Critical factors influencing the in vivo performance of long-acting lipophilic solutions-impact on in vitro release method design

AAPS Journal

Volumn 11, Issue 4, 2009, Pages 762-770

  Weng Larsen, Susan ^a   Larsen, Claus ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Depot effect; In vitro in vivo correlations; In vitro release methods; Lipophilic solutions; Parenteral administration

Indexed keywords

BUPIVACAINE; BUPRENORPHINE; CASTOR OIL; COCONUT OIL; COTTON SEED OIL; ESTRADIOL VALERATE; FLUPHENAZINE DECANOATE; HALOPERIDOL DECANOATE; SESAME SEED OIL; TESTOSTERONE CIPIONATE; TESTOSTERONE UNDECANOATE; ZUCLOPENTHIXOL ACETATE;

BIOEQUIVALENCE; CONTROLLED DRUG RELEASE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG LYMPH LEVEL; DRUG TRANSPORT; DRUG UPTAKE; HALF LIFE TIME; HUMAN; HYPOGONADISM; INTERFACE PRESSURE; LIPOPHILICITY; MEAN RESIDENCE TIME; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; REVIEW; SINGLE DRUG DOSE;

ANIMALS; BODY FLUIDS; DELAYED-ACTION PREPARATIONS; DRUG DESIGN; HUMANS; INJECTIONS; LIPIDS; LYMPHATIC SYSTEM; PHARMACEUTICAL SOLUTIONS; SOLUBILITY;

EID: 72949121224     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-009-9153-9     Document Type: Review

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