Revisiting the parietal cell

American Journal of Physiology - Cell Physiology

Volumn 298, Issue 1, 2010, Pages

  Kopic, Sascha ^a   Murek, Michael ^a   Geibel, John P ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Gastric acid secretion; H+ K+ ATPase; Hydrochloric acid; pH; Stomach

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; ANTITHROMBOCYTIC AGENT; BENATOPRAZOLE; BUMETANIDE; CALMIDAZOLIUM; CARBACHOL; CHLORIDE; CHLORIDE CHANNEL; CLOPIDOGREL; FUROSEMIDE; HISTAMINE H2 RECEPTOR ANTAGONIST; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; OMEPRAZOLE; POTASSIUM; PROTON PUMP INHIBITOR; SODIUM PROTON EXCHANGE PROTEIN; SODIUM PROTON EXCHANGE PROTEIN 4; TETRACYCLINE; UNCLASSIFIED DRUG;

APICAL MEMBRANE; BASOLATERAL MEMBRANE; CELL FUNCTION; CELL MIGRATION; CELL TRANSPORT; CELLULAR DISTRIBUTION; CHLORIDE CURRENT; CHLORIDE TRANSPORT; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG HALF LIFE; DRUG INHIBITION; DRUG MECHANISM; ELECTRIC CONDUCTIVITY; HOMEOSTASIS; HUMAN; ION CURRENT; ION TRANSPORT; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PHARMACODYNAMICS; PHARMACOLOGICAL PARAMETERS; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN LOCALIZATION; PROTEIN SECRETION; RABBIT; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; STOMACH ACID SECRETION; STOMACH MUCOSA; STOMACH PARIETAL CELL; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADENYLATE KINASE; ANTIPORTERS; BIOLOGICAL TRANSPORT; CATION TRANSPORT PROTEINS; DIGESTION; GASTRIC ACID; H(+)-K(+)-EXCHANGING ATPASE; HUMANS; HYDROGEN-ION CONCENTRATION; IONS; MODELS, BIOLOGICAL; PARIETAL CELLS, GASTRIC; STOMACH;

EID: 73549098636     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00478.2009     Document Type: Review

References (165)

1. Abe K, Kaya S, Taniguchi K, Hayashi Y, Imagawa T, Kikumoto M, Oiwa K, Sakaguchi K. Evidence for a relationship between activity and the tetraprotomeric assembly of solubilized pig gastric H/K-ATPase. J Biochem (Tokyo) 138: 293-301, 2005.
2. Anderson NG, Hanson PJ. Involvement of calcium-sensitive phospholipid-dependent protein kinase in control of acid secretion by isolated rat parietal cells. Biochem J 232: 609-611, 1985.
3. Andersson K, Carlsson E. Potassium-competitive acid blockade: a new therapeutic strategy in acid-related diseases. Pharmacol Ther 108: 294-307, 2005.
4. Ayalon A, Corcia A, Klemperer G, Caplan SR. Suppression of gastric acid secretion by furosemide in isolated gastric mucosa of guinea pig. Am J Physiol Gastrointest Liver Physiol 239: G532-G535, 1980.
5. Bachmann O, Heinzmann A, Mack A, Manns MP, Seidler U. Mechanisms of secretion-associated shrinkage and volume recovery in cultured rabbit parietal cells. Am J Physiol Gastrointest Liver Physiol 292:G711-G717, 2007.
6. + exchanger isoforms in rabbit parietal cells. Am J Physiol Gastrointest Liver Physiol 275: G1085-G1093, 1998.
7. Beil W, Mannschedel W, Sewing KF. Protein kinase C and parietal cell function. Biochem Biophys Res Commun 149: 720-728, 1987.
8. Bell SM, Schreiner CM, Schultheis PJ, Miller ML, Evans RL, Vorhees CV, Shull GE, Scott WJ. Targeted disruption of the murine Nhe1 locus induces ataxia, growth retardation, and seizures. Am J Physiol Cell Physiol 276: C788-C795, 1999.
9. Bengtsson P, Lundqvist G, Nilsson G. Inhibition of acid formation and stimulation of somatostatin release by cholecystokinin-related peptides in rabbit gastric glands. J Physiol 419: 765-774, 1989.
10. Bosl MR, Stein V, Hubner C, Zdebik AA, Jordt SE, Mukhopadhyay AK, Davidoff MS, Holstein AF, Jentsch TJ. Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl(-) channel disruption. EMBO J 20: 1289-1299, 2001.
11. Brown EM, Pollak M, Chou YH, Seidman CE, Seidman JG, Hebert SC. The cloning of extracellular Ca(2+)-sensing receptors from parathyroid and kidney: molecular mechanisms of extracellular Ca(2+)-sensing. J Nutr 125: 1965S--1970S, 1995.
12. Brown MR, Chew CS. Multiple effects of phorbol ester on secretory activity in rabbit gastric glands and parietal cells. Can J Physiol Pharmacol 65: 1840-1847, 1987.
13. Busque SM, Kerstetter JE, Geibel JP, Insogna K. L-type amino acids stimulate gastric acid secretion by activation of the calcium-sensing receptor in parietal cells. Am J Physiol Gastrointest Liver Physiol 289: G664-G669, 2005.
