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Volumn 45, Issue 2-3, 2009, Pages 173-184

T helper cytokine patterns: Defined subsets, random expression, and external modulation

Author keywords

Commitment; Cytokines; T cells; Th1; Th2

Indexed keywords

CYTOKINE; DIPHTHERIA VACCINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 21; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 9; LYMPHOTOXIN; TETANUS TOXOID;

EID: 72449188293     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12026-009-8098-5     Document Type: Review
Times cited : (40)

References (60)
  • 1
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • 1:CAS:528:DyaL28XhvVClsbk%3D 2419430
    • TR Mosmann H Cherwinski MW Bond MA Giedlin RL Coffman 1986 Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins J Immunol 136 2348 57 1:CAS:528: DyaL28XhvVClsbk%3D 2419430
    • (1986) J Immunol , vol.136 , pp. 2348-57
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3    Giedlin, M.A.4    Coffman, R.L.5
  • 2
    • 0023622458 scopus 로고
    • Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies
    • 10.1084/jem.166.5.1229 1:CAS:528:DyaL1cXitVaqtbk%3D 2960769
    • HM Cherwinski JH Schumacher KD Brown TR Mosmann 1987 Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies J Exp Med 166 1229 44 10.1084/jem.166.5. 1229 1:CAS:528:DyaL1cXitVaqtbk%3D 2960769
    • (1987) J Exp Med , vol.166 , pp. 1229-44
    • Cherwinski, H.M.1    Schumacher, J.H.2    Brown, K.D.3    Mosmann, T.R.4
  • 3
  • 4
    • 0025807152 scopus 로고
    • Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production
    • 10.1172/JCI115300 1:CAS:528:DyaK3MXkvFSntLs%3D 1829097
    • GF Del Prete M De Carli C Mastromauro R Biagiotti D Macchia P Falagiani M Ricci S Romagnani 1991 Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production J Clin Invest 88 346 50 10.1172/JCI115300 1:CAS:528:DyaK3MXkvFSntLs%3D 1829097
    • (1991) J Clin Invest , vol.88 , pp. 346-50
    • Del Prete, G.F.1    De Carli, M.2    Mastromauro, C.3    Biagiotti, R.4    MacChia, D.5    Falagiani, P.6    Ricci, M.7    Romagnani, S.8
  • 5
    • 0029847368 scopus 로고    scopus 로고
    • Functional diversity of helper T lymphocytes
    • DOI 10.1038/383787a0
    • AK Abbas KM Murphy A Sher 1996 Functional diversity of helper T lymphocytes Nature 383 787 93 10.1038/383787a0 1:CAS:528:DyaK28XmsF2qsLY%3D 8893001 (Pubitemid 26372655)
    • (1996) Nature , vol.383 , Issue.6603 , pp. 787-793
    • Abbas, A.K.1    Murphy, K.M.2    Sher, A.3
  • 6
    • 0036885067 scopus 로고    scopus 로고
    • The lineage decisions of helper T cells
    • DOI 10.1038/nri954
    • KM Murphy SL Reiner 2002 The lineage decisions of helper T cells Nat Rev Immunol 2 933 44 10.1038/nri954 1:CAS:528:DC%2BD38XptFKnu7g%3D 12461566 (Pubitemid 37323214)
    • (2002) Nature Reviews Immunology , vol.2 , Issue.12 , pp. 933-944
    • Murphy, K.M.1    Reiner, S.L.2
  • 7
    • 0038195719 scopus 로고    scopus 로고
    • Molecular mechanisms regulating Th1 immune responses
    • DOI 10.1146/annurev.immunol.21.120601.140942
    • SJ Szabo BM Sullivan SL Peng LH Glimcher 2003 Molecular mechanisms regulating Th1 immune responses Annu Rev Immunol 21 713 58 10.1146/annurev. immunol.21.120601.140942 1:CAS:528:DC%2BD3sXjtF2is7k%3D 12500979 (Pubitemid 37174546)
    • (2003) Annual Review of Immunology , vol.21 , pp. 713-758
    • Szabo, S.J.1    Sullivan, B.M.2    Peng, S.L.3    Glimcher, L.H.4
  • 8
    • 9644262463 scopus 로고    scopus 로고
    • Signaling pathways in Th2 development
    • DOI 10.1111/j.0105-2896.2004.00209.x
    • KA Mowen LH Glimcher 2004 Signaling pathways in Th2 development Immunol Rev 202 203 22 10.1111/j.0105-2896.2004.00209.x 1:CAS:528:DC%2BD2MXhs1Ohtw%3D%3D 15546395 (Pubitemid 39576914)
    • (2004) Immunological Reviews , vol.202 , pp. 203-222
