Synthesis and antifungal activity of new 1-halogenobenzyl-3-imidazolylmethylindole derivatives

European Journal of Medicinal Chemistry

Volumn 38, Issue 1, 2003, Pages 75-87

  Na, Young Min ^a,b   Le Borgne, Marc ^a   Pagniez, Fabrice ^a   Le Baut, Guillaume ^a   Le Pape, Patrice ^a  

^a UNIVERSITÉ DE NANTES   (France)

^b Yang Ji Chemical Co Ltd   (South Korea)

Author keywords

Antifungal activity; Aspergillus fumigatus; Azoles; Candida albicans; Imidazolylmethylindoles

Indexed keywords

1 (2,4 DICHLOROBENZYL) 3 (1H IMIDAZOL 1 YLMETHYL) 1H INDOLE; 1 (2,4 DICHLOROBENZYL) 3 (1H IMIDAZOL 1 YLMETHYL) 2 METHYL 1H INDOLE; 1 (2,4 DICHLOROBENZYL) 3 [1 (1H IMIDAZOL 1 YL)ETHYL] 1H INDOLE; 1 (2,4 DICHLOROBENZYL) 3 [1 (1H IMIDAZOL 1 YL)ETHYL] 2 METHYL 1H INDOLE; 1 (2,4 DIFLUOROBENZYL) 3 (1H IMIDAZOL 1 YLMETHYL) 1H INDOLE; 1 (2,4 DIFLUOROBENZYL) 3 [1 (1H IMIDAZOL 1 YL)ETHYL] 1H INDOLE; 1 (4 BROMOBENZYL) 3 [1 (1H IMIDAZOL 1 YL)ETHYL] 2 METHYL 1H INDOLE; 1 (4 CHLOROBENZYL) 3 (1H IMIDAZOL 1 YLMETHYL) 1H INDOLE; 1 (4 CHLOROBENZYL) 3 (1H IMIDAZOL 1 YLMETHYL) 2 METHYL 1H INDOLE; 1 (4 CHLOROBENZYL) 3 [1 (1H IMIDAZOL 1 YL) 2 METHYLPROPYL] 1H INDOLE; 1 (4 CHLOROBENZYL) 3 [1 (1H IMIDAZOL 1 YL) 2,2 DIMETHYLPROPYL] 1H INDOLE; 1 (4 CHLOROBENZYL) 3 [1 (1H IMIDAZOL 1 YL)BUT 3 ENYL] 1H INDOLE; 1 (4 CHLOROBENZYL) 3 [1 (1H IMIDAZOL 1 YL)BUTYL] 1H INDOLE; 1 (4 CHLOROBENZYL) 3 [1 (1H IMIDAZOL 1 YL)ETHYL] 1H INDOLE; 1 (4 CHLOROBENZYL) 3 [1 (1H IMIDAZOL 1 YL)PENTYL] 1H INDOLE; 1 (4 CHLOROBENZYL) 3 [1 (1H IMIDAZOL 1 YL)PROPYL] 1H INDOLE; 1 (4 FLUOROBENZYL) 3 (1H IMIDAZOL 1 YLMETHYL) 1H INDOLE; 1 (4 FLUOROBENZYL) 3 (1H IMIDAZOL 1 YLMETHYL) 2 METHYL 1H INDOLE; 1 (4 FLUOROBENZYL) 3 [1 (1H IMIDAZOL 1 YL)ETHYL] 1H INDOLE; 1 (4 FLUOROBENZYL) 3 [1 (1H IMIDAZOL 1 YL)ETHYL] 2 METHYL 1H INDOLE; 3 ACETYL 1 (4 CHLOROBENZYL) 1H INDOLE; 3 BUTYRYL 1 (4 CHLOROBENZYL) 1H INDOLE; 3 ISOBUTYRYL 1 (4 CHLOROBENZYL) 1H INDOLE; 3 VALERYL 1 (4 CHLOROBENZYL) 1H INDOLE; 5 BROMO 1 (2 CHLOROBENZYL) 3 (1H IMIDAZOL 1 YLMETHYL) 1H INDOLE; 5 BROMO 1 (2 FLUOROBENZYL) 3 (1H IMIDAZOL 1 YLMETHYL) 1H INDOLE; 5 BROMO 1 (4 CHLOROBENZYL) 3 (1H IMIDAZOL 1 YLMETHYL) 1H INDOLE; 5 BROMO 1 (4 CHLOROBENZYL) 3 [1 (1H IMIDAZOL 1 YL)BUTYL] 1H INDOLE; INDOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CHEMICAL PROCEDURES; CHEMICAL REACTION; CHEMICAL STRUCTURE; DRUG POTENCY; DRUG SCREENING; FUNGUS; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MODULATION; NONHUMAN; PATHOGENESIS; PROTON NUCLEAR MAGNETIC RESONANCE; SYNTHESIS;

ANTIFUNGAL AGENTS; ASPERGILLUS FUMIGATUS; AZOLES; BENZENE DERIVATIVES; CANDIDA ALBICANS; FUMARATES; HUMANS; IMIDAZOLES; INDOLES; MICROBIAL SENSITIVITY TESTS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; NITRATES;

EID: 0037367439     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(02)00005-3     Document Type: Article

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