14. Calhoun BC, Lapierre LA, Chew CS, Goldenring JR. Rab11a redistributes to apical secretory canaliculus during stimulation of gastric parietal cells. Am J Physiol Cell Physiol 275: C163-C170, 1998.
15. Cheng I, Qureshi I, Chattopadhyay N, Qureshi A, Butters RR, Hall AE, Cima RR, Rogers KV, Hebert SC, Geibel JP, Brown EM, Soybel DI. Expression of an extracellular calcium-sensing receptor in rat stomach. Gastroenterology 116: 118-126, 1999.
16. Chew CS. Parietal cell protein kinases. Selective activation of type I cAMP-dependent protein kinase by histamine. J Biol Chem 260: 7540-7550, 1985.
17. Chew CS, Brown MR. Release of intracellular Ca2+ and elevation of inositol trisphosphate by secretagogues in parietal and chief cells isolated from rabbit gastric mucosa. Biochim Biophys Acta 888: 116-125, 1986.
18. Chew CS, Chen X, Bollag RJ, Isales C, Ding KH, Zhang H. Targeted disruption of the Lasp-1 gene is linked to increases in histaminestimulated gastric HCl secretion. Am J Physiol Gastrointest Liver Physiol 295: G37-G44, 2008.
19. Chew CS, Hersey SJ, Sachs G, Berglindh T. Histamine responsiveness of isolated gastric glands. Am J Physiol Gastrointest Liver Physiol 238: G312-G320, 1980.
20. Chew CS, Parente JA Jr, Chen X, Chaponnier C, and Cameron RS. The LIM and SH3 domain-containing protein, lasp-1, may link the cAMP signaling pathway with dynamic membrane restructuring activities in ion transporting epithelia. J Cell Sci 113: 2035-2045, 2000.
21. Chew CS, Parente JA Jr, Zhou C, Baranco E, Chen X. Lasp-1 is a regulated phosphoprotein within the cAMP signaling pathway in the gastric parietal cell. Am J Physiol Cell Physiol 275: C56-C67, 1998.
22. Codina J, Li J, Dubose TD Jr. A carboxy-terminus motif of HKalpha2 is necessary for assembly and function. Kidney Int 66: 2283-2292, 2004.
23. Counillon L, Pouysségur J. The expanding family of eucaryotic Na+/H+ exchangers. J Biol Chem 275: 1-4, 2000.
24. Cox KH, Adair-Kirk TL, Cox JV. Variant AE2 anion exchanger transcripts accumulate in multiple cell types in the chicken gastric epithelium. J Biol Chem 271: 8895-8902, 1996.
25. Cuppoletti J, Baker AM, Malinowska DH. Cl- channels of the gastric parietal cell that are active at low pH. Am J Physiol Cell Physiol 264: C1609-C1618, 1993.
26. Cuppoletti J, Sachs G. Regulation of gastric acid secretion via modulation of a chloride conductance. J Biol Chem 259: 14952-14959, 1984.
27. Dean BB, Gano AD Jr, Knight K, Ofman JJ, Fass R. Effectiveness of proton pump inhibitors in nonerosive reflux disease. Clin Gastroenterol Hepatol 2: 656-664, 2004.
28. Dedek K, Waldegger S. Colocalization of KCNQ1/KCNE channel subunits in the mouse gastrointestinal tract. Pflügers Arch 442: 896-902, 2001.
29. Dent J, El-Serag HB, Wallander MA, Johansson S. Epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut 54: 710-717, 2005.
30. Duman JG, Pathak NJ, Ladinsky MS, McDonald KL, Forte JG. Three-dimensional reconstruction of cytoplasmic membrane networks in parietal cells. J Cell Sci 115: 1251-1258, 2002.
31. +-ATPase. Am J Physiol Cell Physiol 277: C361-C372, 1999.
32. Engqvist-Goldstein AE, Warren RA, Kessels MM, Keen JH, Heuser J, Drubin DG. The actin-binding protein Hip1R associates with clathrin during early stages of endocytosis and promotes clathrin assembly in vitro. J Cell Biol 154: 1209-1223, 2001.
33. Flagella M, Clarke LL, Miller ML, Erway LC, Giannella RA, Andringa A, Gawenis LR, Kramer J, Duffy JJ, Doetschman T, Lorenz JN, Yamoah EN, Cardell EL, Shull GE. Mice lacking the basolateral Na-K-2Cl cotransporter have impaired epithelial chloride secretion and are profoundly deaf. J Biol Chem 274: 26946-26955, 1999.
34. Freeman LC, Lippold JJ, Mitchell KE. Glycosylation influences gating and pH sensitivity of I(sK). J Membr Biol 177: 65-79, 2000.
35. Fritsch J, Edelman A. Modulation of the hyperpolarization- activated Cl- current in human intestinal T84 epithelial cells by phosphorylation. J Physiol 490: 115-128, 1996.
