In vivo priming of CD4 T cells that produce interleukin (IL)-2 but not IL-4 or interferon (IFN)-γ, and can subsequently differentiate into IL-4- or IFN-γ-secreting cells

Journal of Experimental Medicine

Volumn 194, Issue 8, 2001, Pages 1069-1080

  Wang, X ^a   Mosmann, T ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Cell differentiation; Cytokine; Immunization; Mice; T lymphocyte subsets

Indexed keywords

ADJUVANT; GAMMA INTERFERON; GAMMA INTERFERON ANTIBODY; INTERLEUKIN 2; INTERLEUKIN 4; T LYMPHOCYTE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; IMMUNE RESPONSE; MOLECULAR CLONING; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGENS; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEMOCYANIN; IMMUNIZATION; INTERFERON TYPE II; INTERLEUKIN-2; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL; SPLEEN; TH1 CELLS; TIME FACTORS;

EID: 0035886928     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.194.8.1069     Document Type: Article

References (36)

1. Distinct regulation of lymphokine production is found in fresh versus in vitro primed murine helper T cells
2. Heterogeneity of mouse helper T cells. Evidence from bulk cultures and limiting dilution cloning for precursors of Th1 and Th2 cells
3. Differentiation of T cell lymphokine gene expression: The in vitro acquisition of T cell memory
4. + T-cell phenotype development
5. The expanding universe of T-cell subsets: Th1, Th2 and more
6. Regulation of immunity to parasites by T cells and T cell-derived cytokines
7. Cytokine regulation of host defense against parasitic gastrointestinal nematodes: Lessons from studies with rodent models
8. Flow cytometric determination of cytokines in activated murine T helper lymphocytes: Expression of interleukin-10 in interferon-γ and in interleukin-4-expressing cells
9. Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T-cells by flow-cytometry
10. + T cell subset
11. + T cell populations
12. Single-cytokine-producing CD4 memory cells predominate in type 1 and type 2 immunity
13. + T cell clones
14. Profiles of lymphokine activities and helper function for IgE in human T cell clones
15. + T cell subset with an unrestricted cytokine profile
16. Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
17. + T cell subset inhibits antigen-specific T-cell responses and prevents colitis
18. Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype
19. Primed and replicating but uncommitted T helper precursor cells show kinetics of differentiation and commitment similar to those of naive T helper cells
20. + T cells producing IL-2 or IL-4
21. Migration and function of antigen-primed nonpolarized T lymphocytes in vivo
22. The cytokines I1-I4, IFN-γ and I1-12 regulate the development of subsets of memory effector helper T-cells in- vitro
23. Visualizing the generation of memory CD4 T cells in the whole body
24. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
25. Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1
26. Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies
27. Monoclonal antibodies against murine γ interferon
28. Species-specificity of T cell stimulating activities of IL 2 and BSF-1 (IL 4): Comparison of normal and recombinant, mouse and human IL 2 and BSF-1 (IL 4)
29. + T cell responses: The alternative approaches
30. A new foreign policy: MHC class I molecules monitor the outside world
31. Distinction of virgin and memory T lymphocytes. Stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation
32. + memory T cells from the spleen lack MEL-14, the lymph node homing receptor
33. T cell memory
34. + T cells are hyperreactive to antigenic challenge in vitro
35. Heterogeneity of single cell cytokine gene expression in clonal T cell populations
36. Physiological actions and clinical applications of transforming growth factor-β (TGF-β)