메뉴 건너뛰기




Volumn 24, Issue 1, 2010, Pages 178-192

Role of Insulin-Like Growth Factor-Binding Protein 5 (IGFBP5) in Organismal and Pancreatic β-Cell Growth

Author keywords

[No Author keywords available]

Indexed keywords

SOMATOMEDIN BINDING PROTEIN 5;

EID: 73549091003     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2009-0167     Document Type: Article
Times cited : (39)

References (56)
  • 1
    • 0036319371 scopus 로고    scopus 로고
    • Pancreatic β-cell growth and survival: A role in obesity-linked type 2 diabetes?
    • Lingohr MK, Buettner R, Rhodes CJ 2002 Pancreatic β-cell growth and survival: a role in obesity-linked type 2 diabetes? Trends Mol Med 8:375-384
    • (2002) Trends Mol Med , vol.8 , pp. 375-384
    • Lingohr, M.K.1    Buettner, R.2    Rhodes, C.J.3
  • 2
    • 0033524937 scopus 로고    scopus 로고
    • Tissue-specific knockout of the insulin receptor in pancreatic β-cells creates an insulin secretory defect similar to that in type 2 diabetes
    • Kulkarni RN, Brüning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR 1999 Tissue-specific knockout of the insulin receptor in pancreatic β-cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 96:329-339
    • (1999) Cell , vol.96 , pp. 329-339
    • Kulkarni, R.N.1    Brüning, J.C.2    Winnay, J.N.3    Postic, C.4    Magnuson, M.A.5    Kahn, C.R.6
  • 3
    • 0036578921 scopus 로고    scopus 로고
    • β-Cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass
    • Kulkarni RN, Holzenberger M, Shih DQ, Ozcan U, Stoffel M, Magnuson MA, Kahn CR 2002 β-Cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass. Nat Genet 31:111-115
    • (2002) Nat Genet , vol.31 , pp. 111-115
    • Kulkarni, R.N.1    Holzenberger, M.2    Shih, D.Q.3    Ozcan, U.4    Stoffel, M.5    Magnuson, M.A.6    Kahn, C.R.7
  • 5
    • 33745863033 scopus 로고    scopus 로고
    • Islet β-cell failure in type 2 diabetes
    • Prentki M, Nolan CJ 2006 Islet β-cell failure in type 2 diabetes. J Clin Invest 116:1802-1812
    • (2006) J Clin Invest , vol.116 , pp. 1802-1812
    • Prentki, M.1    Nolan, C.J.2
  • 6
    • 33244464562 scopus 로고    scopus 로고
    • Critical nodes in signalling pathways: Insights into insulin action
    • Taniguchi CM, Emanuelli B, Kahn CR 2006 Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 7:85-96
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 85-96
    • Taniguchi, C.M.1    Emanuelli, B.2    Kahn, C.R.3
  • 7
    • 0035210374 scopus 로고    scopus 로고
    • Islet β-cell expression of constitutively active Akt1/PKBα induces striking hypertrophy, hyperplasia, and hyperinsulinemia
    • Bernal-Mizrachi E, Wen W, Stahlhut S, Welling CM, Permutt MA 2001 Islet β-cell expression of constitutively active Akt1/PKBα induces striking hypertrophy, hyperplasia, and hyperinsulinemia. J Clin Invest 108:1631-1638
    • (2001) J Clin Invest , vol.108 , pp. 1631-1638
    • Bernal-Mizrachi, E.1    Wen, W.2    Stahlhut, S.3    Welling, C.M.4    Permutt, M.A.5
  • 9
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • Manning BD, Cantley LC 2007 AKT/PKB signaling: navigating downstream. Cell 129:1261-1274
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 11
    • 0034745353 scopus 로고    scopus 로고
    • Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells
    • Zhou BP, Liao Y, Xia W, Spohn B, Lee MH, Hung MC 2001 Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol 3:245-252
    • (2001) Nat Cell Biol , vol.3 , pp. 245-252
    • Zhou, B.P.1    Liao, Y.2    Xia, W.3    Spohn, B.4    Lee, M.H.5    Hung, M.C.6
  • 12
    • 0034643331 scopus 로고    scopus 로고
    • AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
    • Medema RH, Kops GJ, Bos JL, Burgering BM 2000 AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 404:782-787
    • (2000) Nature , vol.404 , pp. 782-787
    • Medema, R.H.1    Kops, G.J.2    Bos, J.L.3    Burgering, B.M.4
  • 14
    • 0032937751 scopus 로고    scopus 로고
    • Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia
    • Rane SG, Dubus P, Mettus RV, Galbreath EJ, Boden G, Reddy EP, Barbacid M 1999 Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia. Nat Genet 22:44-52
    • (1999) Nat Genet , vol.22 , pp. 44-52
    • Rane, S.G.1    Dubus, P.2    Mettus, R.V.3    Galbreath, E.J.4    Boden, G.5    Reddy, E.P.6    Barbacid, M.7
  • 15
    • 33644754585 scopus 로고    scopus 로고
    • Akt induces β-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity
    • Fatrai S, Elghazi L, Balcazar N, Cras-Méneur C, Krits I, Kiyokawa H, Bernal-Mizrachi E 2006 Akt induces β-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity. Diabetes 55:318-325
    • (2006) Diabetes , vol.55 , pp. 318-325
    • Fatrai, S.1    Elghazi, L.2    Balcazar, N.3    Cras-Méneur, C.4    Krits, I.5    Kiyokawa, H.6    Bernal-Mizrachi, E.7
  • 16
    • 27744540798 scopus 로고    scopus 로고
    • Emerging role of protein kinase B/Akt signaling in pancreatic β-cell mass and function
    • Elghazi L, Balcazar N, Bernal-Mizrachi E 2006 Emerging role of protein kinase B/Akt signaling in pancreatic β-cell mass and function. Int J Biochem Cell Biol 38:157-163
    • (2006) Int J Biochem Cell Biol , vol.38 , pp. 157-163
    • Elghazi, L.1    Balcazar, N.2    Bernal-Mizrachi, E.3
  • 18
    • 0030825432 scopus 로고    scopus 로고
    • Adaptation of islets of Langerhans to pregnancy: β-cell growth, enhanced insulin secretion and the role of lactogenic hormones
    • Sorenson RL, Brelje TC 1997 Adaptation of islets of Langerhans to pregnancy: β-cell growth, enhanced insulin secretion and the role of lactogenic hormones. Horm Metab Res 29:301-307
    • (1997) Horm Metab Res , vol.29 , pp. 301-307
    • Sorenson, R.L.1    Brelje, T.C.2
  • 19
    • 0036905115 scopus 로고    scopus 로고
    • Cellular actions of the insulin-like growth factor binding proteins
    • Firth SM, Baxter RC 2002 Cellular actions of the insulin-like growth factor binding proteins. Endocr Rev 23:824-854
    • (2002) Endocr Rev , vol.23 , pp. 824-854
    • Firth, S.M.1    Baxter, R.C.2
  • 20
    • 0030029454 scopus 로고    scopus 로고
    • Insulin-like growth factor-I (IGF-I) regulates IGF-binding protein-5 synthesis through transcriptional activation of the gene in aortic smooth muscle cells
    • Duan C, Hawes SB, Prevette T, Clemmons DR 1996 Insulin-like growth factor-I (IGF-I) regulates IGF-binding protein-5 synthesis through transcriptional activation of the gene in aortic smooth muscle cells. J Biol Chem 271:4280-4288
    • (1996) J Biol Chem , vol.271 , pp. 4280-4288
    • Duan, C.1    Hawes, S.B.2    Prevette, T.3    Clemmons, D.R.4
