메뉴 건너뛰기




Volumn 34, Issue 4, 2005, Pages 178-187

Pharmacokinetics and pharmacodynamics of injectable testosterone undecanoate in castrated cynomolgus monkeys (Macaca fascicularis) are independent of different oil vehicles

Author keywords

Castor oil; Macaque; Pharmacokinetics; Soybean oil; Tea seed oil; Testosterone undecanoate

Indexed keywords

CASTOR OIL; ESTRADIOL; FOLLITROPIN; LUTEINIZING HORMONE; SOYBEAN OIL; TESTOSTERONE; TESTOSTERONE UNDECANOATE;

EID: 21644451146     PISSN: 00472565     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0684.2005.00115.x     Document Type: Article
Times cited : (9)

References (40)
  • 1
    • 0033014486 scopus 로고    scopus 로고
    • Intramuscular injection of testosterone undecanoate for the treatment of male hypogonadism: Phase I studies
    • Behre HM, Abshagen K, Oettel M, Hubler D, Nieschlag E: Intramuscular injection of testosterone undecanoate for the treatment of male hypogonadism: phase I studies. Eur J Endocrinol 140:414-419, 1999.
    • (1999) Eur. J. Endocrinol. , vol.140 , pp. 414-419
    • Behre, H.M.1    Abshagen, K.2    Oettel, M.3    Hubler, D.4    Nieschlag, E.5
  • 2
    • 0015547910 scopus 로고
    • Comparative studies on the enzymatic cleavage of steroid esters in different tissues of the rat and in adipose human tissue
    • Bellman O, Gerhards E: Comparative studies on the enzymatic cleavage of steroid esters in different tissues of the rat and in adipose human tissue. Acta Endocrinol Suppl (Copenh) 173:138-143, 1973.
    • (1973) Acta. Endocrinol. Suppl. (Copenh.) , vol.173 , pp. 138-143
    • Bellman, O.1    Gerhards, E.2
  • 4
    • 0023872773 scopus 로고
    • Estrogen and androgen dynamics in the cynomolgus monkey
    • Bourget C, Femino A, Franz C, Longcope C: Estrogen and androgen dynamics in the cynomolgus monkey. Endocrinology 122:202-206, 1988.
    • (1988) Endocrinology , vol.122 , pp. 202-206
    • Bourget, C.1    Femino, A.2    Franz, C.3    Longcope, C.4
  • 5
    • 0015892306 scopus 로고
    • The effect of short-term testosterone administration on serum FSH, LH and testosterone levels: Evidence for selective abnormality in LH control in patients with Klinefelter's syndrome
    • Capell PT, Paulsen CA, Derleth D, Skoglund R, Plymate S: The effect of short-term testosterone administration on serum FSH, LH and testosterone levels: evidence for selective abnormality in LH control in patients with Klinefelter's syndrome. J Clin Endocrinol Metab 37:752-759, 1973.
    • (1973) J. Clin. Endocrinol. Metab. , vol.37 , pp. 752-759
    • Capell, P.T.1    Paulsen, C.A.2    Derleth, D.3    Skoglund, R.4    Plymate, S.5
  • 6
    • 0028220079 scopus 로고
    • Effects of castration and recombinant human inhibin administration on circulating levels of inhibin and gonadotropins in adult male monkeys
    • Christensen RB, Forage RB, Steiner RA, Bremner WJ: Effects of castration and recombinant human inhibin administration on circulating levels of inhibin and gonadotropins in adult male monkeys. J Androl 15:125-131, 1994.
    • (1994) J. Androl. , vol.15 , pp. 125-131
    • Christensen, R.B.1    Forage, R.B.2    Steiner, R.A.3    Bremner, W.J.4
  • 7
    • 0023578432 scopus 로고
    • In the rhesus monkey (Macaca mulatta), the negative feedback regulation of follicle-stimulating hormone secretion by an action of testicular hormone directly at the level of the anterior pituitary gland cannot be accounted for by either testosterone or estradiol
    • Dubey AK, Zeleznik AJ, Plant TM: In the rhesus monkey ( Macaca mulatta), the negative feedback regulation of follicle-stimulating hormone secretion by an action of testicular hormone directly at the level of the anterior pituitary gland cannot be accounted for by either testosterone or estradiol. Endocrinology 121:2229-2237, 1987.
