Functional activation of monoamine transporters by luteolin and apigenin isolated from the fruit of Perilla frutescens (L.) Britt

Neurochemistry International

Volumn 56, Issue 1, 2010, Pages 168-176

  Zhao, Gang ^a,b   Qin, Guo Wei ^c   Wang, Jie ^a   Chu, Wen Jing ^a   Guo, Li He ^a,b  

^a Cell Star Bio Technologies Co Limited   (China)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^c SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Activator; Hypermonoaminergic; Luteolin; Monoamine transporters

Indexed keywords

APIGENIN; COCAINE; DOPAMINE TRANSPORTER; LUTEOLIN; NORADRENALIN TRANSPORTER; PERILLA FRUTESCENS EXTRACT; PLANT EXTRACT; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

AMINE TRANSPORT; ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DRUG MECHANISM; FEMALE; FRUIT; NONHUMAN; PERILLA FRUTESCENS; PRIORITY JOURNAL;

ANIMALS; ANTIOXIDANTS; APIGENIN; CELL LINE; CHO CELLS; COCAINE; COCAINE-RELATED DISORDERS; CRICETINAE; CRICETULUS; DOPAMINE; DOPAMINE UPTAKE INHIBITORS; LUTEOLIN; MICE; NEURONS; NOREPINEPHRINE; PERILLA FRUTESCENS; PLANT EXTRACTS; RATS; SEROTONIN; UP-REGULATION; VESICULAR MONOAMINE TRANSPORT PROTEINS;

CRICETULUS GRISEUS; PERILLA FRUTESCENS;

EID: 73449092141     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2009.09.015     Document Type: Article

References (49)

