Mechanisms of tolerance induction by a gene-transferred peptide-IgG fusion protein expressed in B lineage cells

Journal of Immunology

Volumn 165, Issue 10, 2000, Pages 5631-5636

  El Amine, M ^a   Melo, M ^a   Kang, Y ^a   Nguyen, H ^a   Qian, J ^a   Scott, D W ^a  

^a HOLLAND LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; HYBRID PROTEIN; IMMUNOGLOBULIN G; INTERLEUKIN 10; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; B LYMPHOCYTE; CELL LINEAGE; CONTROLLED STUDY; GENE INDUCTION; GENE THERAPY; GENE TRANSFER; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REPRESSOR GENE; SIGNAL TRANSDUCTION;

EID: 0034669953     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.10.5631     Document Type: Article

References (25)

1. Multiple pathways of B lymphocyte tolerance
2. Epitope-specific tolerance induction with an engineered immunoglobulin
3. Both resting and activated B lymphocytes expressing engineered peptide-Ig molecules serve as highly efficient tolerogenic vehicles in immunocompetent adult recipients
4. Genetically transferred central and peripheral immune tolerance via retroviral-mediated expression of immunogenic epitopes in hematopoietic progenitors or peripheral B lymphocytes
5. Murine MHC polymorphism and T cell specificities
6. Long-term expression of a T-cell receptor beta-chain gene in mice reconstituted with retrovirus-infected hematopoietic stem cells
7. Induction of hyporesponsiveness to intact foreign protein via retroviral-mediated gene expression: The IgG scaffold is important for induction and maintenance of immune hyporesponsiveness
8. Antigen presentation in acquired immunological tolerance
9. Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens
10. Parameters of tolerance induction by antigen targeted to B lymphocytes
11. B cells turn off virgin but not memory T cells
12. T cell epitope selection: Dominance may be determined by both affinity for major histocompatibility complex and stoichiometry of epitope
13. MHC class II-restricted presentation of intracellular antigen
14. Interleukin 10, a novel B cell stimulatory factor: Unresponsiveness of X chromosome-linked immunodeficiency B cells
15. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes
16. Interleukin 10 and transforming growth factor β cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A
17. Interleukin-10 gene knock-out mice: A model of chronic inflammation
18. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement
19. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation [see comments]
20. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
21. CTLA-4 ligation blocks CD28-dependent T cell activation
22. Is CTLA-4 a master switch for peripheral T cell tolerance?
23. Comparative analysis of B7-1 and B7-2 costimulatory ligands: Expression and function
24. Neonatal exposure to a self-peptide-immunoglobulin chimera circumvents the use of adjuvant and confers resistance to autoimmune disease by a novel mechanism involving interleukin 4 lymph node deviation and interferon-γ-mediated splenic anergy
25. Retroviral gene transfer of an immunoglobulin-antigen fusion construct protects from experimental autoimmune uveitis