    • (1987) Endocrinology , vol.121 , pp. 2229-2237
    • Dubey, A.K.1    Zeleznik, A.J.2    Plant, T.M.3
  • 8
    • 0036220738 scopus 로고    scopus 로고
    • Treatment of male hypogonadism with testosterone undecanoate injected at extended intervals of 12 weeks: A phase II study
    • von Eckardstein S, Nieschlag E: Treatment of male hypogonadism with testosterone undecanoate injected at extended intervals of 12 weeks: a phase II study. J Androl 23:419-425, 2002.
    • (2002) J. Androl. , vol.23 , pp. 419-425
    • von Eckardstein, S.1    Nieschlag, E.2
  • 9
    • 0021058820 scopus 로고
    • Effects of pharmacological doses of testosterone and dihydrotestosterone on the hypothalamic-pituitary axis function of Klinefelter patients
    • Forti G, Vannucchi PL, Borghi A, Giusti G, Fusi S, Serio M: Effects of pharmacological doses of testosterone and dihydrotestosterone on the hypothalamic-pituitary axis function of Klinefelter patients. J Endocrinol Invest 6:297-300, 1983.
    • (1983) J. Endocrinol. Invest. , vol.6 , pp. 297-300
    • Forti, G.1    Vannucchi, P.L.2    Borghi, A.3    Giusti, G.4    Fusi, S.5    Serio, M.6
  • 10
    • 0019362160 scopus 로고
    • Hydrogenated soybean oil (HSO) as a vehicle for the chronic and controlled administration of testosterone in the orchidectomized rat
    • Gerrity M, Freund M, Peterson RN, Falvo RE: Hydrogenated soybean oil (HSO) as a vehicle for the chronic and controlled administration of testosterone in the orchidectomized rat. Int J Androl 4:494-504, 1981.
    • (1981) Int. J. Androl. , vol.4 , pp. 494-504
    • Gerrity, M.1    Freund, M.2    Peterson, R.N.3    Falvo, R.E.4
  • 12
    • 0024241665 scopus 로고
    • The periurethral zone of the prostate of the cynomolgus monkey is the most sensitive prostate part for an estrogenic stimulus
    • Habenicht UF, el Etreby MF: The periurethral zone of the prostate of the cynomolgus monkey is the most sensitive prostate part for an estrogenic stimulus. Prostate 13:305-316, 1988.
    • (1988) Prostate , vol.13 , pp. 305-316
    • Habenicht, U.F.1    el Etreby, M.F.2
  • 13
    • 0023578910 scopus 로고
    • Induction of estrogen-related hyperplastic changes in the prostate of the cynomolgus monkey (Macaca fascicularis) by androstenedione and its antagonization by the aromatase inhibitor 1-methyl-androsta-1,4-diene-3,17-dione
    • Habenicht UF, Schwarz K, Neumann F, el Etreby MF: Induction of estrogen-related hyperplastic changes in the prostate of the cynomolgus monkey (Macaca fascicularis) by androstenedione and its antagonization by the aromatase inhibitor 1-methyl-androsta-1,4-diene-3,17-dione. Prostate 11:313-326, 1987.
    • (1987) Prostate , vol.11 , pp. 313-326
    • Habenicht, U.F.1    Schwarz, K.2    Neumann, F.3    el Etreby, M.F.4
  • 15
  • 16
    • 0031005249 scopus 로고    scopus 로고
    • The cynomolgus monkey prostate under physiological and hypogonadal conditions: An ultrasonographic study
    • Kamischke A, Behre HM, Weinbauer GF, Nieschlag E: The cynomolgus monkey prostate under physiological and hypogonadal conditions: an ultrasonographic study. J Urol 157:2340-2344, 1997.
    • (1997) J. Urol. , vol.157 , pp. 2340-2344
    • Kamischke, A.1    Behre, H.M.2    Weinbauer, G.F.3    Nieschlag, E.4
  • 17
    • 0013104891 scopus 로고    scopus 로고
    • Prostate volume measurement in the cynomolgus monkey by ultrasonography
    • Weinbauer & Korte (eds). Münster: Waxmann
    • Kamischke A, Weinbauer GF, Nieschlag E: Prostate volume measurement in the cynomolgus monkey by ultrasonography. In: Reproduction in Non-human Primates. Weinbauer & Korte (eds). Münster: Waxmann 141-149, 1999.
