5-Lipoxygenase inhibitors potentiate 1α,25-dihydroxyvitamin D 3-induced monocytic differentiation by activating p38 MAPK pathway

Molecular and Cellular Biochemistry

Volumn 330, Issue 1-2, 2009, Pages 229-238

  Stixová, Lenka ^a   Procházková, Jiřina ^a,b   Souček, Karel ^a   Hofmanová, Jiřina ^a   Kozubík, Alois ^a  

^a INSTITUTE OF BIOPHYSICS   (Czech Republic)

^b MASARYK UNIVERSITY   (Czech Republic)

Author keywords

1 ,25 Dihydroxyvitamin D3; 5 Lipoxygenase inhibitors; Differentiation; P38 MAPK; Promyelocytic leukemia; SB202190

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CALCITRIOL; CD11B ANTIGEN; CD14 ANTIGEN; DOCEBENONE; I KAPPA B; LIPOXYGENASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BCL 2; PROTEIN C JUN; PROTEIN MCL 1; REACTIVE OXYGEN METABOLITE; ZYMOSAN;

ANTIGEN EXPRESSION; ARTICLE; CANCER CELL CULTURE; CELL DIFFERENTIATION; CHEMOLUMINESCENCE; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MACROPHAGE; MONOCYTE; PROMYELOCYTIC LEUKEMIA; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ARACHIDONATE 5-LIPOXYGENASE; BENZOQUINONES; CELL DIFFERENTIATION; HL-60 CELLS; HUMANS; INDOLES; LIPOXYGENASE INHIBITORS; MONOCYTES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; VITAMIN D;

EID: 73349100314     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-009-0138-x     Document Type: Article

References (68)

