메뉴 건너뛰기




Volumn 29, Issue 1, 2009, Pages 63-72

Curcumin reduces the toxic effects of iron loading in rat liver epithelial cells

Author keywords

Curcumin; Iron; Liver disease; Oxidative stress; Stress activated MAP kinase

Indexed keywords

8 QUINOLINOL; ACETYLCYSTEINE; ALPHA TOCOPHEROL; CURCUMIN; DEFEROXAMINE; FERRIC AMMONIUM CITRATE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN C JUN; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE;

EID: 57749178645     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2008.01793.x     Document Type: Article
Times cited : (57)

References (61)
  • 1
    • 0029330272 scopus 로고
    • Iron as a hepatotoxin
    • Stal P. Iron as a hepatotoxin. Dig Dis 1995; 13: 205-22.
    • (1995) Dig Dis , vol.13 , pp. 205-222
    • Stal, P.1
  • 2
    • 0036569986 scopus 로고    scopus 로고
    • Molecular bases of cellular iron toxicity
    • Eaton JW, Qian M. Molecular bases of cellular iron toxicity. Free Radic Biol Med 2002; 32: 833-40.
    • (2002) Free Radic Biol Med , vol.32 , pp. 833-840
    • Eaton, J.W.1    Qian, M.2
  • 3
    • 0000162325 scopus 로고
    • The catalytic decompostion of hydrogen peroxide by iron salts
    • Haber F, Weiss J. The catalytic decompostion of hydrogen peroxide by iron salts. Proc R Soc Lond Sect A 1934; 147: 332-51.
    • (1934) Proc R Soc Lond Sect A , vol.147 , pp. 332-351
    • Haber, F.1    Weiss, J.2
  • 4
    • 18544371009 scopus 로고    scopus 로고
    • Metals, toxicity and oxidative stress
    • Valko M, Morris H, Cronin MT. Metals, toxicity and oxidative stress. Curr Med Chem 2005; 12: 1161-208.
    • (2005) Curr Med Chem , vol.12 , pp. 1161-1208
    • Valko, M.1    Morris, H.2    Cronin, M.T.3
  • 6
    • 0036196205 scopus 로고    scopus 로고
    • Mechanisms of iron accumulation in hereditary hemochromatosis
    • Fleming RE, Sly WS. Mechanisms of iron accumulation in hereditary hemochromatosis. Annu Rev Physiol 2002; 64: 663-80.
    • (2002) Annu Rev Physiol , vol.64 , pp. 663-680
    • Fleming, R.E.1    Sly, W.S.2
  • 7
    • 2042546096 scopus 로고    scopus 로고
    • Balancing acts: Molecular control of mammalian iron metabolism
    • Hentze MW, Muckenthaler MU, Andrews NC. Balancing acts: Molecular control of mammalian iron metabolism. Cell 2004; 117: 285-97.
    • (2004) Cell , vol.117 , pp. 285-297
    • Hentze, M.W.1    Muckenthaler, M.U.2    Andrews, N.C.3
  • 9
    • 7044222320 scopus 로고    scopus 로고
    • Iron, hemochromatosis, and hepatocellular carcinoma
    • Kowdley KV. Iron, hemochromatosis, and hepatocellular carcinoma. Gastroenterology 2004; 127 (Suppl. 1): S79-86.
    • (2004) Gastroenterology , vol.127 , Issue.SUPPL. 1
    • Kowdley, K.V.1
  • 10
    • 33646028804 scopus 로고    scopus 로고
    • Molecular targets of dietary agents for prevention and therapy of cancer
    • Aggarwal BB, Shishodia S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 2006; 71: 1397-421.
    • (2006) Biochem Pharmacol , vol.71 , pp. 1397-1421
    • Aggarwal, B.B.1    Shishodia, S.2
  • 11
    • 0033024541 scopus 로고    scopus 로고
    • A review of plants used in the treatment of liver disease: Part two
    • Luper S. A review of plants used in the treatment of liver disease: Part two. Altern Med Rev 1999; 4: 178-88.