    • (1999) Reproduction in Non-human Primates , pp. 141-149
    • Kamischke, A.1    Weinbauer, G.F.2    Nieschlag, E.3
  • 18
    • 0032846108 scopus 로고    scopus 로고
    • Estradiol and high-dose dihydrotestosterone treatment causes changes in cynomolgus monkey prostate volume and histology identical to those caused by testosterone alone
    • Kamischke A, Weinbauer GF, Semjonow A, Lerchl A, Richter KD, Nieschlag E: Estradiol and high-dose dihydrotestosterone treatment causes changes in cynomolgus monkey prostate volume and histology identical to those caused by testosterone alone. J Androl 20:601-610, 1999.
    • (1999) J. Androl. , vol.20 , pp. 601-610
    • Kamischke, A.1    Weinbauer, G.F.2    Semjonow, A.3    Lerchl, A.4    Richter, K.D.5    Nieschlag, E.6
  • 20
    • 0020616186 scopus 로고
    • Heterologous radioimmunoassays for monkey gonadotrophins. I. Assessment of the reagents proposed for the assay of FSH
    • Khan SA, Diczfalusy E: Heterologous radioimmunoassays for monkey gonadotrophins. I. Assessment of the reagents proposed for the assay of FSH. Acta Endocrinol (Copenh) 104:15-22. 1983.
    • (1983) Acta Endocrinol. (Copenh.) , vol.104 , pp. 15-22
    • Khan, S.A.1    Diczfalusy, E.2
  • 21
    • 0019862562 scopus 로고
    • The prostate of the nonhuman primate: Normal anatomy and pathology
    • Lewis RW, Kim JC, Irani D, Roberts JA: The prostate of the nonhuman primate: normal anatomy and pathology. Prostate 2:51-70, 1981.
    • (1981) Prostate , vol.2 , pp. 51-70
    • Lewis, R.W.1    Kim, J.C.2    Irani, D.3    Roberts, J.A.4
  • 22
    • 1842483372 scopus 로고    scopus 로고
    • Hormonal contraception in chinese men: Variations in suppression of spermatogenesis with injectable testosterone undecanoate and levonorgestrel implants
    • Liu S, Gui Y, Lin C, He C: Hormonal contraception in chinese men: variations in suppression of spermatogenesis with injectable testosterone undecanoate and levonorgestrel implants. Asian J Androl 6:41-46, 2004.
    • (2004) Asian J. Androl. , vol.6 , pp. 41-46
    • Liu, S.1    Gui, Y.2    Lin, C.3    He, C.4
  • 24
    • 3242693878 scopus 로고    scopus 로고
    • Clinical use of testosterone in hypogonadism and other conditions
    • 3rd edn. Nieschlag & Behre (eds). Cambridge: Cambridge University Press
    • Nieschlag E, Behre HM: Clinical use of testosterone in hypogonadism and other conditions. In: Testosterone: Action, Deficiency, Substitution, 3rd edn. Nieschlag & Behre (eds). Cambridge: Cambridge University Press 375-404, 2004.
    • (2004) Testosterone: Action, Deficiency, Substitution , pp. 375-404
    • Nieschlag, E.1    Behre, H.M.2
  • 25
    • 0033383771 scopus 로고    scopus 로고
    • Repeated intramuscular injections of testosterone undecanoate for substitution therapy in hypogonadal men
    • (Oxford)
    • Nieschlag E, Büchter D, von Eckardstein S, Abshagen K, Simoni M, Behre HM: Repeated intramuscular injections of testosterone undecanoate for substitution therapy in hypogonadal men. Clin Endocrinol (Oxford) 51:757-763, 1999.
    • (1999) Clin. Endocrinol. , vol.51 , pp. 757-763
    • Nieschlag, E.1    Büchter, D.2    von Eckardstein, S.3    Abshagen, K.4    Simoni, M.5    Behre, H.M.6
  • 26
    • 13844290475 scopus 로고    scopus 로고
    • Hormonal male contraception: The essential role of testosterone
    • 3rd edn. Nieschlag & Behre (eds). Cambridge: Cambridge University Press
    • Nieschlag E, Kamischke A, Behre HM: Hormonal male contraception: the essential role of testosterone. In: Testosterone: Action, Deficiency, Substitution, 3rd edn. Nieschlag & Behre (eds). Cambridge: Cambridge University Press 685-714, 2004.
