Synthesis and SAR of azalide 3, 6-ketal aromatic derivatives as potent gram-positive and gram-negative antibacterial agents

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 17, 2002, Pages 2431-2434

  Cheng, Hengmiao ^a   Dirlam, John P ^a   Ziegler, Carl B ^a   Lundy, Kristin M ^a   Hayashi, Shigeru F ^a   Kamicker, Barbara J ^a   Dutra, Jason K ^a   Daniel, Kirsten L ^a   Santoro, Sheryl L ^a   George, David M ^a   Bertsche, Camilla D ^a   Sakya, Subas M ^a   Suarez Contreras, Melani ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAL DERIVATIVE; ANTIINFECTIVE AGENT; AROMATIC COMPOUND; MACROLIDE; AZITHROMYCIN; DRUG DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; ANIMAL; DRUG EFFECT; FEMALE; MASTITIS; MICROBIOLOGICAL EXAMINATION; STAPHYLOCOCCUS AUREUS; SYNTHESIS;

NEGIBACTERIA; POSIBACTERIA;

ANIMALS; ANTI-BACTERIAL AGENTS; AZITHROMYCIN; FEMALE; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MASTITIS; MICE; MICROBIAL SENSITIVITY TESTS; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037009281     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00434-1     Document Type: Article

References (11)