  • 21
    • 0033601224 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-I regulates IGF-binding protein-5 gene expression through the phosphatidylinositol 3-kinase, protein kinase B/Akt, and p70 S6 kinase signaling pathway
    • Duan C, Liimatta MB, Bottum OL 1999 Insulin-like growth factor (IGF)-I regulates IGF-binding protein-5 gene expression through the phosphatidylinositol 3-kinase, protein kinase B/Akt, and p70 S6 kinase signaling pathway. J Biol Chem 274:37147-37153
    • (1999) J Biol Chem , vol.274 , pp. 37147-37153
    • Duan, C.1    Liimatta, M.B.2    Bottum, O.L.3
  • 22
    • 18144407972 scopus 로고    scopus 로고
    • Roles of insulin-like growth factor (IGF) binding proteins in regulating IGF actions
    • Duan C, Xu Q 2005 Roles of insulin-like growth factor (IGF) binding proteins in regulating IGF actions. Gen Comp Endocrinol 142: 44-52
    • (2005) Gen Comp Endocrinol , vol.142 , pp. 44-52
    • Duan, C.1    Xu, Q.2
  • 23
    • 0036126026 scopus 로고    scopus 로고
    • IGF-binding protein-5: Flexible player in the IGF system and effector on its own
    • Schneider MR, Wolf E, Hoeflich A, Lahm H 2002 IGF-binding protein-5: flexible player in the IGF system and effector on its own. J Endocrinol 172:423-440
    • (2002) J Endocrinol , vol.172 , pp. 423-440
    • Schneider, M.R.1    Wolf, E.2    Hoeflich, A.3    Lahm, H.4
  • 24
    • 34249809738 scopus 로고    scopus 로고
    • Delayed mammary gland involution in mice with mutation of the insulin-like growth factor binding protein 5 gene
    • Ning Y, Hoang B, Schuller AG, Cominski TP, Hsu MS, Wood TL, Pintar JE 2007 Delayed mammary gland involution in mice with mutation of the insulin-like growth factor binding protein 5 gene. Endocrinology 148:2138-2147
    • (2007) Endocrinology , vol.148 , pp. 2138-2147
    • Ning, Y.1    Hoang, B.2    Schuller, A.G.3    Cominski, T.P.4    Hsu, M.S.5    Wood, T.L.6    Pintar, J.E.7
  • 25
    • 0026515343 scopus 로고
    • Pancreatic β-cell growth and diabetes mellitus
    • Swenne I 1992 Pancreatic β-cell growth and diabetes mellitus. Diabetologia 35:193-201
    • (1992) Diabetologia , vol.35 , pp. 193-201
    • Swenne, I.1
  • 26
    • 0032504211 scopus 로고    scopus 로고
    • Insulin-like growth factor I (IGF-I)-stimulated pancreatic β-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells
    • Hügl SR, White MF, Rhodes CJ 1998 Insulin-like growth factor I (IGF-I)-stimulated pancreatic β-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells. J Biol Chem 273:17771-17779
    • (1998) J Biol Chem , vol.273 , pp. 17771-17779
    • Hügl, S.R.1    White, M.F.2    Rhodes, C.J.3
  • 30
    • 3543017301 scopus 로고    scopus 로고
    • Paradoxical actions of endogenous and exogenous insulin-like growth factor-binding protein-5 revealed by RNA interference analysis
    • Yin P, Xu Q, Duan C 2004 Paradoxical actions of endogenous and exogenous insulin-like growth factor-binding protein-5 revealed by RNA interference analysis. J Biol Chem 279:32660-32666
    • (2004) J Biol Chem , vol.279 , pp. 32660-32666
    • Yin, P.1    Xu, Q.2    Duan, C.3
  • 31
    • 0036768299 scopus 로고    scopus 로고
    • SAGE identification of differentiation responsive genes in P19 embryonic cells induced to form cardiomyocytes in vitro