    • (1999) Altern Med Rev , vol.4 , pp. 178-188
    • Luper, S.1
  • 13
    • 0026548715 scopus 로고
    • Toxicity studies on Alpinia galanga and Curcuma longa
    • Qureshi S, Shah AH, Ageel AM. Toxicity studies on Alpinia galanga and Curcuma longa. Planta Med 1992; 58: 124-7.
    • (1992) Planta Med , vol.58 , pp. 124-127
    • Qureshi, S.1    Shah, A.H.2    Ageel, A.M.3
  • 14
    • 0035174504 scopus 로고    scopus 로고
    • Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions
    • Cheng AL, Hsu CH, Lin JK, et al. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res 2001; 21: 2895-900.
    • (2001) Anticancer Res , vol.21 , pp. 2895-2900
    • Cheng, A.L.1    Hsu, C.H.2    Lin, J.K.3
  • 15
    • 6044276740 scopus 로고    scopus 로고
    • Phase I clinical trial of oral curcumin: Biomarkers of systemic activity and compliance
    • Sharma RA, Euden SA, Platton SL, et al. Phase I clinical trial of oral curcumin: Biomarkers of systemic activity and compliance. Clin Cancer Res 2004; 10: 6847-54.
    • (2004) Clin Cancer Res , vol.10 , pp. 6847-6854
    • Sharma, R.A.1    Euden, S.A.2    Platton, S.L.3
  • 20
    • 0030906612 scopus 로고    scopus 로고
    • Protective effect of food additives on aflatoxin-induced mutagenicity and hepatocarcinogenicity
    • Soni KB, Lahiri M, Chackradeo P, Bhide SV, Kuttan R. Protective effect of food additives on aflatoxin-induced mutagenicity and hepatocarcinogenicity. Cancer Lett 1997; 115: 129-33.
    • (1997) Cancer Lett , vol.115 , pp. 129-133
    • Soni, K.B.1    Lahiri, M.2    Chackradeo, P.3    Bhide, S.V.4    Kuttan, R.5
  • 21
    • 0033969490 scopus 로고    scopus 로고
    • Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis
    • Chuang SE, Kuo ML, Hsu CH, et al. Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis. Carcinogenesis 2000; 21: 331-5.
    • (2000) Carcinogenesis , vol.21 , pp. 331-335
    • Chuang, S.E.1    Kuo, M.L.2    Hsu, C.H.3
  • 22
    • 0037457285 scopus 로고    scopus 로고
    • Inhibition of nitrosodiethylamine-induced hepatocarcinogenesis by dietary turmeric in rats
    • Thapliyal R, Naresh KN, Rao KV, Maru GB. Inhibition of nitrosodiethylamine-induced hepatocarcinogenesis by dietary turmeric in rats. Toxicol Lett 2003; 139: 45-54.
    • (2003) Toxicol Lett , vol.139 , pp. 45-54
    • Thapliyal, R.1    Naresh, K.N.2    Rao, K.V.3    Maru, G.B.4
  • 23
    • 9644295733 scopus 로고    scopus 로고
    • Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice
    • Leclercq IA, Farrell GC, Sempoux C, dela Pena A, Horsmans Y. Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice. J Hepatol 2004; 41: 926-34.
    • (2004) J Hepatol , vol.41 , pp. 926-934
    • Leclercq, I.A.1    Farrell, G.C.2    Sempoux, C.3    dela Pena, A.4    Horsmans, Y.5
  • 24
    • 33947277886 scopus 로고    scopus 로고
    • Prevention of liver cirrhosis in rats by curcumin
    • Bruck R, Ashkenazi M, Weiss S, et al. Prevention of liver cirrhosis in rats by curcumin. Liver Int 2007; 27: 373-83.
    • (2007) Liver Int , vol.27 , pp. 373-383
    • Bruck, R.1    Ashkenazi, M.2    Weiss, S.3
  • 25
    • 0028587702 scopus 로고
    • Curcuminoids as potent inhibitors of lipid peroxidation
    • Sreejayan Rao MN. Curcuminoids as potent inhibitors of lipid peroxidation. J Pharm Pharmacol 1994; 46: 1013-6.