1. R Bouillon L Verlinden G Eelen, et al. 2005 Mechanisms for the selective action of vitamin D analogs J Steroid Biochem Mol Biol 97 21 30 10.1016/j.jsbmb.2005.06.013 10.1016/j.jsbmb.2005.06.013 16111885 1:CAS:528:DC%2BD2MXhtFyks7jM (Pubitemid 41546210)
2. QT Luong HP Koeffler 2005 Vitamin D compounds in leukemia J Steroid Biochem Mol Biol 97 195 202 10.1016/j.jsbmb.2005.06.017 10.1016/j.jsbmb.2005.06. 017 16085411 1:CAS:528:DC%2BD2MXhtFyks7vE (Pubitemid 41546229)
3. SY James MA Williams AC Newland, et al. 1999 Leukemia cell differentiation: cellular and molecular interactions of retinoids and vitamin D Gen Pharmacol 32 143 154 10.1016/S0306-3623(98)00098-6 10.1016/S0306-3623(98) 00098-6 9888267 1:CAS:528:DyaK1cXnsFOqt7o%3D (Pubitemid 28540803)
4. JB Weinberg JW Larrick 1987 Receptor-mediated monocytoid differentiation of human promyelocytic cells by tumor necrosis factor: synergistic actions with interferon-gamma and 1,25-dihydroxyvitamin D3 Blood 70 994 1002 2820533 1:CAS:528:DyaL2sXmtFGqtr4%3D
5. YL Cho C Christensen DE Saunders, et al. 1991 Combined effects of 1,25-dihydroxyvitamin D3 and platinum drugs on the growth of MCF-7 cells Cancer Res 51 2848 2853 2032225 1:CAS:528:DyaK3MXkt1Wku7g%3D
6. A Ravid D Rocker A Machlenkin, et al. 1999 1,25-Dihydroxyvitamin D3 enhances the susceptibility of breast cancer cells to doxorubicin-induced oxidative damage Cancer Res 59 862 867 10029076 1:CAS:528:DyaK1MXht1Sis7c%3D
7. S Sundaram DA Gewirtz 1999 The vitamin D3 analog EB 1089 enhances the response of human breast tumor cells to radiation Radiat Res 152 479 486 10.2307/3580143 10.2307/3580143 10521924 1:CAS:528:DyaK1MXntFCitb4%3D (Pubitemid 29514149)
8. O Werz D Steinhilber 2006 Therapeutic options for 5-lipoxygenase inhibitors Pharmacol Ther 112 701 718 10.1016/j.pharmthera.2006.05.009 10.1016/j.pharmthera.2006.05.009 16837050 1:CAS:528:DC%2BD28XhtFSksr7L (Pubitemid 44592614)
9. D Visnjic D Batinic H Banfic 1997 Arachidonic acid mediates interferon-gamma-induced sphingomyelin hydrolysis and monocytic marker expression in HL-60 cell line Blood 89 81 91 8978280 1:CAS:528: DyaK2sXhsFarsg%3D%3D
10. J Hofmanova A Kozubik L Dusek, et al. 1998 Inhibitors of lipoxygenase metabolism exert synergistic effects with retinoic acid on differentiation of human leukemia HL-60 cells Eur J Pharmacol 350 273 284 10.1016/S0014-2999(98) 00264-7 10.1016/S0014-2999(98)00264-7 9696418 1:CAS:528:DyaK1cXktlKqtrw%3D (Pubitemid 28294056)
11. A Kozubik J Hofmanova L Dusek, et al. 1997 5-Lipoxygenase inhibitors potentiate effects of TGF-beta 1 on the differentiation of human leukemia HL-60 cells J Leukoc Biol 62 240 248 9261338 1:CAS:528:DyaK2sXltl2ju74%3D
12. J Stika J Vondracek J Hofmanova, et al. 2006 MK-886 enhances tumour necrosis factor-alpha-induced differentiation and apoptosis Cancer Lett 237 263 271 10.1016/j.canlet.2005.06.012 10.1016/j.canlet.2005.06.012 16039040 1:CAS:528:DC%2BD28XltF2qt78%3D (Pubitemid 43777082)
13. Y Ji GP Studzinski 2004 Retinoblastoma protein and CCAAT/enhancer-binding protein beta are required for 1,25-dihydroxyvitamin D3-induced monocytic differentiation of HL60 cells Cancer Res 64 370 377 10.1158/0008-5472.CAN-03- 3029 10.1158/0008-5472.CAN-03-3029 14729647 1:CAS:528:DC%2BD2cXkslyrtQ%3D%3D (Pubitemid 38114120)
14. AK Tse CK Wan XL Shen, et al. 2007 1,25-dihydroxyvitamin D3 induces biphasic NF-kappaB responses during HL-60 leukemia cells differentiation through protein induction and PI3K/Akt-dependent phosphorylation/degradation of IkappaB Exp Cell Res 313 1722 1734 10.1016/j.yexcr.2007.02.022 10.1016/j.yexcr.2007.02. 022 17397830 1:CAS:528:DC%2BD2sXksV2ku78%3D (Pubitemid 46589445)