    • Mowen, K.A.1    Glimcher, L.H.2
  • 9
    • 0035062386 scopus 로고    scopus 로고
    • IL-12-induced reversal of human Th2 cells is accompanied by full restoration of IL-12 responsiveness and loss of GATA-3 expression
    • DOI 10.1002/1521-4141(200104)31:4<1055::AID-IMMU1055>3.0.CO;2-7
    • HH Smits JG van Rietschoten CM Hilkens R Sayilir F Stiekema ML Kapsenberg EA Wierenga 2001 IL-12-induced reversal of human Th2 cells is accompanied by full restoration of IL-12 responsiveness and loss of GATA-3 expression Eur J Immunol 31 1055 65 10.1002/1521-4141(200104)31:4<1055::AID-IMMU1055>3.0. CO;2-7 1:CAS:528:DC%2BD3MXivFyjsr4%3D 11298330 (Pubitemid 32331610)
    • (2001) European Journal of Immunology , vol.31 , Issue.4 , pp. 1055-1065
    • Harris, S.G.1    Phipps, R.P.2
  • 10
    • 47549112840 scopus 로고    scopus 로고
    • IL-21 and TGF-beta are required for differentiation of human T(H)17 cells
    • 10.1038/nature07021 1:CAS:528:DC%2BD1cXosFCqs7o%3D 18469800
    • L Yang DE Anderson C Baecher-Allan WD Hastings E Bettelli M Oukka VK Kuchroo DA Hafler 2008 IL-21 and TGF-beta are required for differentiation of human T(H)17 cells Nature 454 350 2 10.1038/nature07021 1:CAS:528: DC%2BD1cXosFCqs7o%3D 18469800
    • (2008) Nature , vol.454 , pp. 350-2
    • Yang, L.1    Anderson, D.E.2    Baecher-Allan, C.3    Hastings, W.D.4    Bettelli, E.5    Oukka, M.6    Kuchroo, V.K.7    Hafler, D.A.8
  • 11
    • 44049104564 scopus 로고    scopus 로고
    • H-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt
    • DOI 10.1038/ni.1610, PII NI.1610
    • N Manel D Unutmaz DR Littman 2008 The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat Nat Immunol 9 641 9 10.1038/ni.1610 1:CAS:528: DC%2BD1cXmtVWqurg%3D 18454151 (Pubitemid 351714729)
    • (2008) Nature Immunology , vol.9 , Issue.6 , pp. 641-649
    • Manel, N.1    Unutmaz, D.2    Littman, D.R.3
  • 12
    • 34548125305 scopus 로고    scopus 로고
    • Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells
    • DOI 10.1038/ni1496, PII NI1496
    • EV Acosta-Rodriguez G Napolitani A Lanzavecchia F Sallusto 2007 Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells Nat Immunol 8 942 9 10.1038/ni1496 1:CAS:528:DC%2BD2sXptlSku7w%3D 17676045 (Pubitemid 47300008)
    • (2007) Nature Immunology , vol.8 , Issue.9 , pp. 942-949
    • Acosta-Rodriguez, E.V.1    Napolitani, G.2    Lanzavecchia, A.3    Sallusto, F.4
  • 13
    • 32244442562 scopus 로고    scopus 로고
    • TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • DOI 10.1016/j.immuni.2006.01.001, PII S1074761306000045
    • M Veldhoen RJ Hocking CJ Atkins RM Locksley B Stockinger 2006 TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells Immunity 24 179 89 10.1016/j.immuni.2006.01.001 1:CAS:528:DC%2BD28XitVOks7s%3D 16473830 (Pubitemid 43214587)
    • (2006) Immunity , vol.24 , Issue.2 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 14
    • 0027959893 scopus 로고
    • Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype
    • 1:CAS:528:DyaK2cXmsFensbY%3D 7930573
    • S Sad TR Mosmann 1994 Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype J Immunol 153 3514 22 1:CAS:528:DyaK2cXmsFensbY%3D 7930573
    • (1994) J Immunol , vol.153 , pp. 3514-22
    • Sad, S.1    Mosmann, T.R.2
  • 15
    • 0032856952 scopus 로고    scopus 로고
    • Primed and replicating but uncommitted T helper precursor cells show kinetics of differentiation and commitment similar to those of naive T helper cells
    • DOI 10.1016/S1286-4579(99)80014-8
    • PS Akai TR Mosmann 1999 Primed and replicating but uncommitted T helper precursor cells show kinetics of differentiation and commitment similar to those of naive T helper cells Microbes Infect 1 51 8 10.1016/S1286-4579(99)80014-8 1:STN:280:DC%2BD3czgtlKktA%3D%3D 10847766 (Pubitemid 29364912)