    • Anisimov SV, Tarasov KV, Riordon D, Wobus AM, Boheler KR 2002 SAGE identification of differentiation responsive genes in P19 embryonic cells induced to form cardiomyocytes in vitro. Mech Dev 117:25-74
    • (2002) Mech Dev , vol.117 , pp. 25-74
    • Anisimov, S.V.1    Tarasov, K.V.2    Riordon, D.3    Wobus, A.M.4    Boheler, K.R.5
  • 33
    • 33750473748 scopus 로고    scopus 로고
    • Differential expression of insulin-like growth factor binding protein-5 in pancreatic adenocarcinomas: Identification using DNA microarray
    • Johnson SK, Dennis RA, Barone GW, Lamps LW, Haun RS 2006 Differential expression of insulin-like growth factor binding protein-5 in pancreatic adenocarcinomas: identification using DNA microarray. Mol Carcinog 45:814-827
    • (2006) Mol Carcinog , vol.45 , pp. 814-827
    • Johnson, S.K.1    Dennis, R.A.2    Barone, G.W.3    Lamps, L.W.4    Haun, R.S.5
  • 34
    • 0034455310 scopus 로고    scopus 로고
    • Overexpression of insulin-like growth factor binding protein-5 helps accelerate progression to androgen-independence in the human prostate LNCaP tumor model through activation of phosphatidylinositol 3′-kinase pathway
    • Miyake H, Nelson C, Rennie PS, Gleave ME 2000 Overexpression of insulin-like growth factor binding protein-5 helps accelerate progression to androgen-independence in the human prostate LNCaP tumor model through activation of phosphatidylinositol 3′-kinase pathway. Endocrinology 141:2257-2265
    • (2000) Endocrinology , vol.141 , pp. 2257-2265
    • Miyake, H.1    Nelson, C.2    Rennie, P.S.3    Gleave, M.E.4
  • 35
    • 0027256032 scopus 로고
    • Regulation of insulin-like growth factor-binding-protein-1, 2, 3, 4, 5, and 6: Synthesis, secretion, and gene expression in estrogen receptor-negative human breast carcinoma cells
    • Sheikh MS, Shao ZM, Hussain A, Clemmons DR, Chen JC, Roberts Jr CT, LeRoith D, Fontana JA 1993 Regulation of insulin-like growth factor-binding-protein-1, 2, 3, 4, 5, and 6: synthesis, secretion, and gene expression in estrogen receptor-negative human breast carcinoma cells. J Cell Physiol 155:556-567
    • (1993) J Cell Physiol , vol.155 , pp. 556-567
    • Sheikh, M.S.1    Shao, Z.M.2    Hussain, A.3    Clemmons, D.R.4    Chen, J.C.5    Roberts Jr, C.T.6    LeRoith, D.7    Fontana, J.A.8
  • 37
    • 22144494185 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-I stimulates cell proliferation and induces IGF binding protein (IGFBP)-3 and IGFBP-5 gene expression in cultured growth plate chondrocytes via distinct signaling pathways
    • Kiepe D, Ciarmatori S, Hoeflich A, Wolf E, Tönshoff B 2005 Insulin-like growth factor (IGF)-I stimulates cell proliferation and induces IGF binding protein (IGFBP)-3 and IGFBP-5 gene expression in cultured growth plate chondrocytes via distinct signaling pathways. Endocrinology 146:3096-3104
    • (2005) Endocrinology , vol.146 , pp. 3096-3104
    • Kiepe, D.1    Ciarmatori, S.2    Hoeflich, A.3    Wolf, E.4    Tönshoff, B.5
  • 38
    • 0037151101 scopus 로고    scopus 로고
    • Transcriptional effects of chronic Akt activation in the heart
    • Cook SA, Matsui T, Li L, Rosenzweig A 2002 Transcriptional effects of chronic Akt activation in the heart. J Biol Chem 277: 22528-22533
