Leucine reduces the duration of insulin-induced PI 3-kinase activity in rat skeletal muscle

American Journal of Physiology - Endocrinology and Metabolism

Volumn 288, Issue 1 51-1, 2005, Pages

  Baum, Jamie I ^a   O'Connor, Jason C ^a   Seyler, Jennifer E ^a   Anthony, Tracy G ^b   Freund, Gregory G ^a   Layman, Donald K ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b Indiana University School of Medicine Evansville   (United States)

Author keywords

Glucose; Initiation factors; Insulin receptor substrate 1; Phosphatidylinositol 3 kinase

Indexed keywords

GLUCOSE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; LEUCINE; PHOSPHATIDYLINOSITOL 3 KINASE; TARGET OF RAPAMYCIN KINASE;

AMINO ACID METABOLISM; AMINOACYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GASTROCNEMIUS MUSCLE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TRANSPORT; INSULIN METABOLISM; INSULIN SENSITIVITY; MALE; MEMBRANE BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; SKELETAL MUSCLE; TRANSLATION INITIATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BLOOD GLUCOSE; CARRIER PROTEINS; DIETARY CARBOHYDRATES; INSULIN; LEUCINE; MALE; MUSCLE, SKELETAL; PHOSPHOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 11144342783     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00272.2004     Document Type: Article

References (32)