15. PJ Hughes A Steinmeyer RA Chandraratna, et al. 2005 1alpha, 25-dihydroxyvitamin D3 stimulates steroid sulphatase activity in HL60 and NB4 acute myeloid leukaemia cell lines by different receptor-mediated mechanisms J Cell Biochem 94 1175 1189 10.1002/jcb.20377 10.1002/jcb.20377 15696548 1:CAS:528:DC%2BD2MXjtlOktrc%3D (Pubitemid 41420239)
16. X Wang GP Studzinski 2006 The requirement for and changing composition of the activating protein-1 transcription factor during differentiation of human leukemia HL60 cells induced by 1,25-dihydroxyvitamin D3 Cancer Res 66 4402 4409 10.1158/0008-5472.CAN-05-3109 10.1158/0008-5472.CAN-05-3109 16618766 1:CAS:528:DC%2BD28XjsFSlurw%3D
17. A Chen BH Davis M Bissonnette, et al. 1999 1,25-Dihydroxyvitamin D(3) stimulates activator protein-1-dependent Caco-2 cell differentiation J Biol Chem 274 35505 35513 10.1074/jbc.274.50.35505 10.1074/jbc.274.50.35505 10585423 1:CAS:528:DyaK1MXotVGns70%3D
18. S Krajewski S Bodrug M Krajewska, et al. 1995 Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo Am J Pathol 146 1309 1319 7778670 1:CAS:528:DyaK2MXms1SkurY%3D
19. M Leszczyniecka T Roberts P Dent, et al. 2001 Differentiation therapy of human cancer: basic science and clinical applications Pharmacol Ther 90 105 156 10.1016/S0163-7258(01)00132-2 10.1016/S0163-7258(01)00132-2 11578655 1:CAS:528:DC%2BD3MXntV2htbY%3D (Pubitemid 32926714)
20. S Inoshita K Takeda T Hatai, et al. 2002 Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress J Biol Chem 277 43730 43734 10.1074/jbc.M207951200 12223490 1:CAS:528:DC%2BD38Xos1alurs%3D (Pubitemid 36157790)
21. F Franek O Hohenwarter H Katinger 2000 Plant protein hydrolysates: preparation of defined peptide fractions promoting growth and production in animal cells cultures Biotechnol Prog 16 688 692 10.1021/bp0001011 10.1021/bp0001011 11027157 1:CAS:528:DC%2BD3cXmsFeisbs%3D (Pubitemid 30778861)
22. JA Sokoloski R Narayanan AC Sartorelli 1998 Enhancement by antisense oligonucleotides to NF-kappaB of the differentiation of HL-60 promyelocytic leukemia cells induced by vitamin D3 Cancer Lett 125 157 164 10.1016/S0304-3835(97)00505-3 10.1016/S0304-3835(97)00505-3 9566710 1:CAS:528:DyaK1cXhtVWht7g%3D (Pubitemid 28151923)
23. SY Wang LY Chen SJ Wang, et al. 1991 Growth inhibition and differentiation in HL-60 leukemia cells induced by 1,25-dihydroxyvitamin D3 and tumor necrosis factor alpha Exp Hematol 19 1025 1030 1915703 1:CAS:528:DyaK38Xlt1ansA%3D%3D
24. A Siwinska A Opolski A Chrobak, et al. 2001 Potentiation of the antiproliferative effect in vitro of doxorubicin, cisplatin and genistein by new analogues of vitamin D Anticancer Res 21 1925 1929 11497279 1:CAS:528:DC%2BD3MXmt1eqsL0%3D
25. GE Weitsman R Koren E Zuck, et al. 2005 Vitamin D sensitizes breast cancer cells to the action of H2O2: mitochondria as a convergence point in the death pathway Free Radic Biol Med 39 266 278 10.1016/j.freeradbiomed.2005.03.018 10.1016/j.freeradbiomed.2005.03.018 15964518 1:CAS:528:DC%2BD2MXlt1WitbY%3D (Pubitemid 40814552)
26. M Brungs O Radmark B Samuelsson, et al. 1994 On the induction of 5-lipoxygenase expression and activity in HL-60 cells: effects of vitamin D3, retinoic acid, DMSO and TGF beta Biochem Biophys Res Commun 205 1572 1580 10.1006/bbrc.1994.2846 10.1006/bbrc.1994.2846 7811238 1:CAS:528: DyaK2MXivV2rt7c%3D
27. H Suzuki N Katayama Y Ikuta, et al. 2004 Activities of granulocyte-macrophage colony-stimulating factor and interleukin-3 on monocytes Am J Hematol 75 179 189 10.1002/ajh.20010 10.1002/ajh.20010 15054806 1:CAS:528:DC%2BD2cXjslyktrk%3D (Pubitemid 38451090)
28. H Tanaka E Abe C Miyaura, et al. 1983 1Alpha,25-dihydroxyvitamin D3 induces differentiation of human promyelocytic leukemia cells (HL-60) into monocyte-macrophages, but not into granulocytes Biochem Biophys Res Commun 117 86 92 10.1016/0006-291X(83)91544-9 10.1016/0006-291X(83)91544-9 6581807 1:CAS:528:DyaL2cXjtVamsg%3D%3D