    • (2002) J Biol Chem , vol.277 , pp. 22528-22533
    • Cook, S.A.1    Matsui, T.2    Li, L.3    Rosenzweig, A.4
  • 39
    • 33845707842 scopus 로고    scopus 로고
    • Microarray analysis of Akt1 activation in transgenic mouse hearts reveals transcript expression profiles associated with compensatory hypertrophy and failure
    • Schiekofer S, Shiojima I, Sato K, Galasso G, Oshima Y, Walsh K 2006 Microarray analysis of Akt1 activation in transgenic mouse hearts reveals transcript expression profiles associated with compensatory hypertrophy and failure. Physiol Genomics 27:156-170
    • (2006) Physiol Genomics , vol.27 , pp. 156-170
    • Schiekofer, S.1    Shiojima, I.2    Sato, K.3    Galasso, G.4    Oshima, Y.5    Walsh, K.6
  • 40
    • 0033012057 scopus 로고    scopus 로고
    • Cellular distribution and ontogeny of insulin-like growth factors (IGFs) and IGF binding protein messenger RNAs and peptides in developing rat pancreas
    • Hill DJ, Hogg J, Petrik J, Arany E, Han VK 1999 Cellular distribution and ontogeny of insulin-like growth factors (IGFs) and IGF binding protein messenger RNAs and peptides in developing rat pancreas. J Endocrinol 160:305-317
    • (1999) J Endocrinol , vol.160 , pp. 305-317
    • Hill, D.J.1    Hogg, J.2    Petrik, J.3    Arany, E.4    Han, V.K.5
  • 41
    • 1642474003 scopus 로고    scopus 로고
    • Global expression analysis of gene regulatory pathways during endocrine pancreatic development
    • Gu G, Wells JM, Dombkowski D, Preffer F, Aronow B, Melton DA 2004 Global expression analysis of gene regulatory pathways during endocrine pancreatic development. Development 131:165-179
    • (2004) Development , vol.131 , pp. 165-179
    • Gu, G.1    Wells, J.M.2    Dombkowski, D.3    Preffer, F.4    Aronow, B.5    Melton, D.A.6
  • 43
    • 33747822985 scopus 로고    scopus 로고
    • Diminished growth and enhanced glucose metabolism in triple knockout mice containing mutations of insulin-like growth factor binding protein-3, -4, and -5
    • Ning Y, Schuller AG, Bradshaw S, Rotwein P, Ludwig T, Frystyk J, Pintar JE 2006 Diminished growth and enhanced glucose metabolism in triple knockout mice containing mutations of insulin-like growth factor binding protein-3, -4, and -5. Mol Endocrinol 20: 2173-2186
    • (2006) Mol Endocrinol , vol.20 , pp. 2173-2186
    • Ning, Y.1    Schuller, A.G.2    Bradshaw, S.3    Rotwein, P.4    Ludwig, T.5    Frystyk, J.6    Pintar, J.E.7
  • 44
    • 0033305250 scopus 로고    scopus 로고
    • Effects of Igf1 gene deletion on postnatal growth patterns
    • Wang J, Zhou J, Powell-Braxton L, Bondy C 1999 Effects of Igf1 gene deletion on postnatal growth patterns. Endocrinology 140: 3391-3394
    • (1999) Endocrinology , vol.140 , pp. 3391-3394
    • Wang, J.1    Zhou, J.2    Powell-Braxton, L.3    Bondy, C.4
  • 47
    • 0031009731 scopus 로고    scopus 로고
    • Hypoglycemic effect of insulin-like growth factor-1 in mice lacking insulin receptors
    • Di Cola G, Cool MH, Accili D 1997 Hypoglycemic effect of insulin-like growth factor-1 in mice lacking insulin receptors. J Clin Invest 99:2538-2544
    • (1997) J Clin Invest , vol.99 , pp. 2538-2544
    • Di Cola, G.1    Cool, M.H.2    Accili, D.3
  • 48
    • 0029861209 scopus 로고    scopus 로고