36. Galmiche JP, Bruley Des Varannes S, Ducrotte P, Sacher-Huvelin S, Vavasseur F, Taccoen A, Fiorentini P, and Homerin M. Tenatoprazole, a novel proton pump inhibitor with a prolonged plasma half-life: effects on intragastric pH and comparison with esomeprazole in healthy volunteers. Aliment Pharmacol Ther 19: 655-662, 2004.
37. Gawenis LR, Greeb JM, Prasad V, Grisham C, Sanford LP, Doetschman T, Andringa A, Miller ML, Shull GE. Impaired gastric acid secretion in mice with a targeted disruption of the NHE4 Na+/H+ exchanger. J Biol Chem 280: 12781-12789, 2005.
38. - exchanger are achlorhydric. J Biol Chem 279: 30531-30539, 2004.
39. Geibel JP, Wagner C. An update on acid secretion. In: Reviews of Physiology, Biochemistry and Pharmacology, 2006, p. 45-60.
40. Geibel JP, Wagner CA, Caroppo R, Qureshi I, Gloeckner J, Manuelidis L, Kirchhoff P, Radebold K. The stomach divalent ion-sensing receptor scar is a modulator of gastric acid secretion. J Biol Chem 276: 39549-39552, 2001.
41. Goldenring JR, Shen KR, Vaughan HD, Modlin IM. Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney, and lung. J Biol Chem 268: 18419-18422, 1993.
42. Goldenring JR, Soroka CJ, Shen KR, Tang LH, Rodriguez W, Vaughan HD, Stoch SA, Modlin IM. Enrichment of rab11, a small GTP-binding protein, in gastric parietal cells. Am J Physiol Gastrointest Liver Physiol 267: G187-G194, 1994.
43. Grahammer F, Herling AW, Lang HJ, Schmitt-Graff A, Wittekindt OH, Nitschke R, Bleich M, Barhanin J, Warth R. The cardiac K+ channel KCNQ1 is essential for gastric acid secretion. Gastroenterology 120: 1363-1371, 2001.
44. Grunewald TG, Kammerer U, Kapp M, Eck M, Dietl J, Butt E, Honig A. Nuclear localization and cytosolic overexpression of LASP-1 correlates with tumor size and nodal-positivity of human breast carcinoma. BMC Cancer 7: 198, 2007.
45. Gyomorey K, Yeger H, Ackerley C, Garami E, Bear CE. Expression of the chloride channel ClC-2 in the murine small intestine epithelium. Am J Physiol Cell Physiol 279: C1787-C1794, 2000.
46. Haas M and Forbush III B. The Na-K-Cl cotransporter secretory epithelia. Ann Rev Physiol 62: 515-534, 2000.
47. + channel in bullfrog oxyntic cells. Am J Physiol Gastrointest Liver Physiol 279: G400-G410, 2000.
48. Hales CM, Griner R, Hobdy-Henderson KC, Dorn MC, Hardy D, Kumar R, Navarre J, Chan EK, Lapierre LA, Goldenring JR. Identification and characterization of a family of Rab11-interacting proteins. J Biol Chem 276: 39067-39075, 2001.
49. Han KS, Choi HC, Yoo JK, Lee JW, Lee MG. Determination of a new proton pump inhibitor, YH1885, in human plasma and urine by highperformance liquid chromatography. J Chromatogr B Biomed Sci Appl 696: 312-316, 1997.
50. Hanson PJ, Hatt JF. Intracellular signalling and regulation of gastric acid secretion. Q J Exp Physiol 74: 607-634, 1989.
51. Hanzel D, Reggio H, Bretscher A, Forte JG, Mangeat P. The secretion-stimulated 80K phosphoprotein of parietal cells is ezrin, and has properties of a membrane cytoskeletal linker in the induced apical microvilli. EMBO J 10: 2363-2373, 1991.
52. Hardie DG, Hawley SA, Scott JW. AMP-activated protein kinase-development of the energy sensor concept. J Physiol 574: 7-15, 2006.
53. Heitzmann D, Koren V, Wagner M, Sterner C, Reichold M, Tegtmeier I, Volk T, Warth R. KCNE beta subunits determine pH sensitivity of KCNQ1 potassium channels. Cell Physiol Biochem 19: 21-32, 2007.
54. Heitzmann D, Warth R. No potassium, no acid: K+ channels and gastric acid secretion. Physiology (Bethesda) 22: 335-341, 2007.
55. Helander HF. Ultrastructure and function of gastric parietal cells in the rat during development. Gastroenterology 56: 35-52, 1969.
56. Hori K, Takahashi Y, Horikawa N, Furukawa T, Tsukada K, Takeguchi N, Sakai H. Is the ClC-2 chloride channel involved in the Clsecretory mechanism of gastric parietal cells? FEBS Lett 575: 105-108, 2004.
57. Horie S, Maruyama T, Yano S, Watanabe K. Neurogenic stimulation of gastric acid secretion by the Na+, K(+)-ATPase inhibitor ouabain in mouse isolated stomach. Gen Pharmacol 27: 905-909, 1996.
58. Horie S, Yano S, Watanabe K. Differential effects of Na+, K(+)-ATPase inhibition by ouabain on acid secretory responses to histamine and bethanechol in the mouse isolated stomach. Br J Pharmacol 112: 87-92, 1994.