    • (1994) J Pharm Pharmacol , vol.46 , pp. 1013-1016
    • Sreejayan Rao, M.N.1
  • 26
    • 4644275696 scopus 로고    scopus 로고
    • Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models
    • discussion 369-443
    • Baum L, Ng A. Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models. J Alzheimers Dis 2004; 6: 367-77; discussion 369-443.
    • (2004) J Alzheimers Dis , vol.6 , pp. 367-377
    • Baum, L.1    Ng, A.2
  • 28
    • 0019226776 scopus 로고
    • Regulation of proliferation of normal and neoplastic rat liver cells by calcium and cyclic AMP
    • Swierenga SH, Whitfield JF, Boynton AL, et al. Regulation of proliferation of normal and neoplastic rat liver cells by calcium and cyclic AMP. Ann NY Acad Sci 1980; 349: 294-311.
    • (1980) Ann NY Acad Sci , vol.349 , pp. 294-311
    • Swierenga, S.H.1    Whitfield, J.F.2    Boynton, A.L.3
  • 29
    • 0027462404 scopus 로고
    • Cytokeratin 14 expression in rat liver cells in culture and localization in vivo
    • Blouin R, Blouin MJ, Royal I, et al. Cytokeratin 14 expression in rat liver cells in culture and localization in vivo. Differentiation 1992; 52: 45-54.
    • (1992) Differentiation , vol.52 , pp. 45-54
    • Blouin, R.1    Blouin, M.J.2    Royal, I.3
  • 30
    • 0035039515 scopus 로고    scopus 로고
    • Hydrogen peroxide promotes transformation of rat liver non-neoplastic epithelial cells through activation of epidermal growth factor receptor
    • Huang RP, Peng A, Golard A, et al. Hydrogen peroxide promotes transformation of rat liver non-neoplastic epithelial cells through activation of epidermal growth factor receptor. Mol Carcinogr 2001; 30: 209-17.
    • (2001) Mol Carcinogr , vol.30 , pp. 209-217
    • Huang, R.P.1    Peng, A.2    Golard, A.3
  • 31
    • 0021323345 scopus 로고
    • Relation between colony formation in calcium-deficient medium, colony formation in soft agar, and tumor formation by T51B rat liver cells
    • Boynton AL, Kleine LP, Whitfield JF. Relation between colony formation in calcium-deficient medium, colony formation in soft agar, and tumor formation by T51B rat liver cells. Cancer Lett 1984; 21: 293-302.
    • (1984) Cancer Lett , vol.21 , pp. 293-302
    • Boynton, A.L.1    Kleine, L.P.2    Whitfield, J.F.3
  • 33
    • 0034902975 scopus 로고    scopus 로고
    • Abbreviated cell cycle progression induced by the serine/threonine protein phosphatase inhibitor okadaic acid at concentrations that promote neoplastic transformation
    • Messner DJ, Ao P, Jagdale AB, Boynton AL. Abbreviated cell cycle progression induced by the serine/threonine protein phosphatase inhibitor okadaic acid at concentrations that promote neoplastic transformation. Carcinogenesis 2001; 22: 1163-72.
    • (2001) Carcinogenesis , vol.22 , pp. 1163-1172
    • Messner, D.J.1    Ao, P.2    Jagdale, A.B.3    Boynton, A.L.4
  • 34
    • 41549165222 scopus 로고    scopus 로고
    • Neoplastic transformation of rat liver epithelial cells is enhanced by non-transferrin-bound iron
    • Messner DJ, Kowdley KV. Neoplastic transformation of rat liver epithelial cells is enhanced by non-transferrin-bound iron. BMC Gastroenterol 2008; 8: 2.