    • (1999) Microbes and Infection , vol.1 , Issue.1 , pp. 51-58
    • Akai, P.S.1    Mosmann, T.R.2
  • 16
    • 0035886928 scopus 로고    scopus 로고
    • In vivo priming of CD4 T cells that produce interleukin (IL)-2 but not IL-4 or interferon (IFN)-γ, and can subsequently differentiate into IL-4- or IFN-γ-secreting cells
    • DOI 10.1084/jem.194.8.1069
    • X Wang T Mosmann 2001 In vivo priming of CD4 T cells that produce interleukin (IL)-2 but not IL-4 or interferon (IFN)-gamma, and can subsequently differentiate into IL-4- or IFN-gamma-secreting cells J Exp Med 194 1069 80 10.1084/jem.194.8.1069 1:CAS:528:DC%2BD3MXnslGju7c%3D 11602637 (Pubitemid 32995778)
    • (2001) Journal of Experimental Medicine , vol.194 , Issue.8 , pp. 1069-1080
    • Wang, X.1    Mosmann, T.2
  • 17
    • 0033554726 scopus 로고    scopus 로고
    • Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
    • DOI 10.1038/44385
    • F Sallusto D Lenig R Forster M Lipp A Lanzavecchia 1999 Two subsets of memory T lymphocytes with distinct homing potentials and effector functions Nature 401 708 12 10.1038/44385 1:CAS:528:DyaK1MXntVWntrw%3D 10537110 (Pubitemid 29485217)
    • (1999) Nature , vol.401 , Issue.6754 , pp. 708-712
    • Sallusto, F.1    Lenig, D.2    Forster, R.3    Lipp, M.4    Lanzavecchia, A.5
  • 19
  • 20
    • 7044254507 scopus 로고    scopus 로고
    • Central memory T cells mediate long-term immunity to Leishmania major in the absence of persistent parasites
    • DOI 10.1038/nm1108
    • C Zaph J Uzonna SM Beverley P Scott 2004 Central memory T cells mediate long-term immunity to Leishmania major in the absence of persistent parasites Nat Med 10 1104 10 10.1038/nm1108 1:CAS:528:DC%2BD2cXnvFyntb0%3D 15448686 (Pubitemid 39424872)
    • (2004) Nature Medicine , vol.10 , Issue.10 , pp. 1104-1110
    • Zaph, C.1    Uzonna, J.2    Beverley, S.M.3    Scott, P.4
  • 21
    • 0035905477 scopus 로고    scopus 로고
    • + T cells
    • DOI 10.1084/jem.194.12.1711
    • J Geginat F Sallusto A Lanzavecchia 2001 Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4(+) T cells J Exp Med 194 1711 9 10.1084/jem.194.12.1711 1:CAS:528:DC%2BD38Xpt1Wm 11748273 (Pubitemid 34028651)
    • (2001) Journal of Experimental Medicine , vol.194 , Issue.12 , pp. 1711-1719
    • Geginat, J.1    Sallusto, F.2    Lanzavecchia, A.3
  • 22
    • 0035854521 scopus 로고    scopus 로고
    • Arrested differentiation, the self-renewing memory lymphocyte, vaccination
    • DOI 10.1126/science.1062589
    • DT Fearon P Manders SD Wagner 2001 Arrested differentiation, the self-renewing memory lymphocyte, and vaccination Science 293 248 50 10.1126/science.1062589 1:CAS:528:DC%2BD3MXlt1yisL8%3D 11452114 (Pubitemid 32694731)
    • (2001) Science , vol.293 , Issue.5528 , pp. 248-250
    • Fearon, D.T.1    Manders, P.2    Wagner, S.D.3
  • 23
    • 31144457737 scopus 로고    scopus 로고
    • Protein vaccines induce uncommitted IL-2-secreting human and mouse CD4 T cells, whereas infections induce more IFN-gamma-secreting cells
    • 1:CAS:528:DC%2BD28XlsFyhug%3D%3D 16424174
    • AA Divekar DM Zaiss FE Lee D Liu DJ Topham AJ Sijts TR Mosmann 2006 Protein vaccines induce uncommitted IL-2-secreting human and mouse CD4 T cells, whereas infections induce more IFN-gamma-secreting cells J Immunol 176 1465 73 1:CAS:528:DC%2BD28XlsFyhug%3D%3D 16424174
    • (2006) J Immunol , vol.176 , pp. 1465-73
    • Divekar, A.A.1    Zaiss, D.M.2    Lee, F.E.3    Liu, D.4    Topham, D.J.5    Sijts, A.J.6    Mosmann, T.R.7
  • 24
    • 3242733265 scopus 로고    scopus 로고
    • Synthesis of several chemokines but few cytokines by primed uncommitted precursor CD4 T cells suggests that these cells recruit other immune cells without exerting direct effector functions
    • DOI 10.1002/eji.200424939
