Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivo

Molecular and Cellular Biology

Volumn 30, Issue 1, 2010, Pages 98-105

  Hübner, Anette ^a   Cavanagh Kyros, Julie ^a   Rincon, Mercedes ^b   Flavell, Richard A ^c   Davis, Roger J ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; BMF PROTEIN; PROTEIN; PROTEIN BCL 2; SERINE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; FEMALE; GENE; GENE MUTATION; HOMEOSTASIS; HYDROMETROCOLPOS; IN VIVO STUDY; LYMPHOCYTE; MALE; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; VAGINA ATRESIA;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL SURVIVAL; FEMALE; HOMEOSTASIS; HYDROCOLPOS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIMB DEFORMITIES, CONGENITAL; LYMPHOCYTES; MEMBRANE PROTEINS; MICE; MICE, MUTANT STRAINS; MUTATION; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; SERINE; VAGINA;

MUS;

EID: 73549092480     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.01155-09     Document Type: Article

References (34)

1. Bouillet, P., D. Metcalf, D. C. Huang, D. M. Tarlinton, T. W. Kay, F. Kontgen, J. M. Adams, and A. Strasser. 1999. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286:1735-1738.
2. Cecconi, F., G. Alvarez-Bolado, B. I. Meyer, K. A. Roth, and P. Gruss. 1998. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell 94:727-737.
3. Davis, R. J. 2000. Signal transduction by the JNK group of MAP kinases. Cell 103:239-252.
4. Diehl, S., C. W. Chow, L. Weiss, A. Palmetshofer, T. Twardzik, L. Rounds, E. Serfling, R. J. Davis, J. Anguita, and M. Rincon. 2002. Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation. J. Exp. Med. 196:39-49.
5. Farley, N., G. Pedraza-Alva, D. Serrano-Gomez, V. Nagaleekar, A. Aronshtam, T. Krahl, T. Thornton, and M. Rincon. 2006. p38 mitogen-activated protein kinase mediates the Fas-induced mitochondrial death pathway in CD8+ T cells. Mol. Cell. Biol. 26:2118-2129.
6. Gavathiotis, E., M. Suzuki, M. L. Davis, K. Pitter, G. H. Bird, S. G. Katz, H. C. Tu, H. Kim, E. H. Cheng, N. Tjandra, and L. D. Walensky. 2008. BAX activation is initiated at a novel interaction site. Nature 455:1076-1081.
7. Hakem, R., A. Hakem, G. S. Duncan, J. T. Henderson, M. Woo, M. S. Soengas, A. Elia, J. L. de la Pompa, D. Kagi, W. Khoo, J. Potter, R. Yoshida, S. A. Kaufman, S. W. Lowe, J. M. Penninger, and T. W. Mak. 1998. Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell 94:339-352.
8. Hitomi, J., D. E. Christofferson, A. Ng, J. Yao, A. Degterev, R. J. Xavier, and J. Yuan. 2008. Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell 135:1311- 1323.
9. Honarpour, N., C. Du, J. A. Richardson, R. E. Hammer, X. Wang, and J. Herz. 2000. Adult Apaf-1-deficient mice exhibit male infertility. Dev. Biol. 218:248-258.
10. Hubner, A., T. Barrett, R. A. Flavell, and R. J. Davis. 2008. Multisite phosphorylation regulates Bim stability and apoptotic activity. Mol. Cell 30:415-425.
11. Hutcheson, J., J. C. Scatizzi, E. Bickel, N. J. Brown, P. Bouillet, A. Strasser, and H. Perlman. 2005. Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis. J. Exp. Med. 201:1949-1960.
12. Kepp, O., K. Gottschalk, Y. Churin, K. Rajalingam, V. Brinkmann, N. Machuy, G. Kroemer, and T. Rudel. 2009. Bim and Bmf synergize to induce apoptosis in Neisseria gonorrhoeae infection. PLoS Pathog. 5:e1000348.
13. Kuida, K., T. F. Haydar, C. Y. Kuan, Y. Gu, C. Taya, H. Karasuyama, M. S. Su, P. Rakic, and R. A. Flavell. 1998. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94:325-337.
14. Labi, V., M. Erlacher, S. Kiessling, C. Manzl, A. Frenzel, L. O'Reilly, A. Strasser, and A. Villunger. 2008. Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development. J. Exp. Med. 205:641-655.
15. Lei, K., and R. J. Davis. 2003. JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proc. Natl. Acad. Sci. U. S. A. 100:2432-2437.