29. D Brackman F Lund-Johansen D Aarskog 1995 Expression of leukocyte differentiation antigens during the differentiation of HL-60 cells induced by 1,25-dihydroxyvitamin D3: comparison with the maturation of normal monocytic and granulocytic bone marrow cells J Leukoc Biol 58 547 555 7595056 1:CAS:528:DyaK2MXptleitrY%3D
30. E Marcinkowska A Kutner 2002 Side-chain modified vitamin D analogs require activation of both PI 3-K and erk1, 2 signal transduction pathways to induce differentiation of human promyelocytic leukemia cells Acta Biochim Pol 49 393 406 12362981 1:CAS:528:DC%2BD38XlsFCruro%3D
31. M Bhatia JB Kirkland KA Meckling-Gill 1994 M-CSF and 1,25 dihydroxy vitamin D3 synergize with 12-O-tetradecanoylphorbol-13-acetate to induce macrophage differentiation in acute promyelocytic leukemia NB4 cells Leukemia 8 1744 1749 7934171 1:STN:280:DyaK2M%2FhvFyiug%3D%3D
32. M Gianni M Terao C Gambacorti-Passerini, et al. 1996 Effects of 1,25-dihydroxy vitamin D3 on all-trans retinoic acid sensitive and resistant acute promyelocytic leukemia cells Biochem Biophys Res Commun 224 50 56 10.1006/bbrc.1996.0983 10.1006/bbrc.1996.0983 8694833 1:CAS:528: DyaK28XktF2rsLo%3D (Pubitemid 26252410)
33. U Testa F Grignani T Barberi, et al. 1994 PML/RAR alpha + U937 mutant and NB4 cell lines: retinoic acid restores the monocytic differentiation response to vitamin D3 Cancer Res 54 4508 4515 7519122 1:CAS:528:DyaK2cXlsV2ksrY%3D
34. M Bhatia JB Kirkland KA Meckling-Gill 1995 Monocytic differentiation of acute promyelocytic leukemia cells in response to 1, 25-dihydroxyvitamin D3 is independent of nuclear receptor binding J Biol Chem 270 15962 15965 10.1074/jbc.270.27.15962 10.1074/jbc.270.27.15962 7608152 1:CAS:528: DyaK2MXmvVGnsr4%3D
35. M Bhatia JB Kirkland KA Meckling-Gill 1996 1, 25-Dihydroxyvitamin D3 primes acute promyelocytic cells for TPA-induced monocytic differentiation through both PKC and tyrosine phosphorylation cascades Exp Cell Res 222 61 69 10.1006/excr.1996.0008 10.1006/excr.1996.0008 8549674 1:CAS:528: DyaK28Xnt1Ohtg%3D%3D
36. CS Clark JE Konyer KA Meckling 2004 1 Alpha, 25-dihydroxyvitamin D3 and bryostatin-1 synergize to induce monocytic differentiation of NB4 acute promyelocytic leukemia cells by modulating cell cycle progression Exp Cell Res 294 301 311 10.1016/j.yexcr.2003.11.013 10.1016/j.yexcr.2003.11.013 14980523 1:CAS:528:DC%2BD2cXhsV2gsbY%3D (Pubitemid 38229800)
37. XD Song AW Norman 1999 Bryostatin-1 and 1alpha, 25-dihydroxyvitamin D3 synergistically stimulate the differentiation of NB4 acute promyelocytic leukemia cells Leukemia 13 275 281 10.1038/sj.leu.2401261 10.1038/sj.leu.2401261 10025902 1:CAS:528:DyaK1MXhvVSjsbo%3D
38. CF Bennett MY Chiang BP Monia, et al. 1993 Regulation of 5-lipoxygenase and 5-lipoxygenase-activating protein expression in HL-60 cells Biochem J 289 Pt 1 33 39 8380989 1:CAS:528:DyaK3sXnslyhsw%3D%3D
39. M Brungs O Radmark B Samuelsson, et al. 1995 Sequential induction of 5-lipoxygenase gene expression and activity in Mono Mac 6 cells by transforming growth factor beta and 1, 25-dihydroxyvitamin D3 Proc Natl Acad Sci USA 92 107 111 10.1073/pnas.92.1.107 10.1073/pnas.92.1.107 7816797 1:CAS:528: DyaK2MXjtVegtbY%3D
40. O Werz N Schneider M Brungs, et al. 1997 A test system for leukotriene synthesis inhibitors based on the in vitro differentiation of the human leukemic cell lines HL-60 and Mono Mac 6 Naunyn Schmiedebergs Arch Pharmacol 356 441 445 10.1007/PL00005074 10.1007/PL00005074 9349629 1:CAS:528:DyaK2sXlvFOmu7c%3D (Pubitemid 27402082)
