KCNQ1 loss-of-function mutation impairs gastric acid secretion in mice

Molecular Biology Reports

Volumn 37, Issue 3, 2010, Pages 1329-1333

  Pan, Qin ^a   Ma, Jun ^a   Zhou, Qinshu ^a   Li, Jun ^a   Tang, Yongqing ^a   Liu, Yi ^a   Yang, Yiqing ^a   Xiao, Junjie ^a   Peng, Luying ^a   Li, Pengjuan ^a   Liang, Dandan ^a   Zhang, Hong ^a   Chen, Yi Han ^a  

^a TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Gastric acid; K+ channel; Mice; Molecular genetics

Indexed keywords

HISTAMINE; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; POTASSIUM CHANNEL KCNQ1; KCNQ1 PROTEIN, MOUSE;

ACIDIFICATION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR TRANSPORT; LOSS OF FUNCTION MUTATION; MOUSE; MOUSE STRAIN; MUTAGENESIS; MUTATIONAL ANALYSIS; NONHUMAN; PH MEASUREMENT; PROTEIN FUNCTION; STOMACH ACID SECRETION; STOMACH FUNCTION DISORDER; STOMACH GLAND FUNCTION; STOMACH PARIETAL CELL; STRAIN DIFFERENCE; ANALYSIS OF VARIANCE; ANIMAL; C57BL MOUSE; GENETICS; METABOLISM; MUTATION; PH; SECRETION; STOMACH ACID;

MUS;

ANALYSIS OF VARIANCE; ANIMALS; GASTRIC ACID; H(+)-K(+)-EXCHANGING ATPASE; HYDROGEN-ION CONCENTRATION; KCNQ1 POTASSIUM CHANNEL; MICE; MICE, INBRED C57BL; MUTATION; PARIETAL CELLS, GASTRIC;

EID: 77951884442     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-009-9511-9     Document Type: Article

References (19)

1. Robbins J (2001) KCNQ potassium channels: Physiology, pathophysiology, and pharmacology. Pharmacol Ther 90:1-19. doi: 10.1016/S0163-7258(01)00116-4
2. Sanguinetti MC, Curran ME, Zou A, Shen J, Spector PS, Atkinson DL, Keating MT (1996) Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel. Nature 384:80-83. doi:10.1038/384080a0
3. Lee MP, Ravenel JD, Hu RJ, Lusting LR, Tomaselli G, Berger RD, Brandenburg SA, Litzi TJ, Bunton TE, Limb C, Francis H, Gorelokow M, Gu H, Washington K, Argain P, Goldenring JR, Coffey RJ, Feinberg AP (2000) Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice. J Clin Invest 106:1447-1455. doi:10.1172/JCI10897
4. Dedek K, Waldegger S (2001) Colocalization of KCNQ1/KCNE channel subunits in the mouse gastrointestinal tract. Pflugers Arch 442:896-902. doi:10.1007/s004240100609
5. Lambrecht NW, Yakubov I, Scott D, Sachs G (2005) Identification of the K efflux channel coupled to the gastric H-K-ATPase during acid secretion. Physiol Genomics 21:81-91. doi:10.1152/ physiolgenomics.00212.2004
6. Waldegger S (2003) Heartburn: Cardiac potassium channels involved in parietal cell acid secretion. Pflugers Arch 446:143-147
7. Grahammer F, Herling AW, Lang HJ, Schmitt-Gräff A, Wittekindt OH, Nitschke R, Bleich M, Barhanin J, Warth R (2001) The cardiacK+ channel KCNQ1 is essential for gastric acid secretion. Gastroenterology 120:1363-1371. doi:10.1053/gast.2001. 24053
8. Heitzmann D, Warth R (2008) Physiology and pathophysiology of potassium channels in gastrointestinal epithelia. Physiol Rev 88:1119-1182. doi:10.1152/physrev.00020.2007
9. Heitzmann D, Warth R (2007) No potassium, no acid:K+channels and gastric acid secretion. Physiology (Bethesda) 22:335-341. doi: 10.1152/physiol.00016. 2007
10. Casimiro MC, Knollmann BC, Yamoah EN, Nie L, Vary JC Jr, Sirenko SG, Greene AE, Grinberg A, Huang SP, Ebert SN, Pfeifer K (2004) Targeted point mutagenesis of mouse Kcnq1: Phenotypic analysis of mice with point mutations that cause Romano-Ward syndrome in humans. Genomics 84:555-564. doi: 10.1016/j.ygeno.2004.06.007
11. Chen L, Sun XD, Zhao J, Yang AG, Huang WQ (2005) Distribution, cloning and sequencing of GnRH, its receptor, and effects of gastric acid secretion of GnRH analogue in gastric parietal cells of rats. Life Sci 76:1351-1365. doi:10.1016/j.lfs.2004.10. 005
12. Huber SM, Braun GS, Segerer S, Veh RW, Horster MF (2000) Metanephrogenic mesenchyme-to-epithelium transition induces profound expression changes of ion channels. Am J Physiol Renal Physiol 279:F65-F76
13. Kirchhoff P, Wagner CA, Gaetzschmann F, Radebold K, Geibel JP (2003) Demonstration of a functional apical sodium hydrogen exchanger in isolated rat gastric glands. Am J Physiol Gastrointest Liver Physiol 285:G1242-G1248
14. Vallon V, Grahammer F, Volkl H, Sandu CD, Richter K, Rexhepaj R, Gerlach U, Rong Q, Pfeifer K, Lang F (2005) KCNQ1-dependent transport in renal and gastrointestinal epithelia. Proc Natl Acad Sci USA 102:17864-17869. doi:10.1073/pnas.0505860102
15. Heitzmann D, Grahammer F, von Hahn T, Schmitt-Gräff A, Romeo E, Nitschke R, Gerlach U, Lang HJ, Verrey F, Barhanin J, Warth R (2004) Heteromeric KCNE2/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells. J Physiol 561:547-557. doi:10.1113/jphysiol.2004.075168
16. Schroeder BC, Waldegger S, Fehr S, Bleich M, Warth R, Greger R, Jentsch TJ (2000) A constitutively open potassium channel formed by KCNQ1 and KCNE3. Nature 403:196-199. doi: 10.1038/35003200
17. Warth R, Garcia Alzamora M, Kim JK, Zdebik A, Nitschke R, Bleich M, Gerlach U, Barhanin J, Kim SJ (2002) The role of KCNQ1/KCNE1 K(+) channels in intestine and pancreas: Lessons from the KCNE1 knockout mouse. Pflugers Arch 443:822-828. doi:10.1007/s00424-001-0751-3
18. Tinel N, Diochot S, Borsotto M, Lazdunski M, Barhanin J (2000) KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel. EMBO J 19:6326-6330. doi:10.1093/ emboj/19.23.6326
19. Spicer Z, Miller ML, Andringa A, Riddle TM, Duffy JJ, Doetschman T, Shull GE (2000) Stomachs of mice lacking the gastric H, K-ATPase alpha-subunit have achlorhydria, abnormal parietal cells, and ciliated metaplasia. J Biol Chem 275:21555-21565. doi:10.1074/jbc.M001558200