1. Alcaro A., et al. Behavioral functions of the mesolimbic dopaminergic system: an affective neuroethological perspective. Brain Res. Rev. 56 (2007) 283-321
2. Boudanova E., et al. Amphetamine-induced decreases in dopamine transporter surface expression are protein kinase C-independent. Neuropharmacology 54 (2008) 605-612
3. Chen R., et al. Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 9333-9338
4. Chlopcikova S., et al. Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part II. Caffeic, chlorogenic and rosmarinic acids. Phytother. Res. 18 (2004) 408-413
5. Choi S.H., et al. Beta-secretase (BACE1) inhibitors from Perilla frutescens var. acuta. Arch. Pharm. Res. 31 (2008) 183-187
6. Coleta M., et al. Assessment of luteolin (3′,4′,5,7-tetrahydroxyflavone) neuropharmacological activity. Behav. Brain Res. 189 (2008) 75-82
7. Dajas F., et al. Cell culture protection and in vivo neuroprotective capacity of flavonoids. Neurotox. Res. 5 (2003) 425-432
8. Goodman A. Neurobiology of addiction. An integrative review. Biochem. Pharmacol. 75 (2008) 266-322
9. Guo R., et al. Herbal medicines for the treatment of allergic rhinitis: a systematic review. Ann. Allergy. Asthma. Immunol. 99 (2007) 483-495
10. Harbone J.B., and Mabry T.J. The Flavonoids: Advance in Research (1982), Chapman and Hall, London, New York
11. Hersch S.M., et al. Subcellular locallization and molecular topology of dopamine transporter in the striatum and substantia nigra. J. Comp. Neurol. 388 (1997) 221-227
12. Hou Y., et al. Luteolin inhibits proliferation and affects the function of stimulated rat synovial fibroblasts. Cell Biol. Int. 33 (2009) 135-147
13. Itoigawa M., et al. Structure-activity relationship of cardiotonic flavonoids in guinea-pig papillary muscle. J. Ethnopharmacol. 65 (1999) 267-272
14. Kauer J.A., and Malenka R.C. Synaptic plasticity and addiction. Nat. Rev. Neurosci. 8 (2007) 844-858
15. Kienast T., and Heinz A. Dopamine and the diseased brain. CNS Neurol. Disord. Drug Targets 5 (2006) 109-131
16. Kim D.S., et al. Inhibitory effects of rosmarinic acid on adriamycin-induced apoptosis in H9c2 cardiac muscle cells by inhibiting reactive oxygen species and the activations of c-Jun N-terminal kinase and extracellular signal-regulated kinase. Biochem. Pharmacol. 70 (2005) 1066-1078
17. Kim M.K., et al. Protective effect of aqueous extract of Perilla frutescens on tert-butyl hydroperoxide-induced oxidative hepatotoxicity in rats. Food Chem. Toxicol. 45 (2007) 1738-1744
18. Korotkich I., et al. Inotropic and lusitropic effects of Perilla frutescens (L.) Britton extract on the rabbit myocardium. Medicina (Kaunas) 42 (2006) 406-412
19. Kumazawa Y., et al. Immunomodulating effects of flavonoids on acute and chronic inflammatory responses caused by tumor necrosis factor alpha. Curr. Pharm. Des. 12 (2006) 4271-4279
20. LaHoste G.J., et al. Carbamazepine reduces dopamine-mediated behavior in chronic neuroleptic-treated and untreated rats: implications for treatment of tardive dyskinesia and hyperdopaminergic states. Exp. Clin. Psychopharmacol. 8 (2000) 125-132
21. Lin C.S., et al. Growth inhibitory and apoptosis inducing effect of Perilla frutescens extract on human hepatoma HepG2 cells. J. Ethnopharmacol. 112 (2007) 557-567
22. Liu Z., et al. Peptide derived from insulin with regulatory activity of dopamine transporter. Neuropharmacology 41 (2001) 464-471
23. Masutani, H., et al., 2009. Fragrant unsaturated aldehydes elicit activation of the Keap1/Nrf2 system leading to the up-regulation of thioredoxin expression and protection against oxidative stress. Antioxid. Redox. Signal (Epub ahead of print).
24. Meng L., et al. Antioxidant activities of polyphenols extracted from Perilla frutescens varieties. Molecules 14 (2008) 133-140
25. - neurotransmitter transporters. J. Neurochem. 71 (1998) 1785-1803
26. Osakabe N., et al. Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine twostage skin model. Carcinogenesis 25 (2004) 549-557
27. Owen R.W., et al. Isolation, structure elucidation and antioxidant potential of the major phenolic and flavonoid compounds in brined olive drups. Food Chem. Toxicol. 41 (2003) 703-717
28. Ozeren M., et al. Caffeic acid phenethyl ester (CAPE) supplemented St. Thomas' hospital cardioplegic solution improves the antioxidant defense system of rat myocardium during ischemia-reperfusion injury. Pharmacol. Res. 52 (2005) 258-263
29. Peng Y., et al. Determination of phenolic compounds in Perilla frutescens L. by capillary electrophoresis with electrochemical detection. J. Agric. Food Chem. 53 (2005) 8141-8147
30. Ragažinskienė O., et al. Krūminė perilė (Perilla frutescens (L.) Britton)-perspektyvus imunomoduliatorius. (Common perilla (Perilla frutescens (L.) Britton.) as a perspective immunomodulator). Medicina (Kaunas) 40 (2004) 220-224
31. Ravna A.W., et al. Putative drug binding conformations of monoamine transporters. Bioorg. Med. Chem. 14 (2006) 666-675
32. Ritz M.C., et al. Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science 237 4819 (1987) 1219-1223
33. Rothstein J.D., et al. β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature 433 (2005) 73-77
34. Sanbongi C., et al. Rosmarinic acid in perilla extract inhibits allergic inflammation induced by mite allergen, in a mouse model. Clin. Exp. Allergy 34 (2004) 971-977
35. Sokolski K.N., and DeMet E.M. Pupillary cholinergic sensitivity to pilocarpine increases in manic lithium responders. Biol. Psychiatry 45 (1999) 1580-1584
36. Takano H., et al. Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, inhibits seasonal allergic rhinoconjunctivitis in humans. Exp. Biol. Med. (Maywood) 229 (2004) 247-254
37. Tilley M.R., et al. Cocaine reward and locomotion stimulation in mice with reduced dopamine transporter expression. BMC Neurosci. 8 (2007) 42
38. Torres G.E. The dopamine transporter proteome. J. Neurochem. 97 Suppl 1 (2006) 3-10
39. Torres G.E., et al. Plasma membrane monoamine transporters: structure, regulation and function. Nat. Rev. Neurosci. 4 (2003) 13-25
40. Tsai F.S., et al. Effects of luteolin on learning acquisition in rats: involvement of the central cholinergic system. Life Sci. 80 (2007) 1692-1698
41. Ueda H., et al. Inhibitory effect of Perilla leaf extract and luteolin on mouse skin tumor promotion. Biol. Pharm. Bull. 26 (2003) 560-563
42. van Meeteren M.E., et al. Dietary compounds prevent oxidative damage and nitric oxide production by cells involved in demyelinating disease. Biochem. Pharmacol. 67 (2004) 967-975
43. van Zanden J.J., et al. Structural requirements for the flavonoid-mediated modulation of glutathione S-transferase P1-1 and GS-X pump activity in MCF7 breast cancer cells. Biochem. Pharmacol. 67 (2004) 1607-1617
44. Woodman O.L., and Chan E. Vascular and anti-oxidant actions of flavonols and flavones. Clin. Exp. Pharmacol. Physiol. 31 (2004) 786-790
45. Verbeek R., et al. Oral flavonoids delay recovery from experimental autoimmune encephalomyelitis in SJL mice. Biochem. Pharmacol. 70 (2005) 220-228
46. Xu L.F., et al. Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models. Neuropharmacology 50 (2006) 934-940
47. Yamamoto H., and Ogawa T. Antimicrobial activity of perilla seed polyphenols against oral pathogenic bacteria. Biosci. Biotechnol. Biochem. 66 (2002) 921-924
48. Zhao G., et al. Dopamine transporter inhibitory and antiparkinsonian effect of common flowering quince extract. Pharmacol. Biochem. Behav. 90 (2008) 363-371
49. Zhao G., et al. Bakuchiol analogs inhibit monoamine transporters and regulate monoaminergic functions. Biochem. Pharmacol. 75 (2008) 1835-1847