE; NONHUMAN; PENIS ERECTION; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ETHYLAMINES; HUMANS; INDAZOLES; PENILE ERECTION; RATS; RECEPTOR, SEROTONIN, 5-HT2C; SEROTONIN AGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 38949134180     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.10.100     Document Type: Article

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