    • (2004) Testosterone: Action, Deficiency, Substitution , pp. 685-714
    • Nieschlag, E.1    Kamischke, A.2    Behre, H.M.3
  • 27
    • 0028949882 scopus 로고
    • Injectable testosterone undecanoate has more favourable pharmacokinetics and pharmacodynamics than testosterone enanthate
    • Partsch CJ, Weinbauer GF, Fang R, Nieschlag E: Injectable testosterone undecanoate has more favourable pharmacokinetics and pharmacodynamics than testosterone enanthate. Eur J Endocrinol 132:514-519. 1995.
    • (1995) Eur. J. Endocrinol. , vol.132 , pp. 514-519
    • Partsch, C.J.1    Weinbauer, G.F.2    Fang, R.3    Nieschlag, E.4
  • 28
    • 0024847311 scopus 로고
    • Testosterone therapy in Klinefelter's syndrome (a prolonged observation)
    • Ruvalcaba RH: Testosterone therapy in Klinefelter's syndrome (a prolonged observation). Andrologia 21:535-541, 1989.
    • (1989) Andrologia , vol.21 , pp. 535-541
    • Ruvalcaba, R.H.1
  • 29
    • 0034969634 scopus 로고    scopus 로고
    • Studies on the oestrogenic activity of soybean oil on albino rats
    • el Sattar El Baltran SA: Studies on the oestrogenic activity of soybean oil on albino rats. Boll Chim Farm 140:119-124, 2001.
    • (2001) Boll. Chim. Farm. , vol.140 , pp. 119-124
    • el Sattar, El.1    Baltran, S.A.2
  • 30
    • 0032880734 scopus 로고    scopus 로고
    • Cloning and expression of cynomolgus monkey (Macaca fascicularis) gonadotropins luteinizing hormone and follicle-stimulating hormone and identification of two polymorphic sites in the luteinizing hormone β subunit
    • Schmidt A, Gromoll J, Weinbauer GF, Galla HJ, Chappel, S, Simoni M: Cloning and expression of cynomolgus monkey (Macaca fascicularis) gonadotropins luteinizing hormone and follicle-stimulating hormone and identification of two polymorphic sites in the luteinizing hormone β subunit. Mol Cell Endocrinol 156:73-83, 1999.
    • (1999) Mol. Cell. Endocrinol. , vol.156 , pp. 73-83
    • Schmidt, A.1    Gromoll, J.2    Weinbauer, G.F.3    Galla, H.J.4    Chappel, S.5    Simoni, M.6
  • 31
    • 0022445577 scopus 로고
    • New injectable testosterone ester maintains serum testosterone of castrated monkeys in the normal range for four months
    • Weinbauer GF, Marshall GR, Nieschlag E: New injectable testosterone ester maintains serum testosterone of castrated monkeys in the normal range for four months. Acta Endocrinol (Copenh) 113:128-132, 1986.
    • (1986) Acta Endocrinol. (Copenh.) , vol.113 , pp. 128-132
    • Weinbauer, G.F.1    Marshall, G.R.2    Nieschlag, E.3
  • 32
    • 0025240037 scopus 로고
    • Pharmacokinetics and pharmacodynamics of testosterone enanthate and dihydrotestosterone enanthate in non-human primates
    • Weinbauer GF, Jackwerth B, Yoon YD, Behre HM, Yeung CH, Nieschlag E: Pharmacokinetics and pharmacodynamics of testosterone enanthate and dihydrotestosterone enanthate in non-human primates. Acta Endocrinol (Copenh) 122:432-442, 1990.