41. C Carlberg 1995 Mechanisms of nuclear signalling by vitamin D3. Interplay with retinoid and thyroid hormone signalling Eur J Biochem 231 517 527 10.1111/j.1432-1033.1995.tb20727.x 10.1111/j.1432-1033.1995.tb20727.x 7649150 1:CAS:528:DyaK2MXns1Ois7g%3D
42. S Seuter S Vaisanen O Radmark, et al. 2007 Functional characterization of vitamin D responding regions in the human 5-lipoxygenase gene Biochim Biophys Acta 1771 864 872 17500032 1:CAS:528:DC%2BD2sXmsFCmt78%3D
43. D Harle O Radmark B Samuelsson, et al. 1998 Calcitriol and transforming growth factor-beta upregulate 5-lipoxygenase mRNA expression by increasing gene transcription and mRNA maturation Eur J Biochem 254 275 281 10.1046/j.1432-1327. 1998.2540275.x 10.1046/j.1432-1327.1998.2540275.x 9660180 1:CAS:528: DyaK1cXjvFegsbY%3D (Pubitemid 28289380)
44. DE Zhang CJ Hetherington DA Gonzalez HM Chen DG Tenen 1994 Regulation of CD14 expression during monocytic differentiation induced with 1 alpha, 25-dihydroxyvitamin D3 J Immunol 153 3276 3284 7522257 1:CAS:528: DyaK2cXmt1yhsrg%3D
45. RW Craig 2002 MCL1 provides a window on the role of the BCL2 family in cell proliferation, differentiation and tumorigenesis Leukemia 16 444 454 10.1038/sj.leu.2402416 10.1038/sj.leu.2402416 11960321 1:CAS:528: DC%2BD38XjvFGnurw%3D
46. P Zhou L Qian CK Bieszczad, et al. 1998 Mcl-1 in transgenic mice promotes survival in a spectrum of hematopoietic cell types and immortalization in the myeloid lineage Blood 92 3226 3239 9787159 1:CAS:528:DyaK1cXntFCqsbg%3D
47. JT Opferman 2006 Unraveling MCL-1 degradation Cell Death Differ 13 1260 1262 10.1038/sj.cdd.4401978 10.1038/sj.cdd.4401978 16710358 1:CAS:528: DC%2BD28XmvFaitb8%3D (Pubitemid 44057455)
48. C Yang V Kaushal SV Shah, et al. 2007 Mcl-1 is downregulated in cisplatin-induced apoptosis, and proteasome inhibitors restore Mcl-1 and promote survival in renal tubular epithelial cells Am J Physiol Renal Physiol 292 F1710 F1717 10.1152/ajprenal.00505.2006 10.1152/ajprenal.00505.2006 17311906 1:CAS:528:DC%2BD2sXmvF2kurs%3D
49. HF Yang-Yen 2006 Mcl-1: a highly regulated cell death and survival controller J Biomed Sci 13 201 204 10.1007/s11373-005-9064-4 10.1007/s11373-005-9064-4 16456709 1:CAS:528:DC%2BD28XlvFehsrk%3D
50. X Wang GP Studzinski 1997 Antiapoptotic action of 1, 25-dihydroxyvitamin D3 is associated with increased mitochondrial MCL-1 and RAF-1 proteins and reduced release of cytochrome c Exp Cell Res 235 210 217 10.1006/excr.1997.3667 10.1006/excr.1997.3667 9281370 1:CAS:528:DyaK2sXlvVKgtL4%3D (Pubitemid 27381699)
51. AA van Puijenbroek S Wissink PT van der Saag, et al. 1999 Phospholipase A2 inhibitors and leukotriene synthesis inhibitors block TNF-induced NF-kappaB activation Cytokine 11 104 110 10.1006/cyto.1998.0404 10.1006/cyto.1998.0404 10089130 (Pubitemid 29116547)
52. Y Ji A Kutner A Verstuyf, et al. 2002 Derivatives of vitamins D2 and D3 activate three MAPK pathways and upregulate pRb expression in differentiating HL60 cells Cell Cycle 1 410 415 12548017 1:CAS:528:DC%2BD3sXitlOktbo%3D
53. E Marcinkowska E Garay E Gocek, et al. 2006 Regulation of C/EBPbeta isoforms by MAPK pathways in HL60 cells induced to differentiate by 1, 25-dihydroxyvitamin D3 Exp Cell Res 312 2054 2065 10.1016/j.yexcr.2006.03.003 10.1016/j.yexcr.2006.03.003 16624284 1:CAS:528:DC%2BD28Xls1Gqs7c%3D (Pubitemid 43850930)
54. X Wang J Rao GP Studzinski 2000 Inhibition of p38 MAP kinase activity up-regulates multiple MAP kinase pathways and potentiates 1, 25-dihydroxyvitamin D(3)-induced differentiation of human leukemia HL60 cells Exp Cell Res 258 425 437 10.1006/excr.2000.4939 10.1006/excr.2000.4939 10896794 1:CAS:528: DC%2BD3cXkvVWrsbc%3D (Pubitemid 30483521)
