Addition of hydrogen bond donating excipients to oil solution: Effect on in vitro drug release rate and viscosity

European Journal of Pharmaceutical Sciences

Volumn 13, Issue 4, 2001, Pages 403-410

  Larsen, Dorrit Bjerg ^a   Fredholt, Karin ^a   Larsen, Claus ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Hydrogen bonding; Modified release; Oil mixtures; Parenteral depots; Partition coefficients; Viscosity

Indexed keywords

CELLS; DIALYSIS; ELECTROLYTES; PH EFFECTS; RATE CONSTANTS; VISCOSITY;

DRUG RELEASE RATE;

HYDROGEN BONDS;

2 OCTANOL; BUFFER; CASTOR OIL; DECANOL; ELECTROLYTE; EXCIPIENT; FLUPENTIXOL DECANOATE; LAURYL ALCOHOL; LIDOCAINE; MYRISTIC ACID ISOPROPYL ESTER; NAPROXEN; OCTANOL; OIL; PHOSPHATE; SESAME SEED OIL; TESTOSTERONE;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION FUNCTION; DRUG RELEASE; HYDROGEN BOND; PARTITION COEFFICIENT; PH; PRIORITY JOURNAL; REGRESSION ANALYSIS; SUSTAINED DRUG RELEASE; VISCOSITY;

ANESTHETICS, LOCAL; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; EXCIPIENTS; HYDROGEN BONDING; LIDOCAINE; NAPROXEN; OILS; SOLUTIONS; VISCOSITY;

EID: 0034963991     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(01)00136-1     Document Type: Article

References (26)

1. Pharmacokinetics of three different injectable zuclopenthixol preparations
2. Influence of solvent on the availability of testosterone propionate from oily, intramuscular injections in the rat
3. Syringeability of nonaqueous parenteral formulations - development and evaluation of a testing apparatus
4. The evaluation of the force to expel oily injection vehicles from syringes
5. Molecular forces governing non-electrolyte permeation through cell membranes
6. 14C-fluphenazine enanthate and decanoate esters administered in sesame oil to dogs
7. Modification of in vitro drug release rate from oily parenteral depots using a formulation approach
8. Phase behaviour of mixtures containing antibiotics. Chloramphenicol partitioning
9. Tissue irritation evaluation of potential parenteral vehicles
10. 14C]testosterone and some of its esters after injection into the rat
11. Mixture experiments with the oil phase of parenteral emulsions
12. The effect of oil components and homogenization conditions on the physicochemical properties and stability of parenteral fat emulsions
13. Prolonged release from the injection site of morphine from morphine esters in an oil vehicle given by intramuscular injection to pigs
14. Phase behaviour of mixtures containing antibiotics. Effect of hydrogen bonding on tetracycline partitioning
15. Partitioning of oxytetracycline between aqueous and organic solvents. Effect of hydrogen bonding
16. Assessment of rate of drug release from oil vehicle using a rotating dialysis cell
17. Lidocaine: a case of intraamide hydrogen bonding
18. The solution conformations of lidocaine analogues
19. QSAR analysis of membrane permeability to organic compounds
20. In vitro testing of injectability
21. Rotating dialysis cell as in vitro release method for oily parenteral depot solutions
22. Low-melting phenytoin prodrugs as alternative oral delivery methods for phenytoin: A model for other high-melting sparingly water-soluble drugs
23. Optimal formulation of an angiogenesis inhibitor, TNP-470, for arterial injection determined by in vitro drug release and stability, and in vivo antitumor activity
24. Determination of rate constants for in vitro three-compartment transfer using a two-phase system