2-Aryl-3-(1H-azol-1-yl)-1H-indole derivatives: A new class of antimycobacterial compounds - Conventional heating in comparison with MW-assisted synthesis

Archiv der Pharmazie

Volumn 342, Issue 12, 2009, Pages 716-722

  Zampieri, Daniele ^a   Mamolo, Maria Grazia ^a   Laurini, Erik ^a   Scialino, Giuditta ^a   Banfi, Elena ^a   Vio, Luciano ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

Author keywords

Antifungal activity; Antimycobacterial activity; Indole; MW assisted synthesis

Indexed keywords

2 (4 CHLOROPHENYL) 3 (1H 1,2,4 TRIAZOL 1 YL) 1H INDOLE; 2 (4 CHLOROPHENYL) 3 (1H IMIDAZOL 1 YL) 1H INDOLE; 2 (4 METHYLPHENYL) 3 (1H 1,2,4 TRIAZOL 1 YL) 1H INDOLE; 2 (BIPHENYL 4 YL) 3 (1H 1,2,4 TRIAZOL 1 YL) 1H INDOLE; 2 (BIPHENYL 4 YL) 3 (1H IMIDAZOL 1 YL) 1H INDOLE; 2 PHENYL 3 (1H 1,2,4 TRIAZOL 1 YL) 1H INDOLE; 3 (1H IMIDAZOL 1 YL) 2 (4 METHYLPHENYL) 1H INDOLE; AMPHOTERICIN B; ANTIFUNGAL AGENT; INDOLE DERIVATIVE; MICONAZOLE; N [1 (2 BIPHENYL 4 YL) 2 (1H 1,2,4 TRIAZOL 1 YL) ETHYLIDENE] N' PHENYLHYDRAZINE; N [1 (2 BIPHENYL 4 YL) 2 (1H IMIDAZOL 1 YL)ETHYLIDENE] N' PHENYLHYDRAZINE; N [1 (4 BROMOPHENYL) 2 (1H 1,2,4 TRIAZOL 1 YL) ETHYLIDENE] N' PHENYLHYDRAZINE; N [1 (4 BROMOPHENYL) 2 (1H IMIDAZOL 1 YL)ETHYLIDENE] N' PHENYLHYDRAZINE; N [1 (4 CHLOROPHENYL) 2 (1H 1,2,4 TRIAZOL 1 YL) ETHYLIDENE] N' PHENYLHYDRAZINE; N [1 (4 CHLOROPHENYL) 2 (1H IMIDAZOL 1 YL)ETHYLIDENE] N' PHENYLHYDRAZINE; N [1 (4 METHYLPHENYL) 2 (1H 1,2,4 TRIAZOL 1 YL) ETHYLIDENE] N' PHENYLHYDRAZINE; N [1 PHENYL 2 (1H 1,2,4 TRIAZOL 1 YL) ETHYLIDENE] N' PHENYLHYDRAZINE; N [2 (1H IMIDAZOL 1 YL) 1 (4 METHYLPHENYL)ETHYLIDENE] N' PHENYLHYDRAZINE; N [2 (1H IMIDAZOL 1 YL) 1-PHENYLETHYLIDENE] N' PHENYL HYDRAZINE; RIFAMPICIN; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; ZINOCONAZOLE;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HEATING; INTERMETHOD COMPARISON; MICROWAVE IRRADIATION; MOLECULAR WEIGHT; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; CANDIDA; CHEMISTRY, PHARMACEUTICAL; INDOLES; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 73449131179     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200900031     Document Type: Article

References (20)

1. S. Morris, G. H. Bai, P. Suffys, L. Portilo-Gomez, et al., J. Infect. Dis. 1995, 171, 954-955.
2. E. E. Telzak, K. Sepkowitz, P. Alpert, S. Mannheimer, et al., N. Engl. J. Med. 1995, 333, 907-911.
3. L. A. Basso, J. S. Blanchard, Adv. Exp. Med. Biol. 1998, 456, 115-144.
4. I. Bastian, R. Colebuuders, Drugs 1999, 58, 633-661.
5. C. B. Inderlied, C. A. Kemper, L. E. M. Bermudez, Clin. Microbiol. Rev. 1993, 6, 266-310.
6. M. G. Mamolo, D. Zampieri, V. Falagiani, L. Vio, et al., Arkivoc 2004, V, 231-250.
7. D. Zampieri, M. G. Mamolo, L. Vio, E. Banfi, et al., Bioorg. Med. Chem. 2007, 15, 7444-7458.
8. D. Zampieri, M. G. Mamolo, E. Laurini, G. Scialino, et al., Bioorg. Med. Chem. 2008, 16, 4516-4522.
9. A. Bellamine, A. T. Mangla, W. D. Nes, M. R. Waterman, Proc. Natl. Acad. Sci. U. S. A. 1999, 96, 8937-8942.
10. H. M. Guardiola-Diaz, L. A. Foster, D. Mushrush, A. D. N. Vaz, Biochem. Pharmacol. 2001, 61, 1463-1470.
11. W. Zhang, Y. Ramamoorthy, T. Kilicarslan, H. Nolte, et al., Drug Metab. Dispos. 2002, 30, 314-318.
12. R. Fioravanti, M. Biava, G. C. Porretta, M. Artico, et al., Med. Chem. Res. 1997, 7, 87-97.
13. M. Biava, R. Fioravanti, G. C. Porretta, G. Sleiter, et al., Med. Chem. Res. 1997, 7, 228-250.
14. V. Cavrini, R. Gatti, P. Roveri, M. R. Cesaroni, Arch. Pharm. 1984, 317, 662 - 668.
15. R. Gatti, V. Cavrini, P. Roveri, G. Luglio, Arch. Phar. 1985, 318, 157-160.
16. Y. M. Na, M. Le Borgne, F. Pagniez, G. Le Baut, P. Le Pape, Eur. J. Med. Chem. 2003, 38, 75-87.
17. D. Lamb, D. Kelly, S. Kelly, Drug Res. Updates 1999, 2, 390-402.
18. A. Macchiarulo, G. Costantino, D. Fringuelli, A. Vecchiarelli, et al., Bioorg. Med. Chem. 2002, 10, 3415-3423.
19. R. L. Dyer, G. J. Ellames, B. J. Hamill, P. W. Manley, A. M. S. Pope, J.Med.Chem. 1983, 26, 442-445.
20. E. Banfi, G. Scialino, C. Monti-Bragadin, J. Antimicrob. Chemother. 2003, 52, 796-800.