    • L Yang T Mosmann 2004 Synthesis of several chemokines but few cytokines by primed uncommitted precursor CD4 T cells suggests that these cells recruit other immune cells without exerting direct effector functions Eur J Immunol 34 1617 26 10.1002/eji.200424939 1:CAS:528:DC%2BD2cXltFKru78%3D 15162431 (Pubitemid 39256043)
    • (2004) European Journal of Immunology , vol.34 , Issue.6 , pp. 1617-1626
    • Yang, L.1    Mosmann, T.2
  • 25
    • 27744484754 scopus 로고    scopus 로고
    • CD73 and Ly-6A/E distinguish in vivo primed but uncommitted mouse CD4 T cells from type 1 or type 2 effector cells
    • 1:CAS:528:DC%2BD2MXhtF2jurvM 16272299
    • L Yang JJ Kobie TR Mosmann 2005 CD73 and Ly-6A/E distinguish in vivo primed but uncommitted mouse CD4 T cells from type 1 or type 2 effector cells J Immunol 175 6458 64 1:CAS:528:DC%2BD2MXhtF2jurvM 16272299
    • (2005) J Immunol , vol.175 , pp. 6458-64
    • Yang, L.1    Kobie, J.J.2    Mosmann, T.R.3
  • 26
    • 33750832563 scopus 로고    scopus 로고
    • T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5′-adenosine monophosphate to adenosine
    • 1:CAS:528:DC%2BD28XhtFGrtrzO 17082591
    • JJ Kobie PR Shah L Yang JA Rebhahn DJ Fowell TR Mosmann 2006 T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5′-adenosine monophosphate to adenosine J Immunol 177 6780 6 1:CAS:528:DC%2BD28XhtFGrtrzO 17082591
    • (2006) J Immunol , vol.177 , pp. 6780-6
    • Kobie, J.J.1    Shah, P.R.2    Yang, L.3    Rebhahn, J.A.4    Fowell, D.J.5    Mosmann, T.R.6
  • 27
    • 0027937374 scopus 로고
    • Heterogeneity of single cell cytokine gene expression in clonal T cell populations
    • 10.1084/jem.180.4.1251 1:CAS:528:DyaK2cXlslOnsLc%3D 7523568
    • RP Bucy A Panoskaltsis-Mortari GQ Huang J Li L Karr M Ross JH Russell KM Murphy CT Weaver 1994 Heterogeneity of single cell cytokine gene expression in clonal T cell populations J Exp Med 180 1251 62 10.1084/jem.180.4.1251 1:CAS:528:DyaK2cXlslOnsLc%3D 7523568
    • (1994) J Exp Med , vol.180 , pp. 1251-62
    • Bucy, R.P.1    Panoskaltsis-Mortari, A.2    Huang, G.Q.3    Li, J.4    Karr, L.5    Ross, M.6    Russell, J.H.7    Murphy, K.M.8    Weaver, C.T.9
  • 28
    • 0029160098 scopus 로고
    • Single cell analysis of cytokine gene coexpression during CD4+ T-cell phenotype development
    • 10.1073/pnas.92.16.7565 1:CAS:528:DyaK2MXntlKlsrc%3D 7638231
    • RP Bucy L Karr GQ Huang J Li D Carter K Honjo JA Lemons KM Murphy CT Weaver 1995 Single cell analysis of cytokine gene coexpression during CD4+ T-cell phenotype development Proc Natl Acad Sci USA 92 7565 9 10.1073/pnas.92.16.7565 1:CAS:528:DyaK2MXntlKlsrc%3D 7638231
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 7565-9
    • Bucy, R.P.1    Karr, L.2    Huang, G.Q.3    Li, J.4    Carter, D.5    Honjo, K.6    Lemons, J.A.7    Murphy, K.M.8    Weaver, C.T.9
  • 29
    • 0032900121 scopus 로고    scopus 로고
    • Single-cell analysis by RT-PCR reveals differential expression of multiple type 1 and 2 cytokine genes among cells within polarized CD4+ T cell populations
    • 10.1093/intimm/11.4.617 1:CAS:528:DyaK1MXivVeksbk%3D 10323215
    • A Kelso P Groves L Ramm AG Doyle 1999 Single-cell analysis by RT-PCR reveals differential expression of multiple type 1 and 2 cytokine genes among cells within polarized CD4+ T cell populations Int Immunol 11 617 21 10.1093/intimm/11.4.617 1:CAS:528:DyaK1MXivVeksbk%3D 10323215
    • (1999) Int Immunol , vol.11 , pp. 617-21
    • Kelso, A.1    Groves, P.2    Ramm, L.3    Doyle, A.G.4
  • 30
    • 0028267766 scopus 로고
    • Flow cytometric determination of cytokines in activated murine T helper lymphocytes: Expression of interleukin-10 in interferon-gamma and in interleukin-4-expressing cells
    • 10.1002/eji.1830240513 1:CAS:528:DyaK2cXktVKqtb4%3D 7910138