    • Impaired glucose homeostasis in insulin-like growth factor binding protein-1 transgenic mice
    • Rajkumar K, Krsek M, Dheen ST, Murphy LJ 1996 Impaired glucose homeostasis in insulin-like growth factor binding protein-1 transgenic mice. J Clin Invest 98:1818-1825
    • (1996) J Clin Invest , vol.98 , pp. 1818-1825
    • Rajkumar, K.1    Krsek, M.2    Dheen, S.T.3    Murphy, L.J.4
  • 49
    • 0036838455 scopus 로고    scopus 로고
    • Impaired glucose homeostasis in insulin-like growth factor-binding protein-3-transgenic mice
    • Silha JV, Gui Y, Murphy LJ 2002 Impaired glucose homeostasis in insulin-like growth factor-binding protein-3-transgenic mice. Am J Physiol Endocrinol Metab 283:E937-E945
    • (2002) Am J Physiol Endocrinol Metab , vol.283
    • Silha, J.V.1    Gui, Y.2    Murphy, L.J.3
  • 50
    • 0015767411 scopus 로고
    • The use of ficoll in the preparation of viable islets of langerhans from the rat pancreas
    • Scharp DW, Kemp CB, Knight MJ, Ballinger WF, Lacy PE 1973 The use of ficoll in the preparation of viable islets of langerhans from the rat pancreas. Transplantation 16:686-689
    • (1973) Transplantation , vol.16 , pp. 686-689
    • Scharp, D.W.1    Kemp, C.B.2    Knight, M.J.3    Ballinger, W.F.4    Lacy, P.E.5
  • 52
    • 1342294092 scopus 로고    scopus 로고
    • Normalization for cDNA microarray data: A robust composite method addressing single and multiple slide systematic variation
    • Yang YH, Dudoit S, Luu P, Lin DM, Peng V, Ngai J, Speed TP 2002 Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Res 30:e15
    • (2002) Nucleic Acids Res , vol.30
    • Yang, Y.H.1    Dudoit, S.2    Luu, P.3    Lin, D.M.4    Peng, V.5    Ngai, J.6    Speed, T.P.7
  • 53
    • 0035942271 scopus 로고    scopus 로고
    • Significance analysis of microarrays applied to the ionizing radiation response
    • Tusher VG, Tibshirani R, Chu G 2001 Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 98:5116-5121
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5116-5121
    • Tusher, V.G.1    Tibshirani, R.2    Chu, G.3
  • 54
    • 0034947806 scopus 로고    scopus 로고
    • ADP-ribosylation factor 6 delineates separate pathways used by endothelin 1 and insulin for stimulating glucose uptake in 3T3-L1 adipocytes
    • Lawrence JT, Birnbaum MJ 2001 ADP-ribosylation factor 6 delineates separate pathways used by endothelin 1 and insulin for stimulating glucose uptake in 3T3-L1 adipocytes. Mol Cell Biol 21: 5276-5285
    • (2001) Mol Cell Biol , vol.21 , pp. 5276-5285
    • Lawrence, J.T.1    Birnbaum, M.J.2
  • 55
    • 1542781732 scopus 로고    scopus 로고
    • Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B
    • Bae SS, Cho H, Mu J, Birnbaum MJ 2003 Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B. J Biol Chem 278:49530-49536
    • (2003) J Biol Chem , vol.278 , pp. 49530-49536
    • Bae, S.S.1    Cho, H.2    Mu, J.3    Birnbaum, M.J.4
  • 56
    • 0034651983 scopus 로고    scopus 로고
    • Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart
    • Fujio Y, Nguyen T, Wencker D, Kitsis RN, Walsh K 2000 Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation 101:660-667
    • (2000) Circulation , vol.101 , pp. 660-667
    • Fujio, Y.1    Nguyen, T.2    Wencker, D.3    Kitsis, R.N.4    Walsh, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.