    • (1990) Acta Endocrinol. (Copenh.) , vol.122 , pp. 432-442
    • Weinbauer, G.F.1    Jackwerth, B.2    Yoon, Y.D.3    Behre, H.M.4    Yeung, C.H.5    Nieschlag, E.6
  • 33
    • 0035144309 scopus 로고    scopus 로고
    • Testosterone-induced inhibition of spermatogenesis is more closely related to suppression of FSH than to testicular androgen levels in the cynomolgus monkey model (Macaca fascicularis)
    • Weinbauer GF, Schlatt S, Walter V, Nieschlag E: Testosterone-induced inhibition of spermatogenesis is more closely related to suppression of FSH than to testicular androgen levels in the cynomolgus monkey model (Macaca fascicularis). J Endocrinol 168:25-38, 2001.
    • (2001) J. Endocrinol. , vol.168 , pp. 25-38
    • Weinbauer, G.F.1    Schlatt, S.2    Walter, V.3    Nieschlag, E.4
  • 34
    • 0642373679 scopus 로고    scopus 로고
    • Pharmacokinetics and degree of aromatization rather than total dose of different preparations determine the effects of testosterone: A nonhuman primate study in Macaca fascicularis
    • Weinbauer GF, Partsch CJ, Zitzmann M, Schlatt S, Nieschlag E: Pharmacokinetics and degree of aromatization rather than total dose of different preparations determine the effects of testosterone: a nonhuman primate study in Macaca fascicularis. J Androl 24:765-774, 2003.
    • (2003) J. Androl. , vol.24 , pp. 765-774
    • Weinbauer, G.F.1    Partsch, C.J.2    Zitzmann, M.3    Schlatt, S.4    Nieschlag, E.5
  • 35
    • 0023781546 scopus 로고
    • Estrogen and progestin receptors and aromatase activity in rhesus monkey prostate
    • West NB, Roselli CE, Resko JA, Greene GL, Brenner RM: Estrogen and progestin receptors and aromatase activity in rhesus monkey prostate. Endocrinology 123:2312-2322, 1988.
    • (1988) Endocrinology , vol.123 , pp. 2312-2322
    • West, N.B.1    Roselli, C.E.2    Resko, J.A.3    Greene, G.L.4    Brenner, R.M.5
  • 36
    • 0018913067 scopus 로고
    • Seasonality in endocrine and exocrine testicular function of the adult rhesus monkey (Macaca mulatta) maintained in a controlled laboratory environment
    • Wickings EJ, Nieschlag E: Seasonality in endocrine and exocrine testicular function of the adult rhesus monkey (Macaca mulatta) maintained in a controlled laboratory environment. Int J Androl 3:87-104, 1980.
    • (1980) Int. J. Androl. , vol.3 , pp. 87-104
    • Wickings, E.J.1    Nieschlag, E.2
  • 37
    • 0018537702 scopus 로고
    • Determination of biologically active LH in the serum of male rhesus monkeys
    • Wickings EJ, Quazi MH, Nieschlag E: Determination of biologically active LH in the serum of male rhesus monkeys. J Reprod Fertil 57:497-504, 1979.
    • (1979) J. Reprod. Fertil. , vol.57 , pp. 497-504
    • Wickings, E.J.1    Quazi, M.H.2    Nieschlag, E.3
  • 38
    • 0023119364 scopus 로고
    • The role of gonadal steroids in feedback regulation of gonadotropin secretion at different stages of primate development
    • Winter JSD, Ellsworth L, Fuller G, Hobson WC, Reyes FI, Faiman C: The role of gonadal steroids in feedback regulation of gonadotropin secretion at different stages of primate development. Acta Endocrinol (Copenh) 114:257-268, 1987.
    • (1987) Acta Endocrinol. (Copenh.) , vol.114 , pp. 257-268
    • Winter, J.S.D.1    Ellsworth, L.2    Fuller, G.3    Hobson, W.C.4    Reyes, F.I.5    Faiman, C.6
  • 40
    • 0033304546 scopus 로고    scopus 로고
    • A clinical trial of injectable testosterone undecanoate as a potential male contraceptive in normal Chinese men
    • Zhang GY, Gu YQ, Wang XH, Cui YG, Bremner WJ: A clinical trial of injectable testosterone undecanoate as a potential male contraceptive in normal Chinese men. J Clin Endocrinol Metab 84:3642-3647, 1999.
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , pp. 3642-3647
    • Zhang, G.Y.1    Gu, Y.Q.2    Wang, X.H.3    Cui, Y.G.4    Bremner, W.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.