Genetic ablation of calcium-independent phospholipase A2γ leads to alterations in hippocampal cardiolipin content and molecular species distribution, mitochondrial degeneration, autophagy, and cognitive dysfunction

Journal of Biological Chemistry

Volumn 284, Issue 51, 2009, Pages 35632-35644

  Mancuso, David J ^a   Kotzbauer, Paul ^a   Wozniak, David F ^a   Sims, Harold F ^a   Jenkins, Christopher M ^a   Guan, Shaoping ^a   Han, Xianlin ^a   Yang, Kui ^a   Sun, Gang ^a   Malik, Ibrahim ^a   Conyers, Sara ^a   Green, Karen G ^a   Schmidt, Robert E ^a   Gross, Richard W ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHAGY; BUOYANT DENSITY; CARDIOLIPINS; CERAMIDES; ETHANOLAMINES; GENETIC ABLATION; GLYCEROPHOSPHOLIPIDS; INCLUSION BODIES; LIPID METABOLISMS; MEMBRANE STRUCTURES; MOLECULAR SPECIES; NEURODEGENERATIVE DISORDERS; PHOSPHATIDYLETHANOLAMINE; PHOSPHOLIPASE A; PROTEOMICS; SDS-PAGE; SHORTER CHAINS; SHOTGUN LIPIDOMICS; UBIQUITIN;

ABLATION; AMIDES; ANTIGENS; BIOCHEMISTRY; CALCIUM; CALCIUM ALLOYS; CENTRIFUGATION; DIFFUSERS (OPTICAL); FLEXIBLE STRUCTURES; METABOLISM; MICROSCOPIC EXAMINATION; MITOCHONDRIA; MOLECULAR BIOLOGY; MOLECULAR STRUCTURE; PHOSPHOLIPIDS; PHYSIOLOGY; PROTEINS;

LAMELLAR STRUCTURES;

CALCIUM INDEPENDENT PHOSPHOLIPASE A2; CALCIUM INDEPENDENT PHOSPHOLIPASE A2 GAMMA; CARDIOLIPIN; CERAMIDE; CHOLINE; ETHANOLAMINE; PHOSPHATIDYLETHANOLAMINE; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CELL INCLUSION; CELL STRUCTURE; CELLULAR DISTRIBUTION; CENTRIFUGATION; COGNITIVE DEFECT; CONTROLLED STUDY; ELECTRON MICROSCOPY; FAT CONTENT; HIPPOCAMPUS; LAMELLAR BODY; LIPID ANALYSIS; LIPID METABOLISM; MITOCHONDRIAL RESPIRATION; MOUSE; NERVE DEGENERATION; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; STRUCTURAL PROTEOMICS;

ANIMALS; AUTOPHAGY; CARDIOLIPINS; COGNITION DISORDERS; HIPPOCAMPUS; LIPID METABOLISM; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; PHOSPHOLIPASES A2, CALCIUM-INDEPENDENT;

MUS;

EID: 72149127390     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.055194     Document Type: Article

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