    • (2008) BMC Gastroenterol , vol.8 , pp. 2
    • Messner, D.J.1    Kowdley, K.V.2
  • 35
    • 0024564712 scopus 로고
    • Non-transferrin-bound iron in plasma or serum from patients with idiopathic hemochromatosis. Characterization by high performance liquid chromatography and nuclear magnetic resonance spectroscopy
    • Grootveld M, Bell JD, Halliwell B, Aruoma OI, Bomford A, Sadler PJ. Non-transferrin-bound iron in plasma or serum from patients with idiopathic hemochromatosis. Characterization by high performance liquid chromatography and nuclear magnetic resonance spectroscopy. J Biol Chem 1989; 264: 4417-22.
    • (1989) J Biol Chem , vol.264 , pp. 4417-4422
    • Grootveld, M.1    Bell, J.D.2    Halliwell, B.3    Aruoma, O.I.4    Bomford, A.5    Sadler, P.J.6
  • 36
    • 0001189076 scopus 로고
    • Effect of transferrin saturation on iron absorption in man
    • Wheby MS, Umpierre G. Effect of transferrin saturation on iron absorption in man. N Engl J Med 1964; 271: 1391-5.
    • (1964) N Engl J Med , vol.271 , pp. 1391-1395
    • Wheby, M.S.1    Umpierre, G.2
  • 37
    • 0029978237 scopus 로고    scopus 로고
    • Iron bound to the lipophilic iron chelator, 8-hydroxyquinoline, causes DNA strand breakage in cultured lung cells
    • Leanderson P, Tagesson C. Iron bound to the lipophilic iron chelator, 8-hydroxyquinoline, causes DNA strand breakage in cultured lung cells. Carcinogenesis 1996; 17: 545-50.
    • (1996) Carcinogenesis , vol.17 , pp. 545-550
    • Leanderson, P.1    Tagesson, C.2
  • 38
    • 0034582184 scopus 로고    scopus 로고
    • Detection and sequencing of phosphopeptides affinity bound to immobilized metal ion beads by matrix-assisted laser desorption/ ionization mass spectrometry
    • Zhou W, Merrick BA, Khaledi MG, Tomer KB. Detection and sequencing of phosphopeptides affinity bound to immobilized metal ion beads by matrix-assisted laser desorption/ionization mass spectrometry. J Am Soc Mass Spectrom 2000; 11: 273-82.
    • (2000) J Am Soc Mass Spectrom , vol.11 , pp. 273-282
    • Zhou, W.1    Merrick, B.A.2    Khaledi, M.G.3    Tomer, K.B.4
  • 39
    • 0032992695 scopus 로고    scopus 로고
    • Differential response of non-transferrin bound iron uptake in rat liver cells on long-term and short-term treatment with iron
    • Scheiber-Mojdehkar B, Zimmermann I, Dresow B, Goldenberg H. Differential response of non-transferrin bound iron uptake in rat liver cells on long-term and short-term treatment with iron. J Hepatol 1999; 31: 61-70.
    • (1999) J Hepatol , vol.31 , pp. 61-70
    • Scheiber-Mojdehkar, B.1    Zimmermann, I.2    Dresow, B.3    Goldenberg, H.4
  • 40
    • 33748040410 scopus 로고    scopus 로고
    • Inhibition of PP2A, but not PP5, mediates p53 activation by low levels of okadaic acid in rat liver epithelial cells
    • Messner DJ, Romeo C, Boynton A, Rossie S. Inhibition of PP2A, but not PP5, mediates p53 activation by low levels of okadaic acid in rat liver epithelial cells. J Cell Biochem 2006; 99: 241-55.
    • (2006) J Cell Biochem , vol.99 , pp. 241-255
    • Messner, D.J.1    Romeo, C.2    Boynton, A.3    Rossie, S.4
  • 41
    • 84945732206 scopus 로고
    • The MTT tetrazolium salt assay scrutinized: How to use this assay reliably to measure metabolic activity of cell cultures in vitro for the assessment of growth characteristics, IC50-values and cell survival
    • Sieuwerts AM, Klijn JG, Peters HA, Foekens JA. The MTT tetrazolium salt assay scrutinized: How to use this assay reliably to measure metabolic activity of cell cultures in vitro for the assessment of growth characteristics, IC50-values and cell survival. Eur J Clin Chem Clin Biochem 1995; 33: 813-23.