    • M Assenmacher J Schmitz A Radbruch 1994 Flow cytometric determination of cytokines in activated murine T helper lymphocytes: expression of interleukin-10 in interferon-gamma and in interleukin-4-expressing cells Eur J Immunol 24 1097 101 10.1002/eji.1830240513 1:CAS:528:DyaK2cXktVKqtb4%3D 7910138
    • (1994) Eur J Immunol , vol.24 , pp. 1097-101
    • Assenmacher, M.1    Schmitz, J.2    Radbruch, A.3
  • 31
    • 0034651907 scopus 로고    scopus 로고
    • Single-cytokine-producing CD4 memory cells predominate in type 1 and type 2 immunity
    • 1:CAS:528:DC%2BD3cXhtlymtL8%3D 10657635
    • AY Karulin MD Hesse M Tary-Lehmann PV Lehmann 2000 Single-cytokine- producing CD4 memory cells predominate in type 1 and type 2 immunity J Immunol 164 1862 72 1:CAS:528:DC%2BD3cXhtlymtL8%3D 10657635
    • (2000) J Immunol , vol.164 , pp. 1862-72
    • Karulin, A.Y.1    Hesse, M.D.2    Tary-Lehmann, M.3    Lehmann, P.V.4
  • 32
    • 0029131491 scopus 로고
    • Interleukin-4 and interleukin-5 are rarely co-expressed by human T cells
    • 10.1002/eji.1830250843 1:CAS:528:DyaK2MXns1KqtLc%3D 7664804
    • T Jung U Schauer C Rieger K Wagner K Einsle C Neumann C Heusser 1995 Interleukin-4 and interleukin-5 are rarely co-expressed by human T cells Eur J Immunol 25 2413 6 10.1002/eji.1830250843 1:CAS:528:DyaK2MXns1KqtLc%3D 7664804
    • (1995) Eur J Immunol , vol.25 , pp. 2413-6
    • Jung, T.1    Schauer, U.2    Rieger, C.3    Wagner, K.4    Einsle, K.5    Neumann, C.6    Heusser, C.7
  • 33
    • 0029057855 scopus 로고
    • Evidence for the stochastic acquisition of cytokine profile by CD4+ T cells activated in a T helper type 2-like response in vivo
    • 10.1002/eji.1830250506 1:CAS:528:DyaK2MXmtV2ht70%3D 7774620
    • A Kelso P Groves AB Troutt K Francis 1995 Evidence for the stochastic acquisition of cytokine profile by CD4+ T cells activated in a T helper type 2-like response in vivo Eur J Immunol 25 1168 75 10.1002/eji.1830250506 1:CAS:528:DyaK2MXmtV2ht70%3D 7774620
    • (1995) Eur J Immunol , vol.25 , pp. 1168-75
    • Kelso, A.1    Groves, P.2    Troutt, A.B.3    Francis, K.4
  • 37
    • 25144438916 scopus 로고    scopus 로고
    • The balance between influenza- and RSV-specific CD4 T cells secreting IL-10 or IFNγ in young and healthy-elderly subjects
    • DOI 10.1016/j.mad.2005.06.011, PII S0047637405001521
    • FE Lee EE Walsh AR Falsey N Liu D Liu A Divekar JE Snyder-Cappione TR Mosmann 2005 The balance between influenza- and RSV-specific CD4 T cells secreting IL-10 or IFNgamma in young and healthy-elderly subjects Mech Ageing Dev 126 1223 9 10.1016/j.mad.2005.06.011 1:CAS:528:DC%2BD2MXhtVKjs7jL 16098562 (Pubitemid 41356524)
    • (2005) Mechanisms of Ageing and Development , vol.126 , Issue.11 , pp. 1223-1229
    • Lee, F.E.-H.1    Walsh, E.E.2    Falsey, A.R.3    Liu, N.4    Liu, D.5    Divekar, A.6    Snyder-Cappione, J.E.7    Mosmann, T.R.8
  • 39
    • 33947685007 scopus 로고    scopus 로고
    • Collagen distribution and expression of collagen-binding alpha1beta1 (VLA-1) and alpha2beta1 (VLA-2) integrins on CD4 and CD8 T cells during influenza infection
    • 1:CAS:528:DC%2BD2sXjt1Wks7w%3D 17372009
    • M Richter SJ Ray TJ Chapman SJ Austin J Rebhahn TR Mosmann H Gardner V Kotelianski AR de Fougerolles DJ Topham 2007 Collagen distribution and expression of collagen-binding alpha1beta1 (VLA-1) and alpha2beta1 (VLA-2) integrins on CD4 and CD8 T cells during influenza infection J Immunol 178 4506 16 1:CAS:528:DC%2BD2sXjt1Wks7w%3D 17372009
    • (2007) J Immunol , vol.178 , pp. 4506-16
    • Richter, M.1    Ray, S.J.2    Chapman, T.J.3    Austin, S.J.4    Rebhahn, J.5    Mosmann, T.R.6    Gardner, H.7    Kotelianski, V.8    De Fougerolles, A.R.9    Topham, D.J.10
  • 40
    • 0028960201 scopus 로고
    • Analysis and sorting of live cells according to secreted molecules, relocated to a cell-surface affinity matrix