16. Lindsten, T., A. J. Ross, A. King, W. X. Zong, J. C. Rathmell, H. A. Shiels, E. Ulrich, K. G. Waymire, P. Mahar, K. Frauwirth, Y. Chen, M. Wei, V. M. Eng, D. M. Adelman, M. C. Simon, A. Ma, J. A. Golden, G. Evan, S. J. Korsmeyer, G. R. MacGregor, and C. B. Thompson. 2000. The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol. Cell 6:1389-1399.
17. Mailleux, A. A., M. Overholtzer, T. Schmelzle, P. Bouillet, A. Strasser, and J. S. Brugge. 2007. BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms. Dev. Cell 12:221-234.
18. Merino, D., M. Giam, P. D. Hughes, O. M. Siggs, K. Heger, L. A. O'Reilly, J. M. Adams, A. Strasser, E. F. Lee, W. D. Fairlie, and P. Bouillet. 2009. The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins. J. Cell Biol. 186:355-362.
19. Morales, A. A., D. Gutman, K. P. Lee, and L. H. Boise. 2008. BH3-only proteins Noxa, Bmf, and Bim are necessary for arsenic trioxide-induced cell death in myeloma. Blood 111:5152-5162.
20. Morel, C., S. Carlson, F. M. White, and R. J. Davis. 2009. Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis. Mol. Cell. Biol. 29:3845-3852.
21. Ogilvy, S., D. Metcalf, C. G. Print, M. L. Bath, A. W. Harris, and J. M. Adams. 1999. Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival. Proc. Natl. Acad. Sci. U. S. A. 96:14943-14948.
22. Puthalakath, H., D. C. Huang, L. A. O'Reilly, S. M. King, and A. Strasser. 1999. The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. Mol. Cell 3:287-296.
23. Puthalakath, H., A. Villunger, L. A. O'Reilly, J. G. Beaumont, L. Coultas, R. E. Cheney, D. C. Huang, and A. Strasser. 2001. Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science 293:1829-1832.
24. Ramjaun, A. R., S. Tomlinson, A. Eddaoudi, and J. Downward. 2007. Upregulation of two BH3-only proteins, Bmf and Bim, during TGF beta-induced apoptosis. Oncogene 26:970-981.
25. Rodriguez, I., K. Araki, K. Khatib, J. C. Martinou, and P. Vassalli. 1997. Mouse vaginal opening is an apoptosis-dependent process which can be prevented by the overexpression of Bcl2. Dev. Biol. 184:115-121.
26. Schmelzle, T., A. A. Mailleux, M. Overholtzer, J. S. Carroll, N. L. Solimini, E. S. Lightcap, O. P. Veiby, and J. S. Brugge. 2007. Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis. Proc. Natl. Acad. Sci. U. S. A. 104: 3787-3792.
27. Show, M. D., C. M. Hill, M. D. Anway, W. W. Wright, and B. R. Zirkin. 2008. Phosphorylation of mitogen-activated protein kinase 8 (MAPK8) is associated with germ cell apoptosis and redistribution of the Bcl2-modifying factor (BMF). J. Androl. 29:338-344.
28. Strasser, A., H. Puthalakath, P. Bouillet, D. C. Huang, L. O'Connor, L. A. O'Reilly, L. Cullen, S. Cory, and J. M. Adams. 2000. The role of bim, a proapoptotic BH3-only member of the Bcl-2 family in cell-death control. Ann. N. Y. Acad. Sci. 917:541-548.
29. VanBrocklin, M. W., M. Verhaegen, M. S. Soengas, and S. L. Holmen. 2009. Mitogen-activated protein kinase inhibition induces translocation of Bmf to promote apoptosis in melanoma. Cancer Res. 69:1985-1994.
30. Weston, C. R., and R. J. Davis. 2007. The JNK signal transduction pathway. Curr. Opin. Cell Biol. 19:142-149.
31. Willis, S. N., J. I. Fletcher, T. Kaufmann, M. F. van Delft, L. Chen, P. E. Czabotar, H. Ierino, E. F. Lee, W. D. Fairlie, P. Bouillet, A. Strasser, R. M. Kluck, J. M. Adams, and D. C. Huang. 2007. Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science 315:856-859.
32. Yoshida, H., Y. Y. Kong, R. Yoshida, A. J. Elia, A. Hakem, R. Hakem, J. M. Penninger, and T. W. Mak. 1998. Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell 94:739-750.
33. Zhang, Y., M. Adachi, R. Kawamura, and K. Imai. 2006. Bmf is a possible mediator in histone deacetylase inhibitors FK228 and CBHA-induced apoptosis. Cell Death Differ. 13:129-140.
34. Zhang, Y., M. Adachi, R. Kawamura, H. C. Zou, K. Imai, M. Hareyama, and Y. Shinomura. 2006. Bmf contributes to histone deacetylase inhibitor-mediated enhancing effects on apoptosis after ionizing radiation. Apoptosis 11: 1349-1357.