Radioprotective action of extracellular adenosine on bone marrow cells in mice exposed to gamma rays as assayed by the micronucleus test

Radiation Research

Volumn 154, Issue 2, 2000, Pages 217-221

  Hofer, M ^a   Mazur, L ^b   Pospisil M ^a   Weiterova L ^a   Znojil, V ^c  

^a INSTITUTE OF BIOPHYSICS   (Czech Republic)

^b JAGIELLONIAN UNIVERSITY   (Poland)

^c MASARYK UNIVERSITY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; DIPYRIDAMOLE;

ANIMAL CELL; ANIMAL EXPERIMENT; BONE MARROW CELL; CONFERENCE PAPER; CONTROLLED STUDY; GAMMA RADIATION; MALE; MICRONUCLEUS TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION EXPOSURE; RADIATION PROTECTION;

ANIMALIA;

EID: 0033861953     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/0033-7587(2000)154[0217:RAOEAO]2.0.CO;2     Document Type: Conference Paper

References (29)

1. H. Langendorff and M. Langendorff, Adenosin-Nukleotide und Strahlenempfindlichkeit. Strahlentherapie 144, 451-456 (1972).
2. G. A. Grant, J. A. Barlow and K. E. Leach, Modification of survival of gamma irradiated mice by adenosine nucleotides. Strahlentherapie 152, 285-291 (1976).
3. M. V. Tikhomirova and P. N. Yashkin, Comparative radioprotective effects of adenylates against short-term and long-term gamma irradiation. Radiobiologiya 23, 100-104 (1986). [in Russian]
4. S. B. Coade and J. D. Pearson, Metabolism of adenine nucleotides in human blood. Circ. Res. 65, 531-537 (1989).
5. J. W. Daly, Adenosine receptors: Target for future drugs. J. Med. Chem. 25, 197-207 (1982).
6. M. Pospíšil, M. Hofer, J. Netíková, S. Viklická, I. Pipalová and A. Bartonícková, Effect of dipyridamole and adenosine monophosphate on cell proliferation in the hemopoietic tissue of normal and gamma-irradiated mice. Experientia 48, 253-257 (1992).
7. M. Pospíšil, M. Hofer, J. Netíková, I. Pipalová, A. Vacek, A. Bartonícková and K. Volenec, Elevation of extracellular adenosine induces radioprotective effects in mice. Radiat. Res. 134, 323-330 (1993).
8. M. Pospíšil, M. Hofer, V. Znojil, J. Vácha, J. Netíková and J. Hola, Radioprotection of mouse hemopoiesis by dipyridamole and adenosine monophosphate in fractionated treatment. Radiat. Res. 142, 16-22 (1995).
9. M. Hofer, M. Pospíšil, J. Netíková, V. Znojil, J. Vácha and J. Holá, Radioprotective efficacy of dipyridamole and AMP combination in fractionated radiation regimen, and its dependence on the time of administration of the drugs prior to irradiation. Physiol. Res. 44, 93-98 (1995).
10. B. Hosek, J. Bohácek, J. Sikulová, M. Pospíšil and A. Vacek, Protection of early cellular damage in 1 Gy-irradiated mice by the elevation of extracellular adenosine. Radiat. Environ. Biophys. 31, 289-297 (1992).
11. J. Bohácek, B. Hosek and M. Pospíšil, Postirradiation administration of adenosine monophosphate combined with dipyridamole reduces early cellular damage in mice. Life Sci. 53, 1317-1324 (1993).
12. S-A. Poulsen and R. J. Quinn, Adenosine receptors: New opportunities for future drugs. Bioorg. Med. Chem. 6, 619-641 (1998).
13. M. P. Abbracchio and G. Burnstock, Purinergic signalling: Pathophysiological roles. Jpn. J. Pharmacol. 78, 113-145 (1998).
14. W. Schmidt, The micronucleus test. Mutat. Res. 31, 9-15 (1975).
15. J. A. Heddle and M. F. Salamone, Chromosomal aberrations and bone marrow toxicity. Environ. Health Perspect. 39, 23-27 (1981).
16. Z. Almassy, A. B. Krepinsky, A. Bianco and G. J. Koteles, The present state and perspectives of micronucleus assay in radiation protection. A review. Appl. Radiat, Isot. 38, 241-249 (1987).
17. K. H. Mavournin, D. H. Blakey, M. C. Cimino, M. F. Salamone and J. A. Heddle, The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat. Res. 239, 29-80 (1990).
18. S. Pascoe and D. Gatehouse, The use of a simple hematoxylin and eosin staining procedure to demonstrate micronuclei within rodent hone marrow. Mutat. Res. 164, 237-243 (1986).
19. S. Holm, A simple sequentially rejective multiple test procedure. Scand. J.Stat. 6, 65-70 (1979).
20. L. Mazur, Induction of micronucleated erythrocytes by MEA, AET, WR-2721 and X-rays. Mutat. Res. 334, 317-322 (1995).
21. A. Ganasoundari, P. Uma Devi and B. S. S. Rao, Enhancement of hone marrow radioprotection and reduction of WR-2721 toxicity by Ocimum sanctum. Mutat. Res. 397, 303-312 (1998).
22. A. P. Simula and B. G. Priestley, Influence of vegetable oil vehicles on bone-marrow proliferation in the mouse micronucleus test. Mutat. Res. 261, 83-84 (1991).
23. F. Zalman, M. A. Maloney and H. M. Patt, Differential response of early erythropoietic and granulopoietic progenitors to dexamethasone and cortisone. J. Exp. Med. 149, 67-72 (1979).
24. M. G. Collis, The vasodilator role of adenosine. Pharmacol. Ther. 41, 143-162 (1989).
25. L. Belardinelli, J. Linden and R. M. Berne, The cardiac effects of adenosine. Prog. Cardiovasc. Dis. 32, 73-97 (1989).
26. L. Iuliano, F. Violi, A. Ghiselli, C. Alessandri and F. Balsano, Dipyridamole inhibits lipid peroxidation and scavenges oxygen radicals. Lipids 24, 430-433 (1989).
27. T. L. Phillips and G. E. Hanks, Apparent absence of recovery in endogenous colony-forming cells after irradiation under hypoxic conditions. Radiat. Res. 33, 517-532 (1968).
28. B. Littbrand, Survival characteristics of mammalian cell lines after single or multiple exposures to roentgen radiation under oxic or anoxic conditions. Acta Radiol. Ther. Phys. Biol. 9, 257-281 (1970).
29. J. M. Yuhas, J. O. Proctor and L. H. Smith, Some pharmacologic effects of WR-2721: Their role in toxicity and radioprotection. Radiat. Res. 54, 222-233 (1973).