Synthesis by microwave irradiation and antidiarrhoeal activity of benzotriazinone and saccharine derivatives

Archiv der Pharmazie

Volumn 338, Issue 11, 2005, Pages 548-555

  Fiorino, Ferdinando ^a   Caliendo, Giuseppe ^a   Perissutti, Elisa ^a   Severino, Beatrice ^a   Frecentese, Francesco ^a   Preziosi, Barbara ^a   Izzo, Angelo A ^a   Capasso, Raffaele ^a   Santagada, Vincenzo ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Antidiarrhoeal agents; Benzotriazinone; Microwave; Saccharine

Indexed keywords

3 [3 [4 (4 CHLOROPHENYL) 4 HYDROXYPIPERIDIN 1 YL]PROPOXY] 1,2,3 BENZOTRIAZIN 4(3H) ONE; ANTIDIARRHEAL AGENT; BENZOTRIAZINONE; DIPHENOXYLATE; LOPERAMIDE; SACCHARIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG INHIBITION; DRUG SYNTHESIS; HEAT TREATMENT; INTESTINE MOTILITY; MICROWAVE IRRADIATION; NONHUMAN; PRIORITY JOURNAL; RAT; REACTION TIME;

ANIMALS; ANTIDIARRHEALS; CHEMISTRY, PHARMACEUTICAL; ELECTRIC STIMULATION; GASTROINTESTINAL TRANSIT; GUINEA PIGS; ILEUM; MICE; MICE, INBRED ICR; MICROWAVES; MOLECULAR STRUCTURE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; SACCHARIN; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

EID: 28544448218     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/ardp.200500134     Document Type: Article

References (15)

1. S. Guandalini, Acta Gastroenterol. Belg. 2002, 65, 33-36.
2. E. C. Oldfield, M. R. Wallace, K. C. Hyams, A. A. Yousif, D. E. Lewis, A. L. Burgeois, Rev. Infect. Dis. 1991, 13 (Suppl 3), 5199-5217.
3. H. L. DuPont, C. D. Ericsson, N. Engl. J. Med 1993, 328, 1821-1827.
4. th Edition, 1990, pp. 925-928.
5. F. Awouters, C. J. Niemegeers, P. A. Janssen, Annu Rev. Pharmacol. Toxicol. 1983, 25, 279-301.
6. L. Bueno, J. Fioramonti, Baillieres Clin. Gastroenterol 1988, 2, 123-139
7. G. Caliendo, F. Fiorino, E. Perissutti, B. Severino, S. Gessi, E. Cattabriga, P. A. Borea, V. Santagada, Eur. J. Med. Chem. 2001, 36, 873-886.
8. V. Santagada, E. Perissutti, F. Fiorino, B. Vivenzio, G. Caliendo, Tetrahedron Lett. 2001, 42, 2397-2400.
9. V. Santagada, F. Fiorino, E. Perissutti, B. Severino, V. De Filippis, B. Vivenzio, G. Caliendo, Tetrahedron Lett. 2001, 42, 5171-5173.
10. V. Santagada, E. Perissutti, G. Caliendo, Current Medicinal Chemistry 2002, 9, 1251-1283.
11. V. Santagada, F. Fiorino, E. Perissutti, B. Severino, S. Terracciano, C. E. Teixeira, G. Caliendo, Tetrahedron Lett. 2003, 44, 1149-1152.
12. V. Santagada, F. Frecentese, E. Perissutti, D. Cirillo, S. Terracciano, G. Caliendo, Bioorg. Med. Chem. Lett. 2004, 14, 4491-4493.
13. A. Loupy, Microwaves in Organic Synthesis. Wiley-VCH, 2002.
14. M. Larhed, A. Hallberg, Drug Discovery Today, 2001, 6, 404-416.
15. A. A. Izzo, R. Capasso, L. Pinto, G. Di Carlo, N. Mascolo, F. Capasso, Br. J. Pharm. 2001, 132, 1411-1415.