Efficient microwave-assisted synthesis of 4-amino-2-benzazepin-3-ones as conformationally restricted dipeptide mimetics

Tetrahedron

Volumn 65, Issue 1, 2009, Pages 206-211

  Severino, Beatrice ^a   Fiorino, Ferdinando ^a   Esposito, Antonella ^a   Frecentese, Francesco ^a   De Angelis, Francesca ^a   Perissutti, Elisa ^a   Caliendo, Giuseppe ^a   Santagada, Vincenzo ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Constrained amino acids; Friedel Crafts cyclization; Intramolecular; Microwave irradiation; Peptide mimetic

Indexed keywords

2 [4 (1,3 DIOXOISOINDOLIN 2 YL) 3 OXO 4,5 DIHYDRO 1H BENZO[C]AZEPIN 2(3H) YL] 3 METHYLBUTANOIC ACID; 2 [4 (1,3 DIOXOISOINDOLIN 2 YL) 3 OXO 4,5 DIHYDRO 1H BENZO[C]AZEPIN 2(3H) YL] 3 METHYLPENTANOIC ACID; 2 [4 (1,3 DIOXOISOINDOLIN 2 YL) 3 OXO 4,5 DIHYDRO 1H BENZO[C]AZEPIN 2(3H) YL] 3 PHENYLPROPANOIC ACID; 2 [4 (1,3 DIOXOISOINDOLIN 2 YL) 3 OXO 4,5 DIHYDRO 1H BENZO[C]AZEPIN 2(3H) YL] 4 METHYLPENTANOIC ACID; 2 [4 (1,3 DIOXOISOINDOLIN 2 YL) 3 OXO 4,5 DIHYDRO 1H BENZO[C]AZEPIN 2(3H) YL]ACETIC ACID; 2 [4 (1,3 DIOXOISOINDOLIN 2 YL) 3 OXO 4,5 DIHYDRO 1H BENZO[C]AZEPIN 2(3H) YL]PROPANOIC ACID; 4 AMINO 2 BENZAZEPIN 3 ONE; ENZYME INHIBITOR; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CYCLIZATION; DRUG CONFORMATION; DRUG STRUCTURE; MICROWAVE IRRADIATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RACEMIZATION;

EID: 56949098415     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2008.10.072     Document Type: Article

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