    • (1995) Eur J Clin Chem Clin Biochem , vol.33 , pp. 813-823
    • Sieuwerts, A.M.1    Klijn, J.G.2    Peters, H.A.3    Foekens, J.A.4
  • 43
    • 0029562526 scopus 로고
    • Metabolization of iron by plant cells using O-Trensox, a high-affinity abiotic iron-chelating agent
    • Caris C, Baret P, Beguin C, Serratrice G, Pierre JL, Laulhere JP. Metabolization of iron by plant cells using O-Trensox, a high-affinity abiotic iron-chelating agent. Biochem J 1995; 312(Part 3): 879-85.
    • (1995) Biochem J , vol.312 , Issue.PART 3 , pp. 879-885
    • Caris, C.1    Baret, P.2    Beguin, C.3    Serratrice, G.4    Pierre, J.L.5    Laulhere, J.P.6
  • 44
    • 33746019297 scopus 로고    scopus 로고
    • Design of iron chelators: Syntheses and iron (III) complexing abilities of tripodal tris-bidentate ligands
    • d'Hardemare Adu M, Torelli S, Serratrice G, Pierre JL. Design of iron chelators: Syntheses and iron (III) complexing abilities of tripodal tris-bidentate ligands. Biometals 2006; 19: 349-66.
    • (2006) Biometals , vol.19 , pp. 349-366
    • d'Hardemare Adu, M.1    Torelli, S.2    Serratrice, G.3    Pierre, J.L.4
  • 47
    • 34548126843 scopus 로고    scopus 로고
    • Fluorescent and luminescent probes for measurement of oxidative and nitrosative species in cells and tissues: Progress, pitfalls, and prospects
    • Wardman P. Fluorescent and luminescent probes for measurement of oxidative and nitrosative species in cells and tissues: Progress, pitfalls, and prospects. Free Radic Biol Med 2007; 43: 995-1022.
    • (2007) Free Radic Biol Med , vol.43 , pp. 995-1022
    • Wardman, P.1
  • 48
    • 0037201941 scopus 로고    scopus 로고
    • Iron toxicity and antioxidant nutrients
    • Fraga CG, Oteiza PI. Iron toxicity and antioxidant nutrients. Toxicology 2002; 180: 23-32.
    • (2002) Toxicology , vol.180 , pp. 23-32
    • Fraga, C.G.1    Oteiza, P.I.2
  • 49
    • 0028116672 scopus 로고
    • Studies on the inhibitory effects of curcumin and eugenol on the formation of reactive oxygen species and the oxidation of ferrous iron
    • Reddy AC, Lokesh BR. Studies on the inhibitory effects of curcumin and eugenol on the formation of reactive oxygen species and the oxidation of ferrous iron. Mol Cell Biochem 1994; 137: 1-8.
    • (1994) Mol Cell Biochem , vol.137 , pp. 1-8
    • Reddy, A.C.1    Lokesh, B.R.2
  • 50
    • 0343618374 scopus 로고    scopus 로고
    • Effect of curcumin and eugenol on iron-induced hepatic toxicity in rats
    • Reddy AC, Lokesh BR. Effect of curcumin and eugenol on iron-induced hepatic toxicity in rats. Toxicology 1996; 107: 39-45.
    • (1996) Toxicology , vol.107 , pp. 39-45
    • Reddy, A.C.1    Lokesh, B.R.2
  • 51
    • 21644477778 scopus 로고    scopus 로고
    • Thioredoxin reductase is irreversibly modified by curcumin: A novel molecular mechanism for its anticancer activity
    • Fang J, Lu J, Holmgren A. Thioredoxin reductase is irreversibly modified by curcumin: A novel molecular mechanism for its anticancer activity. J Biol Chem 2005; 280: 25284-90.