    • 10.1073/pnas.92.6.1921 1:CAS:528:DyaK2MXksVCqs74%3D 7892200
    • R Manz M Assenmacher E Pfluger S Miltenyi A Radbruch 1995 Analysis and sorting of live cells according to secreted molecules, relocated to a cell-surface affinity matrix Proc Natl Acad Sci USA 92 1921 5 10.1073/pnas.92.6.1921 1:CAS:528:DyaK2MXksVCqs74%3D 7892200
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 1921-5
    • Manz, R.1    Assenmacher, M.2    Pfluger, E.3    Miltenyi, S.4    Radbruch, A.5
  • 41
    • 34347232370 scopus 로고    scopus 로고
    • Intracellular cytokine optimization and standard operating procedure
    • 10.1038/nprot.2006.268 1:CAS:528:DC%2BD28Xht1eitL%2FP 17406442
    • L Lamoreaux M Roederer R Koup 2006 Intracellular cytokine optimization and standard operating procedure Nat Protoc 1 1507 16 10.1038/nprot.2006.268 1:CAS:528:DC%2BD28Xht1eitL%2FP 17406442
    • (2006) Nat Protoc , vol.1 , pp. 1507-16
    • Lamoreaux, L.1    Roederer, M.2    Koup, R.3
  • 42
    • 1242306183 scopus 로고    scopus 로고
    • CD28 costimulation enhances the sensitivity of the ELISPOT assay for detection of antigen-specific memory effector CD4 and CD8 cell populations in human diseases
    • DOI 10.1016/j.jim.2003.12.007
    • PA Ott BR Berner BA Herzog R Guerkov NL Yonkers I Durinovic-Bello M Tary-Lehmann PV Lehmann DD Anthony 2004 CD28 co-stimulation enhances the sensitivity of the ELISPOT assay for detection of antigen-specific memory effector CD4 and CD8 cell populations in human diseases J Immunol Methods 285 223 35 10.1016/j.jim.2003.12.007 1:CAS:528:DC%2BD2cXht1yks74%3D 14980436 (Pubitemid 38224564)
    • (2004) Journal of Immunological Methods , vol.285 , Issue.2 , pp. 223-235
    • Ott, P.A.1    Berner, B.R.2    Herzog, B.A.3    Guerkov, R.4    Yonkers, N.L.5    Durinovic-Bello, I.6    Tary-Lehmann, M.7    Lehmann, P.V.8    Anthony, D.D.9
  • 43
    • 0036887588 scopus 로고    scopus 로고
    • Enhanced ELISPOT detection of antigen-specific T cell responses from cryopreserved specimens with addition of both IL-7 and IL-15-the Amplispot assay
    • 1:CAS:528:DC%2BD38XnvVOnsL0%3D 12379342
    • W Jennes L Kestens DF Nixon BL Shacklett 2002 Enhanced ELISPOT detection of antigen-specific T cell responses from cryopreserved specimens with addition of both IL-7 and IL-15-the Amplispot assay J Immunol Methods 270 99 108 1:CAS:528:DC%2BD38XnvVOnsL0%3D 12379342
    • (2002) J Immunol Methods , vol.270 , pp. 99-108
    • Jennes, W.1    Kestens, L.2    Nixon, D.F.3    Shacklett, B.L.4
  • 44
    • 21244465847 scopus 로고    scopus 로고
    • Simultaneous Th1-type cytokine expression is a signature of peritoneal CD4+ lymphocytes responding to infection with Listeria monocytogenes
    • 1:CAS:528:DC%2BD2MXltlymsr4%3D 15972673
    • MM Freeman HK Ziegler 2005 Simultaneous Th1-type cytokine expression is a signature of peritoneal CD4+ lymphocytes responding to infection with Listeria monocytogenes J Immunol 175 394 403 1:CAS:528:DC%2BD2MXltlymsr4%3D 15972673
    • (2005) J Immunol , vol.175 , pp. 394-403
    • Freeman, M.M.1    Ziegler, H.K.2
  • 45
    • 0030846262 scopus 로고    scopus 로고
    • + T cells
    • DOI 10.1084/jem.186.5.757
    • Y Itoh RN Germain 1997 Single cell analysis reveals regulated hierarchical T cell antigen receptor signaling thresholds and intraclonal heterogeneity for individual cytokine responses of CD4+ T cells J Exp Med 186 757 66 10.1084/jem.186.5.757 1:CAS:528:DyaK2sXlvVeitL0%3D 9271591 (Pubitemid 27381540)
    • (1997) Journal of Experimental Medicine , vol.186 , Issue.5 , pp. 757-766
    • Itoh, Y.1    Germain, R.N.2
  • 46
    • 56349154943 scopus 로고    scopus 로고
    • Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
    • 10.1038/ni.1659