1. Abumrad NN, Jefferson LS, Rannels SR, and Williams PE. Role of insulin in the regulation of leucine kinetics in the conscious dog. J Clin Invest 70: 1031-1041, 1982.
2. Ahlborg G, Felig P, Hagenfeldt L, Hendler R, and Wahren J. Substrate turnover during prolonged exercise in man. J Clin Invest 53: 1080-1090, 1974.
3. Anthony JC, Anthony TG, Kimball SR, and Jefferson LS. Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine. J Nutr 131: 856S-860S, 2001.
4. Anthony JC, Gautsch TA, Kimball SR, Vary TC, and Jefferson LS. Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rat in association with increased eIF4F formation. J Nutr 130: 139-145, 2000.
5. Anthony JC, Yoshizawa, Anthony TG, Vary TC, Jefferson LS, and Kimball SR. Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. J Nutr 130: 2413-2419, 2000.
6. Boden G and Tappy L. Effects of amino acids on glucose disposal. Diabetes 39: 1079-1084, 1990.
7. Buse MG and Reid SS. Leucine. A possible regulator of protein turnover in muscle. J Clin Invest 56: 1250-1261, 1975.
8. Felig P, Marliss E, and Cahill GF. Plasma amino acid levels and insulin secretion in obesity. N Engl J Med 281: 811-816, 1969.
9. Ferrannini E, Bevilacqua S, Lanzone L, Bonadonna R, Brandi L, Oleggini M, Boni C, Buzzigoli G, Ciociaro D, Luzi L, and DeFronzo RA. Metabolic interactions of amino acids and glucose in healthy humans. Diab Nutr Metab 3: 175-186, 1988.
10. Flakholl PJ, Kulaylat M, Frexes-Steed M, Hill JO, and Abumrad NN. Amino acids enhance insulin resistance to exogenous glucose infusion in overnight-fasted humans. J Parenter Enteral Nutr 15: 123-127, 1991.
11. Floyd JC, Fajans SS, Conn JW, Knopf RF, and Rull J. Insulin secretion in response to protein ingestions. J Clin Invest 45: 1479-1486, 1966.
12. Floyd JC, Fajans SS, Conn JW, Knopf RF, and Rull J. Stimulation of insulin secretion by amino acids. J Clin Invest 45: 1487-1502, 1966.
13. Gannon MC, Nuttall JA, and Nuttall FQ. Oral arginine does not stimulate an increase in insulin concentration but delays glucose disposal. Am J Clin Nutr 76: 1016-1022, 2002.
14. Gautsch TA, Anthony JC, Kimball SR, Paul GL, Layman DK, and Jefferson LS. Availability of eIF4E regulates skeletal muscle protein synthesis during recovery from exercise. Am J Physiol Cell Physiol 274: C406-C414, 1998.
15. Krebs M, Krssak M, Bernroider E, Anderwald C, Brehm A, Meyespeer M, Nowotny P, Roth E, Waldhausl W, and Roden M. Mechanism of amino acid-induced skeletal muscle insulin resistance in humans. Diabetes 51: 599-605, 2002.
16. Krezowski PA, Nuttall FQ, Gannon M, and Bartosh NH. The effect of protein ingestion on the metabolic response to oral glucose in normal individuals. Am J Clin Nutr 44: 847-856, 1986.
17. Lawrence JC Jr. mTOR-dependent control of skeletal muscle protein synthesis. Int J Sport Nutr Exerc Metab 11: S177-S185, 2001.
18. Li JB and Jefferson LS. Influence of amino acid availability on protein turnover in perfused skeletal muscle. Biochim Biophys Acta 544: 351-359, 1978.
19. Malaisse WJ. Branched chain amino and keto acids as regulators of insulin and glucagon release. In: Branched Chain Amino and Keto Acids in Health and Disease, edited by Adibi SA, Fekl W, Langenbeck U, and Schauder P. Basel, Switzerland: Karger, 1984, chapt. 9, p. 119-133.
20. Morens C, Gaudichon C, Fromentin G, Marsset-Baglieri A, Bensaid A, Larue-Achagiotis C, Luengo C, and Tome D. Daily delivery of dietary nitrogen to the periphery is stable in rats adapted to increased protein intake. Am J Physiol Endocrinol Metab 281: E826-E836, 2001.
21. Nuttall FQ, Gannon MC, Wald JL, and Ahmed M. Plasma glucose and insulin profiles in normal subjects ingesting diets of varying carbohydrate, fat, and protein content. J Am Coll Nutr 4: 437-450, 1985.
22. O'Connor JC and Freund GG. Vanadate and rapamycin synergistically enhance insulin-stimulated glucose uptake. Metabolism 52: 666-674, 2003.
23. Ohishima K, Shargill NS, Chan TM, and Bray GA. Adrenalectomy reverses insulin resistance in muscle from obese (ob/ob) mice. Am J Physiol Endocrinol Metab 246: E193-E197, 1984.
24. Patti M-E, Brambilla E, Luzi L, Landaker EJ, and Kahn CR. Bidirectional modulation of insulin action by amino acids. J Clin Invest 101: 1519-1529, 1998.
25. Pisters PWT, Restifo NP, Cersosimo E, and Brennan MF. The effects of euglycemic hyperinsulinemia and amino acid infustion on regional and whole body glucose disposal in man. Metabolism 40: 59-65, 1991.
26. Proud CG. Role of mTOR signaling in the control of translation initiation and elongation by nutrients. Curr Top Microbiol Immunol 279: 215-244, 2004.
27. Rossetti L, Rothman DL, DeFronzo RA, and Shulman GI. Effect of dietary protein on in vivo insulin action and liver glycogen repletion. Am J Physiol Endocrinol Metab 257: E212-E219, 1989.
28. Saltiel AR and Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414: 799-806, 2001.
29. Schwenk WF and Haymond MW. Decreased uptake of glucose by human forearm during infusion of leucine, isoleucine, or threonine. Diabetes 36: 199-204, 1987.
30. Takano A, Usui I, Haruta T, Kawahara J, Uno T, Iwata M, and Kobayashi M. Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin. Mol Cell Biol 21: 5050-5062, 2001.
31. Tischler ME, Desautels M, and Goldberg AL. Does leucine, leucyl-tRNA, or some metabolite of leucine regulate protein synthesis in degradation in skeletal and cardiac muscle? J Biol Chem 257: 1613-1621, 1982.
32. Tremblay F and Marette A. Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. J Biol. Chem 276: 38052-38060, 2001.