    • (2005) J Biol Chem , vol.280 , pp. 25284-25290
    • Fang, J.1    Lu, J.2    Holmgren, A.3
  • 52
    • 0042169007 scopus 로고    scopus 로고
    • Molecular mechanisms of curcumin-induced cytotoxicity: Induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt
    • Woo JH, Kim YH, Choi YJ, et al. Molecular mechanisms of curcumin-induced cytotoxicity: Induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt. Carcinogenesis 2003; 24: 1199-208.
    • (2003) Carcinogenesis , vol.24 , pp. 1199-1208
    • Woo, J.H.1    Kim, Y.H.2    Choi, Y.J.3
  • 53
    • 4644364745 scopus 로고    scopus 로고
    • Effect of curcumin on normal and tumor cells: Role of glutathione and bcl-2
    • Syng-Ai C, Kumari AL, Khar A. Effect of curcumin on normal and tumor cells: Role of glutathione and bcl-2. Mol Cancer Ther 2004; 3: 1101-8.
    • (2004) Mol Cancer Ther , vol.3 , pp. 1101-1108
    • Syng-Ai, C.1    Kumari, A.L.2    Khar, A.3
  • 54
    • 2442571064 scopus 로고    scopus 로고
    • Cytotoxicity, ROS-generation activity and radical-scavenging activity of curcumin and related compounds
    • Fujisawa S, Atsumi T, Ishihara M, Kadoma Y. Cytotoxicity, ROS-generation activity and radical-scavenging activity of curcumin and related compounds. Anticancer Res 2004; 24: 563-9.
    • (2004) Anticancer Res , vol.24 , pp. 563-569
    • Fujisawa, S.1    Atsumi, T.2    Ishihara, M.3    Kadoma, Y.4
  • 55
    • 0026628343 scopus 로고
    • Induction of glutathione S-transferase activity by curcumin in mice
    • Susan M, Rao MN. Induction of glutathione S-transferase activity by curcumin in mice. Arzneimittelforschung 1992; 42: 962-4.
    • (1992) Arzneimittelforschung , vol.42 , pp. 962-964
    • Susan, M.1    Rao, M.N.2
  • 56
    • 0037569694 scopus 로고    scopus 로고
    • Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element
    • Balogun E, Hoque M, Gong P, et al. Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element. Biochem J 2003; 371(Part 3): 887-95.
    • (2003) Biochem J , vol.371 , Issue.PART 3 , pp. 887-895
    • Balogun, E.1    Hoque, M.2    Gong, P.3
  • 57
    • 0032908758 scopus 로고    scopus 로고
    • Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes
    • Dinkova-Kostova AT, Talalay P. Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes. Carcinogenesis 1999; 20: 911-4.
    • (1999) Carcinogenesis , vol.20 , pp. 911-914
    • Dinkova-Kostova, A.T.1    Talalay, P.2
  • 58
    • 33748541580 scopus 로고    scopus 로고
    • TPA-induced up-regulation of activator protein-1 can be inhibited or enhanced by analogs of the natural product curcumin
    • Weber WM, Hunsaker LA, Gonzales AM, et al. TPA-induced up-regulation of activator protein-1 can be inhibited or enhanced by analogs of the natural product curcumin. Biochem Pharmacol 2006; 72: 928-40.
    • (2006) Biochem Pharmacol , vol.72 , pp. 928-940
    • Weber, W.M.1    Hunsaker, L.A.2    Gonzales, A.M.3
  • 59
    • 32844463364 scopus 로고    scopus 로고
    • Activation of NFkappaB is inhibited by curcumin and related enones
    • Weber WM, Hunsaker LA, Roybal CN, et al. Activation of NFkappaB is inhibited by curcumin and related enones. Bioorg Med Chem 2006; 14: 2450-61.
    • (2006) Bioorg Med Chem , vol.14 , pp. 2450-2461
    • Weber, W.M.1    Hunsaker, L.A.2    Roybal, C.N.3
  • 60
    • 0035114277 scopus 로고    scopus 로고
    • Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production
    • Ireson C, Orr S, Jones DJ, et al. Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production. Cancer Res 2001; 61: 1058-64.
    • (2001) Cancer Res , vol.61 , pp. 1058-1064
    • Ireson, C.1    Orr, S.2    Jones, D.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.