59. - and Na+-H+ exchanges on acid secretion in the rat gastric mucosa sheet preparation. Eur J Pharmacol 229: 15-19, 1992.
60. Jöns T, Drenckhahn D. Anion exchanger 2 (AE2) binds to erythrocyte ankyrin and is colocalized with ankyrin along the basolateral plasma membrane of human gastric parietal cells. Eur J Pharmacol 75: 232-236, 1998.
61. Jain RN, Al-Menhali AA, Keeley TM, Ren J, El-Zaatari M, Chen X, Merchant JL, Ross TS, Chew CS, Samuelson LC. Hip1r is expressed in gastric parietal cells and is required for tubulovesicle formation and cell survival in mice. J Clin Invest 118: 2459-2470, 2008.
62. Karvar S, Yao X, Crothers JM Jr, Liu Y, and Forte JG. Localization and function of soluble N-ethylmaleimide-sensitive factor attachment protein-25 and vesicle-associated membrane protein-2 in functioning gastric parietal cells. J Biol Chem 277: 50030-50035, 2002.
63. Karvar S, Zhu L, Crothers J, Jr, Wong W, Turkoz M, and Forte JG. Cellular localization and stimulation-associated distribution dynamics of syntaxin-1 and syntaxin-3 in gastric parietal cells. Traffic 6: 654-666, 2005.
64. Kasbekar DK, Forte GM, Forte JG. Phospholipid turnover and ultrastructural changes in resting and secreting bullfrog gastric mucosa. Biochim Biophys Acta 163: 1-13, 1968.
65. Kaufhold MA, Krabbenhoft A, Song P, Engelhardt R, Riederer B, Fahrmann M, Klocker N, Beil W, Manns M, Hagen SJ, Seidler U. Localization, trafficking, and significance for acid secretion of parietal cell Kir4.1 and KCNQ1 K+ channels. Gastroenterology 134: 1058-1069, 2008.
66. Kim KH, Shcheynikov N, Wang Y, Muallem S. SLC26A7 is a Cl-channel regulated by intracellular pH. J Biol Chem 280: 6463-6470,2005.
67. +-ATPase inhibitor AZD0865 in isolated rat gastric glands. Am J Physiol Gastrointest Liver Physiol 291: G838-G843, 2006.
68. Kirchhoff P, Wagner CA, Gaetzschmann F, Radebold K, Geibel JP. Demonstration of a functional apical sodium hydrogen exchanger in isolated rat gastric glands. Am J Physiol Gastrointest Liver Physiol 285: G1242-G1248, 2003.
69. Klingensmith ME, Hallonquist H, McCoy BP, Cima RR, Delpire E, Soybel DI. Pentagastrin selectively modulates levels of mRNAs encoding apical H/K adenosine triphosphatase and basolateral Na-K-Cl cotransporter in rat gastric fundic mucosa. Surgery 120: 242-247, 1996.
70. Kobayashi T, Tonai S, Ishihara Y, Koga R, Okabe S, Watanabe T. Abnormal functional and morphological regulation of the gastric mucosa in histamine H2 receptor-deficient mice. J Clin Invest 105: 1741-1749, 2000.
71. Kosiek O, Busque SM, Foller M, Shcheynikov N, Kirchhoff P, Bleich M, Muallem S, Geibel JP. SLC26A7 can function as a chloride-loading mechanism in parietal cells. Pflügers Arch 454: 989-998, 2007.
72. Kudo N, Barr AJ, Barr RL, Desai S, Lopaschuk GD. High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5′-AMPactivated protein kinase inhibition of acetyl-CoA carboxylase. J Biol Chem 270: 17513-17520, 1995.
73. Kurschat CE, Shmukler BE, Jiang L, Wilhelm S, Kim EH, Chernova MN, Kinne RKH, Stewart AK, Alper SL. Alkaline-shifted pHo sensitivity of AE2c1-mediated anion exchange reveals novel regulatory determinants in the AE2 N-terminal cytoplasmic domain. J Biol Chem 281: 1885-1896, 2006.
74. Lamprecht G, Seidler U, Classen M. Intracellular pH-regulating ion transport mechanisms in parietal cell basolateral membrane vesicles. Am J Physiol Gastrointest Liver Physiol 265: G903-G910, 1993.
75. Lapierre LA, Avant KM, Caldwell CM, Ham AJ, Hill S, Williams JA, Smolka AJ, Goldenring JR. Characterization of immunoisolated human gastric parietal cells tubulovesicles: identification of regulators of apical recycling. Am J Physiol Gastrointest Liver Physiol 292: G1249-G1262, 2007.
76. Lapierre LA, Dorn MC, Zimmerman CF, Navarre J, Burnette JO, Goldenring JR. Rab11b resides in a vesicular compartment distinct from Rab11a in parietal cells and other epithelial cells. Exp Cell Res 290: 322-331, 2003.
77. Lee HC, Forte JG. A study of H+ transport in gastric microsomal vesicles using fluorescent probes. Biochim Biophys Acta 508: 339-356, 1978.