    • M Veldhoen C Uyttenhove J van Snick H Helmby A Westendorf J Buer B Martin C Wilhelm B Stockinger 2008 Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset Nat Immunol 19 12 1341 1346 10.1038/ni.1659
    • (2008) Nat Immunol , vol.19 , Issue.12 , pp. 1341-1346
    • Veldhoen, M.1    Uyttenhove, C.2    Van Snick, J.3    Helmby, H.4    Westendorf, A.5    Buer, J.6    Martin, B.7    Wilhelm, C.8    Stockinger, B.9
  • 47
    • 0024408824 scopus 로고
    • Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
    • DOI 10.1084/jem.170.6.2081
    • DF Fiorentino MW Bond TR Mosmann 1989 Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones J Exp Med 170 2081 95 10.1084/jem.170.6.2081 1:CAS:528:DyaK3cXhtFKqtL0%3D 2531194 (Pubitemid 20010086)
    • (1989) Journal of Experimental Medicine , vol.170 , Issue.6 , pp. 2081-20095
    • Fiorentino, D.F.1    Bond, M.W.2    Mosmann, T.R.3
  • 48
    • 29244483404 scopus 로고    scopus 로고
    • IL-2 absorption affects IFN-γ and IL-5, but not IL-4 producing memory T cells in double color cytokine ELISPOT assays
    • DOI 10.1016/j.cellimm.2005.09.002, PII S000887490500198X
    • S Quast W Zhang C Shive D Kovalovski PA Ott BA Herzog BO Boehm M Tary-Lehmann AY Karulin PV Lehmann 2005 IL-2 absorption affects IFN-gamma and IL-5, but not IL-4 producing memory T cells in double color cytokine ELISPOT assays Cell Immunol 237 28 36 10.1016/j.cellimm.2005.09.002 1:CAS:528: DC%2BD2MXhtlGisbvM 16256965 (Pubitemid 41821079)
    • (2005) Cellular Immunology , vol.237 , Issue.1 , pp. 28-36
    • Quast, S.1    Zhang, W.2    Shive, C.3    Kovalovski, D.4    Ott, P.A.5    Herzog, B.A.6    Boehm, B.O.7    Tary-Lehmann, M.8    Karulin, A.Y.9    Lehmann, P.V.10
  • 49
    • 0025763807 scopus 로고
    • IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells
    • 1:CAS:528:DyaK3MXltleksLg%3D 1827484
    • DF Fiorentino A Zlotnik P Vieira TR Mosmann M Howard KW Moore A O'Garra 1991 IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells J Immunol 146 3444 51 1:CAS:528:DyaK3MXltleksLg%3D 1827484
    • (1991) J Immunol , vol.146 , pp. 3444-51
    • Fiorentino, D.F.1    Zlotnik, A.2    Vieira, P.3    Mosmann, T.R.4    Howard, M.5    Moore, K.W.6    O'Garra, A.7
  • 50
    • 33845713725 scopus 로고    scopus 로고
    • H2 cytokine enhancing resistance to nematodes
    • DOI 10.1126/science.1133715
    • DM Zaiss L Yang PR Shah JJ Kobie JF Urban TR Mosmann 2006 Amphiregulin, a TH2 cytokine enhancing resistance to nematodes Science 314 1746 10.1126/science.1133715 1:CAS:528:DC%2BD28XhtlSqtLnE 17170297 (Pubitemid 44969079)
    • (2006) Science , vol.314 , Issue.5806 , pp. 1746
    • Zaiss, D.M.1    Yang, L.2    Shah, P.R.3    Kobie, J.J.4    Urban, J.F.5    Mosmann, T.R.6
  • 51
    • 20444502955 scopus 로고    scopus 로고
    • PU.1 expression delineates heterogeneity in primary Th2 cells
    • DOI 10.1016/j.immuni.2005.03.016, PII S107476130500138X
    • HC Chang S Zhang VT Thieu RB Slee HA Bruns RN Laribee MJ Klemsz MH Kaplan 2005 PU.1 expression delineates heterogeneity in primary Th2 cells Immunity 22 693 703 10.1016/j.immuni.2005.03.016 1:CAS:528:DC%2BD2MXmtVartbY%3D 15963784 (Pubitemid 40814500)
    • (2005) Immunity , vol.22 , Issue.6 , pp. 693-703
    • Chang, H.-C.1    Zhang, S.2    Thieu, V.T.3    Slee, R.B.4    Bruns, H.A.5    Laribee, R.N.6    Klemsz, M.J.7    Kaplan, M.H.8
  • 53
    • 0027336689 scopus 로고
    • Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages
    • 10.1126/science.8097338 1:CAS:528:DyaK3sXitlajsLg%3D 8097338 see comments
    • CS Hsieh SE Macatonia CS Tripp SF Wolf A O'Garra KM Murphy 1993 Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages Science 260 547 9 10.1126/science.8097338 1:CAS:528: DyaK3sXitlajsLg%3D 8097338 see comments
    • (1993) Science , vol.260 , pp. 547-9
    • Hsieh, C.S.1    MacAtonia, S.E.2    Tripp, C.S.3    Wolf, S.F.4    O'Garra, A.5    Murphy, K.M.6