55. X Wang GP Studzinski 2001 Inhibition of p38MAP kinase potentiates the JNK/SAPK pathway and AP-1 activity in monocytic but not in macrophage or granulocytic differentiation of HL60 cells J Cell Biochem 82 68 77 10.1002/jcb.1141 10.1002/jcb.1141 11400164 1:CAS:528:DC%2BD3MXktFaju74%3D (Pubitemid 32500142)
56. H Ishigamori M Hosokawa H Kohno, et al. 2005 Docosahexaenoic acid-containing phosphatidylethanolamine enhances HL-60 cell differentiation by regulation of c-jun and c-myc expression Mol Cell Biochem 275 127 133 10.1007/s11010-005-1090-z 10.1007/s11010-005-1090-z 16335792 1:CAS:528:DC%2BD2MXmt1Gnsbk%3D (Pubitemid 41030988)
57. M Humar T Loop R Schmidt, et al. 2007 The mitogen-activated protein kinase p38 regulates activator protein 1 by direct phosphorylation of c-Jun Int J Biochem Cell Biol 39 2278 2288 10.1016/j.biocel.2007.06.013 10.1016/j.biocel.2007.06.013 17689131 1:CAS:528:DC%2BD2sXhtFWgsL3L (Pubitemid 47484282)
58. S Yamagishi M Yamada Y Ishikawa, et al. 2001 p38 mitogen-activated protein kinase regulates low potassium-induced c-Jun phosphorylation and apoptosis in cultured cerebellar granule neurons J Biol Chem 276 5129 5133 10.1074/jbc.M007258200 10.1074/jbc.M007258200 11083864 1:CAS:528: DC%2BD3MXhtlyjsr0%3D
59. JC Lee S Kumar DE Griswold, et al. 2000 Inhibition of p38 MAP kinase as a therapeutic strategy Immunopharmacology 47 185 201 10.1016/S0162-3109(00)00206- X 10.1016/S0162-3109(00)00206-X 10878289 1:CAS:528:DC%2BD3cXktlKkt7Y%3D (Pubitemid 30394538)
60. T Zarubin J Han 2005 Activation and signaling of the p38 MAP kinase pathway Cell Res 15 11 18 10.1038/sj.cr.7290257 10.1038/sj.cr.7290257 15686620 1:CAS:528:DC%2BD2MXkslGisb4%3D (Pubitemid 41653958)
61. SP Davies H Reddy M Caivano, et al. 2000 Specificity and mechanism of action of some commonly used protein kinase inhibitors Biochem J 351 95 105 10.1042/0264-6021:3510095 10.1042/0264-6021:3510095 10998351 1:CAS:528:DC%2BD3cXnslWltrY%3D (Pubitemid 30781561)
62. CL Manthey SW Wang SD Kinney, et al. 1998 SB202190, a selective inhibitor of p38 mitogen-activated protein kinase, is a powerful regulator of LPS-induced mRNAs in monocytes J Leukoc Biol 64 409 417 9738669 1:CAS:528: DyaK1cXmtVOlsLo%3D
63. PR Young MM McLaughlin S Kumar, et al. 1997 Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site J Biol Chem 272 12116 12121 10.1074/jbc.272.18.12116 10.1074/jbc.272.18.12116 9115281 1:CAS:528:DyaK2sXivF2kt7w%3D (Pubitemid 27202792)
64. Y Ishii S Sakai Y Honma 2001 Pyridinyl imidazole inhibitor SB203580 activates p44/42 mitogen-activated protein kinase and induces the differentiation of human myeloid leukemia cells Leuk Res 25 813 820 10.1016/S0145-2126(01)00026-1 10.1016/S0145-2126(01)00026-1 11489475 1:CAS:528:DC%2BD3MXlslertbs%3D (Pubitemid 32727983)
65. Zhang J, Posner GH, Danilenko M et al. (2007) Differentiation-inducing potency of the seco-steroid JK-1624F2-2 can be increased by combination with an antioxidant and a p38MAPK inhibitor which upregulates the JNK pathway. J Steroid Biochem Mol Biol 105:140-149
66. JM Wang MZ Lai HF Yang-Yen 2003 Interleukin-3 stimulation of mcl-1 gene transcription involves activation of the PU.1 transcription factor through a p38 mitogen-activated protein kinase-dependent pathway Mol Cell Biol 23 1896 1909 10.1128/MCB.23.6.1896-1909.2003 10.1128/MCB.23.6.1896-1909.2003 12612065 1:CAS:528:DC%2BD3sXhvF2isL4%3D (Pubitemid 36278804)
67. DE Zhang CJ Hetherington HM Chen, et al. 1994 The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor Mol Cell Biol 14 373 381 8264604 1:CAS:528:DyaK2cXnsFWqug%3D%3D
68. HL Pahl RJ Scheibe DE Zhang, et al. 1993 The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter J Biol Chem 268 5014 5020 8095266 1:CAS:528:DyaK3sXit1OgtLo%3D