78. Li ZQ, Mardh S. Interactions between Ca2+- and cAMP-dependent stimulatory pathways in parietal cells. Biochim Biophys Acta 1311: 133-142, 1996.
79. Lin YH, Park ZY, Lin D, Brahmbhatt AA, Rio MC, Yates JR, 3rd, Klemke RL. Regulation of cell migration and survival by focal adhesion targeting of Lasp-1. J Cell Biol 165: 421-432, 2004.
80. Lytle C, Xu JC, Biemesderfer D, and Forbush B III. Distribution and diversity of Na-K-Cl cotransport proteins: a study with monoclonal antibodies. Am J Physiol Cell Physiol 269: C1496-C1505, 1995.
81. Maeda M, Oshiman K, Tamura S, Futai Human gastric-ATPase gene M. Similarity to (Na+ + K+)-ATPase genes in exon/intron organization but difference in control region. J Biol Chem 265: 9027-9032, 1990.
82. Malinowska DH. Cl-channel blockers inhibit acid secretion in rabbit parietal cells. Am J Physiol Gastrointest Liver Physiol 259: G536-G543, 1990.
83. Malinowska DH, Kupert EY, Bahinski A, Sherry AM, Cuppoletti J. Cloning, functional expression, and characterization of a PKA-activated gastric Cl- channel. Am J Physiol Cell Physiol 268: C191-C200, 1995.
84. Malinowska DH, Sherry AM, Tewari KP, Cuppoletti J. Gastric parietal cell secretory membrane contains PKA- and acid-activated Kir2.1 K+ channels. Am J Physiol Cell Physiol 286: C495-C506, 2004.
85. Mamiya N, Goldenring JR, Tsunoda Y, Modlin IM, Yasui K, Usuda N, Ishikawa T, Natsume A, Hidaka H. Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-93. Biochem Biophys Res Commun 195: 608-615, 1993.
86. Marsin AS, Bertrand L, Rider MH, Deprez J, Beauloye C, Vincent MF, Van den Berghe G, Carling D, Hue L. Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia. Curr Biol 10: 1247-1255, 2000.
87. McColl KE, Gillen D. Evidence that proton-pump inhibitor therapy induces the symptoms it is used to treat. Gastroenterology 137: 20-22, 2009.
88. McDaniel N, Lytle C. Parietal cells express high levels of Na-K-2Cl cotransporter on migrating into the gastric gland neck. Am J Physiol Gastrointest Liver Physiol 276: G1273-G1278, 1999.
89. McDaniel N, Lytle C. Parietal cells express high levels of Na-K-2Cl cotransporter on migrating into the gastric gland neck. Am J Physiol Gastrointest Liver Physiol 276: G1273-G1278, 1999.
90. McDaniel N, Pace AJ, Spiegel S, Engelhardt R, Koller BH, Seidler U, Lytle C. Role of Na-K-2Cl cotransporter-1 in gastric secretion of nonacidic fluid and pepsinogen. Am J Physiol Gastrointest Liver Physiol 289: G550-G560, 2005.
91. McDaniel NK. Role of Na-K-2Cl Cotransport in Gastric Secretion 2000.
92. Melle-Milovanovic D, Milovanovic M, Nagpal S, Sachs G, Shin JM. Regions of association between the alpha and the beta subunit of the gastric H,K-ATPase. J Biol Chem 273: 11075-11081, 1998.
93. Mizukawa Y, Nishizawa T, Nagao T, Kitamura K, Urushidani T. Cellular distribution of parchorin, a chloride intracellular channel-related protein, in various tissues. Am J Physiol Cell Physiol 282: C786-C795, 2002.
94. Morth JP, Pedersen BP, Toustrup-Jensen MS, Sorensen TL, Petersen J, Andersen JP, Vilsen B, Nissen P. Crystal structure of the sodium-potassium pump. Nature 450: 1043-1049, 2007.
95. Munson K, Garcia R, Sachs G. Inhibitor and ion binding sites on the gastric H,K-ATPase. Biochemistry 44: 5267-5284, 2005.
96. Nagahara A, Wang L, Del Valle J, Todisco A. Regulation of c-Jun NH2-terminal kinases in isolated canine gastric parietal cells. Am J Physiol Gastrointest Liver Physiol 275: G740-G748, 1998.
97. Negulescu PA, Machen TE. Release and reloading of intracellular Ca stores after cholinergic stimulation of the parietal cell. Am J Physiol Cell Physiol 254: C498-C504, 1988.
98. Nishizawa T, Nagao T, Iwatsubo T, Forte JG, Urushidani T. Molecular cloning and characterization of a novel chloride intracellular channel-related protein, parchorin, expressed in water-secreting cells. J Biol Chem 275: 11164-11173, 2000.
99. + exchanger isoforms. Am J Physiol Cell Physiol 268: C283-C296, 1995.
100. O'Donoghue ML, Braunwald E, Antman EM, Murphy SA, Bates ER, Rozenman Y, Michelson AD, Hautvast RW, Ver Lee PN, Close SL, Shen L, Mega JL, Sabatine MS, Wiviott SD. Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials. Lancet 374: 989-997, 2009.
