Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models

Neuropharmacology

Volumn 50, Issue 8, 2006, Pages 934-940

  Xu, Lin Feng ^a   Chu, Wen Jing ^a   Qing, Xiao Yun ^a   Li, Sheng ^a   Wang, Xue Song ^a   Qing, Guo Wei ^c   Fei, Jian ^a,d   Guo, Li He ^a,b  

^a Shanghai Celstar Institute of Biotechnology   (China)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^c SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^d Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

Author keywords

5 HT (5 hydroxytryptamine, serotonin); Antidepressant; Dactylicapnos scandens Hutch; Noradrenaline (NE); Reuptake inhibitor; Transporter

Indexed keywords

ANTIDEPRESSANT AGENT; DACTYLICAPNOS SCANDENS EXTRACT; DESIPRAMINE; FLUOXETINE; HERBACEOUS AGENT; NORADRENALIN TRANSPORTER; PROTOPINE; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDEPRESSION EFFECT; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DEPRESSION; DOSE RESPONSE; DRUG EFFECT; EXPERIMENTAL MODEL; EXPERIMENTAL MOUSE; EXPERIMENTAL TEST; HEAD TWITCH; IMMOBILIZATION; IN VITRO STUDY; MALE; MOOD DISORDER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSYCHOPHARMACOLOGY; STATISTICAL SIGNIFICANCE; TAIL SUSPENSION TEST;

ANALYSIS OF VARIANCE; ANIMALS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; BENZOPHENANTHRIDINES; BERBERINE ALKALOIDS; CHO CELLS; CRICETINAE; CRICETULUS; DEPRESSION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HEAD MOVEMENTS; HINDLIMB SUSPENSION; INHIBITORY CONCENTRATION 50; MALE; MICE; MICE, INBRED BALB C; MOTOR ACTIVITY; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; PROTEIN BINDING; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TETRAZOLIUM SALTS; THIAZOLES; TRANSFECTION;

EID: 33646905684     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2006.01.003     Document Type: Article

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