  • 54
    • 0026507228 scopus 로고
    • Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones
    • 1:CAS:528:DyaK38XisFekt7o%3D 1532000
    • E Maggi P Parronchi R Manetti C Simonelli MP Piccinni FS Rugiu M De Carli M Ricci S Romagnani 1992 Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones J Immunol 148 2142 7 1:CAS:528:DyaK38XisFekt7o%3D 1532000
    • (1992) J Immunol , vol.148 , pp. 2142-7
    • Maggi, E.1    Parronchi, P.2    Manetti, R.3    Simonelli, C.4    Piccinni, M.P.5    Rugiu, F.S.6    De Carli, M.7    Ricci, M.8    Romagnani, S.9
  • 55
    • 0025951644 scopus 로고
    • Transforming growth factor-beta and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype
    • 1:CAS:528:DyaK38XltVWn 1680924
    • SL Swain G Huston S Tonkonogy A Weinberg 1991 Transforming growth factor-beta and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype J Immunol 147 2991 3000 1:CAS:528:DyaK38XltVWn 1680924
    • (1991) J Immunol , vol.147 , pp. 2991-3000
    • Swain, S.L.1    Huston, G.2    Tonkonogy, S.3    Weinberg, A.4
  • 56
    • 0027409793 scopus 로고
    • Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells
    • 10.1084/jem.177.4.1199 1:CAS:528:DyaK3sXhsVGkt7o%3D 8096238
    • R Manetti P Parronchi MG Giudizi MP Piccinni E Maggi G Trinchieri S Romagnani 1993 Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells J Exp Med 177 1199 204 10.1084/jem.177.4.1199 1:CAS:528:DyaK3sXhsVGkt7o%3D 8096238
    • (1993) J Exp Med , vol.177 , pp. 1199-204
    • Manetti, R.1    Parronchi, P.2    Giudizi, M.G.3    Piccinni, M.P.4    Maggi, E.5    Trinchieri, G.6    Romagnani, S.7
  • 57
    • 0023782871 scopus 로고
    • Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones
    • 1:CAS:528:DyaL1cXkvFWjsr8%3D 2969394
    • X Paliard R l Malefijt H Yssel D Blanchard I Chretien J Abrams J de Vries H Spits 1988 Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones J Immunol 141 849 55 1:CAS:528: DyaL1cXkvFWjsr8%3D 2969394
    • (1988) J Immunol , vol.141 , pp. 849-55
    • Paliard, X.1    Malefijt R, L.2    Yssel, H.3    Blanchard, D.4    Chretien, I.5    Abrams, J.6    De Vries, J.7    Spits, H.8
  • 58
    • 0032103969 scopus 로고    scopus 로고
    • Generation, persistence, and modulation of Th0 effector cells: Role of autocrine IL-4 and IFN-gamma
    • 1:CAS:528:DyaK1cXjt1GntL8%3D 9605125
    • KT Miner M Croft 1998 Generation, persistence, and modulation of Th0 effector cells: role of autocrine IL-4 and IFN-gamma J Immunol 160 5280 7 1:CAS:528:DyaK1cXjt1GntL8%3D 9605125
    • (1998) J Immunol , vol.160 , pp. 5280-7
    • Miner, K.T.1    Croft, M.2
  • 59
    • 0030704726 scopus 로고    scopus 로고
    • + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
    • DOI 10.1038/39614
    • H Groux A O'Garra M Bigler M Rouleau S Antonenko JE de Vries MG Roncarolo 1997 A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis Nature 389 737 42 10.1038/39614 1:CAS:528:DyaK2sXmvVSgtb0%3D 9338786 (Pubitemid 27458961)
    • (1997) Nature , vol.389 , Issue.6652 , pp. 737-742
    • Groux, H.1    O'Garra, A.2    Bigler, M.3    Rouleau, M.4    Antonenko, S.5    De Vries, J.E.6    Roncarolo, M.G.7
  • 60
    • 34447503805 scopus 로고    scopus 로고
    • H17 and regulatory T cell differentiation mediated by retinoic acid
    • DOI 10.1126/science.1145697
    • D Mucida Y Park G Kim O Turovskaya I Scott M Kronenberg H Cheroutre 2007 Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid Science 317 256 60 10.1126/science.1145697 1:CAS:528:DC%2BD2sXnsFaqt78%3D 17569825 (Pubitemid 47076203)
    • (2007) Science , vol.317 , Issue.5835 , pp. 256-260
    • Mucida, D.1    Park, Y.2    Kim, G.3    Turovskaya, O.4    Scott, I.5    Kronenberg, M.6    Cheroutre, H.7


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