101. Okamoto CT, Forte JG. Vesicular trafficking machinery, the actin cytoskeleton, and H+-K+-ATPase recycling in the gastric parietal cell. J Physiol 532: 287-296, 2001.
102. Okamoto CT, Karam SM, Jeng YY, Forte JG, Goldenring JR. Identification of clathrin and clathrin adaptors on tubulovesicles of gastric acid secretory (oxyntic) cells. Am J Physiol Cell Physiol 274: C1017-C1029, 1998.
103. Olesen C, Picard M, Winther AM, Gyrup C, Morth JP, Oxvig C, Moller JV, Nissen P. The structural basis of calcium transport by the calcium pump. Nature 450: 1036-1042, 2007.
104. Pagliocca A, Hegyi P, Venglovecz V, Rackstraw SA, Khan Z, Burdyga G, Wang TC, Dimaline R, Varro A, Dockray GJ. Identification of ezrin as a target of gastrin in immature mouse gastric parietal cells. Exp Physiol 93: 1174-1189, 2008.
105. Palmgren MG, Axelsen KB. Evolution of P-type ATPases. Biochim Biophys Acta 1365: 37-45, 1998.
106. Pan Q, Ma J, Zhou Q, Li J, Tang Y, Liu Y, Yang Y, Xiao J, Peng L, Li P, Liang D, Zhang H, Chen YH. KCNQ1 loss-of-function mutation impairs gastric acid secretion in mice. Mol Biol Rep In press.
107. Parente JA, Goldenring JR, Petropoulos AC, Hellman U, Chew CS. Purification, cloning, and expression of a novel, endogenous, calciumsensitive, 28-kDa phosphoprotein. J Biol Chem 271: 20096-20101, 1996.
108. Park J, Chiba T, Yamada T. Mechanisms for direct inhibition of canine gastric parietal cells by somatostatin. J Biol Chem 262: 14190-14196, 1987.
109. Payne JA and Forbush III B. Molecular characterization of the epithelial Na-K-Cl cotransporter isoforms. Curr Opin Cell Biol 7: 493-503, 1995.
110. Peng XR, Yao X, Chow DC, Forte JG, Bennett MK. Association of syntaxin 3 and vesicle-associated membrane protein (VAMP) with H+/K(+)-ATPase-containing tubulovesicles in gastric parietal cells. Mol Biol Cell 8: 399-407, 1997.
111. Peretz A, Schottelndreier H, Aharon-Shamgar LB, Attali B. Modulation of homomeric and heteromeric KCNQ1 channels by external acidification. J Physiol 545: 751-766, 2002.
112. - exchanger specific to gastric parietal cells. Am J Physiol Gastrointest Liver Physiol 284: G1093-G1103, 2003.
113. - exchanger PAT1 and gastric H-K-ATPase in stomach parietal cells. Am J Physiol Gastrointest Liver Physiol 283: G1207-G1216, 2002.
114. + exchanger isoform NHE4. Am J Physiol Renal Physiol 275: F510-F517, 1998.
115. Post RL, Hegyvary C, Kume S. Activation by adenosine triphosphate in the phosphorylation kinetics of sodium and potassium ion transport adenosine triphosphatase. J Biol Chem 247: 6530-6540, 1972.
116. Prinz C, Zanner R, Gerhard M, Mahr S, Neumayer N, Hohne-Zell B, Gratzl M. The mechanism of histamine secretion from gastric enterochromaffin-like cells. Am J Physiol Cell Physiol 277: C845-C855, 1999.
117. -, CO3 2-) transporters: classification, function, structure, genetic diseases, and knockout models. Am J Physiol Renal Physiol 290: F580-F599, 2006.
118. Recalde S, Muruzabal F, Looije N, Kunne C, Burrell MA, Saez E, Martinez-Anso E, Salas JT, Mardones P, Prieto J, Medina JF, Elferink RP. Inefficient chronic activation of parietal cells in Ae2a,b(-/-) mice. Am J Pathol 169: 165-176, 2006.
119. Reimer C, Sondergaard B, Hilsted L, Bytzer P. Proton-pump inhibitor therapy induces acid-related symptoms in healthy volunteers after withdrawal of therapy. Gastroenterology 137: 80-87, 87 e81, 2009.
120. Remy C, Kirchhoff P, Hafner P, Busque SM, Mueller MK, Geibel JP, Wagner CA. Stimulatory pathways of the Calcium-sensing receptor on acid secretion in freshly isolated human gastric glands. Cell Physiol Biochem 19: 33-42, 2007.
121. Reuben MA, Lasater LS, Sachs G. Characterization of a beta subunit of the gastric H+/K(+)-transporting ATPase. Proc Natl Acad Sci USA 87: 6767-6771, 1990.
122. Roepke TK, Anantharam A, Kirchhoff P, Busque SM, Young JB, Geibel JP, Lerner DJ, Abbott GW. The KCNE2 potassium channel ancillary subunit is essential for gastric acid secretion. J Biol Chem 281: 23740-23747, 2006.
123. Rossmann H, Bachmann O, Wang Z, Shull GE, Obermaier B, Stuart-Tilley A, Alper SL, Seidler U. Differential expression and regulation of AE2 anion exchanger subtypes in rabbit parietal and mucous cells. J Physiol 534: 837-848, 2001.
124. + exchanger isoforms in rabbit parietal and mucous cells. Am J Physiol Gastrointest Liver Physiol 281: G447-G458, 2001.
125. Sachs G, Prinz C, Loo D, Bamberg K, Besancon M, Shin JM. Gastric acid secretion: activation and inhibition. Yale J Biol Med 67: 81-95, 1994.
126. Sachs G, Shin JM, Howden CW. Review article: the clinical pharmacology of proton pump inhibitors. Aliment Pharmacol Ther 23, Suppl 2: 2-8, 2006.
127. Sakamoto K, Zarrinpashneh E, Budas GR, Pouleur AC, Dutta A, Prescott AR, Vanoverschelde JL, Ashworth A, Jovanovic A, Alessi DR, Bertrand L. Deficiency of LKB1 in heart prevents ischemiamediated activation of AMPKalpha2 but not AMPKalpha1. Am J Physiol Endocrinol Metab 290: E780-E788, 2006.
128. Salt IP, Johnson G, Ashcroft SJ, Hardie DG. AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release. Biochem J 335: 533-539, 1998.
129. Samuelson LC, Hinkle KL. Insights into the regulation of gastric acid secretion through analysis of genetically engineered mice. Annu Rev Physiol 65: 383-400, 2003.
130. Schmidtler J, Rosenthal W, Offermanns S, Schusdziarra V, Classen M, Schepp W. Pertussis toxin reverses prostaglandin E2- and somatostatin-induced inhibition of rat parietal cell H(+)-production. Cell Signal 4: 321-329, 1992.
131. Schultheis PJ, Clarke LL, Meneton P, Harline M, Boivin GP, Stemmermann G, Duffy JJ, Doetschman T, Miller ML, Shull GE. Targeted disruption of the murine Na+/H+ exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion. J Clin Invest 101: 1243-1253, 1998.
132. Sherry AM, Malinowska DH, Morris RE, Ciraolo GM, Cuppoletti J. Localization of ClC-2 Cl- channels in rabbit gastric mucosa. Am J Physiol Cell Physiol 280: C1599-C1606, 2001.
133. Shin JM, Besancon M, Bamberg K, Sachs G. Structural aspects of the gastric H,K ATPase. Ann NY Acad Sci 834: 65-76, 1997.
134. Shin JM, Munson K, Vagin O, Sachs G. The gastric HK-ATPase: structure, function, and inhibition. Pflügers Arch 457: 609-622, 2009.
135. Shin JM, Sachs G. Dimerization of the gastric H+, K(+)-ATPase. J Biol Chem 271: 1904-1908, 1996.
136. Shin JM, Sachs G. Identification of a region of the H,K-ATPase alpha subunit associated with the beta subunit. J Biol Chem 269: 8642-8646, 1994.
137. Shyjan AW, Canfield VA, Levenson R. Evolution of the Na,K- and H,K-ATPase beta subunit gene family: structure of the murine Na,KATPase beta 2 subunit gene. Genomics 11: 435-442, 1991.
138. Sidani S, Kopic S, Socrates T, Kirchhoff P, Foller M, Murek M, Capasso A, Geibel JP. AMP-activated protein kinase: a physiological off switch for murine gastric acid secretion. Pflugers Arch 2009.
139. Sidani SM, Kirchhoff P, Socrates T, Stelter L, Ferreira E, Caputo C, Roberts KE, Bell RL, Egan ME, Geibel JP. DeltaF508 mutation results in impaired gastric acid secretion. J Biol Chem 282: 6068-6074, 2007.
140. Skou JC. The influence of some cations on an adenosine triphosphatase from peripheral nerves. Biochim Biophys Acta 23: 394-401, 1957.
141. Song P, Groos S, Riederer B, Feng Z, Krabbenhoft A, Smolka A, Seidler U. KCNQ1 is the luminal K+ recycling channel during stimulation of gastric acid secretion. J Physiol 587: 3955-3965, 2009.
142. Sonnentag T, Siegel WK, Bachmann O, Rossmann H, Mack A, Wagner HJ, Gregor M, Seidler U. Agonist-induced cytoplasmic volume changes in cultured rabbit parietal cells. Am J Physiol Gastrointest Liver Physiol 279: G40-G48, 2000.
143. Soybel DI, Gullans SR, Maxwell F, Delpire E. Role of basolateral Na+-K+-Cl- cotransport in HCl secretion by amphibian gastric mucosa. Am J Physiol Cell Physiol 269: C242-C249, 1995.
144. Stewart AK, Chernova MN, Shmukler BE, Wilhelm S, Alper SL. Regulation of AE2-mediated Cl- transport by intracellular or by extracellular pH requires highly conserved amino acid residues of the AE2 NH2-terminal cytoplasmic domain. J Gen Physiol 120: 707-722, 2002.
145. Strong TV, Boehm K, Collins FS. Localization of cystic fibrosis transmembrane conductance regulator mRNA in the human gastrointestinal tract by in situ hybridization. J Clin Invest 93: 347-354, 1994.
146. Stuart-Tilley A, Sardet C, Pouyssegur J, Schwartz MA, Brown DA, Alper SL. Immunolocalization of anion exchanger AE2 and cation exchanger NHE-1 in distinct adjacent cells of gastric mucosa. Am J Physiol Cell Physiol 266: C559-C568, 1994.
147. Takeuchi Y, Pausawasdi N, Todisco A. Carbachol activates ERK2 in isolated gastric parietal cells via multiple signaling pathways. Am J Physiol Gastrointest Liver Physiol 276: G1484-G1492, 1999.
148. Takeuchi Y, Yamada J, Yamada T, Todisco A. Functional role of extracellular signal-regulated protein kinases in gastric acid secretion. Am J Physiol Gastrointest Liver Physiol 273: G1263-G1272, 1997.
149. Tamura A, Kikuchi S, Hata M, Katsuno T, Matsui T, Hayashi H, Suzuki Y, Noda T, Tsukita S. Achlorhydria by ezrin knockdown: defects in the formation/expansion of apical canaliculi in gastric parietal cells. J Cell Biol 169: 21-28, 2005.
150. Tang LH, Stoch SA, Modlin IM, Goldenring JR. Identification of rab2 as a tubulovesicle-membrane-associated protein in rabbit gastric parietal cells. Biochem J 285: 715-719, 1992.
151. Todisco A, Ramamoorthy S, Pausawasdi N, Tacey K. Carbachol activates IkappaB kinase in isolated canine gastric parietal cells. Biochem Biophys Res Commun 261: 877-884, 1999.
152. Toyoshima C, Nomura H. Structural changes in the calcium pump accompanying the dissociation of calcium. Nature 418: 605-611, 2002.
153. Toyoshima C, Nomura H, Sugita Y. Crystal structures of Ca2+-ATPase in various physiological states. Ann NY Acad Sci 986: 1-8, 2003.
154. Trischitta F, Denaro MG, Faggio C, Mandolfino M, Schettino T. H+ and Cl- secretion in the stomach of the teleost fish, Anguilla anguilla: Stimulation by histamine and carbachol. J Comp Physiol B Biochem Syst Environ Physiol 168: 1-8, 1998.
155. Vagin O, Denevich S, Munson K, Sachs G. SCH28080, a K+-competitive inhibitor of the gastric H,K-ATPase, binds near the M5-6 luminal loop, preventing K+ access to the ion binding domain. Biochemistry 41: 12755-12762, 2002.
156. Wang Q, Curran ME, Splawski I, Burn TC, Millholland JM, VanRaay TJ, Shen J, Timothy KW, Vincent GM, de Jager T, Schwartz PJ, Toubin JA, Moss AJ, Atkinson DL, Landes GM, Connors TD, Keating MT. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat Genet 12: 17-23, 1996.
157. - exchanger are encoded by mRNAs transcribed from alternative promoters. J Biol Chem 271: 7835-7843, 1996.
158. +. Am J Physiol Cell Physiol 289: C493-C505, 2005.
159. Xu J, Song P, Miller ML, Borgese F, Barone S, Riederer B, Wang Z, Alper SL, Forte JG, Shull GE, Ehrenfeld J, Seidler U, Soleimani M. Deletion of the chloride transporter Slc26a9 causes loss of tubulovesicles in parietal cells and impairs acid secretion in the stomach. Proc Natl Acad Sci USA 105: 17955-17960, 2008.
160. Xu J, Song P, Nakamura S, Miller M, Barone S, Alper SL, Riederer B, Bonhagen J, Arend LJ, Amlal H, Seidler U, Soleimani M. Deletion of the chloride transporter Slc26a7 causes distal renal tubular acidosis and impairs gastric acid secretion. J Biol Chem 284: 29470-29479, 2009.
161. Yao X, Forte JG. Cell biology of acid secretion by the parietal cell. Annu Rev Physiol 65: 103-131, 2003.
162. Yu KS, Bae KS, Shon JH, Cho JY, Yi SY, Chung JY, Lim HS, Jang IJ, Shin SG, Song KS, Moon BS. Pharmacokinetic and pharmacodynamic evaluation of a novel proton pump inhibitor, YH1885, in healthy volunteers. J Clin Pharmacol 44: 73-82, 2004.
163. Zdon MJ, Adrian TE, Modlin IM. Gastric somatostatin release: evidence for direct mediation by calcitonin gene-related peptide and vasoactive intestinal peptide. J Surg Res 44: 680-686, 1988.
164. Zhang H, Chen X, Bollag WB, Bollag RJ, Sheehan DJ, Chew CS. Lasp1 gene disruption is linked to enhanced cell migration and tumor formation. Physiol Genomics 38: 372-385, 2009.
165. Zhao CM, Martinez V, Piqueras L, Wang L, Tache Y, Chen D. Control of gastric acid secretion in somatostatin receptor 2 deficient mice: shift from endocrine/paracrine to neurocrine pathways. Endocrinology 149: 498-505, 2008.